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Offlineinnerspeaker1967
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Extremely Low Doses Of THC Protect Brain Before And After Injury * 1
    #18861443 - 09/19/13 02:16 AM (10 years, 4 months ago)

Though marijuana is a well-known recreational drug, extensive scientific research has been conducted on the therapeutic properties of marijuana in the last decade. Medical cannabis is often used by sufferers of chronic ailments, including cancer and post-traumatic stress disorder, to combat pain, insomnia, lack of appetite, and other symptoms.

Now Prof. Yosef Sarne of Tel Aviv University's Adelson Center for the Biology of Addictive Diseases at the Sackler Faculty of Medicine says that the drug has neuroprotective qualities as well. He has found that extremely low doses of THC - the psychoactive component of marijuana - protects the brain from long-term cognitive damage in the wake of injury from hypoxia (lack of oxygen), seizures, or toxic drugs. Brain damage can have consequences ranging from mild cognitive deficits to severe neurological damage.

Previous studies focused on injecting high doses of THC within a very short time frame - approximately 30 minutes - before or after injury. Prof. Sarne's current research, published in the journals Behavioural Brain Research and Experimental Brain Research, demonstrates that even extremely low doses of THC - around 1,000 to 10,000 times less than that in a conventional marijuana cigarette - administered over a wide window of 1 to 7 days before or 1 to 3 days after injury can jumpstart biochemical processes which protect brain cells and preserve cognitive function over time.

This treatment, especially in light of the long time frame for administration and the low dosage, could be applicable to many cases of brain injury and be safer over time, Prof. Sarne says.

Conditioning the brain

While performing experiments on the biology of cannabis, Prof. Sarne and his fellow researchers discovered that low doses of the drug had a big impact on cell signalling, preventing cell death and promoting growth factors. This finding led to a series of experiments designed to test the neuroprotective ability of THC in response to various brain injuries.

In the lab, the researchers injected mice with a single low dose of THC either before or after exposing them to brain trauma. A control group of mice sustained brain injury but did not receive the THC treatment. When the mice were examined 3 to 7 weeks after initial injury, recipients of the THC treatment performed better in behavioral tests measuring learning and memory. Additionally, biochemical studies showed heightened amounts of neuroprotective chemicals in the treatment group compared to the control group.

The use of THC can prevent long-term cognitive damage that results from brain injury, the researchers conclude. One explanation for this effect is pre- and post-conditioning, whereby the drug causes minute damage to the brain to build resistance and trigger protective measures in the face of much more severe injury, explains Prof. Sarne. The low dosage of THC is crucial to initiating this process without causing too much initial damage.

Preventative and long-term use

According to Prof. Sarne, there are several practical benefits to this treatment plan. Due to the long therapeutic time window, this treatment can be used not only to treat injury after the fact, but also to prevent injury that might occur in the future. For example, cardiopulmonary heart-lung machines used in open heart surgery carry the risk of interrupting the blood supply to the brain, and the drug can be delivered beforehand as a preventive measure. In addition, the low dosage makes it safe for regular use in patients at constant risk of brain injury, such as epileptics or people at a high risk of heart attack.

Prof. Sarne is now working in collaboration with Prof. Edith Hochhauser of the Rabin Medical Center to test the ability of low doses of THC to prevent damage to the heart. Preliminary results indicate that they will find the same protective phenomenon in relation to cardiac ischemia, in which the heart muscle receives insufficient blood flow.

http://www.medicalnewstoday.com/releases/261288.php


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InvisibleDickhead
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Re: Extremely Low Doses Of THC Protect Brain Before And After Injury [Re: innerspeaker1967]
    #18861977 - 09/19/13 08:34 AM (10 years, 4 months ago)

Yet still I will need 2 oz's a week for my script to prevent possible head traumas.

Them say, "Why do you smoke all that weed?"

I say, "In the case that I get hit in the head."


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Multiplied


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InvisibleEdibleStereos
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Re: Extremely Low Doses Of THC Protect Brain Before And After Injury [Re: Dickhead]
    #18862035 - 09/19/13 08:58 AM (10 years, 4 months ago)

Shit, I should be able to take a wrecking ball to my head and my brain be still good. Maybe 10 feet from my body after though.


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Offlinethedream
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Registered: 12/25/10
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Re: Extremely Low Doses Of THC Protect Brain Before And After Injury [Re: EdibleStereos]
    #18862655 - 09/19/13 11:34 AM (10 years, 4 months ago)

I have to add an experience I had that relates to the findings of this article, one time I fell backwards because I had fainted and I must have hit the back of my head when I hit the ground. When I awoke my head hurt and I felt like complete shit, almost like I had a hangover. When I tried to get back up I nearly fainted again, however I made it to a couch where I laid down. I tried to take deep breathes and rehydrate but still felt like shit. So after about and hour or two later I realized that this wasn't going to go away anytime soon so I smoked some weed and felt nearly back to normal. Point of this story is marijuana is such a versatile medicine which should be in everyone's medicine cabinet.


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Offlinedark3st
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Re: Extremely Low Doses Of THC Protect Brain Before And After Injury [Re: thedream]
    #18862923 - 09/19/13 12:47 PM (10 years, 4 months ago)

What's old becomes new again


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Back.. I'm going to do it...I'm getting sober from opiates ... I got weed, gabapentin, propranolol, and GHB, I have 100mg tramadol left. I can do this. I can do this.

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OfflineYogi1
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Re: Extremely Low Doses Of THC Protect Brain Before And After Injury [Re: innerspeaker1967]
    #18863059 - 09/19/13 01:21 PM (10 years, 4 months ago)

God I wish the midwest would adopt some fucking medicinal herbs... That shit has always said to have healing powers.


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Offlinehuffinglue
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Re: Extremely Low Doses Of THC Protect Brain Before And After Injury [Re: Yogi1]
    #18863189 - 09/19/13 01:53 PM (10 years, 4 months ago)

THC gives mice brian damage! Ban weed! Save our mice/children!


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I fucking hate grammer nazis! Yes, I can't spell. Yes, I don't have perfect grammer. I post from my phone and dont give a shit about people whose lifes are so boring they get off on putting people down for not having perfect fucking grammer, even though they know excactly what there saying.. Fuck You. It's just a ride mang...


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Offlinedark3st
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Re: Extremely Low Doses Of THC Protect Brain Before And After Injury [Re: huffinglue]
    #18863210 - 09/19/13 01:59 PM (10 years, 4 months ago)

Quote:

huffinglue said:
THC gives mice brian damage! Ban weed! Save our mice/children!





Lol I could see the media spin it that way :shrug:


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Back.. I'm going to do it...I'm getting sober from opiates ... I got weed, gabapentin, propranolol, and GHB, I have 100mg tramadol left. I can do this. I can do this.

OFINTQWGVGAKGCYKBUBX
free dark P. Tampanensis prints to ODD members.

no stamps atm

FREE SEEDS for ODD WCA  members ONLY

I have these seeds:
Orange, red, and yellow sweet peppers, Purple poppies, White Habanero, Yellow Thai, Bolivian rainbow peppers, milk thistle, red chilly pepper, HBWR.


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Offlineweshroom
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Re: Extremely Low Doses Of THC Protect Brain Before And After Injury [Re: dark3st]
    #18863292 - 09/19/13 02:21 PM (10 years, 4 months ago)

Awesome!


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OfflineYogi1
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Registered: 04/01/13
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Re: Extremely Low Doses Of THC Protect Brain Before And After Injury [Re: dark3st]
    #18863726 - 09/19/13 04:27 PM (10 years, 4 months ago)

Quote:

dark3st said:
Quote:

huffinglue said:
THC gives mice brian damage! Ban weed! Save our mice/children!





Lol I could see the media spin it that way :shrug:




Already did back in the 60's when they suffocated monkeys with weed smoke for a minute at a time and claimed it was the weed that gave them brain damage and not the lack of oxygen. I feel awful for the poor monkeys that had to suffer for that propaganda.


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Offlinedark3st
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Re: Extremely Low Doses Of THC Protect Brain Before And After Injury [Re: Yogi1]
    #18863762 - 09/19/13 04:36 PM (10 years, 4 months ago)

I was referring to this study.  Though that study was done by objective scientist sadly.


--------------------
Back.. I'm going to do it...I'm getting sober from opiates ... I got weed, gabapentin, propranolol, and GHB, I have 100mg tramadol left. I can do this. I can do this.

OFINTQWGVGAKGCYKBUBX
free dark P. Tampanensis prints to ODD members.

no stamps atm

FREE SEEDS for ODD WCA  members ONLY

I have these seeds:
Orange, red, and yellow sweet peppers, Purple poppies, White Habanero, Yellow Thai, Bolivian rainbow peppers, milk thistle, red chilly pepper, HBWR.


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Invisibletravelleler
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Re: Extremely Low Doses Of THC Protect Brain Before And After Injury [Re: dark3st]
    #18869064 - 09/20/13 07:04 PM (10 years, 4 months ago)

it would be great if everybody was allowed legal access to this wonderful medicine.  Including normal citizens, not just druggies dealers congressmen and cops.  Serriously, in spite of it's qazi legal status there are a number of occupations and situations where testing positive for pot will land you in prison or rehab.

just sayin


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:sun:Dreams are the fuel of the soul:sun:

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