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Offlinesnoot
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Evidence finally shows n,n-DMT presence in pineal gland. * 4
    #19149639 - 11/17/13 12:54 PM (10 years, 2 months ago)

Quote:

We report here, for the first time, the presence of N,N-dimethyltryptamine in pineal gland microdialysate obtained from the rat. Copyright © 2013 John Wiley & Sons, Ltd.






ABSTRACT

We report a qualitative liquid chromatography–tandem mass spectrometry (LC/MS/MS) method for the simultaneous analysis of the three known N,N-dimethyltryptamine endogenous hallucinogens, their precursors and metabolites, as well as melatonin and its metabolic precursors. The method was characterized using artificial cerebrospinal fluid (aCSF) as the matrix and was subsequently applied to the analysis of rat brain pineal gland-aCSF microdialysate. The method describes the simultaneous analysis of 23 chemically diverse compounds plus a deuterated internal standard by direct injection, requiring no dilution or extraction of the samples. The results demonstrate that this is a simple, sensitive, specific and direct approach to the qualitative analysis of these compounds in this matrix. The protocol also employs stringent MS confirmatory criteria for the detection and confirmation of the compounds examined, including exact mass measurements. The excellent limits of detection and broad scope make it a valuable research tool for examining the endogenous hallucinogen pathways in the central nervous system. We report here, for the first time, the presence of N,N-dimethyltryptamine in pineal gland microdialysate obtained from the rat. Copyright © 2013 John Wiley & Sons, Ltd.


http://onlinelibrary.wiley.com/doi/10.1002/bmc.2981/abstract;jsessionid=7996361A89D7B7A2656009E382B81E07.f03t01

Would be nice to read the article.


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Offlinemorrowasted
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: snoot]
    #19149678 - 11/17/13 01:03 PM (10 years, 2 months ago)

:awethumb: thanks for posting


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OfflineKonyap

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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: morrowasted] * 2
    #19149710 - 11/17/13 01:11 PM (10 years, 2 months ago)

How come a bunch of drugged out hippies knew this already?

God?


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OfflineHeroMike
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: morrowasted]
    #19149717 - 11/17/13 01:12 PM (10 years, 2 months ago)

Cool . :bongload:


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Offlinemorrowasted
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: Konyap] * 5
    #19149720 - 11/17/13 01:14 PM (10 years, 2 months ago)

Quote:

Illyabo said:
How come a bunch of drugged out hippies knew this already?

God?



No, a bunch of drugged out hippies misread Strassman's book which HYPOTHESIZED the presence of DMT in the pineal gland, ran around spreading misinformation by telling everyone it was in fact true that there was DMT in the pineal gland, making the psychedelic community look like a potential bunch of fools if it turned out to be false, so thank god this group of scientists has redeemed it.


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InvisiblePrisoner#1
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: morrowasted] * 2
    #19149732 - 11/17/13 01:16 PM (10 years, 2 months ago)

Quote:

morrowasted said:
Quote:

Illyabo said:
How come a bunch of drugged out hippies knew this already?

God?



No, a bunch of drugged out hippies misread Strassman's book which HYPOTHESIZED the presence of DMT in the pineal gland, ran around spreading misinformation by telling everyone it was in fact true that there was DMT in the pineal gland, making the psychedelic community look like a potential bunch of fools if it turned out to be false, so thank god this group of scientists has redeemed it.





there's still a bit of research to do before we can say it's been redeemed


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Offlineakira_akuma
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: morrowasted] * 2
    #19149733 - 11/17/13 01:17 PM (10 years, 2 months ago)

if freakin' grass has it, i'm presuming humans got it too.


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Offlinemorrowasted
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: Prisoner#1]
    #19149736 - 11/17/13 01:17 PM (10 years, 2 months ago)

Quote:

Prisoner#1 said:
Quote:

morrowasted said:
Quote:

Illyabo said:
How come a bunch of drugged out hippies knew this already?

God?



No, a bunch of drugged out hippies misread Strassman's book which HYPOTHESIZED the presence of DMT in the pineal gland, ran around spreading misinformation by telling everyone it was in fact true that there was DMT in the pineal gland, making the psychedelic community look like a potential bunch of fools if it turned out to be false, so thank god this group of scientists has redeemed it.





there's still a bit of research to do before we can say it's been redeemed


elaborate please. you mean to say as in, proving there is DMT in the pineal gland in humans? rats are pretty damn reliable. or different research?


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Offlinesnoot
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: akira_akuma]
    #19149887 - 11/17/13 01:53 PM (10 years, 2 months ago)

Quote:

akira_akuma said:
if freakin' grass has it, i'm presuming humans got it too.





We've known for some time that dmt was endogenous in the human brain, however the pineal gland has only ever been speculated apon.


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Offlineakira_akuma
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: snoot]
    #19149920 - 11/17/13 02:02 PM (10 years, 2 months ago)

yeah, because it's been shown that DMT (found in plants) is a fundamental building block to their development. you can reasonably assume that DMT has the same building block characteristics for humans, that say Tryptamine does; and thusly can presume that we also share the same instances of having endo-DMT in our molecular make-up.


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InvisibleCidneyIndole
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: akira_akuma]
    #19149951 - 11/17/13 02:12 PM (10 years, 2 months ago)

Yeah, OP should have written "rats" in the title, so as to not make it misleading.

This does NOT confirm DMT in the human pineal. It may suggest it, but that is not the same thing. If rats were 100% perfectly analogous to humans, we'd almost never have to test drugs on people. But that's not the case.


I don't think Strassman was talking out his ass. He had reasons to speculate as he did. And so far, this finding seems like a minor confirmation of that. So it very well may be true. But at this point, it has not been "proven."


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Invisiblecollie man
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: snoot]
    #19149959 - 11/17/13 02:14 PM (10 years, 2 months ago)

So we can now assume that in fear an loathing it was dmt he was droppin and not adrenocrome.


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InvisibleShroomopotamus
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: snoot]
    #19149994 - 11/17/13 02:23 PM (10 years, 2 months ago)

Read about this a while back.
Doesn't prove anything about humans, but it does make the theory seem more plausible than ever.


--------------------
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Edited by Shroomopotamus (11/17/13 02:29 PM)


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Offlinesnoot
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: akira_akuma]
    #19150012 - 11/17/13 02:27 PM (10 years, 2 months ago)

Quote:

akira_akuma said:
yeah, because it's been shown that DMT (found in plants) is a fundamental building block to their development. you can reasonably assume that DMT has the same building block characteristics for humans, that say Tryptamine does; and thusly can presume that we also share the same instances of having endo-DMT in our molecular make-up.




Its been shown? Go on..........


Quote:

CidneyIndole said:
Yeah, OP should have written "rats" in the title, so as to not make it misleading.

This does NOT confirm DMT in the human pineal. It may suggest it, but that is not the same thing. If rats were 100% perfectly analogous to humans, we'd almost never have to test drugs on people. But that's not the case.


I don't think Strassman was talking out his ass. He had reasons to speculate as he did. And so far, this finding seems like a minor confirmation of that. So it very well may be true. But at this point, it has not been "proven."





I never said humans either. This is just merely evidence that supports Strassman. Lets just be glad progress, is progressing.


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InvisibleSophistic Radiance
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: Konyap] * 1
    #19150032 - 11/17/13 02:30 PM (10 years, 2 months ago)

Quote:

morrowasted said:
Quote:

Prisoner#1 said:
Quote:

morrowasted said:
Quote:

Illyabo said:
How come a bunch of drugged out hippies knew this already?

God?



No, a bunch of drugged out hippies misread Strassman's book which HYPOTHESIZED the presence of DMT in the pineal gland, ran around spreading misinformation by telling everyone it was in fact true that there was DMT in the pineal gland, making the psychedelic community look like a potential bunch of fools if it turned out to be false, so thank god this group of scientists has redeemed it.





there's still a bit of research to do before we can say it's been redeemed


elaborate please. you mean to say as in, proving there is DMT in the pineal gland in humans? rats are pretty damn reliable. or different research?




The work needs to be reproduced and confirmed, that's all. :nerd:

Quote:

Illyabo said:
How come a bunch of drugged out hippies knew this already?

God?




Science is still recovering the secrets lost to us when the repeated pummeling of peace demonstrators' skulls led to permanent memory loss. :ancientaliens:


--------------------
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You really are the worst kind of person.



Edited by Sophistic Radiance (11/17/13 02:35 PM)


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Offlineakira_akuma
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: snoot]
    #19150034 - 11/17/13 02:30 PM (10 years, 2 months ago)

Quote:

snoot said:
Quote:

akira_akuma said:
yeah, because it's been shown that DMT (found in plants) is a fundamental building block to their development. you can reasonably assume that DMT has the same building block characteristics for humans, that say Tryptamine does; and thusly can presume that we also share the same instances of having endo-DMT in our molecular make-up.




Its been shown? Go on..........



hypothetically. all you have to do is read Strassman's book. it's hypothesized there.


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InvisibleShroomopotamus
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: Konyap] * 5
    #19150044 - 11/17/13 02:32 PM (10 years, 2 months ago)

Quote:

Illyabo said:
How come a bunch of drugged out hippies knew this already?

God?



Psychedelics can lead you directly to the tree of knowledge... Where all the information of existence awaits those who seek it.


--------------------
*
Live by the mushroom, die by the mushroom
:mushroom2::rainbowdrink:
This is a trap! A trap! You are all busted! Busted! You fools!
:twirlyface:

If a time comes where I fail to appear I've been abducted and I will miss you all
Please smile and pet puppies as often as possible
Be happy
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OfflineMungo man
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: Shroomopotamus]
    #19150308 - 11/17/13 03:31 PM (10 years, 2 months ago)

Progress is progress, but all it really shows us is that rats have DMT in their pineal gland. Are the procedures for detecting hallucinogens dangerous/require dead specimens? Because otherwise... We should have result by now.


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How would you prove it to a court of law?


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InvisibleSophistic Radiance
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: Mungo man]
    #19150321 - 11/17/13 03:34 PM (10 years, 2 months ago)

Quote:

Mungo man said:
Progress is progress, but all it really shows us is that rats have DMT in their pineal gland. Are the procedures for detecting hallucinogens dangerous/require dead specimens? Because otherwise... We should have result by now.




This is a new technique that for the first time makes it possible to inspect the chemistry of a living organism's pineal gland. Prior to this, the only way to check out what was going on in there was to go straight through the brain, which (understandably) causes a lot of chemical changes.


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OfflineMungo man
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Re: Evidence finally shows n,n-DMT presence in pineal gland. [Re: Sophistic Radiance] * 1
    #19150813 - 11/17/13 05:20 PM (10 years, 2 months ago)

Quote:



This is a new technique that for the first time makes it possible to inspect the chemistry of a living organism's pineal gland. Prior to this, the only way to check out what was going on in there was to go straight through the brain, which (understandably) causes a lot of chemical changes.




Brilliant! I didn't know that this was utilizing state of the art technology. This is interesting stuff. I'm going to university for organic chem/neuroscience and this stuff is always intriguing to me. I need to do some reading on this LC/MS/MS stuff. I wonder if this technology is realistically applicable in humans and I also wonder the type of data these tests yield.

Time to do some reading :laugh:


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