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Offlinebradd
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Lethal (or ld50) dose for hyoscyamine and scopolamine? *DELETED*
    #19018976 - 10/23/13 11:48 AM (10 years, 3 months ago)

Post deleted by bradd

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Offlines240779
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Re: Lethal (or ld50) dose for hyoscyamine and scopolamine? [Re: bradd]
    #19019161 - 10/23/13 12:26 PM (10 years, 3 months ago)

You might want to look up the CIA papers on scopolamine. They tested it as a truth drug.


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InvisibleCyclohexylamine
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Re: Lethal (or ld50) dose for hyoscyamine and scopolamine? [Re: bradd]
    #19019244 - 10/23/13 12:49 PM (10 years, 3 months ago)

LD50 refers the point at which 50% of the people taking it will die. Therefore the actual lethal dose is much lower, as most people don't want to gamble with 50% odds of surviving.


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Offlinehidenseek1
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Re: Lethal (or ld50) dose for hyoscyamine and scopolamine? [Re: Cyclohexylamine]
    #19019260 - 10/23/13 12:53 PM (10 years, 3 months ago)

and i think they test ld50 in rats, and its usually lower in humans, but i may be wrong about that


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Invisiblepsi
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Re: Lethal (or ld50) dose for hyoscyamine and scopolamine? [Re: Cyclohexylamine]
    #19019302 - 10/23/13 01:05 PM (10 years, 3 months ago)

The Merck Index often has animal LD50 data for compounds, but mine (12th edition) doesn't have it for hyoscyamine.

For scopolamine:
3800 mg/kg subcutaneously in rats, as the hydrobromide trihydrate.

For atropine: 622 mg/kg orally in rats, as the sulfate monohydrate.

Sounds like atropine is by far the bigger killer gram for gram (at least for rats.)


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Offlines240779
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Re: Lethal (or ld50) dose for hyoscyamine and scopolamine? [Re: psi]
    #19019336 - 10/23/13 01:14 PM (10 years, 3 months ago)

Quote:

psi said:
For scopolamine:
3800 mg/kg subcutaneously in rats, as the hydrobromide trihydrate.





Um, I read a trip report where someone consumed 1.5 mg of scopolamine. It's sold over-the-counter for motion sickness in Britain and Australia in a dose range of about one hundred to several hundred micrograms.


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Offlinehidenseek1
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Re: Lethal (or ld50) dose for hyoscyamine and scopolamine? [Re: s240779]
    #19019341 - 10/23/13 01:15 PM (10 years, 3 months ago)

does scopolamine work better then dph(gravol) for motion sickness, sleep, and tripping ?


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Invisiblefiddle
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Re: Lethal (or ld50) dose for hyoscyamine and scopolamine? [Re: Cyclohexylamine]
    #19019478 - 10/23/13 01:51 PM (10 years, 3 months ago)

Quote:

tymoteusz3 said:
LD50 refers the point at which 50% of the people taking it will die. Therefore the actual lethal dose is much lower, as most people don't want to gamble with 50% odds of surviving.




Exactly. LD50 is the dose which kills 50% of people. You still might die at a lower dose, it's just less likely. Do you want to take that risk?


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Invisiblepsi
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Re: Lethal (or ld50) dose for hyoscyamine and scopolamine? [Re: s240779]
    #19019494 - 10/23/13 01:54 PM (10 years, 3 months ago)

Quote:

Da2ra said:
Quote:

psi said:
For scopolamine:
3800 mg/kg subcutaneously in rats, as the hydrobromide trihydrate.





Um, I read a trip report where someone consumed 1.5 mg of scopolamine. It's sold over-the-counter for motion sickness in Britain and Australia in a dose range of about one hundred to several hundred micrograms.




Are you suggesting that contradicts what I said?


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Invisiblepsi
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Re: Lethal (or ld50) dose for hyoscyamine and scopolamine? [Re: psi]
    #19019616 - 10/23/13 02:19 PM (10 years, 3 months ago)



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Offlinebradd
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Re: Lethal (or ld50) dose for hyoscyamine and scopolamine? [Re: psi]
    #19022050 - 10/23/13 09:23 PM (10 years, 3 months ago)

3800 milligrams per kg is higher than I expected. Thanks for the info and the source psi. (: Now anyone got hyoscyamine?


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Invisiblepsi
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Re: Lethal (or ld50) dose for hyoscyamine and scopolamine? [Re: bradd]
    #19022349 - 10/23/13 10:15 PM (10 years, 3 months ago)

Yeah I found that surprising too, that seems like a fuck of a lot.


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