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Simplepowa
In Pursuit of Knowledge


Registered: 03/06/09
Posts: 4,310
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Cannabidiol: The side of marijuana you don't know
#19179154 - 11/23/13 02:16 PM (10 years, 2 months ago) |
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By Jack Giddingson, Wednesday at 7:11 pm
Cannabidiol: The side of marijuana you don't know
If there's a marijuana-related compound you've heard of, it's likely Tetrahydrocannabinol, or THC.
THC is what makes you high and the reason most recreational users partake. What most don't know is the medicinal value of the plant comes mostly from a different source: cannabidiol.
Cannibidiol (CBD) is a non-psychoactive component of marijuana that possesses a wide range of therapeutic benefits. When present in high quantities, CBD enhances THC's positive effects while negating many of the negatives. It's clear both cannabanoids coexist in the plant for a reason, often acting synergistically.
The problem is growers realized decades ago that THC is what sells; it provides the floating, euphoric feeling people associate with marijuana. In order to enhance THC content, CBD has been bred out of many strains, leaving users with a highly psychoactive experience but not necessarily the healthiest, especially for those with preexisting mental disorders.
This cannabanoid-reliant difference is demonstrated in this video: THC/CBD vs. THC alone
Thankfully, the objective of growers is beginning to change. Recent research suggests CBD is the most important part of the plant and growers/medical dispensaries have increased their focus on high-CBD strains, oils, edibles and tinctures.
Here are some things that should prompt us to give CBD a much closer look...
CBD reverses alcohol-induced brain damage.
According to a recent University of Kentucky study, cannabidiol can prompt physiological brain changes that could help offset the damage caused by chronic alcoholism. The study found that administration of CBD resulted in a 48.8% reduction in entorhinal cortex neurodegeneration. Stoners have known forever that a few tokes provide incredible hangover relief, but this study takes the therapeutic potential of cannabanoids to a whole new level.
CBD is a very effective treatment option for severe social anxiety.
Many people claim to find relief from anxiety with marijuana while others say the opposite. It appears CBD content may be the deciding variable.
A study aimed at determining CBD's impact on social anxiety in public speaking demonstrated that those pretreated with CBD experienced significantly reduced anxiety, cognitive impairment and discomfort during their speech performance. The placebo group experienced noticeably higher levels of anxiety and discomfort. The study's authors stress that CBD holds many advantages over standard social anxiety treatments such as anti-depressants due to its quick onset of efficiency and absence of severe withdrawal symptoms or side effects.
CBD "turns off" the cancer gene found in metastasis.
Scientists at California Pacific Medical Center found that CBD turns off a gene that causes cancer cells to metastasize, or spread. This finding adds credibility to the growing evidence that marijuana is one of the best things a cancer patient can consume, whether for symptom relief or actual prevention. It also makes UCLA's marijuana-doesn't-cause-lung-cancer study that much more interesting; is it possible the cannabanoids themselves offset the carcinogens found in smoke? Could marijuana truly be anti-cancer?
CBD is a potent anti-psychotic medicine.
A clinical trial in Germany found CBD to be as effective in treating schizophrenia as common antipsychotic medication with far fewer side effects. This further clarifies the yin-yang relationship of marijuana, since THC has been shown to trigger psychosis in high doses. CBD is what offsets the negative mental effects of THC alone, and thus, should be the focus of any marijuana user with a history of mental illness.
Last but not least...it's LEGAL!
That's right! If you're an American reading this right now, you can have a CBD-infused product sent to your home safely and legally. CBD is consumed in a variety of forms including oil, tinctures, edibles, capsules, lotion and even chewing gum. My personal favorite place to shop for CBD is Bayshore Botanicals.
There you have it. If you suffer from anxiety, stress, pain or want to take preventative steps against cancer (ie. if you're a human being), you may want to give CBD a try.
If none of the above helps convince you, watch this.
Email me at Jack.Giddingson@Gmail.com with questions, comments or future blog suggestions.
http://www.chicagonow.com/chicago-medical-marijuana/2013/11/cannabidiol-the-side-of-marijuana-you-dont-know/
--------------------
Carl Sagan - "Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people." --- Robert Pirsig - "When one person suffers from a delusion it is called insanity. When many people suffer from a delusion it is called religion." --- Brian Cox - "[One] problem with today’s world is that everyone believes they have the right to express their opinion AND have others listen to it. The correct statement of individual rights is that everyone has the right to an opinion, but crucially, that opinion can be roundly ignored and even made fun of, particularly if it is demonstrably nonsense."
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Konyap

Registered: 06/30/07
Posts: 33,945
Loc: Planet Piss
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Re: Cannabidiol: The side of marijuana you don't know [Re: Simplepowa]
#19179722 - 11/23/13 05:11 PM (10 years, 2 months ago) |
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Wow, didn't know that was legal
Still wish I could smoke it
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Konyap

Registered: 06/30/07
Posts: 33,945
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Re: Cannabidiol: The side of marijuana you don't know [Re: Konyap]
#19179740 - 11/23/13 05:17 PM (10 years, 2 months ago) |
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One of the comments from the article "GW Pharma's Sativex is a 1:1 THC:CBD extract in alcohol tincture with propylene glycol added. It is less safe and less effective than whole plant extract."
Yeah sounded too good to be true
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Atrium
Cunt Tickler

Registered: 08/18/13
Posts: 1,284
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Re: Cannabidiol: The side of marijuana you don't know [Re: Konyap]
#19180186 - 11/23/13 07:23 PM (10 years, 2 months ago) |
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Oh CBD is something I've never heard of? Is that why I always ask people with cards to buy me high CBD content weed and they come back with "fire" or "bomb" instead?
-------------------- The only thing about Chemistry I like is all the psychedelics that come from it. The only reason I study Psychology is to have a legitimate excuse to enjoy Chemistry.
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PurpleHaze147



Registered: 04/09/13
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Re: Cannabidiol: The side of marijuana you don't know [Re: Konyap]
#19180855 - 11/23/13 11:24 PM (10 years, 2 months ago) |
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CannaQuote:
Illyabo said: Wow, didn't know that was legal
Still wish I could smoke it
Yea cannabidiol is legal. You could smoke it legally in public if u could prove it was just CBD and didn't have any parts of the cannabis plant with it. It doesn't get u high tho too much CBD actually could completely block the high from THC. If u kno anything about pharmacology THC is a CB1 receptor agonist (mimics natural endocannabinoids) and CBD is a CB1 antagonist (blocks phyto/synthetic/endocannabinoid agonists).
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Konyap

Registered: 06/30/07
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Re: Cannabidiol: The side of marijuana you don't know [Re: PurpleHaze147]
#19180864 - 11/23/13 11:30 PM (10 years, 2 months ago) |
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so it's like a natural .....
good to know
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tripp23
Kratom Freak



Registered: 05/21/08
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Loc: Florida, US
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Re: Cannabidiol: The side of marijuana you don't know [Re: Konyap]
#19181235 - 11/24/13 01:51 AM (10 years, 2 months ago) |
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Quote:
Illyabo said: One of the comments from the article "GW Pharma's Sativex is a 1:1 THC:CBD extract in alcohol tincture with propylene glycol added. It is less safe and less effective than whole plant extract."
Yeah sounded too good to be true
I dont get it? So is there THC in it? How can there be? If this stuff really works for anxiety, I will order this as fast as I can right now because I know how good weed is for you in general.. The only problem is, I can't smoke because it makes my anxiety worse so if this is a counter product that works, I want it. Any info?
-------------------- Experience my nightmarish first time of smoking Ganja!

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Atrium
Cunt Tickler

Registered: 08/18/13
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Re: Cannabidiol: The side of marijuana you don't know [Re: tripp23]
#19181888 - 11/24/13 09:43 AM (10 years, 2 months ago) |
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^i know how you feel with that anxiety soblet me explain for you. tHC is responsible for that bad anxiety you get. CBD is the other part in marijuana that growers don't care about. Its what causes the sleepy side of it. Because everyone wants to "get blown" and only wants "fire" they ignore CBD content and go for growing plants with a bunch of white THC crystals. Its not a problem to most but for people like me and you, this can cause very adverse reactions that, really, the media got half right. Things like paranoia, heart rate and such.
So yes, CBD will help better than even Xanax which is straight up just tranquilizers.
-------------------- The only thing about Chemistry I like is all the psychedelics that come from it. The only reason I study Psychology is to have a legitimate excuse to enjoy Chemistry.
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Konyap

Registered: 06/30/07
Posts: 33,945
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Re: Cannabidiol: The side of marijuana you don't know [Re: Atrium]
#19182285 - 11/24/13 11:42 AM (10 years, 2 months ago) |
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yeah cbd kind of takes up the spot THC
where as anti-depressents some how fuck with your dopamin and when you stop taking it your brain rattles off
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Konyap

Registered: 06/30/07
Posts: 33,945
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Re: Cannabidiol: The side of marijuana you don't know [Re: tripp23]
#19182295 - 11/24/13 11:45 AM (10 years, 2 months ago) |
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Quote:
tripp23 said:
Quote:
Illyabo said: One of the comments from the article "GW Pharma's Sativex is a 1:1 THC:CBD extract in alcohol tincture with propylene glycol added. It is less safe and less effective than whole plant extract."
Yeah sounded too good to be true
I dont get it? So is there THC in it? How can there be? If this stuff really works for anxiety, I will order this as fast as I can right now because I know how good weed is for you in general.. The only problem is, I can't smoke because it makes my anxiety worse so if this is a counter product that works, I want it. Any info?
I think what they're saying is there are like 269CBD's in some plants and some tincture isn't going to capture the same stuff
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John Nada
Toujours Frais

Registered: 03/03/03
Posts: 97,746
Loc: Hotwings; race car
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Re: Cannabidiol: The side of marijuana you don't know [Re: Konyap]
#19183038 - 11/24/13 03:00 PM (10 years, 2 months ago) |
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No, "CBD" is a single chemical, it is called "cannabidiol". "Sativex" is a single brand-name product from a major international company called "GW pharmaceuticals", and it contains both THC and CBD, in equal portions (1:1). You can take extracts with pure CBD and no THC if you want. Try reading this thread again, it's pretty straight-forward.
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tripp23
Kratom Freak



Registered: 05/21/08
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Re: Cannabidiol: The side of marijuana you don't know [Re: Atrium]
#19185089 - 11/24/13 11:51 PM (10 years, 2 months ago) |
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So the source they provided is just straight CBD correct?
Quote:
Jamesdnh said: ^i know how you feel with that anxiety soblet me explain for you. tHC is responsible for that bad anxiety you get. CBD is the other part in marijuana that growers don't care about. Its what causes the sleepy side of it. Because everyone wants to "get blown" and only wants "fire" they ignore CBD content and go for growing plants with a bunch of white THC crystals. Its not a problem to most but for people like me and you, this can cause very adverse reactions that, really, the media got half right. Things like paranoia, heart rate and such.
So yes, CBD will help better than even Xanax which is straight up just tranquilizers.
I know that lol and thats why I don't smoke. Ill take one dab or something and ill probably be in the hospital haha
This CBD stuff really intregues me. Im definitely going to order some next check!
Anybody else use/test this stuff, on here yet?
-------------------- Experience my nightmarish first time of smoking Ganja!

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LoginName123

Registered: 11/24/13
Posts: 22
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Re: Cannabidiol: The side of marijuana you don't know [Re: tripp23]
#19185147 - 11/25/13 12:12 AM (10 years, 2 months ago) |
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"It has an IC50 of 11 uM. My job is looking for anticancer drugs and we do not even consider anything even remotely interesting unless it kills all cells at 10 uM and even then probably wouldn't even pursue it unless it was ~1 uM or less. I am so tired of seeing these marijuana related articles posted and having very weak activity and people thinking it means something. There are an amazing amount of compounds that would kill these cells at 11 uM. I would even say most of the compounds I test would have this sort of activity and it is not remarkable in any way. You want at least sub micromolar activity, preferably nanomolar activity unless there is overwhelming evidence that the compound targets cancer cells in some way that is totally benign to normal cells. If you tested this CBD compound in normal fibroblasts or primary cells (not cancerous) you would see that it is highly likely it kills them at even lower doses. We don't know the answer to that question because they didn't test that in this paper.
In fact, my coworker right now is testing the U87-MG cell line that is used in this paper and they are extremely sensitive to compounds. She is having to dilute our libraries more than usual as most of our crude extracts are killing the cells. This doesn't mean all of our extracts are interesting anti-glioma compounds, it means that this line is more sensitive than what we are used to."
http://www.reddit.com/r/science/comments/1qtuu3/study_as_cbd_is_a_nonpsychoactive/
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Konyap

Registered: 06/30/07
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Re: Cannabidiol: The side of marijuana you don't know [Re: LoginName123]
#19186030 - 11/25/13 09:25 AM (10 years, 2 months ago) |
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LoginName123

Registered: 11/24/13
Posts: 22
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Re: Cannabidiol: The side of marijuana you don't know [Re: Konyap]
#19186385 - 11/25/13 10:55 AM (10 years, 2 months ago) |
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There could still be potential. While many discoveries don't hold up they can be a good starting place for future innovation. A non-oncology example is mescaline. Mescaline isn't particularly potent or selective. Despite this is served as a foundation for many other chemicals.
Quality cannabis is still medicine in other ways already. It's an effective anti-emetic and anti-anoretic. It just needs to be regulated so people can know what they are getting is quality.
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aysen
Good Ole Boy



Registered: 09/21/09
Posts: 1,870
Loc: On the right path
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Re: Cannabidiol: The side of marijuana you don't know [Re: LoginName123]
#19188576 - 11/25/13 07:18 PM (10 years, 2 months ago) |
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I love cbd.. prolly would have never tried it if I didn't move to Denver.. shit is great.. u can get it from big edible places in Colorado if you order the cbd only stuff anywhere in us
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allseeingike



Registered: 04/06/11
Posts: 2,832
Loc: elgin ill-miami fl
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Re: Cannabidiol: The side of marijuana you don't know [Re: aysen] 1
#19195324 - 11/27/13 07:48 AM (10 years, 2 months ago) |
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i tried gettting some cdb from bayshore botanicals and they took my money but didnt send any product and do not respond to any of my emails
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Jvells
Unity



Registered: 11/05/09
Posts: 3,031
Loc: East coast
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Re: Cannabidiol: The side of marijuana you don't know [Re: allseeingike]
#19197668 - 11/27/13 06:22 PM (10 years, 2 months ago) |
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Why don't you try and reverse the payment it's not that hard
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allseeingike



Registered: 04/06/11
Posts: 2,832
Loc: elgin ill-miami fl
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Re: Cannabidiol: The side of marijuana you don't know [Re: Jvells]
#19197840 - 11/27/13 06:57 PM (10 years, 2 months ago) |
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Quote:
Jvells said: Why don't you try and reverse the payment it's not that hard
How do I do that? I was going to call the bank to see what I could do
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Jvells
Unity



Registered: 11/05/09
Posts: 3,031
Loc: East coast
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Re: Cannabidiol: The side of marijuana you don't know [Re: allseeingike]
#19197952 - 11/27/13 07:21 PM (10 years, 2 months ago) |
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Idk but I've read online multiple times that it's very easy to do reverse payments or something like that when someone fucks you over, even if they didn't...I do believe it might be called a 'reverse payment' but maybe not, I forget. You really don't need a lot of evidence they did scam you either which is why I thought it was fucky and worth mentioning here. Worth a shot though calling your card company and bringing it up is my point. No guarantees though but if it's a good amount o bills it's worth a shottt mang. Oh and I shot that company a nasty email in your honor
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