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Offlinest1llnox
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Does nicotine exacerbate your HPPD?
    #18842792 - 09/14/13 10:55 PM (10 years, 5 months ago)

My HPPD tapered off and (probably) stabilized at such a minor level that I cannot perceive it.

However, I've taken up chainsmoking (yes, I'll have to quit again) while I study and do math to help mollify my ADHD symptoms since I'm between doctors and thus am desperately short on Adderall.

And lo and behold... substantial resurgence of my HPPD, that--at least for me, was/is secondary to my rampant past/recent DXM abuse and possibly also Ambien and Lunesta, although I've only seen one case of zolpidem-induced HPPD.


I did also notice (confirming that this isn't just in my head, for my case), that when my HPPD was at its most acute immediately following administration of nearly a gram of time-release DXM (this would be on the occasion I did 12 different drugs at once-I forgot to include Kratom--as noted in the very beginning of my signature), I noticed when I smoked a cigarette that this SEVERELY exacerbated the symptoms of that HPPD to a degree FAR beyond what I was experiencing, HPPD-wise, at a sober baseline.

A quick google scholar query indicates to me that this hasn't been addressed in the medical literature.

I'm starting a research gig with a WORLD RENOUNED psychiatrist starting on October 1st, to continue indefinitely and as I'm available, and it occurred to me that he might be willing to serve as a research mentor and collaborator if I wanted to undertake doing a survey-type study (akin to as is typical of studies that fall more neatly into Psychology's domain, field-wise) to confirm this hypothesis.

:aweyeah:

It is GLARINGLY evident that use of other psychoactives, or at least (or perhaps, in particular) psychedelic or quasipsychedelic drugs (namely cannabis) can GREATLY exacerbate symptoms acutely or could even abet them long-term (although the latter is purely speculation on my part).


And I don't know if this would be unique to some sort of relation between n-acetecholine and NMDA (or perhaps glutaminergics more generally) as opposed to nicotine affecting HPPD more generally with less respect to the particular receptor subunits involved, such as 5HTP-2A and -2B in the case of LSD and Psilocybin, among others, for example.


That said, establishing the link between CANNABIS and HPPD exacerbation is practically a SITTING DUCK to anyone who'd like to add another notch to their publication count belt.

I think, especially given the nigh-ubiquitous consensus concerning marijuana's penchant for making HPPD acutely worse, at the very least, would make a nice subsection of a study on nicotine and HPPD should I or someone else go through with this. Plus, it's so fundamental to the study of HPPD that weed worsens it that SOMEBODY might as well go ahead and add this to the foundation of the scientific study of HPPD.

Undertaking this might mean I won't be able to go through with my gang study, but gangs are old news and HPPD is much closer to my heart (especially with all the tobacco I'm using :wink:).


Can any of you guys give me a rough sampling just so I can see if a) this is unique to me and b) if this seems to be unique to NMDA-ergic HPPD?

Please note what psychoactive(s) you suspect brought on your HPPD, whether you ALSO use NMDAergic hallucinogens (i.e. if you did a lot of ketamine AND psilocybin, for instance).

Also, if any of you happened to wrack up your own case of HPPD from tryptaminergic (read: LSD, shrooms, DMT... 5HT-2A in general) substances and THEN got into NMDA substances (ketamine, MXE, DXM (:teehee:), nitrous, PCP, MK-801, etc.), what the effects on your HPPD your NMDA adventures befell you.

Thank you SOOO much.

Depending on the input I get, this may lead me into MUCH more meaningful side-research than studying a bunch of 17-year-old gangbangers (pubbers will know what I'm referring to). Plus, I'm a fucking computer scientist, not a sociologist.

Again, thanks in advance, TPE :thumbup: :awebig: :awesomenod:


--------------------
Back, bitches.
st1lln0x: so i'm on weed, temazepam, adderall, dexedrine, dxm, dph, alcohol, nicotine, caffeine, tryptophan, GABA, and kratom
Cavemen_savemen: st1lln0x, do you feel like a robot yet?
st1lln0x: I feel like a fucking Gundam
Click to friend me on Steam for Counter-Strike
:crankey: IS LIFE SKULLFUCKING YOU!? HAVE SOME FREE MORALE! :awesomenod:
Click if you want to feel you alone can do it! Click if you want to feel confident and beastly! Click if you want courage to let go and move on! And click the message if you need someone to talk to -- I'll understand, even if we "hate" each other on here :hug: :sun:


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Offlinest1llnox
dx'd PTSD/ADHD--please don't ask
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Re: Does nicotine exacerbate your HPPD? [Re: st1llnox]
    #18843071 - 09/15/13 12:44 AM (10 years, 5 months ago)

Come fucking on. This is TPE. Some of the 12 of you who've viewed this thread are bound to have had relevant input.

If it comes to it, I'll redo this thread in a much-more-concise form in the hopes of not textwalling people away.


--------------------
Back, bitches.
st1lln0x: so i'm on weed, temazepam, adderall, dexedrine, dxm, dph, alcohol, nicotine, caffeine, tryptophan, GABA, and kratom
Cavemen_savemen: st1lln0x, do you feel like a robot yet?
st1lln0x: I feel like a fucking Gundam
Click to friend me on Steam for Counter-Strike
:crankey: IS LIFE SKULLFUCKING YOU!? HAVE SOME FREE MORALE! :awesomenod:
Click if you want to feel you alone can do it! Click if you want to feel confident and beastly! Click if you want courage to let go and move on! And click the message if you need someone to talk to -- I'll understand, even if we "hate" each other on here :hug: :sun:


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Offlinest1llnox
dx'd PTSD/ADHD--please don't ask
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Registered: 11/27/12
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Re: Does nicotine exacerbate your HPPD? [Re: st1llnox]
    #18843204 - 09/15/13 02:20 AM (10 years, 5 months ago)

Yeah, fuck all 22 of you who viewed this. For the other 200,000-some members, please enlighten us all with your input.


--------------------
Back, bitches.
st1lln0x: so i'm on weed, temazepam, adderall, dexedrine, dxm, dph, alcohol, nicotine, caffeine, tryptophan, GABA, and kratom
Cavemen_savemen: st1lln0x, do you feel like a robot yet?
st1lln0x: I feel like a fucking Gundam
Click to friend me on Steam for Counter-Strike
:crankey: IS LIFE SKULLFUCKING YOU!? HAVE SOME FREE MORALE! :awesomenod:
Click if you want to feel you alone can do it! Click if you want to feel confident and beastly! Click if you want courage to let go and move on! And click the message if you need someone to talk to -- I'll understand, even if we "hate" each other on here :hug: :sun:


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OfflineBawks
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Re: Does nicotine exacerbate your HPPD? [Re: st1llnox]
    #18843272 - 09/15/13 03:00 AM (10 years, 5 months ago)

I can't help you, unfortunately. :sad:


--------------------
Savor the best and embrace the worst


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OfflineKing Klick
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Re: Does nicotine exacerbate your HPPD? [Re: Bawks]
    #18843279 - 09/15/13 03:04 AM (10 years, 5 months ago)

Calm down man. I know nothing.


--------------------
Your god is dead, and I killed him.

When you’re lost, here I am. Forever with your soul



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Offlinest1llnox
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Re: Does nicotine exacerbate your HPPD? [Re: King Klick]
    #18843283 - 09/15/13 03:06 AM (10 years, 5 months ago)

Okay, okay. Sorry and thanks anyway, you two.


--------------------
Back, bitches.
st1lln0x: so i'm on weed, temazepam, adderall, dexedrine, dxm, dph, alcohol, nicotine, caffeine, tryptophan, GABA, and kratom
Cavemen_savemen: st1lln0x, do you feel like a robot yet?
st1lln0x: I feel like a fucking Gundam
Click to friend me on Steam for Counter-Strike
:crankey: IS LIFE SKULLFUCKING YOU!? HAVE SOME FREE MORALE! :awesomenod:
Click if you want to feel you alone can do it! Click if you want to feel confident and beastly! Click if you want courage to let go and move on! And click the message if you need someone to talk to -- I'll understand, even if we "hate" each other on here :hug: :sun:


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OfflineTurtletotem
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Re: Does nicotine exacerbate your HPPD? [Re: st1llnox]
    #18843362 - 09/15/13 04:15 AM (10 years, 5 months ago)

While nicotine doesn't seem to have any effect, whenever I smoke more then one joint I tend to see things like invisible beams and moving shadows again, like I always do when a trip is just starting to kick in.

I was a bit frightened of it at first, but now I realise it doesn't actually interfere with my mental ability, just a little secret thing my brain does, haha.

Sorry I don't know any more, wish I could be of more help.

:smile:


--------------------


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OfflineKing Klick
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Re: Does nicotine exacerbate your HPPD? [Re: Turtletotem]
    #18843367 - 09/15/13 04:17 AM (10 years, 5 months ago)

Oh, actually I do know a little on this. It shouldn't exacerbate your symptoms at all. Nicotine has, how do I say it?, reality bringing compounds. Basically nicotine should keep you closer to reality. Different for everyone I guess.


--------------------
Your god is dead, and I killed him.

When you’re lost, here I am. Forever with your soul



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Offlinest1llnox
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Re: Does nicotine exacerbate your HPPD? [Re: King Klick]
    #18843376 - 09/15/13 04:22 AM (10 years, 5 months ago)

Quote:

King Klick said:
Oh, actually I do know a little on this. It shouldn't exacerbate your symptoms at all. Nicotine has, how do I say it?, reality bringing compounds. Basically nicotine should keep you closer to reality. Different for everyone I guess.




I think anything HPPD-wise would be strictly to do with perception, and that any cognitive effects more interesting than an increase or decrease in acute cognitive ability would fall into the realm of psychotic or dissociation-related disorders.

I may have to focus more narrowly on NMDA-related HPPD, which I think is very rare and largely fleeting, at least in my case.

Also relevant is, as I mentioned in the first post, that DXM has acetylcholine action.



This bears further investigation, but perhaps more narrow and inconvenient inquiry than I'd hoped.

Thanks both of you.


--------------------
Back, bitches.
st1lln0x: so i'm on weed, temazepam, adderall, dexedrine, dxm, dph, alcohol, nicotine, caffeine, tryptophan, GABA, and kratom
Cavemen_savemen: st1lln0x, do you feel like a robot yet?
st1lln0x: I feel like a fucking Gundam
Click to friend me on Steam for Counter-Strike
:crankey: IS LIFE SKULLFUCKING YOU!? HAVE SOME FREE MORALE! :awesomenod:
Click if you want to feel you alone can do it! Click if you want to feel confident and beastly! Click if you want courage to let go and move on! And click the message if you need someone to talk to -- I'll understand, even if we "hate" each other on here :hug: :sun:


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OfflineAgentchewy
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Re: Does nicotine exacerbate your HPPD? [Re: st1llnox]
    #18843415 - 09/15/13 05:07 AM (10 years, 5 months ago)

Isn't nicotine an agonist to the same receptor as delirients.? I know tobacco brews have been used to cause visions in some tribes


--------------------


If I knew the way, I would take you home.


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Offlinesof4r0ckeRs1984
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Re: Does nicotine exacerbate your HPPD? [Re: Agentchewy]
    #18843435 - 09/15/13 05:30 AM (10 years, 5 months ago)

I heard nicotine could make a subtile change in the parasynaptic gap and make men behave like women and women behave like men. It was on TV once. I personally believe that nicotine can make you more nervous than you actually are or should be.


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OfflineKingKnowledge
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Re: Does nicotine exacerbate your HPPD? [Re: sof4r0ckeRs1984]
    #18843921 - 09/15/13 09:57 AM (10 years, 5 months ago)

I loved reading your post. Glad to hear someone else with some neuropharmacological/synaptic transmission background.

I don't smoke nicotine, but when I do, it gives me slightly more intense HPPD. NOT AS MUCH AS WEED THOUGH. Not even close. But I do get it on a heavy buzz.


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Offlinenecrobytez
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Re: Does nicotine exacerbate your HPPD? [Re: KingKnowledge]
    #18843952 - 09/15/13 10:06 AM (10 years, 5 months ago)

When i smoke a cigarette my depersonalization gets slightly better.


--------------------


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Invisiblevolcomstoner
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Re: Does nicotine exacerbate your HPPD? [Re: st1llnox]
    #18844524 - 09/15/13 01:10 PM (10 years, 5 months ago)

:lolwut:
dude, you've never done psyches though?


--------------------

HAIL SATAN

Vas donc jouer dans le traffic


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Offlinest1llnox
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Re: Does nicotine exacerbate your HPPD? [Re: volcomstoner]
    #18844973 - 09/15/13 03:13 PM (10 years, 5 months ago)

Quote:

KingKnowledge said:
I loved reading your post. Glad to hear someone else with some neuropharmacological/synaptic transmission background.

I don't smoke nicotine, but when I do, it gives me slightly more intense HPPD. NOT AS MUCH AS WEED THOUGH. Not even close. But I do get it on a heavy buzz.




Wonderful--seems like I'm on to something after all, potentially. Same to you, regarding neuropharmacology!

Quote:

volcomstoner said:
:lolwut:
dude, you've never done psyches though?



Quote:

volcomstoner said:
:lolwut:
dude, you've never done psyches though?



Quote:

volcomstoner said:
:lolwut:
dude, you've never done psyches though?




Not yet the classical ones, my friend. Nitrous, Ambien, DXM being the main hallucinogenic agents I've used, and from what I can tell I love hallucinating and CANT WAIT to trip properly.

Unfortunately, I can practically smell a subset of my hater posse waiting to swoop in and further peste me about my "progressing drug use"

Some motherfucking dolt, in the DXM megathread, for instance seems to insist I'm worse than ever and wants to know my real name just so he can see my obituary when (he thinks) I "finally" overdose.

Funny thing is, the dumbass waited until I quit all recreational drug use and got back on my prescription meds to inform me that I'm a trainwreck headed downhill. Seems to think I need to be locked in a rubber room for 2 months and given ECT.

I think he needs to be castrated with a butter knife.



HAD TO VENT, sorry.


--------------------
Back, bitches.
st1lln0x: so i'm on weed, temazepam, adderall, dexedrine, dxm, dph, alcohol, nicotine, caffeine, tryptophan, GABA, and kratom
Cavemen_savemen: st1lln0x, do you feel like a robot yet?
st1lln0x: I feel like a fucking Gundam
Click to friend me on Steam for Counter-Strike
:crankey: IS LIFE SKULLFUCKING YOU!? HAVE SOME FREE MORALE! :awesomenod:
Click if you want to feel you alone can do it! Click if you want to feel confident and beastly! Click if you want courage to let go and move on! And click the message if you need someone to talk to -- I'll understand, even if we "hate" each other on here :hug: :sun:


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OfflineLizard Eyes
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Re: Does nicotine exacerbate your HPPD? [Re: st1llnox]
    #18845977 - 09/15/13 07:37 PM (10 years, 5 months ago)

I notice that my HPPD gets more and more apparent the further away I get from baseline sobriety in any sense.  It's like anytime my mental barriers get taken down a bit all the trippy magic comes back.  Even getting drunk is pretty trippy these days for me. I also recently pulled 48 hours with no sleep and by the end I honestly kept thinking I had taken some kind of drug because of how trippy things were getting. I quit cigarettes but I've had 5-10 in the 4 months since I quit and I will say that they did give me some HPPD symptoms, once even a full fledged "flashback" if you will.

I'm  pretty sure my HPPD is from doing blotters (25i,25c, and sometimes LSD) every weekend for 6 months straight. Sorry I don't have a more scientific answer, we can't all be brainiacs like you. :shrug: :lol:


--------------------

Every little thing is gonna be alright:heart:  All you need is love :love: Nobody's right, Nobody's wrong, Life's just a game it's just one epic holiday! :peace:


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Invisiblevolcomstoner
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Re: Does nicotine exacerbate your HPPD? [Re: st1llnox]
    #18847201 - 09/16/13 12:22 AM (10 years, 5 months ago)

Quote:

st1llnox said:
Quote:

KingKnowledge said:
I loved reading your post. Glad to hear someone else with some neuropharmacological/synaptic transmission background.

I don't smoke nicotine, but when I do, it gives me slightly more intense HPPD. NOT AS MUCH AS WEED THOUGH. Not even close. But I do get it on a heavy buzz.




Wonderful--seems like I'm on to something after all, potentially. Same to you, regarding neuropharmacology!

Quote:

volcomstoner said:
:lolwut:
dude, you've never done psyches though?



Quote:

volcomstoner said:
:lolwut:
dude, you've never done psyches though?



Quote:

volcomstoner said:
:lolwut:
dude, you've never done psyches though?




Not yet the classical ones, my friend. Nitrous, Ambien, DXM being the main hallucinogenic agents I've used, and from what I can tell I love hallucinating and CANT WAIT to trip properly.

Unfortunately, I can practically smell a subset of my hater posse waiting to swoop in and further peste me about my "progressing drug use"

Some motherfucking dolt, in the DXM megathread, for instance seems to insist I'm worse than ever and wants to know my real name just so he can see my obituary when (he thinks) I "finally" overdose.

Funny thing is, the dumbass waited until I quit all recreational drug use and got back on my prescription meds to inform me that I'm a trainwreck headed downhill. Seems to think I need to be locked in a rubber room for 2 months and given ECT.

I think he needs to be castrated with a butter knife.



HAD TO VENT, sorry.



I dig what your saying but trust me once you do the proper psyches, your mind will be blown. Dissociative hallucinations can't even be compared to psychedelic hallucinations. Even from holing on MXE doesn't compare to a heavy dose of acid.

Also ma, just take that as a sign to look at your drug useage and exactly why you think you need the drugs that you do. Even what your prescribed, try to find out the exact reasons you feel you need them and weigh out the pro's and cons of not being on them. And always take into account the potential of these drugs to be abused, and become a severe addiction.

Trust me man I know what it's like to be an addict and you DO show signs of addiction. That's comming from someone not only who's dealt with many addicts, but also struggled with addiction.


--------------------

HAIL SATAN

Vas donc jouer dans le traffic


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Offlinest1llnox
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Re: Does nicotine exacerbate your HPPD? [Re: volcomstoner]
    #18847263 - 09/16/13 12:35 AM (10 years, 5 months ago)

Quote:

Lizard Eyes said:
I notice that my HPPD gets more and more apparent the further away I get from baseline sobriety in any sense.  It's like anytime my mental barriers get taken down a bit all the trippy magic comes back.  Even getting drunk is pretty trippy these days for me. I also recently pulled 48 hours with no sleep and by the end I honestly kept thinking I had taken some kind of drug because of how trippy things were getting. I quit cigarettes but I've had 5-10 in the 4 months since I quit and I will say that they did give me some HPPD symptoms, once even a full fledged "flashback" if you will.

I'm  pretty sure my HPPD is from doing blotters (25i,25c, and sometimes LSD) every weekend for 6 months straight. Sorry I don't have a more scientific answer, we can't all be brainiacs like you. :shrug: :lol:




Haha, between me and these Marlboro Red 100s, it's been a trippy ass several days...

Thank you, too, for confirming that I am indeed on to something. I do hope any research that comes out of this greatly benefits the HPPD community at large!

It seems that nicotine doesn't exclusively exacerbate NDMA-ergic HPPD too, then, seeing as yours seems to be tryptaminerogenic.

Thank you SO much for your input!

Quote:

volcomstoner said:
Quote:

st1llnox said:
Quote:

KingKnowledge said:
I loved reading your post. Glad to hear someone else with some neuropharmacological/synaptic transmission background.

I don't smoke nicotine, but when I do, it gives me slightly more intense HPPD. NOT AS MUCH AS WEED THOUGH. Not even close. But I do get it on a heavy buzz.




Wonderful--seems like I'm on to something after all, potentially. Same to you, regarding neuropharmacology!

Quote:

volcomstoner said:
:lolwut:
dude, you've never done psyches though?



Quote:

volcomstoner said:
:lolwut:
dude, you've never done psyches though?



Quote:

volcomstoner said:
:lolwut:
dude, you've never done psyches though?




Not yet the classical ones, my friend. Nitrous, Ambien, DXM being the main hallucinogenic agents I've used, and from what I can tell I love hallucinating and CANT WAIT to trip properly.

Unfortunately, I can practically smell a subset of my hater posse waiting to swoop in and further peste me about my "progressing drug use"

Some motherfucking dolt, in the DXM megathread, for instance seems to insist I'm worse than ever and wants to know my real name just so he can see my obituary when (he thinks) I "finally" overdose.

Funny thing is, the dumbass waited until I quit all recreational drug use and got back on my prescription meds to inform me that I'm a trainwreck headed downhill. Seems to think I need to be locked in a rubber room for 2 months and given ECT.

I think he needs to be castrated with a butter knife.



HAD TO VENT, sorry.



I dig what your saying but trust me once you do the proper psyches, your mind will be blown. Dissociative hallucinations can't even be compared to psychedelic hallucinations. Even from holing on MXE doesn't compare to a heavy dose of acid.

Also ma, just take that as a sign to look at your drug useage and exactly why you think you need the drugs that you do. Even what your prescribed, try to find out the exact reasons you feel you need them and weigh out the pro's and cons of not being on them. And always take into account the potential of these drugs to be abused, and become a severe addiction.

Trust me man I know what it's like to be an addict and you DO show signs of addiction. That's comming from someone not only who's dealt with many addicts, but also struggled with addiction.






I've been trying to hold out for shrooms, but they're horribly scarce in the Midwest.

On the other hand, (REAL) LSD happens to be almost readily available to me.

My best friend first tripped on shrooms. Perhaps it would be a cool compliment if my first time were LSD. What do you think, volcomstoner? I've come to very much value your input and am eager to hear what you have to say on this matter.


--------------------
Back, bitches.
st1lln0x: so i'm on weed, temazepam, adderall, dexedrine, dxm, dph, alcohol, nicotine, caffeine, tryptophan, GABA, and kratom
Cavemen_savemen: st1lln0x, do you feel like a robot yet?
st1lln0x: I feel like a fucking Gundam
Click to friend me on Steam for Counter-Strike
:crankey: IS LIFE SKULLFUCKING YOU!? HAVE SOME FREE MORALE! :awesomenod:
Click if you want to feel you alone can do it! Click if you want to feel confident and beastly! Click if you want courage to let go and move on! And click the message if you need someone to talk to -- I'll understand, even if we "hate" each other on here :hug: :sun:


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InvisibleMetapod

Registered: 03/06/13
Posts: 23
Re: Does nicotine exacerbate your HPPD? *DELETED* [Re: st1llnox]
    #18847342 - 09/16/13 01:04 AM (10 years, 5 months ago)

Post deleted by Metapod

Reason for deletion: .



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Offlinest1llnox
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Re: Does nicotine exacerbate your HPPD? [Re: Metapod]
    #18847371 - 09/16/13 01:24 AM (10 years, 5 months ago)

Quote:

Metapod said:
yeah nicotine makes my hppd, worse
especially after that first morning cig...I get a huge rush of visual snow followed by a brief languorous weed-like head high




This could be big for me, and I hope for the HPPD community but I think--especially since I'm among your ranks--that this might amount to a trivial foundational bit of science as regards HPPD.

That said, SOMEBODY has to fucking establish this in the medical literature and I start a research post with a world-renowned psychiatrist in less than a month...

He's had his books translated into over 46 languages so I dare say if there's a research collaborator that I should establish this under, it's fucking probably pretty damn well this dude...

Thank you so much for ya'll's input.

I hate to have to put off or even discount entirely that gang study I could have done, but HPPD is much closer to my heart and much more in line with the research collaboration I'm going to be undertaking.

I think I may end up using hppdonline.com as my primary source but you all will most ASSUREDLY be in the loop and I commend you.


--------------------
Back, bitches.
st1lln0x: so i'm on weed, temazepam, adderall, dexedrine, dxm, dph, alcohol, nicotine, caffeine, tryptophan, GABA, and kratom
Cavemen_savemen: st1lln0x, do you feel like a robot yet?
st1lln0x: I feel like a fucking Gundam
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:crankey: IS LIFE SKULLFUCKING YOU!? HAVE SOME FREE MORALE! :awesomenod:
Click if you want to feel you alone can do it! Click if you want to feel confident and beastly! Click if you want courage to let go and move on! And click the message if you need someone to talk to -- I'll understand, even if we "hate" each other on here :hug: :sun:


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