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InvisibleMindDrips
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One day tolerance break?
    #18999623 - 10/19/13 12:47 PM (10 years, 3 months ago)

So on Tuesday, I'm going to see Phish in Rochester and rave the fuck out. I plan on taking the 2 doses of LSD I have left there, and I'm hopefully picking more up.

If all goes well and I get more Lucy, my friend N and I had planned on taking 2 doses each and going on a forest adventure the following Thursday.

If I trip Tuesday and take a break on Wednesday, will I still have tolerance buildup on Thursday and not trip quite as hard?
I've heard that LSD usually have a tolerance period of about 2 days, so I was wondering if anyone else has doses one day and then again with a day in-between.


--------------------
"Pebbles and marbles like things on my mind,
Seem to get lost and harder to find.
When I am alone I am inclined,
If I find a pebble in sand,
To think that it fell from my hand..."



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InvisibleDark_Star
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Re: One day tolerance break? [Re: MindDrips]
    #18999671 - 10/19/13 01:00 PM (10 years, 3 months ago)

It takes a while for the tolerance to diminish. You need to wait a least 5 days. Personally I've found that I need to wait at least 2 weeks for my tolerance to clear out. One week works for me as long as I up the dosage, but it's still not as full out an experience as the first one.


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InvisibleMindDrips
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Re: One day tolerance break? [Re: Dark_Star]
    #18999685 - 10/19/13 01:04 PM (10 years, 3 months ago)

Quote:

Dark_Star said:
It takes a while for the tolerance to diminish. You need to wait a least 5 days. Personally I've found that I need to wait at least 2 weeks for my tolerance to clear out. One week works for me as long as I up the dosage, but it's still not as full out an experience as the first one.




Sounds reasonable.
I just found out I may not be getting more Lucy until the next week anyway, so I'll probably just hold off.

Although, I did trip on ~160ug of LSD three days after a 4g mushroom trip, and I tripped really hard. Does cross-tolerance work differently even if they are both tryptamines?


--------------------
"Pebbles and marbles like things on my mind,
Seem to get lost and harder to find.
When I am alone I am inclined,
If I find a pebble in sand,
To think that it fell from my hand..."



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OfflineGreySatyr
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Re: One day tolerance break? [Re: MindDrips]
    #18999854 - 10/19/13 01:52 PM (10 years, 3 months ago)

LSD is an ergoline and cross tolerance does happen with both. Some times your tolerance goes away quickly and sometimes it takes weeks. It just depends on how often you use psychedelics.


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...also, go to hell, huh?


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InvisibletheRAPeutic
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Re: One day tolerance break? [Re: GreySatyr]
    #19000786 - 10/19/13 05:58 PM (10 years, 3 months ago)

LSD tolerance is much higher than shrooms IME. About 2 weeks for acid and a week for shroom tolerance to diminish.... But this is only if you have no tolerance prior, it builds quickly. If you take shrooms one day and acid the next, that works better than acid first day shrooms next, but you will notice the cross tolerance.


Edited by theRAPeutic (10/19/13 05:59 PM)


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OfflinePurpleHaze147
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Re: One day tolerance break? [Re: theRAPeutic]
    #19001041 - 10/19/13 07:10 PM (10 years, 3 months ago)

Half life, frequency of use, and mechanism of action, and probably affinity comes in to play when determining tolerance. Psilocin has a half life of 2-3 hours and LSD has a half life of 3-5 hours, therefore it takes longer for ur tolerence to go down with LSD as opposed to mushrooms. Also LSD has a higher affinity for the 5-ht2a receptors (they both work as full agonists, ~100% of the efficacy of the endogenous serotonin, fyi). Save the Lucy ur trip will be greatly diminished, wait at least a week before tripping unless ur down to take a MAOI, but u gotta be careful if u do because mixing it with certain drugs can kill u.


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:scaryshroom::happyweed::tee:

 


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InvisibleMindDrips
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Re: One day tolerance break? [Re: PurpleHaze147]
    #19001194 - 10/19/13 07:47 PM (10 years, 3 months ago)

Quote:

PurpleHaze147 said:
Half life, frequency of use, and mechanism of action, and probably affinity comes in to play when determining tolerance. Psilocin has a half life of 2-3 hours and LSD has a half life of 3-5 hours, therefore it takes longer for ur tolerence to go down with LSD as opposed to mushrooms. Also LSD has a higher affinity for the 5-ht2a receptors (they both work as full agonists, ~100% of the efficacy of the endogenous serotonin, fyi). Save the Lucy ur trip will be greatly diminished, wait at least a week before tripping unless ur down to take a MAOI, but u gotta be careful if u do because mixing it with certain drugs can kill u.




Thanks for the detailed response! I actually didn't know about the differences between half lives of LSD and psilocin, that actualy makes a lot of sense.
Well in that case, and in the case that I won't have Lucy after Phish anyway, I think I'll save the trip. Thanks guys! I appreciate all the input.
:sun:


--------------------
"Pebbles and marbles like things on my mind,
Seem to get lost and harder to find.
When I am alone I am inclined,
If I find a pebble in sand,
To think that it fell from my hand..."



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OfflineSeriously_trippin
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Re: One day tolerance break? [Re: MindDrips]
    #19002577 - 10/20/13 03:07 AM (10 years, 3 months ago)

IME it takes AT least 11-14 days for all the neuro receptors to regenerate and what not. Waiting only 4 days willl waste you cid especially because its only two tabs,even if its a high mcg you might get little out of it.

I would say save it for the woods


--------------------
R.I.P
Zombi3, Blue Helix
Modest Mouse
Zappa
Slothie
That Kid With The face
ShLong
Le Canard
split_by_nine
& Big Worm Forever
Etched in the sands of time in the shroomery and ever so beloved and deeply missed by many :heart:


Edited by Seriously_trippin (10/20/13 03:08 AM)


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InvisibleInto The Woods
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Re: One day tolerance break? [Re: MindDrips]
    #19002697 - 10/20/13 04:50 AM (10 years, 3 months ago)



You'd have to double your dose on Thursday to reach the same level of effect. :smile:


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InvisibleFruitOfLife
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Re: One day tolerance break? [Re: Into The Woods]
    #19003397 - 10/20/13 11:08 AM (10 years, 3 months ago)

Quote:

Although, I did trip on ~160ug of LSD three days after a 4g mushroom trip, and I tripped really hard. Does cross-tolerance work differently even if they are both tryptamines?




LSD is not a tryptamine


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InvisibleSheekle
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Re: One day tolerance break? [Re: FruitOfLife]
    #19003426 - 10/20/13 11:17 AM (10 years, 3 months ago)

I took AL-LAD at 150ug and tripped really hard, then skipped two days and took 2 WoW blotters nd tripped really hard again


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"Ur cat died because he hated u" - Koods
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InvisibleDark_Star
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Re: One day tolerance break? [Re: FruitOfLife]
    #19003750 - 10/20/13 12:37 PM (10 years, 3 months ago)

Quote:

FruitOfLife said:
Quote:

Although, I did trip on ~160ug of LSD three days after a 4g mushroom trip, and I tripped really hard. Does cross-tolerance work differently even if they are both tryptamines?




LSD is not a tryptamine





Actually it kind of is. While it's an ergoline, and in a category of it's own, it does have a tryptamine core.


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InvisibleMindDrips
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Re: One day tolerance break? [Re: Dark_Star]
    #19004123 - 10/20/13 01:58 PM (10 years, 3 months ago)

Thanks guys. Already made the decision to save it, but I appreciate the conglomerate of information lol


--------------------
"Pebbles and marbles like things on my mind,
Seem to get lost and harder to find.
When I am alone I am inclined,
If I find a pebble in sand,
To think that it fell from my hand..."



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Offlinegamesguru
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Re: One day tolerance break? [Re: MindDrips]
    #19004183 - 10/20/13 02:23 PM (10 years, 3 months ago)

I must be sensitive or just reckless because after a heavy weekend (say 1 dose thursday, 2 friday, and 3-4 saturday), my tolerance drops significantly with just 48-72 hours. I drop twice a week, usually Wed & Sat, and 150 mics gets me about as spun as 90 did when I first started. So there's tolerance, but not huge. Also, I'm not sure exactly how quickly tolerance resets in chronic vs acute users, but I remember my first two trips were only 84 hours apart, two hits of the same blotter, and they were of about equal intensity. So to all the people insisting to wait over a week for a second decent trip, are you really missing all that much magic?


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OfflineKingKnowledge
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Re: One day tolerance break? [Re: MindDrips]
    #19004226 - 10/20/13 02:35 PM (10 years, 3 months ago)

Quote:

MindDrips said:
Thanks guys. Already made the decision to save it, but I appreciate the conglomerate of information lol





Good call. Tolerance is definitely shot for a few days :smile:


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