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InvisibleAsante
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I had a broad spectrum DNA test done, some results surprised me * 2
    #19346165 - 12/30/13 12:48 PM (10 years, 1 month ago)

I had 23 and Me do a full spectrum DNA test of me and got lucky because right after I had my test locked in the FDA banned the company from dispensing medical information, and forced it just to restrict information to ancestry information.

Basically what you do is pay $99 (in Europe €130 due to worldwide express cost) and you'll be sent a tube and a paid for courier express return sleeve. You register the tube, call the courier to schedule a pickup and spit in the tube, package it and give it to the courier guy, then you wait about 1-2 months and presto! your results come in.

Theres a lot of genetic misery in my family, and I was curious and considerably anxious which ones I had picked up, that was my prime reason to do it.  Turns out I dodged the bullet of the worst ones, but theres 6 medical conditions of considerable concern (3 cancers among them) that I'll have to look out for as I have significantly increased odds of contracting them. I found out many things I knew, like I have reduced odds of becoming an alcoholic, when smoking I smoke a LOT, but also that I have considerably increased odds of becoming a heroin addict. Unfortunately I have no immunity to Malaria and AIDS, a real bummer, but my odds of getting Parkinson's or Alsheimers are dramatically less than the average population's, so thats reassuring. If found out that one of my habits, drinking lots of milk, is actually unexpectedly wrong for me as it increases the likelyhood of coming down with an active case of 3 of my dirty half dozen. I also know now that my obesity is NOT due to genetics because my genetics at most would pack +10 lbs to my BMI. This is reassuring as I'm perhaps metabolically but not genetically destined to be obese, which makes the odds to lose weight and keep it off better.

Ancestry!

Turns out I have 0.1% black East African genes :africaface: so that means one of my ancestors was a fullblooded African about 10 generations ago, or at least one with mixed African heritage a shorter while ago. There's also a wee bit Indian/Pakistani genes in me but I am unusually white, 99,8+% West European with 2.4% Neanderthal genes, which is a lot less than most Europeans who have 2,7% neanderthal genes on average. I'm too Sapiens to hang with this crowd :lol:

My father's ancestors were chilling 8,000 BC during the Holocene ice age on the dry land that is now the bottom of the north sea, the lost landmass of Doggerland, which is hilarious cause I was born and raised about 200 miles from there, hold your ground indeed :yesnod: My mother's from a quite rare haplotype that hasnt been pinpointed to a location yet but which likely formed at the crossing over of our ancestors from Africa into the Middle East.

All in all I'm very happy I did that test and beat the FDA in getting the full monty. I got a shitton of medical news that was mostly reassuring and which informed me which things to specifically look out for, and the ancestral news was just a delight to uncover. I know my dad's gonna dig the Doggerland story about his ancestry 10,000 years ago.

All in all, a hundred bucks well spent, my old math teacher said "measuring is knowing" and I'm glad I did.


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OfflineMescalean
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346186 - 12/30/13 12:51 PM (10 years, 1 month ago)

I would want to do it just to know what exactly I am. I know about 75 percent of my lineage the rest is a mystery


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Offlinekoods
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Mescalean]
    #19346203 - 12/30/13 12:56 PM (10 years, 1 month ago)

Do you have the gene that causes you to inhale more deeply when you smoke? I heard Richard Dawkins discussing that one. The implication is a higher chance of getting lung cancer, but it really isn't a cancer gene at all.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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InvisibleInto The Woods
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346215 - 12/30/13 12:58 PM (10 years, 1 month ago)

Wow. That's awesome!

I'd love to have a DNA test done, I wonder how I'd go about it in Australia :strokebeard:

How do they determine your odds of likelihood of becoming an alcoholic/heroin addict?

and neanderthal genes LOL


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OfflineJesus Christ
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346216 - 12/30/13 12:58 PM (10 years, 1 month ago)

this is interesting. how detailed was the report and did it include any other results/conclusions?


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Offlinehidenseek1
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Into The Woods]
    #19346228 - 12/30/13 01:02 PM (10 years, 1 month ago)

shit, how come they arnt aloud to release the medical anymore?


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Offlinekoods
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: hidenseek1]
    #19346235 - 12/30/13 01:04 PM (10 years, 1 month ago)

Quote:

Mescalean said:
I would want to do it just to know what exactly I am. I know about 75 percent of my lineage the rest is a mystery




A lot of people discover that what they thought was their lineage isn't always accurate. Lots of family secrets, and whatnot, I suspect..

Quote:

Jesus Christ said:
this is interesting. how detailed was the report and did it include any other results/conclusions?




Dude! Do it! Let's find out who your REAL dad is!

Quote:

hidenseek1 said:
shit, how come they arnt aloud to release the medical anymore?




Because information that has diagnostic medical value must meet a higher standard.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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Offlinehidenseek1
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: koods]
    #19346238 - 12/30/13 01:05 PM (10 years, 1 month ago)

thats gay a simple disclaimer would do


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Offlinekoods
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: hidenseek1]
    #19346244 - 12/30/13 01:07 PM (10 years, 1 month ago)

You probably still get a list of the genes, but they no longer tell you what they mean. You could probably still look them up.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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Offlinehidenseek1
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: hidenseek1]
    #19346247 - 12/30/13 01:08 PM (10 years, 1 month ago)

i checked the site out, all they do is withhold their interpretation of the data, so im assuming some research you could still figure the health thing out from what they provide

edit: damn beat me to it


--------------------
You can drink at 7 A.M., because the Beastie Boys fought for that right
--------------------------------------------------------------------------
pons asinorum
--------------------------------------------------------------------------
lsd and the vietnam war changed music forever


Edited by hidenseek1 (12/30/13 01:08 PM)


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InvisibleInto The Woods
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: koods] * 1
    #19346254 - 12/30/13 01:09 PM (10 years, 1 month ago)

Quote:

koods said:
Quote:

Jesus Christ said:
this is interesting. how detailed was the report and did it include any other results/conclusions?




Dude! Do it! Let's find out who your REAL dad is!




:rofl:

I fucking love you, koods :lol:

You make me laugh more than anyone else on these boards


Sorry anyone else


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Offlinehidenseek1
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Into The Woods]
    #19346262 - 12/30/13 01:11 PM (10 years, 1 month ago)

i wonder if everyone with neadralthal dna is the same dna, like, could you take everyone's neadralthal dna and have enough dna sequence to create a full neandralthal


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You can drink at 7 A.M., because the Beastie Boys fought for that right
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Invisiblebadchad
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: koods]
    #19346273 - 12/30/13 01:16 PM (10 years, 1 month ago)

Quote:

koods said:

Quote:

hidenseek1 said:
shit, how come they arnt aloud to release the medical anymore?




Because information that has diagnostic medical value must meet a higher standard.




Pretty much this^

The data are incredibly difficult to interpret.  To provide a brief example, many people have heard of the BRCA1 and BRCA2 genes.  These are the "breast cancer" genes, and some of the most widely studied genetic mutations.

However, these genes only account for " about 20 to 25 percent of hereditary breast cancers", and "55 to 65 percent of women who inherit a harmful BRCA1 mutation and around 45 percent of women who inherit a harmful BRCA2 mutation will develop breast cancer by age 70 years".

So basically, if you have the genes, there's about a coin flip chance of getting cancer by 70.  This doesn't really take into account lifestyle factors, interactions with other genes etc.

Essentially, the tests are of questionable clinical relevance.  They don't mean a whole lot.


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...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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InvisibleAsante
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: koods]
    #19346277 - 12/30/13 01:16 PM (10 years, 1 month ago)

Quote:

Because information that has diagnostic medical value must meet a higher standard.




So they say yes, but I think its more to protect the interest of insurance companies and Big Pharma.  I mean if theres 1.2% chance they get a marker wrong, and a condition like my main risk, is based on 12 markers, thats pretty darn unlikely to be incorrect, and they tell you a *tendency to come down with a condition relative to the general population*  not diagnose with certainty an existing condition.
The FDA is full of shit and I hope they are forced to lift the ban on medical info.

Quote:

Do you have the gene that causes you to inhale more deeply when you smoke?




I don't know but I have always consciously took half a breath of air before my puff of smoke to prevent most of the smoke from reaching my lower airways, were the risk of lethal complications is greatest.

Quote:

how detailed was the report and did it include any other results/conclusions?




Quite. I'm still discovering all what is there. They covered somethging like 230 medical conditions, 25 critical medication sensitivities, carrier status on 50 disorders, a whole bunch of traits and a shitton of ancestral information. Its very well documented.

Quote:

how come they arnt aloud to release the medical anymore?




I'm not sure if its still thye case, because the FDA might have forbidden it, but they might still give the raw data of the medical findings without offering interpretation (and intermretation can be gotten elsewhere online)  The company is heavily resisting the restrictions and going for loopholes because of their mission statement to bring as complete as possible genetic information to people without these people having to see a doctor or other official to decide whether they should know things about that which is more their own than anything, their genes.


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OfflineMescalean
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: koods]
    #19346334 - 12/30/13 01:35 PM (10 years, 1 month ago)

Quote:

koods said:
Quote:

Mescalean said:
I would want to do it just to know what exactly I am. I know about 75 percent of my lineage the rest is a mystery




A lot of people discover that what they thought was their lineage isn't always accurate. Lots of family secrets, and whatnot, I suspect..

Quote:

Jesus Christ said:
this is interesting. how detailed was the report and did it include any other results/conclusions?




Dude! Do it! Let's find out who your REAL dad is!

Quote:

hidenseek1 said:
shit, how come they arnt aloud to release the medical anymore?




Because information that has diagnostic medical value must meet a higher standard.




There are tons of family secrets. Certain members of my family shunned and not talked about.

One is supposedly a wiccan or pagan idk the difference. She supposedly is into the darker side of that stuff. Would be a cool person to talk to I think


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Invisiblenatzyshroomer
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Mescalean]
    #19346375 - 12/30/13 01:46 PM (10 years, 1 month ago)

This is awesome
But that's quite conspiracy starting for the USDA to not allow health related genetics

Thus fortifies my point ssri's are killing us


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Offlinekoods
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: natzyshroomer]
    #19346437 - 12/30/13 01:59 PM (10 years, 1 month ago)

USDA regulates steaks, not DNA tests.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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OfflineKingKnowledge
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: koods]
    #19346461 - 12/30/13 02:06 PM (10 years, 1 month ago)

If anybody else finds a source that would do this, I'd happily pay $100 for it. Even more.


I'm just waiting until personal genome sequencers are readily available.


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InvisibleVivaLaMushie
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346466 - 12/30/13 02:06 PM (10 years, 1 month ago)

Cool post, Wiccan. I enjoyed reading it.

Ive never had a DNA test done where they gave me any results, but I did volunteer to give my saliva to this group of doctors who are trying to find a reason why hyperemesis gravidarum happens to some pregnant women, but not others.

Hmmm now I wonder what is in my DNA.


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Offlinehidenseek1
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: koods]
    #19346468 - 12/30/13 02:06 PM (10 years, 1 month ago)

thats what they want you to think, but they are trying to isolate the gene to find which cows are more susceptible to mad cow


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You can drink at 7 A.M., because the Beastie Boys fought for that right
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pons asinorum
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lsd and the vietnam war changed music forever


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Offlinehidenseek1
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: hidenseek1]
    #19346474 - 12/30/13 02:08 PM (10 years, 1 month ago)

sometimes i think wiccan is incahoots with these companies because whenever he mentions a product, i get an urge to buy it


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OfflineKingKnowledge
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346479 - 12/30/13 02:09 PM (10 years, 1 month ago)

Quote:

Wiccan_Seeker said:
Quote:

how detailed was the report and did it include any other results/conclusions?




Quite. I'm still discovering all what is there. They covered somethging like 230 medical conditions, 25 critical medication sensitivities, carrier status on 50 disorders, a whole bunch of traits and a shitton of ancestral information. Its very well documented.






How accurate would you say the report was? Like, does it tell you the percentage chances of every prediction actually being correct? Or just broad "you probably have this" statements based on genes?


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Offlinekoods
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: KingKnowledge]
    #19346487 - 12/30/13 02:11 PM (10 years, 1 month ago)

Quote:

KingKnowledge said:
If anybody else finds a source that would do this, I'd happily pay $100 for it. Even more.


I'm just waiting until personal genome sequencers are readily available.




They sell them at Home Depot - same aisle as the jet packs and cable ready ocular implants.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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OfflineYthanA
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346493 - 12/30/13 02:12 PM (10 years, 1 month ago)

23andMe is pretty cool. I sent you a gene sharing request! (Heh, that sounds like a pick-up line.)

BTW if anyone is wondering what the reports look like, I posted a screenshot of the health results a while ago (there are other ones for ancestry):


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OfflineKingKnowledge
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Ythan]
    #19346507 - 12/30/13 02:14 PM (10 years, 1 month ago)

Thanks Ythan, you answered my question above.


Psoriasis!!!


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Offlinekoods
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: KingKnowledge]
    #19346555 - 12/30/13 02:23 PM (10 years, 1 month ago)

Glaucoma. Lol. I always thought that was a made up condition for sadistic eye doctors and potheads.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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OfflineJesus Christ
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Ythan]
    #19346608 - 12/30/13 02:34 PM (10 years, 1 month ago)

Duuude you better update your age related macular degeneration asap:rasta:


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InvisibleAsante
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Ythan]
    #19346616 - 12/30/13 02:37 PM (10 years, 1 month ago)

OMG that was you, I though some weird guy took me for a chick bahahaha ^_^

Psoriasis too huh?  Got it active or latent still? For me its latent but I do have skin issues that point to sensitive skin.

Its a bold move to show the overview, not as much for the members here as for the future aggression of insurane companies.

What you omitted to tell is you can click each entry and it opens up a wealth of information on what it implies, how to avoid it, if your doctor can screen for it, a doctor's word on the condition etc.

Its quite awesome and I hope they successfully defeat the FDA.

Now that I know you're with 23andMe too I know I made the right choice!  I accepted your share but will keep my results out of public knowoledge, you may know though :thumbup:


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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Jesus Christ]
    #19346635 - 12/30/13 02:40 PM (10 years, 1 month ago)

I looked into this DNA test and its pretty broad, I've worked with professors in RNA/DNA sequencing and the method used for this is really outdated, only because the new sequencing techniques are really expensive! This still doesn't make it wrong, it's just more of a statistic thing matched up with target genes for certain conditions. You could have the target gene for say "breast cancer" but only 20% of cases with that gene really develop the cancer. So even if you express that gene many other factors still affect the genetic outcome.

good road map tho
I'd never want to see mine..  :facepalm:


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InvisibleAsante
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Gorlax]
    #19346650 - 12/30/13 02:48 PM (10 years, 1 month ago)

Quote:

Gorlax said:

good road map tho
I'd never want to see mine..  :facepalm:




I thought my henes were akin to chernobyl, that they might as well built a concrete sarcophagus around my genome and set out a safety perimeter.

But no, its really not at all as bad as I thought it would be.

They have about a 1.2% fail rate on a marker, but most truly positive conditions have a half to whole dozen markers pointing to it, making it pretty accurate.

What they offer, for the PRICE they offer, is a steal.

But yeah its not carved in stone, odds of getting do not mean certainty of getting. It doesnt matter much whether your odds are 10% or 30% its that they're in the significant range that matters.

I suspect that most people who read this thread now will have done a genome pull within a decade. I think it will become as normal as a general blood test when visiting your doctor for a checkup.


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OfflineGorlax
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346659 - 12/30/13 02:52 PM (10 years, 1 month ago)

Yeah they really want to apply it to all medical visits so a doctor can pull up your entire genome but I believe something ethical about having all that information available is preventing it from being invested/implemented.


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Offlinekoods
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346662 - 12/30/13 02:52 PM (10 years, 1 month ago)

There was a really good story on This American Life about DNA testing when the results are deterministic - in this case, Huntington's disease.

http://www.thisamericanlife.org/radio-archives/episode/509/it-says-so-right-here#

It starts at 16:00 exactly.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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OfflineYthanA
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante] * 1
    #19346765 - 12/30/13 03:18 PM (10 years, 1 month ago)

Yeah, they nailed it with psoriasis. I've had patches on my elbows since I was a little kid and it seemed to get worse in my late 20s. I'm sure that increasing my alcohol intake didn't help either. I hope you can avoid it, it kind of sucks. :frown: Especially when it leads to arthritis later in life.

I'm not too worried about sharing my results because frankly, they seem pretty unremarkable to me. If I had a high risk of developing a debilitating or chronic condition that would be expensive to treat, I would think twice before making that public.

I definitely left a lot out of my post about the site... for one thing, compared to my screenshot they have a lot more results now, and increased confidence with their reports. The detailed information about each result is really interesting and that's not even touching on the genealogy aspect. I just didn't want to make it sound too awesome, since it's not available to new subscribers anymore. :wink:

It pisses me off that the FDA is giving them such a hard time. I'm honestly not surprised though. Even when I sent in my spit kit a couple years ago, I had to mail it from a neighboring state because New York prohibited 23andMe from doing business here. It seems completely asinine to me, and reinforces my libertarian beliefs, but there's not much to do except hope they can work things out with the government. And I guess they didn't handle the whole thing very well, which obviously hasn't helped things.

But yeah I think it's a very cool service and I'm glad you were able to get your results before they closed down the health reporting. My dad got his profile done too and it's fun comparing genotypes and seeing all the shared traits. Makes me feel like I'm living in the future! :cool:


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InvisibleEdibleStereos
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Ythan]
    #19346831 - 12/30/13 03:35 PM (10 years, 1 month ago)

Now your DNA is on file so the government can kill you and replace with you with a cloned worker bee version of yourself, and here you are soliciting us to the will of the insect overlords....


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Offlinekoods
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: EdibleStereos]
    #19346883 - 12/30/13 03:45 PM (10 years, 1 month ago)

Quote:

EdibleStereos said:
Now your DNA is on file so the government can kill you and replace with you with a cloned worker bee version of yourself, and here you are soliciting us to the will of the insect overlords....




This entire website is part of the master plan.


--------------------
NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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Invisiblebadchad
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19346926 - 12/30/13 03:55 PM (10 years, 1 month ago)

Quote:

Wiccan_Seeker said:


But yeah its not carved in stone, odds of getting do not mean certainty of getting. It doesnt matter much whether your odds are 10% or 30% its that they're in the significant range that matters.
.




This doesn't matter to you?

You have a company that's marketing a product based on people's fears of disease, yet the predictability of the test (for developing a disease state) is extremely low, and also variable (e.g., 10-30%?)

"YOU HAVE TO TAKE THIS TEST OR YOU'RE DOOMED TO A VARIETY OF THE DISEASES!!"

By the way, based on your results your chances of a disease are 10, maybe 30%. We don't really know, but you should be scared anyway... 

FDA wasn't upset about the tests, per se, rather their accuracy in predicting disease.  The bottom line was that the company couldn't produce the data to support the accuracy of their testing.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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InvisibleAsante
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: badchad]
    #19347540 - 12/30/13 05:36 PM (10 years, 1 month ago)

Badchad thats a very negativistic presentation of events.  23andMe doesnt prey on fears or fearmonger, it has a DNA testing product and that product has a margin of error of about 1.2% per marker.

The test as they offered it would only a few years ago have cost several thousand dollars, ad a decade before it wasnt even possible.  And this for hundreds of conditions and traits, with a small margin of error, for a hundred bucks.

They are clear that they arent 100% predictive and 100% accurate and that their information shouldnt be taken as gospel but what they offer is pretty good and should be seen as a recommendation, not a diagnosis.
You know what you are getting into.

The members only part of the site is very informative and quite the opposite of scare tactics.

I'm a hypochondriac and its had a very calming influence on me.

Sorry to hear about your Psoriasis Ythan.  I have a higher predisposition than you but for me so far its been confined to a tendency to eczema and the fact that I can rub loose impressive amounts of skin on my body when wet.

Yeah the FDA is definitely sucking HARD on this, and its obviously the interests of Big Money they are protecting, and not acting in the best interest of a concerned consumer.


--------------------
Omnicyclion.org
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OfflineGreySatyr
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19347566 - 12/30/13 05:40 PM (10 years, 1 month ago)

Interesting...


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InvisibleAsante
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: GreySatyr]
    #19347642 - 12/30/13 05:56 PM (10 years, 1 month ago)

On another note, here is a North Dakota White Supremacist leader who gets told he has 14% black African genes :africaface:




--------------------
Omnicyclion.org
higher knowledge starts here


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Invisiblebadchad
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: Asante]
    #19347718 - 12/30/13 06:14 PM (10 years, 1 month ago)

I'm not knocking the test.  I'm sure it's pretty accurate at detecting the genes it tests for.  My primary concern is the interpretation of the data reported:

Quote:

Wiccan_Seeker said:
They are clear that they arent 100% predictive and 100% accurate and that their information shouldnt be taken as gospel but what they offer is pretty good and should be seen as a recommendation, not a diagnosis.





^ this is my concern.  Just looking at what Ythan posted (and picking on some of the obvious data points), the report says something like:

"your risk" of melanoma is 2.9% with an "average risk" of 3.3%.  This doesn't seem to even factor in the multitude of behavioral factors involved (e.g. sun bathing).  The same is true of lung cancer, it's obviously heavily influenced by smoking and environmental factors, not necessarily genotype.  In fact, for many diseases, I'd contend that genotype plays a (relatively) minor, perhaps insignificant role.

They also have fields for "intelligence" and "memory", which are utterly ridiculous to assess via genotyping.

Is an increase of prostate cancer from 4% (e.g., from an "average risk" of 17 to "your risk" of 21%) even clinically relevant?  What should someone do with that info?  Should they eat healthier?  get more prostate exams? or just spend years worrying about it? 

They even have a reports on "restless leg syndrome" and ADHD which are based on an entirely behavioral (e.g., non-objective) diagnosis :shrug:.

I agree its a great technology with lots of potential.  But there is a reason some genetic counselors are highly trained.  These data are incredibly difficult to get meaning out of.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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OfflineTopPmz
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: badchad]
    #19347769 - 12/30/13 06:25 PM (10 years, 1 month ago)

You're really over-thinking this.
Behavioral factors are mostly common knowledge.
Your genotype shows your risk, minus behavioral factors.
You increasing your own risk doesn't have anything to do with your genotype.

I certainly don't see it as fearmongering. It's not like there's TV/radio commercials telling everyone they gotta get a broad spectrum DNA test, or they're fucked.


--------------------
"Freedom Isn't Free" is only half correct. True freedom doesn't exist in the society we exist in. What the saying really means is "The Illusion of Freedom Isn't Free"


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Invisiblebadchad
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: TopPmz]
    #19347953 - 12/30/13 07:00 PM (10 years, 1 month ago)

Quote:

TopPmz said:

Your genotype shows your risk, minus behavioral factors.




No.  Your genotype is your genetic makeup.

The site makes no mention of a survey or assessment of behavioral factors, but still calculates your "risk compared to average".  How does it calculate this for lung cancer if it doesn't know whether or not I smoke? 

Further, there isn't a lot of data on how multiple behavioral factors affect a health outcome.  For example, whats the risk of developing lung cancer in someone that smoked for 5 years while working in an asbestos factory, but avoided saccharin, then went on a gluten free diet for ten year, then gave up meat, then turned into a vegan, then started smoking again at the age of 45?


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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OfflineTopPmz
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Re: I had a broad spectrum DNA test done, some results surprised me [Re: badchad]
    #19347977 - 12/30/13 07:05 PM (10 years, 1 month ago)

Your genetic makeup can't show behavioral risks.
They're telling you what your risk is without any behavioral factors.
If you smoke, obviously your chance of getting lung cancer is greater than the 12% (for the sake of the argument) risk the test results show.
If you can't figure that out on your own, don't get the test done. Simple as that.


--------------------
"Freedom Isn't Free" is only half correct. True freedom doesn't exist in the society we exist in. What the saying really means is "The Illusion of Freedom Isn't Free"


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