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MindDrips
Telephasic Workshop



Registered: 09/10/13
Posts: 677
Loc: USA
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One day tolerance break?
#18999623 - 10/19/13 12:47 PM (10 years, 3 months ago) |
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So on Tuesday, I'm going to see Phish in Rochester and rave the fuck out. I plan on taking the 2 doses of LSD I have left there, and I'm hopefully picking more up.
If all goes well and I get more Lucy, my friend N and I had planned on taking 2 doses each and going on a forest adventure the following Thursday.
If I trip Tuesday and take a break on Wednesday, will I still have tolerance buildup on Thursday and not trip quite as hard? I've heard that LSD usually have a tolerance period of about 2 days, so I was wondering if anyone else has doses one day and then again with a day in-between.
-------------------- "Pebbles and marbles like things on my mind, Seem to get lost and harder to find. When I am alone I am inclined, If I find a pebble in sand, To think that it fell from my hand..."

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Dark_Star
train driver pervading a desktop


Registered: 08/20/04
Posts: 31,859
Loc: Uranus
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Re: One day tolerance break? [Re: MindDrips]
#18999671 - 10/19/13 01:00 PM (10 years, 3 months ago) |
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It takes a while for the tolerance to diminish. You need to wait a least 5 days. Personally I've found that I need to wait at least 2 weeks for my tolerance to clear out. One week works for me as long as I up the dosage, but it's still not as full out an experience as the first one.
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MindDrips
Telephasic Workshop



Registered: 09/10/13
Posts: 677
Loc: USA
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Re: One day tolerance break? [Re: Dark_Star]
#18999685 - 10/19/13 01:04 PM (10 years, 3 months ago) |
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Quote:
Dark_Star said: It takes a while for the tolerance to diminish. You need to wait a least 5 days. Personally I've found that I need to wait at least 2 weeks for my tolerance to clear out. One week works for me as long as I up the dosage, but it's still not as full out an experience as the first one.
Sounds reasonable. I just found out I may not be getting more Lucy until the next week anyway, so I'll probably just hold off.
Although, I did trip on ~160ug of LSD three days after a 4g mushroom trip, and I tripped really hard. Does cross-tolerance work differently even if they are both tryptamines?
-------------------- "Pebbles and marbles like things on my mind, Seem to get lost and harder to find. When I am alone I am inclined, If I find a pebble in sand, To think that it fell from my hand..."

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GreySatyr
Pagan-Psyche


Registered: 06/20/13
Posts: 3,376
Loc: North Carolina
Last seen: 9 years, 8 months
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Re: One day tolerance break? [Re: MindDrips]
#18999854 - 10/19/13 01:52 PM (10 years, 3 months ago) |
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LSD is an ergoline and cross tolerance does happen with both. Some times your tolerance goes away quickly and sometimes it takes weeks. It just depends on how often you use psychedelics.
-------------------- ...also, go to hell, huh?
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theRAPeutic
Hueman


Registered: 07/22/13
Posts: 8,702
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Re: One day tolerance break? [Re: GreySatyr]
#19000786 - 10/19/13 05:58 PM (10 years, 3 months ago) |
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LSD tolerance is much higher than shrooms IME. About 2 weeks for acid and a week for shroom tolerance to diminish.... But this is only if you have no tolerance prior, it builds quickly. If you take shrooms one day and acid the next, that works better than acid first day shrooms next, but you will notice the cross tolerance.
Edited by theRAPeutic (10/19/13 05:59 PM)
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PurpleHaze147



Registered: 04/09/13
Posts: 657
Last seen: 6 years, 2 months
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Re: One day tolerance break? [Re: theRAPeutic]
#19001041 - 10/19/13 07:10 PM (10 years, 3 months ago) |
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Half life, frequency of use, and mechanism of action, and probably affinity comes in to play when determining tolerance. Psilocin has a half life of 2-3 hours and LSD has a half life of 3-5 hours, therefore it takes longer for ur tolerence to go down with LSD as opposed to mushrooms. Also LSD has a higher affinity for the 5-ht2a receptors (they both work as full agonists, ~100% of the efficacy of the endogenous serotonin, fyi). Save the Lucy ur trip will be greatly diminished, wait at least a week before tripping unless ur down to take a MAOI, but u gotta be careful if u do because mixing it with certain drugs can kill u.
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MindDrips
Telephasic Workshop



Registered: 09/10/13
Posts: 677
Loc: USA
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Quote:
PurpleHaze147 said: Half life, frequency of use, and mechanism of action, and probably affinity comes in to play when determining tolerance. Psilocin has a half life of 2-3 hours and LSD has a half life of 3-5 hours, therefore it takes longer for ur tolerence to go down with LSD as opposed to mushrooms. Also LSD has a higher affinity for the 5-ht2a receptors (they both work as full agonists, ~100% of the efficacy of the endogenous serotonin, fyi). Save the Lucy ur trip will be greatly diminished, wait at least a week before tripping unless ur down to take a MAOI, but u gotta be careful if u do because mixing it with certain drugs can kill u.
Thanks for the detailed response! I actually didn't know about the differences between half lives of LSD and psilocin, that actualy makes a lot of sense. Well in that case, and in the case that I won't have Lucy after Phish anyway, I think I'll save the trip. Thanks guys! I appreciate all the input.
-------------------- "Pebbles and marbles like things on my mind, Seem to get lost and harder to find. When I am alone I am inclined, If I find a pebble in sand, To think that it fell from my hand..."

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Seriously_trippin
Cosmic Guru Ganesh



Registered: 07/12/13
Posts: 14,471
Last seen: 18 hours, 4 minutes
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Re: One day tolerance break? [Re: MindDrips]
#19002577 - 10/20/13 03:07 AM (10 years, 3 months ago) |
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IME it takes AT least 11-14 days for all the neuro receptors to regenerate and what not. Waiting only 4 days willl waste you cid especially because its only two tabs,even if its a high mcg you might get little out of it.
I would say save it for the woods
-------------------- R.I.P Zombi3, Blue Helix Modest Mouse Zappa Slothie That Kid With The face ShLong Le Canard split_by_nine & Big Worm Forever Etched in the sands of time in the shroomery and ever so beloved and deeply missed by many
Edited by Seriously_trippin (10/20/13 03:08 AM)
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Into The Woods
Quarantine King


Registered: 04/20/13
Posts: 10,864
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Re: One day tolerance break? [Re: MindDrips]
#19002697 - 10/20/13 04:50 AM (10 years, 3 months ago) |
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You'd have to double your dose on Thursday to reach the same level of effect.
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FruitOfLife
Professional Package Handler


Registered: 05/21/12
Posts: 4,832
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Quote:
Although, I did trip on ~160ug of LSD three days after a 4g mushroom trip, and I tripped really hard. Does cross-tolerance work differently even if they are both tryptamines?
LSD is not a tryptamine
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Sheekle
FREE BURKE



Registered: 01/11/10
Posts: 53,153
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Re: One day tolerance break? [Re: FruitOfLife]
#19003426 - 10/20/13 11:17 AM (10 years, 3 months ago) |
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I took AL-LAD at 150ug and tripped really hard, then skipped two days and took 2 WoW blotters nd tripped really hard again
-------------------- "Ur cat died because he hated u" - Koods "I hope JSB kicks your ass one day." - Vandago "you are the biggest 'internet guy' I have ever come across"- Jokeshopbeard "The more I see you post the more I realize you're just this fuckin tie dye loser who trolls the Shroomery 24/7." - Herbologist "Sheekle you cannot vile the dice of bullshit you have posted on this forum over the years, I like databases" - thelastoneleft "or maybe i just come from a blood line of superior intelligence" - trees R.I.P Kelsy, ?/?/?? - 6/11/16
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Dark_Star
train driver pervading a desktop


Registered: 08/20/04
Posts: 31,859
Loc: Uranus
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Re: One day tolerance break? [Re: FruitOfLife]
#19003750 - 10/20/13 12:37 PM (10 years, 3 months ago) |
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Quote:
FruitOfLife said:
Quote:
Although, I did trip on ~160ug of LSD three days after a 4g mushroom trip, and I tripped really hard. Does cross-tolerance work differently even if they are both tryptamines?
LSD is not a tryptamine
Actually it kind of is. While it's an ergoline, and in a category of it's own, it does have a tryptamine core.
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MindDrips
Telephasic Workshop



Registered: 09/10/13
Posts: 677
Loc: USA
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Re: One day tolerance break? [Re: Dark_Star]
#19004123 - 10/20/13 01:58 PM (10 years, 3 months ago) |
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Thanks guys. Already made the decision to save it, but I appreciate the conglomerate of information lol
-------------------- "Pebbles and marbles like things on my mind, Seem to get lost and harder to find. When I am alone I am inclined, If I find a pebble in sand, To think that it fell from my hand..."

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gamesguru



Registered: 05/28/13
Posts: 170
Last seen: 4 months, 23 days
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Re: One day tolerance break? [Re: MindDrips]
#19004183 - 10/20/13 02:23 PM (10 years, 3 months ago) |
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I must be sensitive or just reckless because after a heavy weekend (say 1 dose thursday, 2 friday, and 3-4 saturday), my tolerance drops significantly with just 48-72 hours. I drop twice a week, usually Wed & Sat, and 150 mics gets me about as spun as 90 did when I first started. So there's tolerance, but not huge. Also, I'm not sure exactly how quickly tolerance resets in chronic vs acute users, but I remember my first two trips were only 84 hours apart, two hits of the same blotter, and they were of about equal intensity. So to all the people insisting to wait over a week for a second decent trip, are you really missing all that much magic?
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KingKnowledge
Around



Registered: 03/30/13
Posts: 2,876
Loc: East Coast
Last seen: 4 years, 6 months
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Re: One day tolerance break? [Re: MindDrips]
#19004226 - 10/20/13 02:35 PM (10 years, 3 months ago) |
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Quote:
MindDrips said: Thanks guys. Already made the decision to save it, but I appreciate the conglomerate of information lol
Good call. Tolerance is definitely shot for a few days
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