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OfflineMultipleHightimes
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Registered: 10/17/13
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Last seen: 10 years, 3 months
Could those mushrooms harm our body? Magic or Toxin. Be rational
    #19100569 - 11/07/13 01:28 PM (10 years, 3 months ago)

If you use them every second week once on a weekend.
Withouth any other drugs, or just slightly with DMT, Ganja.

Can we burn our brains with it?
Can it harm organs or other parts of the body?


Now only the neurology side. As I know not much about the mushroom mechanics. I know that we have a brain, with receptors.
If we eat mushrooms with "psilocin,.,." a certain substance.
The substance can enter the brain. And they will sit down on a certain receptor. I know how its called. But I cant work with that.
As I far say at the moment. It does not work like a toxin (or such things like alcohol.).
It works like a normal hormone.

But this is no point to think it is secure to use it(often).

Its also has known effect on the body. The blood presure goes up.
This can lead to head ache. Which can indicate the it destroys something.

But halt. I have no clue.

To get an good overview about the "toxin" I have to look on long-term studies.
Where can I find them?

Has science proven that they are not brain/body damaging?


The psy. side is more comlex. I think.
After I ate my mushrooms last weekend. I experienced enlightment.
It must be it. Iam not sure. But this "thing" can explain all.
Its also dangerous enlightment seems to be very close to crazyness.
But this is not what Iam looking for at the moment. At the moment I want to know how bad those mushrooms can be for the health-system.



You may know the argument that the "death cap" is a deadly mushroom.
We shouldnt forget about that. And be rational.
How comes a person which lived withoud an idea about the existance of a brain to the act to eat them? There will only be thesis about this.
And this will explain nothing. Because thesis are only thesis, this cant be proven.


For me its a Magic at the moment.


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InvisibleK1ngSp4de
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: MultipleHightimes]
    #19100766 - 11/07/13 02:07 PM (10 years, 3 months ago)



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                                    PC Repair and Troubleshooting Forum

If a law is unjust, a man is not only right to disobey it, he is obligated to do so.
                                                - Thomas Jefferson

                    Si peccasse negamus fallimur et nulla est in nobis veritas.


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OfflineBlack_Sunset
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: K1ngSp4de]
    #19100904 - 11/07/13 02:27 PM (10 years, 3 months ago)

Pharmacology[edit]


The neurotransmitter serotonin is structurally similar to psilocybin.
Psilocybin is rapidly dephosphorylated in the body to psilocin, which is a partial agonist for several serotonergic receptors. Psilocin has a high affinity for the 5-HT2A serotonin receptor in the brain, where it mimics the effects of serotonin (5-hydroxytryptamine, or 5-HT). Psilocin binds less tightly to other serotonergic receptors 5-HT1A, 5-HT1D, and 5-HT2C.[1] Serotonin receptors are located in numerous parts of the brain, including the cerebral cortex, and are involved in a wide range of functions, including regulation of mood and motivation.[81] The psychotomimetic (psychosis-mimicking) effects of psilocin can be blocked in a dose-dependent fashion by the 5-HT2A antagonist drugs ketanserin and risperidone.[82] Although the 5-HT2A receptor is responsible for most of the effects of psilocin, various lines of evidence have shown that interactions with non-5-HT2A receptors also contribute to the subjective and behavioral effects of the drug.[83][nb 3] For example, psilocin indirectly increases the concentration of the neurotransmitter dopamine in the basal ganglia, and some psychotomimetic symptoms of psilocin are reduced by haloperidol, a non-selective dopamine receptor antagonist. Taken together, these suggest that there may be an indirect dopaminergic contribution to psilocin's psychotomimetic effects.[85] In contrast to LSD, which binds to all dopamine receptor subtypes,[citation needed] psilocybin and psilocin have no affinity for the dopamine receptors.[1]
The chemical structures of psilocybin and related analogs have been used in computational biology to help model the structure, function, and ligand-binding properties of the 5-HT2C G-protein-coupled receptor.[86][87]


Toxicity and harm potential[edit]


Chart of dependence potential and effective dose/lethal dose ratio of several psychoactive drugs. Source:[88]
The toxicity of psilocybin is low. In rats, the median lethal dose (LD50) when administered orally is 280 milligrams per kilogram (mg/kg), approximately one and a half times that of caffeine. When administered intravenously in rabbits, psilocybin's LD50 is approximately 12.5 mg/kg.[62] Psilocybin comprises approximately 1% of the weight of Psilocybe cubensis mushrooms, and so nearly 1.7 kilograms (3.7 lb) of dried mushrooms, or 17 kilograms (37 lb) of fresh mushrooms, would be required for a 60-kilogram (130 lb) person to reach the 280 mg/kg LD50 value of rats.[45] Based on the results of animal studies, the lethal dose of psilocybin has been extrapolated to be 6 grams, 1000 times greater than the effective dose of 6 milligrams.[89] The Registry of Toxic Effects of Chemical Substances assigns psilocybin a relatively high therapeutic index of 641 (higher values correspond to a better safety profile); for comparison, the therapeutic indices of aspirin and nicotine are 199 and 21, respectively.[90] The lethal dose from psilocybin toxicity alone is unknown at recreational or medicinal levels, and has rarely been documented—as of 2011, only two cases attributed to overdosing on hallucinogenic mushrooms (without concurrent use of other drugs) have been reported in the scientific literature.[45][nb 4]
Most of the comparatively few fatal incidents reported in the literature that are associated with psychedelic mushroom usage involve the simultaneous use of other drugs, especially alcohol. Probably the most common cause of hospital admissions resulting from magic mushroom usage involve "bad trips" or panic reactions, in which affected individuals become extremely anxious, confused, agitated, or disoriented. Accidents, self-injury, or suicide attempts can result from serious cases of acute psychotic episodes.[45]
Repeated use of psilocybin does not lead to physical dependence.[1] A 2008 study concluded that, based on US data from the period 2000–2002, adolescent-onset (defined here as ages 11–17) usage of hallucinogenic drugs (including psilocybin) did not increase the risk of drug dependence in adulthood; this was in contrast to adolescent usage of cannabis, cocaine, inhalants, anxiolytic medicines, and stimulants, all of which were associated with "an excess risk of developing clinical features associated with drug dependence".[93] Similarly, a 2010 Dutch study ranked the relative harm of psilocybin mushrooms compared to a selection of 19 recreational drugs, including alcohol, cannabis, cocaine, ecstasy, heroin, and tobacco. Magic mushrooms were ranked as the illicit drug with the lowest harm,[94] corroborating conclusions reached earlier by expert groups in the United Kingdom.[95]
Although no studies have linked psilocybin with birth defects,[96] it is recommended that pregnant women avoid its usage.[97]


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OfflinebeforeIgetold
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Registered: 10/10/13
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: MultipleHightimes]
    #19101017 - 11/07/13 02:45 PM (10 years, 3 months ago)

Quote:

MultipleHightimes said:
Has science proven that they are not brain/body damaging?

For me its a Magic at the moment.




Yes... science have proven there is no damage... actually it's been on quite a few news sites, so I don't understand why you didn't see it yet.

Google names such as: David Erritzøe, David Nutt (no pun intended), Teri Krebs, Pål ørjan johansen.

Their independed studies (including brain scans while affected by the psychedelics) all show that there are no damage what so ever... this is true for both psilocybin and LSD.

In fact the results were so positive that the Imperial College in London is now studying how psilocybin can be developed to be used as a treatment for fx depression, since what psilocybin does is limit the overactive part of the brain in depressed persons.

So quit worrying and spread the word instead.

"Magic".... come on... that's just silly. Go youtube David Nutt cocktails and science or something like that. Goes into depth on how shrooms work and what it does to the brain.
There's nothing magical about it at all I'm sorry to say.
What happens it that your pre frontal cortex and post anterior cortex get disconnected, so instead of receiving sensory stimuli, the brain almost exclusively works with internal stimuli, ie. things you have already experienced or a lot of it things you didn't notice.
It's quite facinating. The bloodflow in the brain is also vastly descreased which can explain why some people experience paralysis or extremity malfunction during the trip. I know my hands stopped functioning properly hehe.

The only question that pops into my head is how this decreased blood flow in the brain while under psilocybin could cause a risk of blood clogging in the brain?

I definitely wouldn't trip after having been to a chiropractor who cracked my neck (studies have revealed that cracking of necks risks releasing stuff into the blood flow going to the brain)


Edited by beforeIgetold (11/07/13 02:55 PM)


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Invisiblelessismore
Registered: 02/10/13
Posts: 6,268
Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: beforeIgetold]
    #19101065 - 11/07/13 02:52 PM (10 years, 3 months ago)

No brain burning yet, feel better overview of my thoughts than in 10 years+better memory than I can ever remember having

but have only tripped 3.5-7g mushrooms maybe 30-40 times, not sure exact number

it can be beneficial to ask the mushroom to change you :-D heh
trip for self-improvement, who am I? what do I love? what should I do about this?

they have had a great mood lifting effect that seems to be permanent for me, same with LSD
it lasts years afterwards, if you learn from the experience, hasnt faded much

before I was very scientific minded about everything and afraid of drugs(even weed, never smoked weed till I was 26)...
but psychedelics are the only drugs I would want to do now, since they are similar to serotonin in the brain... hack your own brain, but do it right, dont make an ugly hack
set,setting,dose

respect those and I get 95% good trips, 150-200 LSD trips so far, 30-40 mushroom trips, usually high / heroic doses
with lower doses that I feel at ease with I get 99,9% good trips, but I like to take 3.5g+ or 3 hits of LSD  when I trip rarely


Edited by lessismore (11/07/13 02:59 PM)


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Invisiblelessismore
Registered: 02/10/13
Posts: 6,268
Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: lessismore]
    #19101137 - 11/07/13 03:04 PM (10 years, 3 months ago)

oh btw.. I used to binge a lot in the beginning like any psychonaut

sometimes every 3 days (3-10hits lsd)... sometimes every week, or 2 days in a row

when you trip often it just takes much longer to process the trip

I found the learning process was in the integration of the trip, not in tripping often
the fun part is actually putting to use what you just learned, and feeling the love in everyday life

and its easiest to be yourself when you dont trip too often, I trip maybe every 2-4 months currently

the mushroom is a great healing teacher, listen carefully, it often has a message/something to tell you :-)

mushrooms,dmt,mescaline,ayahuasca,lsd  , all are very similar to serotonin iirc
wouldnt be afraid of consuming one instead of the other... about equally dangerous, LD50 is pretty high with psychedelics
they can all heal and teach

would rather do psychedelics than smoke weed, since weed demotivates me more, and makes me crave more
psychedelics dont, next day I feel good and have to go out and do something

if you like the psychedelic experience, try looking into lucid dreaming, its 100x better , and you can do it without any drug (google lucid dreaming how to, anyone can learn it)
better visuals than high dose lsd, feels more real than this reality often etc.
it will make you question everything , but it might not teach as much as psychedelics - just great fun


Edited by lessismore (11/07/13 03:14 PM)


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OfflineYogi1
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: lessismore]
    #19101560 - 11/07/13 04:23 PM (10 years, 3 months ago)

I know a hippie who has significantly altered her natural serotonin levels.

Mushrooms are great but honestly dont do that shit twice a month (24 6 hour trips) in a year and expect nothing to be different after.

Its part of respecting the teacher.


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OfflineGreySatyr
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: Yogi1]
    #19101749 - 11/07/13 05:05 PM (10 years, 3 months ago)

Everything is toxic, even water is toxic. Water is also very healthy. It all boils down to dosage and moderation. I've done lots of reading up on this and psilocybin and LSD are perfectly healthy when used in moderation.


--------------------
...also, go to hell, huh?


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OfflineMultipleHightimes
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Registered: 10/17/13
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: GreySatyr]
    #19104526 - 11/08/13 09:24 AM (10 years, 3 months ago)

Thanks for all that informations.

I want to ask the one who said, that he knows a hippie which altered his serotonin-level for ever.

Can you explain which substances he also consumed?
How much mushrooms he ate.
And so on. For science research.

It could be that m. m. lead to a serotonin-syndrom.



Also thanks for the effort you all made to supply me with wisdom.
I reed carefully.


Its still magic for me. Its no "zamba" or something.


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OfflineAgentchewy
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: MultipleHightimes]
    #19104569 - 11/08/13 09:35 AM (10 years, 3 months ago)

Psilocybin is almost identical to 5 HTP and similar to serotonin and melatonin. Its so matched to sync up with our nervous system that it binds to your receptors almost perfectly which implies intelligence or atleast a relationship between the two over time.

Psilocybin has recently been found to cause neurogenesis at a rate comparable only to that of early childhood.

No wonder its illegal. Its strange as fuck


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If I knew the way, I would take you home.


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InvisibleBill_Oreilly
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: Agentchewy]
    #19104877 - 11/08/13 10:33 AM (10 years, 3 months ago)

I smell bacon and its coming from the top of the page..


--------------------
Something there is mysteriously formed,
Existing before Heaven and Earth,
Silent, still, standing alone, unchanging,
All-pervading, unfailing,
I do not know its name; I call it tao.
If forced to give it a name, I call it
Great (ta). Being great, it flows out;
Flowing out means far-reaching;
Being far-reaching, it is said to return.


It's just a shot away..


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InvisibleThayendanegea
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: Bill_Oreilly]
    #19105300 - 11/08/13 12:02 PM (10 years, 3 months ago)

Quote:

r 17 kilograms (37 lb) of fresh mushrooms, would be required for a 60-kilogram (130 lb) person to reach the 280 mg/kg LD50 value of rats.



Ima gonna go eat me 37 lbs of fresh mushies to test this here theory!lol....that is a shit ton of mush. I thing we are pretty safe with our 3.5G dosages.:wink:


--------------------
Look Deep Into Nature,and Then You Will Understand Everything Better.

Albert Einstein


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OfflineYogi1
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: Thayendanegea]
    #19105598 - 11/08/13 01:05 PM (10 years, 3 months ago)

Ha, "I'm 250 pounds let's see... That should mean I need 3 and a quarter tabzz rite"
:tard:


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OfflinebeforeIgetold
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: Yogi1]
    #19105949 - 11/08/13 02:26 PM (10 years, 3 months ago)

http://link.springer.com/article/10.1007%2Fs00221-013-3579-0

It's pretty damn interesting.... we have the Imperial College study going on, we have the maps.org studies going on, we have the two researchers from Norway removing shrooms and LSD from the list of mentally damaging substances and we have the brain scans from David Erritzøe at the state hospital in Copenhagen.

Basically what that Maps study is potentially showing is that psilocybin might help in decreasing dementia.... that's a really big thing!


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OfflineKingKnowledge
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: Bill_Oreilly]
    #19105979 - 11/08/13 02:32 PM (10 years, 3 months ago)

Quote:

Bill_Oreilly said:
I smell bacon and its coming from the top of the page..





Paranoid.

I always think about whether LSD is harmful in the long run. I just take my time and only dose when I feel ready (ranging from every 6 months to every 2 months).


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OfflineIcyus
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: beforeIgetold]
    #19105986 - 11/08/13 02:34 PM (10 years, 3 months ago)

Hawayan, as any shamanism teaches that sickness comes from stress, fear and anger resulting in subconscious musclecontractions over extended periods of time, resulting in toxin-build up in the cells that once hitting the bloodstream may cause damage.... depending on the amount and consentration...

So as a trip may make you tense and traumatized; it may later get you sick, but if you are traumatized a trip may help you dealing with it, thus maybe prevent a fatal toumor ect...

In the end, the user decides if it shall hurt or heal.


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OfflinePrimalSoup
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: MultipleHightimes]
    #19105997 - 11/08/13 02:36 PM (10 years, 3 months ago)

Quote:

If you use them every second week once on a weekend.
Withouth any other drugs




You're talking psilocybin mushrooms?  Then absolutely not.:thumbup:

But they will make some people entertain delusions. :lol:

:peace:PS


--------------------

if you stand too close to the machine it'll start to eat you
Primal's simple tested teks and projects: :awesomenod: Wheat Prep 2.0  Acidic Tea Tek  Potency Project! 


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InvisibleBill_Oreilly
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Registered: 11/12/11
Posts: 26,370
Loc: Boston
Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: KingKnowledge]
    #19107723 - 11/08/13 08:50 PM (10 years, 3 months ago)

Quote:

KingKnowledge said:
Quote:

Bill_Oreilly said:
I smell bacon and its coming from the top of the page..





Paranoid.

I always think about whether LSD is harmful in the long run. I just take my time and only dose when I feel ready (ranging from every 6 months to every 2 months).





Joke.


--------------------
Something there is mysteriously formed,
Existing before Heaven and Earth,
Silent, still, standing alone, unchanging,
All-pervading, unfailing,
I do not know its name; I call it tao.
If forced to give it a name, I call it
Great (ta). Being great, it flows out;
Flowing out means far-reaching;
Being far-reaching, it is said to return.


It's just a shot away..


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Invisiblelessismore
Registered: 02/10/13
Posts: 6,268
Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: Bill_Oreilly]
    #19108994 - 11/09/13 04:01 AM (10 years, 3 months ago)

we have to face our inner fears, that is the danger

self-reflection, are you ready to face your whole life at once?

else dont go that deep

one trip took me well over 1 year to integrate just a bit... very emotional trip

but what do you expect from a near death experience :wink:
it will change everything you see, your whole view on life when you come back, you dont take anything for granted anymore likely, and you dont fear death anymore either likely so no rush in life, concept of self and time is changed permanently likely

near death experience on psychedelics or for real, I dont think there will be much difference
can be very life changing


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OfflineApeman
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Re: Could those mushrooms harm our body? Magic or Toxin. Be rational [Re: lessismore]
    #19108995 - 11/09/13 04:03 AM (10 years, 3 months ago)



--------------------
"The cost of sanity in this society, is a certain level of alienation”
― Terence McKenna


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