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OfflineOliverJames
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Registered: 02/28/12
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Replenishing Dopamine vs Serotonin
    #19351501 - 12/31/13 03:09 PM (10 years, 30 days ago)

So maybe I'm just not looking hard enough here, but I can't seem to find any studies that compare the length of time it takes for dopamine to replenish compared to serotonin. From what I've gathered, it takes a much longer period of time for serotonin to replenish when compared to dopamine.

This idea might be skewed though. When one takes a single dose of adderall, its obviously not goin to deplete all of ones dopamine, the drug isn't designed to do that (unless one takes a massive dose?). But, a single dose of mdma does seem to have the potential to deplete most of ones serotonin, although this obviously dose dependent as well I'm assuming?

So what's your guys take on this? I've taken up to 30mg of adderall in a night. Once I come down, I obviously feel pretty terrible, but this feeling pretty much passes once I get some good sleep. I might feel slightly less motivated the next day, but that seems to be the extent of the damage.

I should also mention, one of the main reasons I'm currently thinking about this topic is because I'm kicking around taking a 25mg dose of adderall tonight. I recently went through around 400mg of methylone which obviously depleted a good portion of my dopamine. I'm tempted to take some speed tonight though, probably not a fantastic idea.


Edited by OliverJames (12/31/13 03:12 PM)


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Offlinetradjik
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Registered: 12/31/13
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Re: Replenishing Dopamine vs Serotonin [Re: OliverJames]
    #19351522 - 12/31/13 03:15 PM (10 years, 30 days ago)

When I was 14-15 I would ingest large amounts of dextroamphetamine and for the entire next day and a bit of the day after I was a miserable aching depressed sack of shit.


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InvisibleSophistic Radiance
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Re: Replenishing Dopamine vs Serotonin [Re: OliverJames]
    #19351572 - 12/31/13 03:29 PM (10 years, 30 days ago)

I'm going to go out on a limb here and say that it varies greatly between different individuals, and also that trying to subjectively assess your own neurotransmitter levels would be essentially impossible. Even in laboratories it is nearly impossible to make this kind of determination without killing the subject. The subjective differences caused by different levels of neurotransmitter concentration would also owe as much to the concentration of their receptors, which are switched off or reduced by the use of releasing agents such as amp or MDMA. Receptor concentrations would be even harder to track than transmitter concentrations, but if you want to make predictions about mood and behavior based on neurotransmitter levels you'd need to know that as well.

IME, amphetamines build tolerance very slowly, and even after precipitous spikes in use, are still effective at small doses a couple days later. But that's just me. I have ADHD which supposedly means that my brain doesn't routinely burn through dopamine at the same rate as "normal" individuals and I have no idea what specific implications this has for the way I respond to and build tolerance to that drug. If you want my advice, do what feels right. :shrug:


--------------------
Enlil said:
You really are the worst kind of person.



Edited by Sophistic Radiance (12/31/13 03:41 PM)


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OfflineOliverJames
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Re: Replenishing Dopamine vs Serotonin [Re: Sophistic Radiance]
    #19351586 - 12/31/13 03:33 PM (10 years, 30 days ago)

That makes a lot of sense, thanks for info man. I suffer from ADD as well as a large portion of my family members. Seems like most of either have a attention difficult or crippling anxiety, luckily I experience a bit of both but neither are all that bad. I'm gonna see how I feel later and I'll decide then. I'm sorta craving some speed though, it makes me much more out going which is sorta what I'm looking for tonight.


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Invisiblejack_straw2208
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Re: Replenishing Dopamine vs Serotonin [Re: OliverJames]
    #19351667 - 12/31/13 03:53 PM (10 years, 30 days ago)

didn't the guy who invented ADD say on his deathbed that they made it up just to sell amphetamines?

i think everyone has the tendancy to be nervous and/or have trouble focusing on their shitty school and/or work...

speed should only be used recreationaly IMO.

if you can't focus, the key is to eat better food and get regular, solid sleep. try staying away from stimulants, they just make you more scatterbrained in the long run.


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If you can’t tell what you desperately need, it’s probably sleep.


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InvisibleSophistic Radiance
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Re: Replenishing Dopamine vs Serotonin [Re: jack_straw2208]
    #19351687 - 12/31/13 04:00 PM (10 years, 30 days ago)

That's like saying, "the diagnosis of bacterial infection only exists because antibiotics exist". The effectiveness of antibiotics against bacteria pushed germ theory forward, that doesn't mean antibiotics created the bacteria. You are so full of misinformed shit. :flowstone:


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Enlil said:
You really are the worst kind of person.



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InvisibleDark_Star
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Re: Replenishing Dopamine vs Serotonin [Re: Sophistic Radiance] * 1
    #19351708 - 12/31/13 04:05 PM (10 years, 30 days ago)

n-acetylcysteine has been clinically shown to help balance out dopamine & glutamate levels. If they're too high it lowers them, and will raise them if they're too low. It's been shown effective enough that it's being recommended to recovering addicts, especially ones that abused stimulants, as well as individuals that suffer from a variety of mental disorders. NAC is also an incredibly powerful antioxidant that has a very powerful effect on liver health. It's actually used IV as the primary treatment for patients that present in the ER with acetaminophen overdose.


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Invisiblejack_straw2208
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Re: Replenishing Dopamine vs Serotonin [Re: Dark_Star]
    #19351846 - 12/31/13 04:46 PM (10 years, 30 days ago)

i was just lazy in school. all my teachers told my folks to put me on medication.

they prescribe kindergarteners AMPHETAMINES to treat an imaginary disorder.

99% of the population would be more productive and focused if they started taking amphetamines.

every single one of my friends who were prescribed speeders for school said that it made them feel like zombies. not to mention how many tweakers started off getting their fix from a doctor.

its a racket. doctors get paid to encourage children to become dependent on amphetamines, which end up fucking them up in the long run anyway.


sometimes the kids hearts (and/or minds) give out before they even finish school, before they ever even get the chance to assume their role as another faceless cog in the society that destroyed them.

thank you dark star for hepping us to the n-acetylcysteine!


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If you can’t tell what you desperately need, it’s probably sleep.


Edited by jack_straw2208 (12/31/13 04:50 PM)


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OfflineO_Dweeds
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Registered: 09/27/14
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Re: Replenishing Dopamine vs Serotonin [Re: Sophistic Radiance]
    #26203685 - 09/22/19 09:00 PM (4 years, 4 months ago)

Quote:

Sophistic Radiance said:
That's like saying, "the diagnosis of bacterial infection only exists because antibiotics exist". The effectiveness of antibiotics against bacteria pushed germ theory forward, that doesn't mean antibiotics created the bacteria. You are so full of misinformed shit. :flowstone:




Which are directly obtained from fungi and mold. Mushrooms gave us penicillin, the first antibiotic.


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Oxygen. Water. Neil Young

Our word "planet" comes from the Greek word planetes, meaning "wanderer."

"There ain't no revolution, only evolution, but every time I'm in Georgia I eat a peach for peace."
Gregg Allman


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