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cycline
pan-informationist


Registered: 09/11/13
Posts: 164
Loc: Dissoversum
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Smoking Changes Our Genes
#19301645 - 12/20/13 07:02 AM (10 years, 1 month ago) |
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http://www.sciencedaily.com/releases/2013/12/131217085225.htm
The fact that smoking means a considerable health risk is nowadays commonly accepted. New research findings from Uppsala University and Uppsala Clinical Research Center show that smoking alters several genes that can be associated with health problems for smokers, such as increased risk for cancer and diabetes.
We inherit our genes from our parents at birth. Later in life the genetic material can be changed by epigenetic modifications, i.e. chemical alterations of the DNA the affect the activity of the genes. Such alterations are normally caused by aging but can also result from environmental factors and lifestyle.
In a study recently published in the journal Human Molecular Genetics the researchers have examined how the genes are changed in smokers and users of non-smoke tobacco. They could identify a large number of genes that were altered in smokers but found no such effect of non-smoke tobacco.
"This means that the epigenetic modifications are likely not caused by substances in the tobacco, but by the hundreds of different elements that are formed when the tobacco is burnt," says Åsa Johansson, researcher at the Department of Immunology, Genetics and Pathology at Uppsala University and Uppsala Clinical Research Center, who has led the study.
It has been previously known that smokers have an increased risk of developing diabetes and many types of cancer, and have a reduced immune defence and lower sperm quality. The results from the study also showed that genes that increase the risk for cancer and diabetes, or are important for the immune response or sperm quality, are affected by smoking.
"Our results therefore indicate that the increased disease risk associated with smoking is partly a caused by epigenetic changes. A better understanding of the molecular mechanism behind diseases and reduced body function might lead to improved drugs and therapies in the future," says Åsa Johansson.
-------------------- “To see a world in a grain of sand, And a heaven in a wildflower; Hold infinity in the palm of your hand, And eternity in an hour.” — Auguries of Innocence, William Blake
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Beanhead
IS IRONIC PARADOX


Registered: 10/11/08
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Re: Smoking Changes Our Genes [Re: cycline]
#19301673 - 12/20/13 07:14 AM (10 years, 1 month ago) |
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Another reason to never have children and fuck up the gene pool even more (my opinion and view)
Edited by Beanhead (12/20/13 07:15 AM)
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Atrium
Cunt Tickler

Registered: 08/18/13
Posts: 1,284
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Re: Smoking Changes Our Genes [Re: cycline]
#19301790 - 12/20/13 08:01 AM (10 years, 1 month ago) |
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Quote:
cycline said: "This means that the epigenetic modifications are likely not caused by substances in the tobacco, but by the hundreds of different elements that are formed when the tobacco is burnt,"
Which one is it?? Either it's in there already and comes out through burning or some magickal fairy is coming around putting shit only in the burned tobacco.
-------------------- The only thing about Chemistry I like is all the psychedelics that come from it. The only reason I study Psychology is to have a legitimate excuse to enjoy Chemistry.
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demiu5
humans, lol


Registered: 08/18/05
Posts: 43,948
Loc: the popcorn stadium
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Re: Smoking Changes Our Genes [Re: Atrium] 1
#19301942 - 12/20/13 08:58 AM (10 years, 1 month ago) |
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Quote:
Jamesdnh said:
Quote:
cycline said: "This means that the epigenetic modifications are likely not caused by substances in the tobacco, but by the hundreds of different elements that are formed when the tobacco is burnt,"
Which one is it?? Either it's in there already and comes out through burning or some magickal fairy is coming around putting shit only in the burned tobacco.

combustion can cause chemical changes in compounds. are you not aware of this?
anyways, this is interesting. i wonder if they will do a study also using completely chemical-free grown tobacco. it's hard to say if the swedes are getting chemmy or chem-free tobacco
-------------------- channel your inner Larry David
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Atrium
Cunt Tickler

Registered: 08/18/13
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Re: Smoking Changes Our Genes [Re: demiu5]
#19301983 - 12/20/13 09:16 AM (10 years, 1 month ago) |
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Quote:
demiu5 said:
Quote:
Jamesdnh said:
Quote:
cycline said: "This means that the epigenetic modifications are likely not caused by substances in the tobacco, but by the hundreds of different elements that are formed when the tobacco is burnt,"
Which one is it?? Either it's in there already and comes out through burning or some magickal fairy is coming around putting shit only in the burned tobacco.

combustion can cause chemical changes in compounds. are you not aware of this?
anyways, this is interesting. i wonder if they will do a study also using completely chemical-free grown tobacco. it's hard to say if the swedes are getting chemmy or chem-free tobacco
Actually... I wasn't. But doesn't that still mean that simply burning it just brings out what's already in it?
-------------------- The only thing about Chemistry I like is all the psychedelics that come from it. The only reason I study Psychology is to have a legitimate excuse to enjoy Chemistry.
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badchad
Mad Scientist

Registered: 03/02/05
Posts: 13,372
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Re: Smoking Changes Our Genes [Re: demiu5]
#19302007 - 12/20/13 09:21 AM (10 years, 1 month ago) |
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Pretty much everything genes. If I put you in a room with loud music for an hour and stress you out, I'll be able to observe an increase in c-fos and several other genes.
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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passifloracaerulea



Registered: 11/13/10
Posts: 10,485
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Re: Smoking Changes Our Genes [Re: badchad]
#19302135 - 12/20/13 10:01 AM (10 years, 1 month ago) |
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they fail to mention that chewing tobacco gives people cancer. there are plenty of studies implicating polonium 210 as the real cause of cancer from tobacco. tobacco selects and concentrates this isotope from the environment and especially from the chemical fertilizers that are applied.
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pwnasaurus
Stranger



Registered: 07/16/08
Posts: 12,317
Loc: Canada
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Re: Smoking Changes Our Genes [Re: Atrium]
#19302178 - 12/20/13 10:19 AM (10 years, 1 month ago) |
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Quote:
Jamesdnh said: Actually... I wasn't. But doesn't that still mean that simply burning it just brings out what's already in it?
I think you need to go back to grade 8 chemistry and learn what a chemical reaction is.
http://en.wikipedia.org/wiki/Chemical_reaction
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Icyus
KavitārkikasiṃHa



Registered: 11/07/13
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Re: Smoking Changes Our Genes [Re: pwnasaurus]
#19302191 - 12/20/13 10:25 AM (10 years, 1 month ago) |
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You are what uou eat .. eat poision and become toxic and dying.. eat plants and yuo will prosper.. meat is full of energy, but has nasty sideeffects to both the mind and body..
ea4 mushrooms and become weird.. activating unused dna and all..
whatever you eat changes the genes accordingly..
I hqve no evidence for any of this, so have in mind my madness when reading this..
-------------------- And thus begins the reverse-fusing of our one-dimentional understanding, and adds ever-expanding perspectives, in depth and number; splitting our perception, and in so doing, seemingly irrationally, creates yet more one-ness, with all that ever was, is and will ever be, streching across the infinite, inunderstood concept of everything, percievable and not.
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Atrium
Cunt Tickler

Registered: 08/18/13
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Re: Smoking Changes Our Genes [Re: pwnasaurus]
#19302563 - 12/20/13 11:57 AM (10 years, 1 month ago) |
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Quote:
pwnasaurus said:
Quote:
Jamesdnh said: Actually... I wasn't. But doesn't that still mean that simply burning it just brings out what's already in it?
I think you need to go back to grade 8 chemistry and learn what a chemical reaction is.
http://en.wikipedia.org/wiki/Chemical_reaction
Chemistry isn't my interest.
-------------------- The only thing about Chemistry I like is all the psychedelics that come from it. The only reason I study Psychology is to have a legitimate excuse to enjoy Chemistry.
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Invisible_Woe

Registered: 05/25/07
Posts: 11,707
Loc: Mabase
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Re: Smoking Changes Our Genes [Re: Beanhead]
#19302646 - 12/20/13 12:14 PM (10 years, 1 month ago) |
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Quote:
Beanhead said: Another reason to never have children and fuck up the gene pool even more (my opinion and view)
Yeah im never having kids I already had shit genes before I started to use anything.
-------------------- These are not the answers you should be questioning.
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AllGreyThumbs
Storage Container Aficionado


Registered: 09/18/12
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Re: Smoking Changes Our Genes [Re: Atrium] 1
#19302696 - 12/20/13 12:25 PM (10 years, 1 month ago) |
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Quote:
Jamesdnh said:
Quote:
pwnasaurus said:
Quote:
Jamesdnh said: Actually... I wasn't. But doesn't that still mean that simply burning it just brings out what's already in it?
I think you need to go back to grade 8 chemistry and learn what a chemical reaction is.
http://en.wikipedia.org/wiki/Chemical_reaction
Chemistry isn't my interest.
Then just know that all things are composed of 4 elements, Earth, Wind, Water, and Fire. Burning is just letting some of the fire out, but in no way changes what was already in there.
I'm sorry, I just found this all very amusing. If understanding burning stuff requires a deep understanding of chemistry, then not falling down must require a degree in physics...
Again, I'm sorry. I feel like I'm being a jackass, but it is kind of funny. Maybe the school systems have failed us. But I guess that's what the internet is for, to give us a chance to understand what we never paid attention to before. So seriously now, combustion is the combination of some chemical with oxygen in a reaction that produces heat. It is a chemical reaction. This reaction can significantly alter chemical structures. Also the high temperature environment produced by combustion can cause all sorts of additional chemical reactions to occur.
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PurpleHaze147



Registered: 04/09/13
Posts: 657
Last seen: 6 years, 2 months
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Quote:
AllGreyThumbs said: Then just know that all things are composed of 4 elements, Earth, Wind, Water, and Fire. Burning is just letting some of the fire out, but in no way changes what was already in there.
I'm sorry, I just found this all very amusing. If understanding burning stuff requires a deep understanding of chemistry, then not falling down must require a degree in physics...
Again, I'm sorry. I feel like I'm being a jackass, but it is kind of funny. Maybe the school systems have failed us. But I guess that's what the internet is for, to give us a chance to understand what we never paid attention to before. So seriously now, combustion is the combination of some chemical with oxygen in a reaction that produces heat. It is a chemical reaction. This reaction can significantly alter chemical structures. Also the high temperature environment produced by combustion can cause all sorts of additional chemical reactions to occur.
Oh come on u can't be serious. There's like 130 elements that everything's made of not 4 that's like medieval times thinking. Applying heat causes chemical reactions, combustion even more, come on I learned this in 5th grade.
Many things change our genes that's how we evolve. An enzyme gets effected and goes back to the DNA and stores what happens. Maybe if we keep smoking we'll build up a resistance to the carcinogens in smoke. Having our genes changed isn't nessicarily a bad thing.
Edited by PurpleHaze147 (12/20/13 01:37 PM)
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thedream
The Most High


Registered: 12/25/10
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^He was being sarcastic, yanking the previous posters leg so to speak about his lack of knowledge of basic chemistry.
Also your simplistic approach to how enzymes change DNA is entertaining. Care to expand on that?
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2bakednate
Connecting & Growing



Registered: 11/08/10
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Damn it this isnt the 70's when lsd could cause damage and changes to chromosomes.
-------------------- "The reason is for us all"
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natzyshroomer
Star gazer


Registered: 12/01/12
Posts: 405
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Re: Smoking Changes Our Genes [Re: 2bakednate]
#19303145 - 12/20/13 02:18 PM (10 years, 1 month ago) |
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Illogical to think that epigenetic Modifications can only happen when smoking?
-------------------- All submitted posts are by Someone Who Isn't Me and in any event are works of pure fiction or outright lies. Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit
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PurpleHaze147



Registered: 04/09/13
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Last seen: 6 years, 2 months
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Re: Smoking Changes Our Genes [Re: thedream]
#19303162 - 12/20/13 02:20 PM (10 years, 1 month ago) |
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Quote:
thedream said: ^He was being sarcastic, yanking the previous posters leg so to speak about his lack of knowledge of basic chemistry.
Also your simplistic approach to how enzymes change DNA is entertaining. Care to expand on that?
Yes I did simplify it but that's basically what happens. A peptide interacts with an enzyme and an enzyme encodes it's message into the DNA. Enzymes build DNA. Genes r attached to DNA. I've read all this in an official pharmacolgy book.
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PurpleHaze147



Registered: 04/09/13
Posts: 657
Last seen: 6 years, 2 months
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Quote:
natzyshroomer said: Illogical to think that epigenetic Modifications can only happen when smoking?
Yes. Maybe buccal nictotine doesn't change genes but other things besides smoking do.
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tito123


Registered: 01/23/10
Posts: 3,006
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I don't know shit about biology and didn't read this thread but can psychedlics change our genes?
Can they change them for the better?
if so, doesn't that sorta go together with mckenna's stoned ape theory?
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thedream
The Most High


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Re: Smoking Changes Our Genes [Re: tito123] 1
#19304985 - 12/20/13 08:21 PM (10 years, 1 month ago) |
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Quote:
Yes I did simplify it but that's basically what happens. A peptide interacts with an enzyme and an enzyme encodes it's message into the DNA. Enzymes build DNA. Genes r attached to DNA. I've read all this in an official pharmacolgy book.
In most cases it is methyl and acetyl groups that attach to what are called histone tails that are responsible for making changes to genes. Respectively they tighten and loosen DNA that is wrapped around proteins called histones. This tightening and loosening of the strand of DNA affects whether genes are turned off or on.
Enzymes do not contain the instructions to make proteins, DNA or RNA for that matter, they merely facilitate the construction of the DNA molecule itself and have next to no influence on the directions contained within the DNA.
An analogous statement would be like DNA is the architect and enzymes are the contractors who build the building. The enzymes just build whatever the architect has instructed them to do so.
Also, enzymes do not encode "messages" into DNA.
Check this site out if you wish to learn more about epigenetics Epigenetics
A better reference would be a Molecular Biology book.
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