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InvisiblehTx
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Technologicaly Advanced Drugs
    #19190405 - 11/26/13 04:09 AM (10 years, 2 months ago)

anyone else think we will/could use nanotechnology (what if all drugs are a form of nanotechnology) to invent novel "drugs" that would in theory, be able to do friggin amazing things to alter our consciousness, perhaps permanently? 

like enlightenment in a pill, or "how to fight" on blotter.


--------------------
zen by age ten times six hundred lifetimes
Light up the darkness.


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Offlines240779
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Re: Technologicaly Advanced Drugs [Re: hTx]
    #19190425 - 11/26/13 04:16 AM (10 years, 2 months ago)

Was recently entertaining the idea of making drugs with extraordinarily long half-lifes. Imagine a heroin high that lasted 6 months.


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OfflineCaddilac
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Re: Technologicaly Advanced Drugs [Re: s240779]
    #19190553 - 11/26/13 05:59 AM (10 years, 2 months ago)

Recent article states that serotonin agonists make memory more functional. stoned ape theory comes to my mind.      what... peace.


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InvisibleCyclohexylamine
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Re: Technologicaly Advanced Drugs [Re: Caddilac]
    #19190647 - 11/26/13 07:03 AM (10 years, 2 months ago)

Quote:

hTx said:
anyone else think we will/could use nanotechnology (what if all drugs are a form of nanotechnology) to invent novel "drugs" that would in theory, be able to do friggin amazing things to alter our consciousness, perhaps permanently? 

like enlightenment in a pill, or "how to fight" on blotter.




How would it work?

Quote:

Caddilac said:
Recent article states that serotonin agonists make memory more functional. stoned ape theory comes to my mind.      what... peace.




I think you misunderstood the study. It stated that while agonism of 5HT receptors does cause improvements to memory / cognitive function, it also leads to down-regulation of the 5HT receptors (like most agonists). The study then went on to show how a 5HT2A antagonist, SR 46349B, did seem to help without the issues of receptor down-regulation.


--------------------
Yes this is tymo - I just changed my name

Have you ever had a dream that you were so sure was real? What if you were unable to awake from that dream? How would you know the difference between that dream world and the real world?


There is NOTHING better than feeling that warm dissociative fuzz creeping up your body from IM K
Something abut that anaesthetic rush... :inlove:

Qualitative Research Chemical Effects and Experiences
The Wonderful World of Methoxetamine
The 3-Meo-PCP Chapters, Part One


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OfflineKingKnowledge
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Re: Technologicaly Advanced Drugs [Re: Cyclohexylamine]
    #19190675 - 11/26/13 07:13 AM (10 years, 2 months ago)

Quote:

tymoteusz3 said:
Quote:

hTx said:
anyone else think we will/could use nanotechnology (what if all drugs are a form of nanotechnology) to invent novel "drugs" that would in theory, be able to do friggin amazing things to alter our consciousness, perhaps permanently? 

like enlightenment in a pill, or "how to fight" on blotter.




How would it work?

Quote:

Caddilac said:
Recent article states that serotonin agonists make memory more functional. stoned ape theory comes to my mind.      what... peace.




I think you misunderstood the study. It stated that while agonism of 5HT receptors does cause improvements to memory / cognitive function, it also leads to down-regulation of the 5HT receptors (like most agonists). The study then went on to show how a 5HT2A antagonist, SR 46349B, did seem to help without the issues of receptor down-regulation.





Link? And do you mean "did seem to help with the issues of receptor down-regulation?


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InvisibleCyclohexylamine
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Re: Technologicaly Advanced Drugs [Re: KingKnowledge]
    #19190709 - 11/26/13 07:31 AM (10 years, 2 months ago)

Quote:

KingKnowledge said:
Quote:

tymoteusz3 said:
Quote:

hTx said:
anyone else think we will/could use nanotechnology (what if all drugs are a form of nanotechnology) to invent novel "drugs" that would in theory, be able to do friggin amazing things to alter our consciousness, perhaps permanently? 

like enlightenment in a pill, or "how to fight" on blotter.




How would it work?

Quote:

Caddilac said:
Recent article states that serotonin agonists make memory more functional. stoned ape theory comes to my mind.      what... peace.




I think you misunderstood the study. It stated that while agonism of 5HT receptors does cause improvements to memory / cognitive function, it also leads to down-regulation of the 5HT receptors (like most agonists). The study then went on to show how a 5HT2A antagonist, SR 46349B, did seem to help without the issues of receptor down-regulation.





Link? And do you mean "did seem to help with the issues of receptor down-regulation?




*without the issues of receptor down-regulation
www.sciencedirect.com/science/article/pii/S107474271300049X


--------------------
Yes this is tymo - I just changed my name

Have you ever had a dream that you were so sure was real? What if you were unable to awake from that dream? How would you know the difference between that dream world and the real world?


There is NOTHING better than feeling that warm dissociative fuzz creeping up your body from IM K
Something abut that anaesthetic rush... :inlove:

Qualitative Research Chemical Effects and Experiences
The Wonderful World of Methoxetamine
The 3-Meo-PCP Chapters, Part One


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OfflineKingKnowledge
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Re: Technologicaly Advanced Drugs [Re: Cyclohexylamine]
    #19190861 - 11/26/13 08:29 AM (10 years, 2 months ago)

Quote:

tymoteusz3 said:
Quote:

KingKnowledge said:
Quote:

tymoteusz3 said:
Quote:

hTx said:
anyone else think we will/could use nanotechnology (what if all drugs are a form of nanotechnology) to invent novel "drugs" that would in theory, be able to do friggin amazing things to alter our consciousness, perhaps permanently? 

like enlightenment in a pill, or "how to fight" on blotter.




How would it work?

Quote:

Caddilac said:
Recent article states that serotonin agonists make memory more functional. stoned ape theory comes to my mind.      what... peace.




I think you misunderstood the study. It stated that while agonism of 5HT receptors does cause improvements to memory / cognitive function, it also leads to down-regulation of the 5HT receptors (like most agonists). The study then went on to show how a 5HT2A antagonist, SR 46349B, did seem to help without the issues of receptor down-regulation.





Link? And do you mean "did seem to help with the issues of receptor down-regulation?




*without the issues of receptor down-regulation
www.sciencedirect.com/science/article/pii/S107474271300049X




I mean obviously an antagonist won't cause down-regulation...if anything it would be the opposite. Blocking receptors means that they would up-regulate to attempt to compensate for the lack of stimulation. Not very ground breaking :shrug:


Edited by KingKnowledge (11/26/13 08:30 AM)


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InvisibleCyclohexylamine
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Re: Technologicaly Advanced Drugs [Re: KingKnowledge]
    #19190871 - 11/26/13 08:32 AM (10 years, 2 months ago)

Well yes antagonization can cause receptor density increase.
But the cool thing with the study was the effects on memory antagonization of the 5HT2A receptors had.


--------------------
Yes this is tymo - I just changed my name

Have you ever had a dream that you were so sure was real? What if you were unable to awake from that dream? How would you know the difference between that dream world and the real world?


There is NOTHING better than feeling that warm dissociative fuzz creeping up your body from IM K
Something abut that anaesthetic rush... :inlove:

Qualitative Research Chemical Effects and Experiences
The Wonderful World of Methoxetamine
The 3-Meo-PCP Chapters, Part One


Extras: Filter Print Post Top
OfflineKingKnowledge
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Registered: 03/30/13
Posts: 2,876
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Re: Technologicaly Advanced Drugs [Re: Cyclohexylamine]
    #19190876 - 11/26/13 08:33 AM (10 years, 2 months ago)

Quote:

tymoteusz3 said:
Well yes antagonization can cause receptor density increase.
But the cool thing with the study was the effects on memory antagonization of the 5HT2A receptors had.




Quite interesting. I've studied a lot about NMDA's relationship with memory, but in all my classes I've never really heard of Serotonin playing any role. Thanks for the link :smile:


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