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OfflinePurpleHaze147
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Is it mango juice or grapefruit juice that potenates cannabis or is it both?
    #19097047 - 11/06/13 07:03 PM (10 years, 2 months ago)

If I remember correctly drinking mango juice potenates cannabis when comsumed orally or smoked and drinking red grape fruit juice makes cannabis more active orally. I might have them mixed up, I do know at least one of the juices does potenate weed, pretty sure both do in some way, grapefruit juice potenates a lot of drugs. I'd really like to know for a fact. I know that red grape fruit juice contains some sort of maoi like liver(?) enzyme inhibitor, I have no idea what drug mangos have in them, my guess is some sort of FAAH inhibitor. You want to drink juice with the highest actual fruit juice content, drink the nectors, or eat the whole fruit. I know u would wanna do this about a half hour before cannabis consumption. Wouldn't calcium carbonate also possibly potenate weed orally since it lowers stomach pH?


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Offlines240779
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Re: Is it mango juice or grapefruit juice that potenates cannabis or is it both? [Re: PurpleHaze147]
    #19097254 - 11/06/13 07:44 PM (10 years, 2 months ago)
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Grapefruit info, see attached.


Mango is said to enhance cannabis because it contains myrcene. While myrcene is already found in cannabis, it is said that extra myrcene results in stronger effects. A hops supplement, as indicated below, is another option (a much more economical option)


Myrcene is a recognized sedative as part of hops preparations (Humulus lupulus), employed to aid sleep in Germany (Bisset and Wichtl, 2004). Furthermore, myrcene acted as a muscle relaxant in mice, and potentiated barbiturate sleep time at high doses (do Vale et al., 2002). Together, these data would support the hypothesis that myrcene is a prominent sedative terpenoid in cannabis, and combined with THC, may produce the ‘couch-lock’ phenomenon of certain chemotypes that is alternatively decried or appreciated by recreational cannabis consumers.


Russo, EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. 2010, British Journal of Pharmacology, p. 1350


So, allegedly it's not just CBD that is responsible for couch lock.


Edited by s240779 (11/06/13 07:53 PM)


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Offlineweshroom
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Re: Is it mango juice or grapefruit juice that potenates cannabis or is it both? [Re: PurpleHaze147]
    #19097298 - 11/06/13 07:50 PM (10 years, 2 months ago)

Its white grapefruit juice that is notorious for potentiating some drugs. I think star fruit might also produce a similar enzyme inhibition.
I do not know how effective this is in relation to weed edibles.

AS far as I know the mango thing is mainly speculation/myth.... I still will eat a mango sometimes before I smoke/consume herb.

I think Black pepper extract (piperine) could possibly enhance absorption of thc if taken prior to consuming edible.

Also another thing to consider is first pass metabolism. Some people claim that edibles should be consumed 1.5hrs after eating a meal so you avoid first pass metabolism and more thc is absorbed in the body.
        Horny goat weed may inhibit first pass metabolism thereby allowing the body to absorb more thc consumed from an edible.


Thats my 2 cents on the matter.


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Re: Is it mango juice or grapefruit juice that potenates cannabis or is it both? [Re: weshroom]
    #19097308 - 11/06/13 07:51 PM (10 years, 2 months ago)

Interesting da2ura, I never really knew the theory behind the mango thing.


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Offlines240779
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Re: Is it mango juice or grapefruit juice that potenates cannabis or is it both? [Re: weshroom]
    #19097327 - 11/06/13 07:54 PM (10 years, 2 months ago)

:smile:


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OfflinePurpleHaze147
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Re: Is it mango juice or grapefruit juice that potenates cannabis or is it both? [Re: s240779]
    #19097927 - 11/06/13 09:48 PM (10 years, 2 months ago)

Really.. white grape fruit juice? I always thought red was better.

Is THC a monoamine, I don't think it is? I'm aware of the endogenous monoamines and I know psychedlics, stims,  gaba modulators, etc r monoamines. What classifies a molecule as a monoamine? I've been wondering this for a while I have a grasp but im not sure. I can find out my self but it'd b nice if someone here gave me an explanation to back my research up. Can't find my copy of Stahls essential psychopharmacology neuroscientific basis and practical applications at the moment... great book.. Imma b pissed if sum idiot "friend" I had over stole it cuz it's a book about drugs lol

R monoamines just liglands that effect serotonin, dopamine, epiphederine, norepiphederine, gaba, alpha, beta, choline, adenosine, nd I'm sure am forgetting a few the brains so complex. Opioids, sigma, cb... liglands rnt monoamines right? I feel like I'm forgetting a few major neurotranstion systems.

There has to be something specific about the molecular structure for it to b a monoamine... one amine duh lol but idk how to identify. Is it as simple as just havin one amine group in it's full iupac name? But this can't be GHB is a monoamine nd it's iupac name is 4-hydroxybutanoic acid.

Please excuse n correct me if I said something wrong, I learn from my mistakes. I know quite a bit about neuroscience n pharmacology but it's all self taught so some easy parts I may have missed, like how to identify a monoamine.


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Edited by PurpleHaze147 (11/06/13 10:02 PM)


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