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OnlineYthanA
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Everything You've Heard About Crack And Meth Is Wrong * 3
    #19089047 - 11/05/13 08:36 AM (10 years, 3 months ago)

Everything You've Heard About Crack And Meth Is Wrong
forbes.com

Growing familiarity with marijuana has been accompanied by growing support for legalization because people discovered through personal experience that the government was lying to them about the drug’s hazards. But it is easier to demonize less popular drugs such as crack cocaine and methamphetamine, which in the public mind are still linked, as marijuana once was, with addiction, madness, and violence. Any attempt to question the use of force in dealing with these drugs therefore must begin by separating reality from horror stories.

That is where Carl Hart comes in. Hart, a neuropsychopharmacologist at Columbia who grew up in one of Miami’s rougher neighborhoods, has done bold, path-breaking research that challenges widely accepted beliefs about crack and meth. In his inspiring and fascinating new memoir High Price, he describes both how he overcame his early disadvantages to secure a tenured position at an Ivy League university and how he came to question everything he thought he knew about drugs as he learned to think critically about the issue.

Before he became a scientist, Hart believed that people who use crack generally get hooked on it and thereby lose control of their behavior. But when he looked at the data on patterns of drug use as an academic, he could plainly see that only a small minority of people who try crack become heavy users. “Even at the peak [of] widespread use,” he writes, “only 10–20 percent of crack cocaine users became addicted.” According to the National Survey on Drug Use and Health, just 3 percent of Americans who have tried this reputedly irresistible and inescapable drug have smoked it in the last month.

Contrary to what anti-drug ads claim, Hart observes, addiction “is not an equal-opportunity disorder.” He notes that even rats, whose voracious consumption of cocaine in certain contrived conditions supposedly shows how powerfully addictive that drug is, tend to use it in moderation when they have other options, such as food, sex, or an interesting environment to explore.

Crack “gained the popularity that it did in the hood…because there weren’t that many other affordable sources of pleasure and purpose,” Hart writes. “And that was why, despite years of media-hyped predictions that crack’s expansion across classes was imminent, it never ‘ravaged’ the suburbs.”

Furthermore, Hart’s own research with heavy crack smokers found that, in contrast with the stereotypical addict who cannot help but immediately consume whatever crack is available, they frequently rejected the drug in favor of small cash payments or vouchers. He got similar results with meth snorters, even though he deliberately recruited frequent consumers who had no interest in stopping. These findings underline a crucial truth that Hart emphasizes: “The effects of drugs on human behavior and physiology are determined by a complex interaction between the individual drug user and her or his environment.”

Hart debunks various other misconceptions about crack and meth. He notes that the vast majority of violence attributed to crack grew out of black-market disputes, as opposed to the drug’s pharmacological effects. His studies found that cocaine and methamphetamine do increase heart rate and blood pressure, but the effect of typical doses is not dangerous in otherwise healthy people. He argues that research linking meth to brain damage confuses correlation with causation and fails to show that meth users’ cognitive capabilities are outside the normal range. And in case you were wondering, “There is no empirical evidence to support the claim that methamphetamine causes one to become physically unattractive.”

Hart is well aware of the hostility he is apt to provoke by challenging the myths underlying the war on drugs. He describes a 2005 meeting with journalists, arranged by the Office of National Drug Control Policy, where he tried to put the dangers of methamphetamine in perspective, noting that the drug is a government-approved treatment for narcolepsy and attention deficit hyperactivity disorder (ADHD). He cited his own research finding that methamphetamine has “the same effects” as a more familiar ADHD drug, Adderall, which has a “nearly identical” chemical structure. He added that pilots and soldiers commonly use amphetamines to stay alert.

Yet for some reason amphetamine use in these contexts is not considered alarming, physically dangerous, dentally destructive, or apt to produce outbursts of irrational, murderous violence. Hart’s calm and accurate presentation contrasted sharply with the tales of chemical slavery, degradation, and monstrous mayhem told by the other “experts” invited to the meeting: a cop, a prosecutor, and a self-identified meth addict. “My fellow panelists were horrified,” he says.


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OfflineHybridprX
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: Ythan]
    #19089088 - 11/05/13 08:53 AM (10 years, 3 months ago)

lmfao!

Crack and Meth are not addictive?

People who pick up those habbits and the one this article describes are still fairly "habitual" and both drugs are as habit forming as smoking. Someone with enough resources will easily loose it all keeping up with it.

Every crack user I have ever encountered has said "Don't even bother trying it"

Myself was a cocaine user for a few years of my life and it started off with doing it every couple of months, and then every couple of weeks followed by every weekend.

happened that way with E too.... (still love good E/MDMA)

But yea, this article here Ythan is a picture perfect example of world goverments giving us a inch and all of us freedom fighters going for a mile. fighting for legalization of crack and meth is just dumb, clearly whoever wrote this article never grew up in the hood and seen what it does to those (10-20 percent) of people and the psychological effects on their families.


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OfflinePurpleHaze147
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: HybridprX]
    #19089164 - 11/05/13 09:20 AM (10 years, 3 months ago)

This isn't new information. Meth and crack r psychologically addicting and toxic. Users generally don't stay addictited but almost all meth and crack users when the use go on binges for days. Meth is much more neurotoxic than plain (d)-amphetamine even tho the effects r similar. Constant serotonin release is very bad. Crack is shown to rewire the dopamine receptors in high dosages creating a new pathway causing the user to get extreme cravingings because ur brain wants that new pathway to be used again. Also crack blocks sodium ion channels which is y it's cardio toxic. Please don't compare crack nd meth to weed.


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Offlinesky
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: HybridprX]
    #19089172 - 11/05/13 09:22 AM (10 years, 3 months ago)

Well, imo by the time legalization of hard drugs rolls through legislation, the median consciousness level of the average person is going to be at a level at which the availability of the substance in the legal market isn't going to present a threat of mass-addiction to communities. Not only that, but the lacking environments that have promoted the overuse of such substances in the past will by that time likely be turned into more healthy socio-economic neighborhoods.

By the time the government, possibly one of the most densest consciousnesses within our society, reaches a state where it becomes acceptable to let human beings decide for themselves the states of consciousness they want to be in, the masses (so to speak) will have moved on to a point where they no longer need to be "sheltered" from these choices, as there will be alternatives and information to guide people to more harmonious approaches and relationships with these substances.

I'm not saying there will be no addiction. I'm just saying that it won't exist at a level where there will be long lines of people lined up to buy crack from CVS.


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OfflineKonyap

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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: PurpleHaze147]
    #19089234 - 11/05/13 09:42 AM (10 years, 3 months ago)

Quote:

PurpleHaze147 said:
This isn't new information. Meth and crack r psychologically addicting and toxic. Users generally don't stay addictited but almost all meth and crack users when the use go on binges for days. Meth is much more neurotoxic than plain (d)-amphetamine even tho the effects r similar. Constant serotonin release is very bad. Crack is shown to rewire the dopamine receptors in high dosages creating a new pathway causing the user to get extreme cravingings because ur brain wants that new pathway to be used again. Also crack blocks sodium ion channels which is y it's cardio toxic. Please don't compare crack nd meth to weed.




It actually makes the axioms receptors go both ways, it's hilarious.


Edited by Konyap (11/05/13 09:51 AM)


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InvisibleSheekle
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: Konyap]
    #19089243 - 11/05/13 09:45 AM (10 years, 3 months ago)

Lmao what a dramatic title for a news article


--------------------
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OfflineJacksonMetaller
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: PurpleHaze147] * 2
    #19089318 - 11/05/13 10:06 AM (10 years, 3 months ago)

Quote:

HybridprX said:
fighting for legalization of crack and meth is just dumb,




No it's not. A lot of the socioeconomic problems caused by crack and meth use are highly exacerbated by poor drug policy. Legalization and regulation would ensure product quality and prices which are manageable as well as clean up street gangs and violence. A lot of people who use drugs like crack, heroin and meth, are involved with it because it runs the local economy. Poor people striving to make a living through the sale of it. It's all around them. Violence, drugs, etc. It's not much of a wander a lot of them eventually fall in to using.

Quote:

PurpleHaze147 said:
This isn't new information. Meth and crack r psychologically addicting and toxic. Users generally don't stay addictited but almost all meth and crack users when the use go on binges for days. Meth is much more neurotoxic than plain (d)-amphetamine even tho the effects r similar. Constant serotonin release is very bad. Crack is shown to rewire the dopamine receptors in high dosages creating a new pathway causing the user to get extreme cravingings because ur brain wants that new pathway to be used again. Also crack blocks sodium ion channels which is y it's cardio toxic. Please don't compare crack nd meth to weed.




Meth is neurotoxic in high doses. Regular doses don't release mass amounts of serotonin and function very similarly to common prescription stimulants. In fact, meth is prescribed for ADHD under the name desoxyn because pharma companies know that controlled use does not cause significant issues. I don't know much about crack on the other hand, but i think the point Dr. Hart is getting at is that addiction is culturally misunderstood.


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InvisibleCidneyIndole
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: HybridprX] * 3
    #19089624 - 11/05/13 11:33 AM (10 years, 3 months ago)

Quote:

HybridprX said:
lmfao!

Crack and Meth are not addictive?

People who pick up those habbits and the one this article describes are still fairly "habitual" and both drugs are as habit forming as smoking. Someone with enough resources will easily loose it all keeping up with it.

Every crack user I have ever encountered has said "Don't even bother trying it"

Myself was a cocaine user for a few years of my life and it started off with doing it every couple of months, and then every couple of weeks followed by every weekend.

happened that way with E too.... (still love good E/MDMA)

But yea, this article here Ythan is a picture perfect example of world goverments giving us a inch and all of us freedom fighters going for a mile. fighting for legalization of crack and meth is just dumb, clearly whoever wrote this article never grew up in the hood and seen what it does to those (10-20 percent) of people and the psychological effects on their families.









1- That's not quite what the article is saying. It's not saying they're not addictive. There has long been a common drug myth (and often hyped in propaganda) that these drugs are so insidious that you take one hit, and you will be hooked for life.

Like many stereotypes there is some truth to this, but IMO it's somewhat minor. First of all,  virtually anything that can give you pleasure can become "addictive." The greater and more instant the pleasure, the higher the risk. Obviously.  Second, addiction is a very complicated thing. Everyone is wired differently, and some people are obviously far more prone to addiction than others.

Personal differences must be taken into account for more than just propensity for addiction. There is also the fact that some people out there simply will not like the feelings a drug like crack produces, no matter how prone to addiction they are.  That's why some people are "stimulant people" and some are "opiate people," etc etc.  Some of us unlucky bastards enjoy most everything under the sun.

Anyway, all that being said, you absolutely can not expect everyone's, or really anyone's exeprience with a drug like cocaine to be exactly like yours. Some people out there will probably react quite similarly, and many others not even close.

Now, being one of those "poor bastards" who likes a little bit of this, and a little bit of that, and seemingly having a ridiculous propensity for addiction (with tons of family history and other factors, etc)  I have found most hardcore stimulants to be easier to put down than other drugs.  Fortunately I've been a bit more careful with alcohol and benzos than I have with some other types of drugs, but IMO the most difficult drugs to actually stop, at all, once you get a good addiction going are:

Alcohol
Nicotine
Opiates
Benzodiazepines

That's in no particular order. Notice that two of the most addictive drugs are perfectly legal. Alcohol, like benzos, is also one of the most dangerous drugs to withdraw from when seriously addicted.

What stimulants are, is more reinforcing than other drugs.  In more colloquial terms, they are "moreish."  They very quickly elevate and then drop dopamine, making you want to just take more and more. This becomes incredibly more apparent when you move to progressively "harder" ROAs like smoking, vaporizing, injecting, etc...

And this is precisely why crack has the reputation it does.  Once you've stopped using it for a while you still want it really bad. If you use it enough, you may even daydream / dream about it. But generally speaking, you don't start to feel like you "need it" to feel normal, until you've been abusing it very regularly, pretty long term.

Rather unlike the drugs listed above, which can quite effectively snare you long term with (in some cases) as little as a week or two of continuous use.


2-  I find your last comment / paragraph quite terrible, on a number of levels.

First of all, you used to use a bunch of cocaine, and still enjoy MDMA (a modified methamphetamine.... hell, often cut with actual methamphetamine)  and you think others should be arrested for these drugs?  How compassionate of you.....

Next, and I think this is really the big one.... The "War On Drugs" is harmful. Extraordinarily harmful to society as a whole, nevermind the drug users, who are often harmed more by the "War On Drugs" itself, than the harmful drugs they may have been using.

Even if you think some of these drugs are more harmful than they really are (and I'm not saying they can't be harmful-- they can be terribly harmful... just not always) the "War On Drugs" has pretty much never stopped anyone from using drugs.

Did you ever not take a drug you wanted to take, simply because it's illegal? Of course not. People who use drugs, are going to use them anyway. In fact, the numbers seem to almost indicate that the war on drugs has caused more people to use and become addicted to drugs, as well as driven prices down and purity up. The "War On Drugs" is doing pretty much the opposite of its stated goals. For that reason alone it should be ended, entirely.


PS-- I have lived in "the hood."  And as I stated earlier I grew up in a family where addiction is widespread.  And this extensive first hand knowledge is what leads me to believe that this is a (physical / mental) health problem, not a legal problem, and it needs to be treated as such. Fully and exclusively.

If the "War On Drugs" (really, a war on poor and sick people) is really as wonderful and necessary as you make out, why are those families you mention suffering so much?  Look back to history. Is this problem better, the same, or much worse than it was 40-50 years ago, or longer, before "the war on drugs" existed as we know it, today?

Addiction has long been a problem. And short of altering our brains chemically, or with computers, or eliminating every single addictive thing on the planet from human experience, it may always be a problem. We need to focus on making it better, not continuing to employ tactics that have consistently been shown to make it worse. There are some very strong arguments for full legalization if you'd just bother to educate yourself.


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InvisibleCyclohexylamine
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: PurpleHaze147]
    #19089730 - 11/05/13 11:58 AM (10 years, 3 months ago)

JacksonMetaller, CidneyIndole - both good posts.
The article is good too.


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Offlinesunshine
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: CidneyIndole]
    #19089770 - 11/05/13 12:07 PM (10 years, 3 months ago)

If you use more than .1 g of meth you aren't getting to sleep that night, unless you didn't sleep the night before.  I got burned out on sleeping every other day and quit meth.
I smoked crack a few times and the main thrust of the high lasts about five minutes.  Then you ride it down and you're sober in two hours.  I enjoyed smoking the weed after the crack much more than the crack.
Also, you get burned out on cranking your central nervous system in general.


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Offlinestzacrack
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: HybridprX]
    #19089784 - 11/05/13 12:10 PM (10 years, 3 months ago)

no one wants gross tub made gin so to say.

amphetamines, as well as opiates are both prescribed medications.

legalizing means to surrender manufacture of the drugs to the government if it wants.


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InvisiblezZZz
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: Ythan]
    #19089786 - 11/05/13 12:11 PM (10 years, 3 months ago)

they're both bad, end of story!. it is better to say to stay away from them than to promote its use even if it is in moderation. they need to be pointing out it's neurotoxicity in the brain and side effects and shit rather than to debate and crack old myths, no pun intended.





Quote:

He notes that even rats, whose voracious consumption of cocaine in certain contrived conditions supposedly shows how powerfully addictive that drug is, tend to use it in moderation when they have other options, such as food, sex, or an interesting environment to explore.




hilarious  :lolsy:  but interesting :strokebeard: and possibly a clue to a cure for addiction, change in environment etc., etc..


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OfflinePurpleHaze147
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: Konyap]
    #19090133 - 11/05/13 01:21 PM (10 years, 3 months ago)

Quote:

Illyabo said:
Quote:

PurpleHaze147 said:
This isn't new information. Meth and crack r psychologically addicting and toxic. Users generally don't stay addictited but almost all meth and crack users when the use go on binges for days. Meth is much more neurotoxic than plain (d)-amphetamine even tho the effects r similar. Constant serotonin release is very bad. Crack is shown to rewire the dopamine receptors in high dosages creating a new pathway causing the user to get extreme cravingings because ur brain wants that new pathway to be used again. Also crack blocks sodium ion channels which is y it's cardio toxic. Please don't compare crack nd meth to weed.




It actually makes the axioms receptors go both ways, it's hilarious.



Umm I'm not sure how that's possible. Receptors r just the protein that the nuerotransmitter attaches to and theyre coupled by either a g protien which creates a second neurotransmitter in the post synaptic neuron or an ion channel in which the transmitters tell the receptor how to control the ion flow neither of these function would do nything in reverse n can't b reversed. Also a receptor can open or close the synaptic vessel in the pre-synaptic neuron based on the neurotransmitter. Receptors can't go both ways the don't go ny ways they don't move.

Crack cocaine is a triple monoamine reuptake inhibitor which means it stops the enzymes that control the reuptake pump for the serotonin, dopamine, and epinephrine monoamines from working at all thus increasing the neurotransmitters in the synaptic cleft. Amphetamines r releasers for these monoamines which means it makes the enzyme the controls the reuptake pump act in reverse which also increases neurotransmition in the synaptic cleft. Crack can make a new pathway for dopamines second messenger in the post synaptic neuron.


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Offlinemy3rdeye
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: HybridprX] * 2
    #19090176 - 11/05/13 01:30 PM (10 years, 3 months ago)

Quote:

HybridprX said:
lmfao!

Crack and Meth are not addictive?

People who pick up those habbits and the one this article describes are still fairly "habitual" and both drugs are as habit forming as smoking. Someone with enough resources will easily loose it all keeping up with it.

Every crack user I have ever encountered has said "Don't even bother trying it"

Myself was a cocaine user for a few years of my life and it started off with doing it every couple of months, and then every couple of weeks followed by every weekend.

happened that way with E too.... (still love good E/MDMA)

But yea, this article here Ythan is a picture perfect example of world goverments giving us a inch and all of us freedom fighters going for a mile. fighting for legalization of crack and meth is just dumb, clearly whoever wrote this article never grew up in the hood .




Wow so much wrong with your post. So cocaine was addictive for YOU. I am part of the 80-90 percent in the article and cannot get addicted to coke. I have done enough to know this. It's not habit forming for me. I think of all the cocaine users I know and none are habitual. I know exactly one person who lost it and she started dating dealers then becoming a hooker. But that wouldn't have happened if blow were cheap and legal. All the problems are prohibition related even the health ones.
Lots of people are addicted to booze too, does that mean everyone is? I have weekly beers and assure you I am not alcoholic. Is legal booze "dumb"? I ask people all the time "if crack were legal would you do it?" and no one ever says yes. You put these drugs on the addiction level of nicotine, it's more like the level of booze, addictive for some, not for the majority though.
Anyone who supports prohibition is "dumb". Speed is just demonized too. Its been used in other contexts like 60's diet pills, or the air force, or asia and there are no problems. Its just a stimulant, should be sold as pills instead of smoking it or snorting it IMO, that's what happens when you ban things though.
PS I grew up in scarborough where did you grow up son?


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Offlinesunshine
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: my3rdeye] * 1
    #19090241 - 11/05/13 01:44 PM (10 years, 3 months ago)

We had the idea a while back of legalizing coca leaf.  You could make a really strong tea or grind it up and drink it in a slurry with juice or water.  You'd have to be a real asshole to OD on coca leaf.
The idea is to take the game away from the underground.  I would like to drink a strong coca leaf tea on occasion.


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OfflineHybridprX
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: my3rdeye]
    #19090741 - 11/05/13 03:33 PM (10 years, 3 months ago)

Quote:

my3rdeye said:
Quote:

HybridprX said:
lmfao!

Crack and Meth are not addictive?

People who pick up those habbits and the one this article describes are still fairly "habitual" and both drugs are as habit forming as smoking. Someone with enough resources will easily loose it all keeping up with it.

Every crack user I have ever encountered has said "Don't even bother trying it"

Myself was a cocaine user for a few years of my life and it started off with doing it every couple of months, and then every couple of weeks followed by every weekend.

happened that way with E too.... (still love good E/MDMA)

But yea, this article here Ythan is a picture perfect example of world goverments giving us a inch and all of us freedom fighters going for a mile. fighting for legalization of crack and meth is just dumb, clearly whoever wrote this article never grew up in the hood .




Wow so much wrong with your post. So cocaine was addictive for YOU. I am part of the 80-90 percent in the article and cannot get addicted to coke. I have done enough to know this. It's not habit forming for me. I think of all the cocaine users I know and none are habitual. I know exactly one person who lost it and she started dating dealers then becoming a hooker. But that wouldn't have happened if blow were cheap and legal. All the problems are prohibition related even the health ones.
Lots of people are addicted to booze too, does that mean everyone is? I have weekly beers and assure you I am not alcoholic. Is legal booze "dumb"? I ask people all the time "if crack were legal would you do it?" and no one ever says yes. You put these drugs on the addiction level of nicotine, it's more like the level of booze, addictive for some, not for the majority though.
Anyone who supports prohibition is "dumb". Speed is just demonized too. Its been used in other contexts like 60's diet pills, or the air force, or asia and there are no problems. Its just a stimulant, should be sold as pills instead of smoking it or snorting it IMO, that's what happens when you ban things though.
PS I grew up in scarborough where did you grow up son?




Legalizing crack/meth is fine, sure. for the purpose of decriminalization.... Selling it in stores for readily available purchase is never going to happen..

But I do like the idea of taking the $$$'s out of crack dealers pocket books since they're generally more of a problem then the drug itself.

The article is disturbing to me since it's more or less saying "Try crack/meth".

I can't lie and say I've never used meth.... I have on three occasions, the come down was terribly intense and if I had more on hand, I would have used more besides the last time I smoked it.... got buzzed up, went to bed and woke up sweating to death and irritated. Last time I used it more then six months ago....

But I've battled my demons.... you 18-20yr kids won't know what a addiction is until you decide to fight one.


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OfflineKonyap

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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: PurpleHaze147]
    #19090982 - 11/05/13 04:23 PM (10 years, 3 months ago)

Is crack the only thing that can cause re-uptake?

Can coffee addiction do that?

Doesn't that stuff go away after while or is that just brain damage from abusing?


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OfflineJacksonMetaller
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: HybridprX] * 1
    #19091581 - 11/05/13 06:22 PM (10 years, 3 months ago)

Quote:

HybridprX said:


The article is disturbing to me since it's more or less saying "Try crack/meth".






I don't think the article says anywhere "try crack/meth". Your approach is as simplistic as most anti-drug soccer moms. Anything that's debated is automatically supporting it? The author is calling for a revolution in the way we view and treat drug addiction through considering methods of diverting that addiction to other activities, not the wide spread consumption of hard drugs


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OfflinePurpleHaze147
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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: Konyap]
    #19091961 - 11/05/13 07:24 PM (10 years, 3 months ago)

Quote:

Illyabo said:
Is crack the only thing that can cause re-uptake?

Can coffee addiction do that?

Doesn't that stuff go away after while or is that just brain damage from abusing?



What coke doesn't cause reuptake it's the exact opposite, it's a reuptake inhibitor. It stops monoamines from being recycled so more is present in the synaptic cleft. Coffee (caffiene) main mechanism of action is adenosine antagonism (blocks it). Adenosine causes drowsiness so blocking it causes alertness. Also although I'm not 100% sure I think caffiene is a dopamine and epidepherine reuptake inhibitor, a mild one with more effect on the epidepherine reuptake pumps enzyme.

It's not coffee addiction take does that one sip will inhibit reuptake that's the reason people drink it lol (also it tastes good). I don't think u understand what a reuptake INHIBITOR is.


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Edited by PurpleHaze147 (11/05/13 07:32 PM)


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Re: Everything You've Heard About Crack And Meth Is Wrong [Re: PurpleHaze147]
    #19092429 - 11/05/13 08:43 PM (10 years, 3 months ago)

Quote:

PurpleHaze147 said:
Quote:

Illyabo said:
Is crack the only thing that can cause re-uptake?

Can coffee addiction do that?

Doesn't that stuff go away after while or is that just brain damage from abusing?



What coke doesn't cause reuptake it's the exact opposite, it's a reuptake inhibitor. It stops monoamines from being recycled so more is present in the synaptic cleft. Coffee (caffiene) main mechanism of action is adenosine antagonism (blocks it). Adenosine causes drowsiness so blocking it causes alertness. Also although I'm not 100% sure I think caffiene is a dopamine and epidepherine reuptake inhibitor, a mild one with more effect on the epidepherine reuptake pumps enzyme.

It's not coffee addiction take does that one sip will inhibit reuptake that's the reason people drink it lol (also it tastes good). I don't think u understand what a reuptake INHIBITOR is.




Yup caffeine does cause mild dopamine reuptake inhibition.


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