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Invisible404
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mxe's upregulation of NMDA receptors and its subsequent health concerns?
    #19016758 - 10/22/13 10:32 PM (10 years, 3 months ago)

i've been using mxe for several months now, more than every other day in some weeks. i am wondering how much this substance is going to affect my memory, or mental health and cognition. i want to know how this is going to affect my iq, my ability to learn.

my question is then i guess, if this substance is upregulating my NMDA receptors that deal directly with synaptic plasticity, what is this going to do to me in the long run?

could some one please explain what synaptic plasticity is to begin with? i've looked it up times before, but i feel i do not have a proper grasp on this concept


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OfflineMescalean
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: 404]
    #19017030 - 10/22/13 11:37 PM (10 years, 3 months ago)

Damn is mxe really that good?


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OfflineUzziel
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: Mescalean]
    #19017081 - 10/22/13 11:52 PM (10 years, 3 months ago)

There is just not enough research done man. You're basically a guinea pig right now.

BUT, what we DO know is:

Like Ketamine, MXE is a full on NMDA receptor antagonist:

This means that its going to deregulate your natural amounts of Glutamic acid

Glutamine is directly involved with and VERY important in memory and learning and directly affects your everyday cognitive abilities.

There is just really not enough research regarding this drug in particular in its mechanism of action and what it does to the body. You're just gonna have to find out the hard way if you keep it up.

Synapses are just how neurons send signals to each other, if synapses are deregulated you will have what I wrote in above, but for different reasons.


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Invisible404
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: Uzziel]
    #19017199 - 10/23/13 12:23 AM (10 years, 3 months ago)

aren't full agonists bad? don't they cause cell toxicity or something?


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Invisiblemutantmushroom
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: 404]
    #19017205 - 10/23/13 12:27 AM (10 years, 3 months ago)

Ya I'd like to learn more about the health risks as well. I want to try MXE but I don't want to fuck up my mental well being.


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Invisiblethoughts
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: 404]
    #19017214 - 10/23/13 12:33 AM (10 years, 3 months ago)

Damn state, take care of yourself man.

MXE has given me a really bad vibe since everyone's been raving about it.
Doesn't seem like a very enlightening drug and everyone who gets some seems to become a helpless addict to it.
It's a research chemical.
It can't be good to be addicted to it.

Nature is the way to go!


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OfflineUzziel
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: 404]
    #19017229 - 10/23/13 12:37 AM (10 years, 3 months ago)

Quote:

StateOfMind404 said:
aren't full agonists bad? don't they cause cell toxicity or something?




Well, full on are bad yes. There are some studies that link it to a few diseases but there is nothing certain. Most of the studies is done on rats as well and they HAVE developed serious issues, but none of those issues have been reported in humans so its hard to say exactly how bad they are for us.

It really just depends on how much you use. If you use as much as you are saying, you are not allowing your body to reach equilibrium. You're constantly deregulating your synapses (which is the cause of the low levels of glutamine)

and from there, you start to have issues. It won't be immediate, it never is. There could be a lot more going on too. I don't know what the metabolites of MXE are, could be harmless, could be harmful... you never know.

You need to take more time off in between your uses. These drugs aren't harmless. I'd give it at least a week or two in between uses because glutamine is very important.

Good luck man


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Invisible404
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: Uzziel]
    #19017259 - 10/23/13 12:48 AM (10 years, 3 months ago)

oh man.... what have i done to myself... i took some noopept in the process today, isn't that a neuroprotectant? i dont know if it really matters... i ate 40 mg of adderall on top of what i did tonight. i don't know what's wrong with me. i feel horrible and really really depressed.

how do i come back to equilibrium with my glutamine levels?


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Invisible404
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: 404]
    #19017263 - 10/23/13 12:49 AM (10 years, 3 months ago)

I'm such an idiot..


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Invisiblemutantmushroom
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: 404]
    #19017268 - 10/23/13 12:53 AM (10 years, 3 months ago)

Stop using so much, do it like once every 2 weeks. Eat healthy take multivitamins, work out. Is this stuff really that addictive??


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OfflineMescalean
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: mutantmushroom]
    #19017293 - 10/23/13 01:04 AM (10 years, 3 months ago)

Maybe a break from drugs. Shit man. They do sell glutamine supplements but like said above you don't know what else is going on inside you. It is an RC


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Invisible404
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: Mescalean]
    #19017415 - 10/23/13 02:11 AM (10 years, 3 months ago)

I think it's best i just not take it anymore.


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OfflineUzziel
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: 404]
    #19018059 - 10/23/13 09:17 AM (10 years, 3 months ago)

Quote:

Mescalean said:
Maybe a break from drugs. Shit man. They do sell glutamine supplements but like said above you don't know what else is going on inside you. It is an RC




Doesn't matter. If your synapses don't fire off correctly, you could ingest pounds of glutamine and still be deficient.

Quote:

StateOfMind404 said:
oh man.... what have i done to myself... i took some noopept in the process today, isn't that a neuroprotectant? i dont know if it really matters... i ate 40 mg of adderall on top of what i did tonight. i don't know what's wrong with me. i feel horrible and really really depressed.

how do i come back to equilibrium with my glutamine levels?




Just stop using temporarily and you'll reach equilibrium again,. You'd be surprised out how marvelous the human body is, it is always trying to go back in a state of equilibrium. Your synapses will return to normal in time... but if you've been using for months, I seriously advice to take at least a month off or consider quitting if its too hard to not use.


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OfflineMescalean
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: Uzziel]
    #19018778 - 10/23/13 10:58 AM (10 years, 3 months ago)

Would it be possible op could suffer from depersonalization/derealization from this kind of excessive use? Hope you feel better man. Sobriety is sometimes what we need when things get out of hand. Helped me see clear again.


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Invisible404
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: Mescalean]
    #19019252 - 10/23/13 12:52 PM (10 years, 3 months ago)

I don't suffer from depersonalization/derealization, and i have no problem just putting the drug down. yesterday was a bit of a shitstorm as i made the post also coming down from adderall. I was reading up on mxe, apparently it is a serotonin uptake inhibitor... interesting to go along with the NMDA receptor affinity


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OfflineAlmond Flour
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: 404]
    #19019708 - 10/23/13 02:38 PM (10 years, 3 months ago)

That would suck balls if it did some horrible shit to your bladder like Ketamine.....who knows, maybe it will blow out your anus :facepalm:

Take it easy on that stuff dude.


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OfflineMescalean
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: Almond Flour]
    #19020405 - 10/23/13 04:55 PM (10 years, 3 months ago)

Pink sock lol


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Invisibleliquidlounge

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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: 404]
    #19030367 - 10/25/13 10:22 AM (10 years, 3 months ago)

No wonder cure.

Quote:

liquidlounge said:
Acute cerebellar toxicity

I believe I've had this a few times, it literally feels like you're falling apart, you start sweating bad and skin turns yellowish, feet and hands cramp, the smell of your skin is best described as salt out of date. tymoteusz3 might be right but it's nowhere near the feeling of an m-hole nor blacking out, in fact I was rather sober the times it occurred but when you do it day after day it's bound to tax on you. A benzo would calm me down but I would have no chance walking around. Slept for days after it happened although I was able to move around like normal the next day. My psych was best described as tired or running over-time during the last 4 - 5 months, I never experienced full-on psychosis but there were moments I thought my mind was nuts. I fucked up around my parents, especially my father who took care of me over and over again. :heart: Got picked up in ambulance at work as well.

MXE seems like a wonder drug because it has no withdrawal nor major hangover's, MXE sneaks up on you if you're looking for an escape. It gets you high and clouds your mind.

A gram/week was my regular run for 1.5 years, I estimate total consumption to be around 70 grams in this period.




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OfflineUzziel
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Re: mxe's upregulation of NMDA receptors and its subsequent health concerns? [Re: liquidlounge]
    #19031351 - 10/25/13 02:19 PM (10 years, 3 months ago)

Yes. That is exactly what I was warning against. Thanks for posting that, hopefully it will be a wake up call to all these MXE users who are taking this shit like its candy. Not just MXE though, any other full on NMDA antagonist like Ketamine and a ton of other dissociates.

These drugs will seriously fuck with you sooner or later if you abuse them. Taking them on a strange occasion is absolutely fine but daily/weekly use is not recommended.


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