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Offlinemorrowasted
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Study reveals gene expression changes with meditation * 5
    #19254533 - 12/10/13 09:43 AM (10 years, 2 months ago)

Quote:

With evidence growing that meditation can have beneficial health effects, scientists have sought to understand how these practices physically affect the body.

A new study by researchers in Wisconsin, Spain, and France reports the first evidence of specific molecular changes in the body following a period of mindfulness meditation.

The study investigated the effects of a day of intensive mindfulness practice in a group of experienced meditators, compared to a group of untrained control subjects who engaged in quiet non-meditative activities. After eight hours of mindfulness practice, the meditators showed a range of genetic and molecular differences, including altered levels of gene-regulating machinery and reduced levels of pro-inflammatory genes, which in turn correlated with faster physical recovery from a stressful situation.

"To the best of our knowledge, this is the first paper that shows rapid alterations in gene expression within subjects associated with mindfulness meditation practice," says study author Richard J. Davidson, founder of the Center for Investigating Healthy Minds and the William James and Vilas Professor of Psychology and Psychiatry at the University of Wisconsin-Madison.

"Most interestingly, the changes were observed in genes that are the current targets of anti-inflammatory and analgesic drugs," says Perla Kaliman, first author of the article and a researcher at the Institute of Biomedical Research of Barcelona, Spain (IIBB-CSIC-IDIBAPS), where the molecular analyses were conducted.

The study was published in the journal Psychoneuroendocrinology.

Mindfulness-based trainings have shown beneficial effects on inflammatory disorders in prior clinical studies and are endorsed by the American Heart Association as a preventative intervention. The new results provide a possible biological mechanism for therapeutic effects.

The results show a down-regulation of genes that have been implicated in inflammation. The affected genes include the pro-inflammatory genes RIPK2 and COX2 as well as several histone deacetylase (HDAC) genes, which regulate the activity of other genes epigenetically by removing a type of chemical tag. What's more, the extent to which some of those genes were downregulated was associated with faster cortisol recovery to a social stress test involving an impromptu speech and tasks requiring mental calculations performed in front of an audience and video camera.

Perhaps surprisingly, the researchers say, there was no difference in the tested genes between the two groups of people at the start of the study. The observed effects were seen only in the meditators following mindfulness practice. In addition, several other DNA-modifying genes showed no differences between groups, suggesting that the mindfulness practice specifically affected certain regulatory pathways.

However, it is important to note that the study was not designed to distinguish any effects of long-term meditation training from those of a single day of practice. Instead, the key result is that meditators experienced genetic changes following mindfulness practice that were not seen in the non-meditating group after other quiet activities — an outcome providing proof of principle that mindfulness practice can lead to epigenetic alterations of the genome.

Previous studies in rodents and in people have shown dynamic epigenetic responses to physical stimuli such as stress, diet, or exercise within just a few hours.

"Our genes are quite dynamic in their expression and these results suggest that the calmness of our mind can actually have a potential influence on their expression," Davidson says.

"The regulation of HDACs and inflammatory pathways may represent some of the mechanisms underlying the therapeutic potential of mindfulness-based interventions," Kaliman says. "Our findings set the foundation for future studies to further assess meditation strategies for the treatment of chronic inflammatory conditions."

Study funding came from National Center for Complementary and Alternative Medicine (grant number P01-AT004952) and grants from the Fetzer Institute, the John Templeton Foundation, and an anonymous donor to Davidson. The study was conducted at the Center for Investigating Healthy Minds at the UW-Madison Waisman Center.




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OfflineTwinEclipse
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Re: Study reveals gene expression changes with meditation [Re: morrowasted] * 1
    #19254700 - 12/10/13 10:34 AM (10 years, 2 months ago)

very informative. thanks for the read. mindfulness is easy to practice, yet difficult to master.


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My purpose: to love, to share, and to experience....all while conforming to my psychedelic experiences.



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Offlineshivas.wisdom
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Re: Study reveals gene expression changes with meditation [Re: morrowasted]
    #19254746 - 12/10/13 10:47 AM (10 years, 2 months ago)

and on that note, i should go sit for my morning meditation


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Offlineshivas.wisdom
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Re: Study reveals gene expression changes with meditation [Re: shivas.wisdom]
    #19254782 - 12/10/13 10:53 AM (10 years, 2 months ago)

and can you post the source?


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InvisibleAmphibolos
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Re: Study reveals gene expression changes with meditation [Re: shivas.wisdom]
    #19254825 - 12/10/13 11:03 AM (10 years, 2 months ago)

Got the science daily link

Gene expression vary with meditation


i like how the science points out insights that some of the traditional practices considered as esoteric, provide the benefits that they claimed to give since thousands of years.

Energy flow in the body, the CHI changes the expression of the genes?



Edited by Amphibolos (12/10/13 11:13 AM)


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Invisiblebadchad
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Re: Study reveals gene expression changes with meditation [Re: Amphibolos] * 1
    #19254933 - 12/10/13 11:34 AM (10 years, 2 months ago)

The problem with studies like these is interpretation.  The human body is constantly making subtle changes in gene expression and any number of behaviors is likely to result in a transient upregulation of certain genes.

If I go for a run, or drink a cup of coffee, I'll get a change in gene expression.  Some of the genes mentioned in the abstracts (RIPK2 and COX2 as well as several histone deacetylase (HDAC) genes) are affected by lots of different stimuli.


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...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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InvisibleAmphibolos
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Re: Study reveals gene expression changes with meditation [Re: badchad]
    #19255064 - 12/10/13 11:58 AM (10 years, 2 months ago)

Thats just one study.

I guess that they will do more to corner the false positives.


They did show that stress had an influence over the longterm. They just have to control more parameters. Its just that you cant do this types of experiments (with meditation) in a rat model so i guess it will take more time.


You cant deny that there is an interest


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"Homo sum ; humani nihil a me alienum puto"


Edited by Amphibolos (12/10/13 11:59 AM)


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OfflinePatlal
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Re: Study reveals gene expression changes with meditation [Re: badchad]
    #19255070 - 12/10/13 11:59 AM (10 years, 2 months ago)

I really should pick up meditation again. I used to do it in college. then I stopped


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Offlinei like cow poo
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Re: Study reveals gene expression changes with meditation [Re: morrowasted]
    #19256056 - 12/10/13 03:55 PM (10 years, 2 months ago)

this is awesome! It motivates me to meditate!:sunny:
Best post I've seen in a while.:awetrippie:


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