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Offlinehidenseek1
Its got all the dinks.
Registered: 12/22/12
Posts: 5,423
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Last seen: 6 years, 11 months
Re: I had a broad spectrum DNA test done, some results surprised me [Re: hidenseek1]
    #19346474 - 12/30/13 02:08 PM (10 years, 1 month ago)

sometimes i think wiccan is incahoots with these companies because whenever he mentions a product, i get an urge to buy it


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You can drink at 7 A.M., because the Beastie Boys fought for that right
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OfflineKingKnowledge
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Registered: 03/30/13
Posts: 2,876
Loc: East Coast
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346479 - 12/30/13 02:09 PM (10 years, 1 month ago)

Quote:

Wiccan_Seeker said:
Quote:

how detailed was the report and did it include any other results/conclusions?




Quite. I'm still discovering all what is there. They covered somethging like 230 medical conditions, 25 critical medication sensitivities, carrier status on 50 disorders, a whole bunch of traits and a shitton of ancestral information. Its very well documented.






How accurate would you say the report was? Like, does it tell you the percentage chances of every prediction actually being correct? Or just broad "you probably have this" statements based on genes?


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Offlinekoods
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Registered: 05/26/11
Posts: 106,406
Loc: Maryland/DC Burbs
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: KingKnowledge]
    #19346487 - 12/30/13 02:11 PM (10 years, 1 month ago)

Quote:

KingKnowledge said:
If anybody else finds a source that would do this, I'd happily pay $100 for it. Even more.


I'm just waiting until personal genome sequencers are readily available.




They sell them at Home Depot - same aisle as the jet packs and cable ready ocular implants.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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OfflineYthanA
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Registered: 08/08/97
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Loc: NY/MA/VT Borderlands Flag
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346493 - 12/30/13 02:12 PM (10 years, 1 month ago)

23andMe is pretty cool. I sent you a gene sharing request! (Heh, that sounds like a pick-up line.)

BTW if anyone is wondering what the reports look like, I posted a screenshot of the health results a while ago (there are other ones for ancestry):


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OfflineKingKnowledge
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Registered: 03/30/13
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Ythan]
    #19346507 - 12/30/13 02:14 PM (10 years, 1 month ago)

Thanks Ythan, you answered my question above.


Psoriasis!!!


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Offlinekoods
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Registered: 05/26/11
Posts: 106,406
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: KingKnowledge]
    #19346555 - 12/30/13 02:23 PM (10 years, 1 month ago)

Glaucoma. Lol. I always thought that was a made up condition for sadistic eye doctors and potheads.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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OfflineJesus Christ
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Registered: 10/11/13
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Ythan]
    #19346608 - 12/30/13 02:34 PM (10 years, 1 month ago)

Duuude you better update your age related macular degeneration asap:rasta:


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InvisibleAsante
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Registered: 02/06/02
Posts: 87,002
Re: I had a broad spectrum DNA test done, some results surprised me [Re: Ythan]
    #19346616 - 12/30/13 02:37 PM (10 years, 1 month ago)

OMG that was you, I though some weird guy took me for a chick bahahaha ^_^

Psoriasis too huh?  Got it active or latent still? For me its latent but I do have skin issues that point to sensitive skin.

Its a bold move to show the overview, not as much for the members here as for the future aggression of insurane companies.

What you omitted to tell is you can click each entry and it opens up a wealth of information on what it implies, how to avoid it, if your doctor can screen for it, a doctor's word on the condition etc.

Its quite awesome and I hope they successfully defeat the FDA.

Now that I know you're with 23andMe too I know I made the right choice!  I accepted your share but will keep my results out of public knowoledge, you may know though :thumbup:


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Omnicyclion.org
higher knowledge starts here


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OfflineGorlax
Male


Registered: 05/06/08
Posts: 6,697
Last seen: 5 days, 10 hours
Re: I had a broad spectrum DNA test done, some results surprised me [Re: Jesus Christ]
    #19346635 - 12/30/13 02:40 PM (10 years, 1 month ago)

I looked into this DNA test and its pretty broad, I've worked with professors in RNA/DNA sequencing and the method used for this is really outdated, only because the new sequencing techniques are really expensive! This still doesn't make it wrong, it's just more of a statistic thing matched up with target genes for certain conditions. You could have the target gene for say "breast cancer" but only 20% of cases with that gene really develop the cancer. So even if you express that gene many other factors still affect the genetic outcome.

good road map tho
I'd never want to see mine..  :facepalm:


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InvisibleAsante
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Gorlax]
    #19346650 - 12/30/13 02:48 PM (10 years, 1 month ago)

Quote:

Gorlax said:

good road map tho
I'd never want to see mine..  :facepalm:




I thought my henes were akin to chernobyl, that they might as well built a concrete sarcophagus around my genome and set out a safety perimeter.

But no, its really not at all as bad as I thought it would be.

They have about a 1.2% fail rate on a marker, but most truly positive conditions have a half to whole dozen markers pointing to it, making it pretty accurate.

What they offer, for the PRICE they offer, is a steal.

But yeah its not carved in stone, odds of getting do not mean certainty of getting. It doesnt matter much whether your odds are 10% or 30% its that they're in the significant range that matters.

I suspect that most people who read this thread now will have done a genome pull within a decade. I think it will become as normal as a general blood test when visiting your doctor for a checkup.


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Omnicyclion.org
higher knowledge starts here


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OfflineGorlax
Male


Registered: 05/06/08
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346659 - 12/30/13 02:52 PM (10 years, 1 month ago)

Yeah they really want to apply it to all medical visits so a doctor can pull up your entire genome but I believe something ethical about having all that information available is preventing it from being invested/implemented.


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Offlinekoods
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Registered: 05/26/11
Posts: 106,406
Loc: Maryland/DC Burbs
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346662 - 12/30/13 02:52 PM (10 years, 1 month ago)

There was a really good story on This American Life about DNA testing when the results are deterministic - in this case, Huntington's disease.

http://www.thisamericanlife.org/radio-archives/episode/509/it-says-so-right-here#

It starts at 16:00 exactly.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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OfflineYthanA
ᕕ( ᐛ )ᕗ
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Registered: 08/08/97
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante] * 1
    #19346765 - 12/30/13 03:18 PM (10 years, 1 month ago)

Yeah, they nailed it with psoriasis. I've had patches on my elbows since I was a little kid and it seemed to get worse in my late 20s. I'm sure that increasing my alcohol intake didn't help either. I hope you can avoid it, it kind of sucks. :frown: Especially when it leads to arthritis later in life.

I'm not too worried about sharing my results because frankly, they seem pretty unremarkable to me. If I had a high risk of developing a debilitating or chronic condition that would be expensive to treat, I would think twice before making that public.

I definitely left a lot out of my post about the site... for one thing, compared to my screenshot they have a lot more results now, and increased confidence with their reports. The detailed information about each result is really interesting and that's not even touching on the genealogy aspect. I just didn't want to make it sound too awesome, since it's not available to new subscribers anymore. :wink:

It pisses me off that the FDA is giving them such a hard time. I'm honestly not surprised though. Even when I sent in my spit kit a couple years ago, I had to mail it from a neighboring state because New York prohibited 23andMe from doing business here. It seems completely asinine to me, and reinforces my libertarian beliefs, but there's not much to do except hope they can work things out with the government. And I guess they didn't handle the whole thing very well, which obviously hasn't helped things.

But yeah I think it's a very cool service and I'm glad you were able to get your results before they closed down the health reporting. My dad got his profile done too and it's fun comparing genotypes and seeing all the shared traits. Makes me feel like I'm living in the future! :cool:


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InvisibleEdibleStereos
Healthy Body, Sick Mind
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Registered: 01/02/13
Posts: 4,899
Loc: South Africa
Re: I had a broad spectrum DNA test done, some results surprised me [Re: Ythan]
    #19346831 - 12/30/13 03:35 PM (10 years, 1 month ago)

Now your DNA is on file so the government can kill you and replace with you with a cloned worker bee version of yourself, and here you are soliciting us to the will of the insect overlords....


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Offlinekoods
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: EdibleStereos]
    #19346883 - 12/30/13 03:45 PM (10 years, 1 month ago)

Quote:

EdibleStereos said:
Now your DNA is on file so the government can kill you and replace with you with a cloned worker bee version of yourself, and here you are soliciting us to the will of the insect overlords....




This entire website is part of the master plan.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,373
Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346926 - 12/30/13 03:55 PM (10 years, 1 month ago)

Quote:

Wiccan_Seeker said:


But yeah its not carved in stone, odds of getting do not mean certainty of getting. It doesnt matter much whether your odds are 10% or 30% its that they're in the significant range that matters.
.




This doesn't matter to you?

You have a company that's marketing a product based on people's fears of disease, yet the predictability of the test (for developing a disease state) is extremely low, and also variable (e.g., 10-30%?)

"YOU HAVE TO TAKE THIS TEST OR YOU'RE DOOMED TO A VARIETY OF THE DISEASES!!"

By the way, based on your results your chances of a disease are 10, maybe 30%. We don't really know, but you should be scared anyway... 

FDA wasn't upset about the tests, per se, rather their accuracy in predicting disease.  The bottom line was that the company couldn't produce the data to support the accuracy of their testing.


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...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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InvisibleAsante
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: badchad]
    #19347540 - 12/30/13 05:36 PM (10 years, 1 month ago)

Badchad thats a very negativistic presentation of events.  23andMe doesnt prey on fears or fearmonger, it has a DNA testing product and that product has a margin of error of about 1.2% per marker.

The test as they offered it would only a few years ago have cost several thousand dollars, ad a decade before it wasnt even possible.  And this for hundreds of conditions and traits, with a small margin of error, for a hundred bucks.

They are clear that they arent 100% predictive and 100% accurate and that their information shouldnt be taken as gospel but what they offer is pretty good and should be seen as a recommendation, not a diagnosis.
You know what you are getting into.

The members only part of the site is very informative and quite the opposite of scare tactics.

I'm a hypochondriac and its had a very calming influence on me.

Sorry to hear about your Psoriasis Ythan.  I have a higher predisposition than you but for me so far its been confined to a tendency to eczema and the fact that I can rub loose impressive amounts of skin on my body when wet.

Yeah the FDA is definitely sucking HARD on this, and its obviously the interests of Big Money they are protecting, and not acting in the best interest of a concerned consumer.


--------------------
Omnicyclion.org
higher knowledge starts here


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OfflineGreySatyr
Pagan-Psyche
Male

Registered: 06/20/13
Posts: 3,376
Loc: North Carolina
Last seen: 9 years, 9 months
Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19347566 - 12/30/13 05:40 PM (10 years, 1 month ago)

Interesting...


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...also, go to hell, huh?


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InvisibleAsante
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: GreySatyr]
    #19347642 - 12/30/13 05:56 PM (10 years, 1 month ago)

On another note, here is a North Dakota White Supremacist leader who gets told he has 14% black African genes :africaface:




--------------------
Omnicyclion.org
higher knowledge starts here


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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,373
Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19347718 - 12/30/13 06:14 PM (10 years, 1 month ago)

I'm not knocking the test.  I'm sure it's pretty accurate at detecting the genes it tests for.  My primary concern is the interpretation of the data reported:

Quote:

Wiccan_Seeker said:
They are clear that they arent 100% predictive and 100% accurate and that their information shouldnt be taken as gospel but what they offer is pretty good and should be seen as a recommendation, not a diagnosis.





^ this is my concern.  Just looking at what Ythan posted (and picking on some of the obvious data points), the report says something like:

"your risk" of melanoma is 2.9% with an "average risk" of 3.3%.  This doesn't seem to even factor in the multitude of behavioral factors involved (e.g. sun bathing).  The same is true of lung cancer, it's obviously heavily influenced by smoking and environmental factors, not necessarily genotype.  In fact, for many diseases, I'd contend that genotype plays a (relatively) minor, perhaps insignificant role.

They also have fields for "intelligence" and "memory", which are utterly ridiculous to assess via genotyping.

Is an increase of prostate cancer from 4% (e.g., from an "average risk" of 17 to "your risk" of 21%) even clinically relevant?  What should someone do with that info?  Should they eat healthier?  get more prostate exams? or just spend years worrying about it? 

They even have a reports on "restless leg syndrome" and ADHD which are based on an entirely behavioral (e.g., non-objective) diagnosis :shrug:.

I agree its a great technology with lots of potential.  But there is a reason some genetic counselors are highly trained.  These data are incredibly difficult to get meaning out of.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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