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Offlinemorrowasted
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Possible treatment for marijuana abuse found
    #18975778 - 10/14/13 09:18 AM (10 years, 4 months ago)

http://www.foxnews.com/health/2013/10/14/possible-treatment-for-marijuana-abuse-found/

Quote:

Boosting levels of a naturally occurring compound in the brain could prevent people who abuse marijuana but are trying to quit from relapsing, a new study suggests.

Researchers studying drug-addicted rats and monkeys found that a substance called kynurenic acid blunted the rewarding effects of THC, the active ingredient in marijuana. Kynurenic acid works by blocking the receptors that increase the flood of good feelings brought on by the brain chemical dopamine.

"Any drug of abuse has to do with dopamine," said study researcher Robert Schwarcz, a professor of psychiatry at the University of Maryland, in College Park. "We found out few years ago that kynurenic acid controls dopamine. All we had to do was put those things together," Schwarcz said.

More people seek treatment for marijuana use in the United States than for cocaine or heroin use, surveys show. Yet there are no medications approved for treating marijuana addiction. [5 Bad Habits You Should Still Quit]

The THC in marijuana activates dopamine neurons in a brain region called the ventral tegmental area (VTA), causing the cells to release the feel-good chemical from nerves in the nucleus accumbens. Previous attempts to find a treatment for marijuana addiction showed that blocking receptors in the VTA and the nucleus accumbens prevented the surge in dopamine, but those treatments caused side effects.

The researchers speculated that kynurenic acid which is produced by the breakdown of a chemical found in bananas and turkey, called tryptophan may have fewer side effects, because it naturally controls dopamine levels in the brain.

To find out whether kynurenic acid could treat marijuana dependence, Schwarcz's colleagues gave rats and squirrel monkeys a drug that boosted their levels of kynurenic acid, while the animals were self-administering THC or a similar synthetic drug by pushing a lever.

They found the rodents and monkeys were less likely to administer the THC or synthetic drug when they were on the dopamine-stifling drug, the researchers report online today (Oct. 13) in the journal Nature Neuroscience.

In another experiment, the researchers took the animals off of the THC or synthetic drug for a while, and then increased their kynurenic acid levels while giving them a small dose of THC, or a cue associated with taking the drug.

Boosting kynurenic acid prevented the animals from returning to their old drug abuse patterns. "We found that you can reduce dopamine levels and the animals behave differently they don't have relapse, and don't abuse marijuana," Schwarcz told LiveScience.

While the results are promising, they have not yet been validated in humans. Furthermore, its possible the drug used to treat marijuana addiction could act on other parts of the brain, not only those involved in marijuana addiction.



So does this mean that drinking milk really can kill your buzz? I always thought that was BS


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InvisibleRepertoire89
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Re: Possible treatment for marijuana abuse found [Re: morrowasted]
    #18975813 - 10/14/13 09:35 AM (10 years, 4 months ago)

Quote:

morrowasted said:

Kynurenic acid works by blocking the receptors that increase the flood of good feelings brought on by the brain chemical dopamine.




The way this society is geared up with their animosity towards all things good, they'll be pushing this out in droves. Now they can directly target good feelings


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OfflinePsilosopherr
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Re: Possible treatment for marijuana abuse found [Re: Repertoire89]
    #18975857 - 10/14/13 09:47 AM (10 years, 4 months ago)

So it just makes the weed not get you high?

I was hoping it would be like a weed equivalent to suboxone, and just make you feel alright without it.

And does taking this just make it impossible to feel good in general since its fucking with your dopamine pathways?


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InvisibleFuturesight
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Re: Possible treatment for marijuana abuse found [Re: Psilosopherr] * 2
    #18975880 - 10/14/13 09:51 AM (10 years, 4 months ago)

Wow, way to go humans. found a way to literally inhibit good feelings.


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InvisibleJvells
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Re: Possible treatment for marijuana abuse found [Re: Futuresight]
    #18975887 - 10/14/13 09:55 AM (10 years, 4 months ago)

Now I'm confused. I though the cannabis high was from our cannabinoid receptors getting hit? I thought adderall/meth/coke caused their effects by causing an uptake in dopamine and thus was why they were addictive. I figured that mj's 'withdrawals' were from the cannabinoid receptors not getting their daily fix. I had heard that mj has some effect on serotonin also and that's why 5htp worked wonders for some people trying to sleep during their mj withdrawals. Interesting :themoreyouknow:


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Offlinemorrowasted
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Re: Possible treatment for marijuana abuse found [Re: Jvells]
    #18975902 - 10/14/13 10:03 AM (10 years, 4 months ago)

Quote:

I though the cannabis high was from our cannabinoid receptors getting hit?


The intoxication is a direct result of endocannabinoid receptor interaction. The fact that you feel good is an indirect action involving dopamine pathways between the VTA and basal forebrain. The following is a great book for understanding how various things make you feel good



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OfflineLSDreams
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Re: Possible treatment for marijuana abuse found [Re: morrowasted] * 2
    #18975934 - 10/14/13 10:14 AM (10 years, 4 months ago)

Marijuana Abuse?? :lolwut:


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OfflinePsilosopherr
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Re: Possible treatment for marijuana abuse found [Re: LSDreams] * 2
    #18975961 - 10/14/13 10:22 AM (10 years, 4 months ago)

Quote:

LSDreams said:
Marijuana Abuse?? :lolwut:



marijauna withdrawals? :lolwut:


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OfflineRockhound
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Re: Possible treatment for marijuana abuse found [Re: Psilosopherr] * 3
    #18976000 - 10/14/13 10:38 AM (10 years, 4 months ago)

Finally, a way for me to quit that dangerous cannabis addiction without all those life-threatening withdrawal symptoms!


--------------------
Rocks speak to me, and tell me this:
The Hell Creek formation is a gigantic slab of rocks that covers several western states. It contains an account of the dinosaurs' demise.  In the late Cretaceous period, the first Cannabis species appear, and soon after, all the non-bird dinosaurs disappeared. Obviously, marihuana killed the dinosaurs. That giant meteor that smacked the yucatan peninsula right afterwards, coincidence.


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OfflineOk amoismis
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Re: Possible treatment for marijuana abuse found [Re: Psilosopherr]
    #18976019 - 10/14/13 10:43 AM (10 years, 4 months ago)

Quote:

rbalzer said:
So it just makes the weed not get you high?

I was hoping it would be like a weed equivalent to suboxone, and just make you feel alright without it.

And does taking this just make it impossible to feel good in general since its fucking with your dopamine pathways?




Something a little like weed-suboxone does exist. FAAH inhibitors like LY-2183240 and URB597 inhibit fatty acid amide hydrolase, which is what breaks down your natural endocannabinoids like anandamine. So they cause your endocannabinoids to build up and apparently are effective against pain and reduce the desire to smoke cannabis. I read there was actually a clinical trial going on involving LY-2183240 and patients with cannabis "withdrawal" aimed at reducing relapse. I figured that's what this story would be about. But nope, kynurenic acid.

I was under the impression that kynurenic acid blocked glutamate. I thought of it in sort of a comical way as the internal equivalent of dissociative drugs. I've never read anything elsewhere about it affecting dopamine. I have read about increased endogenous levels of kynurenic acid being associated with schizophrenia though.

"So it makes you unable to feel happiness and is tentatively associated with schizophrenia? Well, it sounds better than marijuana. Thank god, now these people can quit smoking weed"


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OfflineOk amoismis
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Re: Possible treatment for marijuana abuse found [Re: morrowasted]
    #18976054 - 10/14/13 10:54 AM (10 years, 4 months ago)

Quote:

More people seek treatment for marijuana use in the United States than for cocaine or heroin use, surveys show. Yet there are no medications approved for treating marijuana addiction. [5 Bad Habits You Should Still Quit]




It's funny too, the only reason that this particular piece of misleading bullshit is repeated again and again is that far more people are arrested for cannabis than for cocaine or heroin. So they end up in court ordered rehab in order to get out of or reduce jail time. Thus, there are more people "seeking treatment" for marijuana than heroin or cocaine.

Totally the same thing as voluntarily checking yourself into rehab out of concern for your own well being (like they make it sound).

Really. I've never met a person in my life, or even met a person who knew a person for that matter, who sought substance abuse treatment due to cannabis alone.


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Offlinesunshine
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Re: Possible treatment for marijuana abuse found [Re: morrowasted]
    #18976167 - 10/14/13 11:26 AM (10 years, 4 months ago)

My favorite treatment for pot is to smoke a lot of pot for a long time.  You get burned out and feel like quitting.  I never noticed any withdrawl symptoms or any problems.


--------------------
One Love True Indeed.  Have Good Trips.  Mike/sunshine's mom.


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Offlinemorrowasted
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Re: Possible treatment for marijuana abuse found [Re: sunshine]
    #18976318 - 10/14/13 12:09 PM (10 years, 4 months ago)

I get withdrawls from synth cannabinomimetics for sure. Less so with real marijuana


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OfflineCamwritesgonzo
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Re: Possible treatment for marijuana abuse found [Re: morrowasted]
    #18976564 - 10/14/13 01:14 PM (10 years, 4 months ago)

Quote:

morrowasted said:
http://www.foxnews.com/health



Leave it to conservative-fux news to publish something like this. Bunch of anti-pot, pro-pharma muckrakers.


--------------------
"I've always maintained that reality is for those who can't face drugs."-Tom Waits
"I feel the same way about disco as I feel about herpes."-Hunter S. Thompson
A squid eating dough in a polyethylene bag is fast and bulbous, got me?


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OfflineMorel Guy
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Re: Possible treatment for marijuana abuse found [Re: Camwritesgonzo]
    #18976599 - 10/14/13 01:22 PM (10 years, 4 months ago)

This is just the wrong direction.  I can see many sick ways this could be forced on people.  They do that with drugs that fit their ideas of the world.


--------------------
"in sterquiliniis invenitur in stercore invenitur"

In filth it will be found in dung it will be found


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OfflinegrimR
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Re: Possible treatment for marijuana abuse found [Re: Morel Guy]
    #18976626 - 10/14/13 01:31 PM (10 years, 4 months ago)

A future medicine that shuts off dopamine, thereby essentially creating suicidal drones. Brilliant. America's kamikazes.


--------------------
- grimR


-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-
http://egolost.com 
"I am already given to the power that rules my fate. And I cling to nothing, so I will have nothing to defend. I have no thoughts, so I will see. I fear nothing, so I will remember myself."

- Don Juan teachings


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Offlinemorrowasted
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Re: Possible treatment for marijuana abuse found [Re: Camwritesgonzo]
    #18976702 - 10/14/13 01:48 PM (10 years, 4 months ago)



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OfflineCamwritesgonzo
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Re: Possible treatment for marijuana abuse found [Re: morrowasted]
    #18976863 - 10/14/13 02:24 PM (10 years, 4 months ago)



--------------------
"I've always maintained that reality is for those who can't face drugs."-Tom Waits
"I feel the same way about disco as I feel about herpes."-Hunter S. Thompson
A squid eating dough in a polyethylene bag is fast and bulbous, got me?


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InvisibleFuturesight
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Re: Possible treatment for marijuana abuse found [Re: Camwritesgonzo]
    #18976888 - 10/14/13 02:31 PM (10 years, 4 months ago)

I think he was stating that Fox news is the main culprit. That there are truthful reporting agencies, but Fox is not one.

At least that's how I feel. Many programs are honest, and well-intended. But Fox is simply a fear-mongering demon butthole.


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Offlineitchmynipple
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Re: Possible treatment for marijuana abuse found [Re: Jvells] * 1
    #18976929 - 10/14/13 02:42 PM (10 years, 4 months ago)

Quote:

Jvells said:
Now I'm confused. I though the cannabis high was from our cannabinoid receptors getting hit? I thought adderall/meth/coke caused their effects by causing an uptake in dopamine and thus was why they were addictive. I figured that mj's 'withdrawals' were from the cannabinoid receptors not getting their daily fix. I had heard that mj has some effect on serotonin also and that's why 5htp worked wonders for some people trying to sleep during their mj withdrawals. Interesting :themoreyouknow:




ive smoked for 5-6 years chronically, but
I have a question for you, maybe it will make you see how dopamine works in your life with weed if you smoke daily or atleast 3-4 days of the week i can see it impacting you or anyone else..

how do you feel when you do not have weed at all but you want to smoke and cant get it? possible answers: angry, agitated, anxious, bored, stressed, pressured, rushing

how do you feel when your on the way to getting the weed once you have found a number, and how do you feel when your packing the bowl? possible answers: excited, happy, natural high,.. maybe this is when you experience your highest 'highs' of the day, being right before you smoke and as your lighting up.. the rest is downhill for me and some of my friends.. this does not apply to everyone, just those i have talked to who have smoked weed and its had a negative impact on them and life.

in my experience, i get really excited before hand, and then after i get sort of depressed and think to myself, wow this is fuckin useless, i want to quit!. but my attitude reverses when im sober for a few hours..its certainly not just me. but ive seen it happen with many of my friends.. but most people on the shroomery think weed is harmless to everyone and its 'something else' that is causing someones depression..
but weed itself is the problem because it will certainly keep you fixated on certain topics if there is something bothering you, and you will start coping' with weed even though its doing more harm, that temporary fix feels amazing 'at first'


--------------------


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