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Offlinesomething cool
meandering

Registered: 01/30/12
Posts: 1,306
Last seen: 7 years, 4 months
Cocaine use boosts learning and decision-making... but only as part of increasing dependency
    #18759654 - 08/26/13 01:43 PM (10 years, 5 months ago)

Cocaine use boosts learning and decision-making

Cocaine increases the brain’s ability to learn new information and make decisions, but only in ways which fuels addiction.

Taking the Class A drug boosts the circuits in the frontal cortex, leading to rapid growth of the brain’s structure.

American researchers injected cocaine into the brains of mice, and saw an almost immediate effect on their behaviour, where they became biased towards environments associated with the drug.


Scientists believe the research is key in understanding how users become dependent on the drug.

Within two hours of the injection, the mice's brains started growing neuron connections in the part of the brain which controls higher functions, such as planning and decision-making.

‘It's been observed that long-term drug users show decreased function in the frontal cortex in connection with mundane cues or tasks, and increased function in response to drug-related activity or information.

‘This research suggests how the brains of drug users might shift towards those drug-related associations.’

The neurons directly affected by cocaine use had the ‘potential to bias decision-making’, she added.

Initially the mice were given access to two adjoining ‘conditioning’ chambers, one smelling of cinnamon and the other vanilla, decorated with different patterns and textures.

Free to explore both compartments, individual mice settled on one they preferred.

They were then injected with cocaine while in the opposite compartment, and given the same choice.

After being given cocaine, each mouse chose the compartment associated with the drug injection.


‘When given the choice, most of the mice preferred to explore the side where they had the cocaine, which indicated that they were looking for more cocaine,’ said Dr Wilbrecht.

‘Their change in preference for the cocaine side correlated with gains in new persistent spines that appeared on the day they experienced cocaine.

‘The animals that showed the highest quantity of robust dendritic spines showed the greatest change in preference towards the chamber where they received the cocaine.

‘This suggests that the new spines might be material for the association that these mice have learned to make between the chamber and the drug.’

The findings are published in the latest edition of the journal Nature Neuroscience.

Previous post-mortem studies of human brains have shown changes in dendritic spine density after weeks of repeated cocaine use.

Earlier this month a study was published which showed that as well as supressing appetite, cocaine reduces the body’s ability to store fat.

The increase in weight when a user stops taking the drug is thought to trigger relapses as it adds further psychological effects to withdrawal symptoms.


Edited by something cool (08/26/13 01:56 PM)


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Offlinesomething cool
meandering

Registered: 01/30/12
Posts: 1,306
Last seen: 7 years, 4 months
Re: Cocaine use boosts learning and decision-making [Re: something cool] * 2
    #18759717 - 08/26/13 02:03 PM (10 years, 5 months ago)

I don't actually see support for the latter portion of the headline, "but only as part of increasing dependency", in the mentioned observations from the study. I don't see any measurement of dependency, or changing degree of dependency in the given information. I also don't see a sound relation between seeking cocaine and the growth of dendritic spines.

What it appears to discover is that as the mice exert more effort to think and decide, more dendritic spines are formed, and that in the environment which they are placed, the number one motivation for the mice to think hard is to figure out where the cocaine came from and where it will next be. If their minds were used for other processes of equal strength, they would surely display the same rate of dendritic spines growth. If they studies this in humans, and had the humans use their time while high to learn a new subject, or perform other mental challenges, they would most likely display the same growth, or more.


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Invisibletito123
Male

Registered: 01/23/10
Posts: 3,006
Re: Cocaine use boosts learning and decision-making [Re: something cool]
    #18760417 - 08/26/13 04:41 PM (10 years, 5 months ago)

So it's a good idea for me to only do coke while studying at the library.


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Invisibletravelleler
a horse-fart in a hurricane
 User Gallery


Registered: 08/30/08
Posts: 3,955
Loc: yonder mountains
Re: Cocaine use boosts learning and decision-making [Re: tito123]
    #18760437 - 08/26/13 04:45 PM (10 years, 5 months ago)

what's cocaine??  I've never heard of it.  is it like a nootropic or something?


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Offlinexbloodwhipx

Registered: 02/24/12
Posts: 12,791
Last seen: 4 years, 6 months
Re: Cocaine use boosts learning and decision-making [Re: travelleler] * 1
    #18760507 - 08/26/13 05:01 PM (10 years, 5 months ago)

I guess the increased decision making explains why people suck dick for coke/crack?


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Offlinesunshine
Sin18DwireWuTang


Registered: 04/03/04
Posts: 43,592
Loc: higher plane of sex
Last seen: 5 years, 25 days
Re: Cocaine use boosts learning and decision-making... but only as part of increasing dependency [Re: something cool]
    #18760595 - 08/26/13 05:29 PM (10 years, 5 months ago)

I like practicing martial arts on cocaine, or the much safer herbal "coca leaf and flowers."  I'm not a huge cocaine fan and I prefer cannabis.
Just to clarify, the herbal coca is legal and is not real coca.  I gave a big bag to the speedfreaks once and they loved it.


--------------------
One Love True Indeed.  Have Good Trips.  Mike/sunshine's mom.


Edited by sunshine (08/26/13 05:31 PM)


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Invisibletravelleler
a horse-fart in a hurricane
 User Gallery


Registered: 08/30/08
Posts: 3,955
Loc: yonder mountains
Re: Cocaine use boosts learning and decision-making... but only as part of increasing dependency [Re: sunshine]
    #18760621 - 08/26/13 05:34 PM (10 years, 5 months ago)

serriously??!!

if you are using the COCA LEAF, then that is awesome!  that stuff is great, there is only a very small amount of active alkaloid in the leaf--- along with a balanced profile of vitamins and minerals.  The whole leaf is really good for people-- unlike the refined prepatation, it wont cause you harm.

the whole leaf is probably the best way to consume it... IMHO

I need to get some more leaves


--------------------




"Whales have deep thoughts"

:sun:Dreams are the fuel of the soul:sun:

:peace:


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OfflineFreedreamer
Out of place


Registered: 06/22/11
Posts: 270
Loc: Here, there and everywher...
Last seen: 1 year, 1 month
Re: Cocaine use boosts learning and decision-making [Re: something cool]
    #18760942 - 08/26/13 06:49 PM (10 years, 5 months ago)

Quote:

something cool said:
I don't actually see support for the latter portion of the headline, "but only as part of increasing dependency", in the mentioned observations from the study. I don't see any measurement of dependency, or changing degree of dependency in the given information. I also don't see a sound relation between seeking cocaine and the growth of dendritic spines.

What it appears to discover is that as the mice exert more effort to think and decide, more dendritic spines are formed, and that in the environment which they are placed, the number one motivation for the mice to think hard is to figure out where the cocaine came from and where it will next be. If their minds were used for other processes of equal strength, they would surely display the same rate of dendritic spines growth. If they studies this in humans, and had the humans use their time while high to learn a new subject, or perform other mental challenges, they would most likely display the same growth, or more.




:whathesaid:


--------------------
"This life is a hospital in which every patient is possessed by the desire of changing his bed. One would prefer to suffer near the fire, and another is certain he would get well if he were by the window."
- Charles Baudelaire


                                                                                                          :potleaf: :pills: :xtc: :rave: :dancingbear: :potleaf:


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Offlinesunshine
Sin18DwireWuTang


Registered: 04/03/04
Posts: 43,592
Loc: higher plane of sex
Last seen: 5 years, 25 days
Re: Cocaine use boosts learning and decision-making... but only as part of increasing dependency [Re: travelleler]
    #18760973 - 08/26/13 06:57 PM (10 years, 5 months ago)

Quote:

travelleler said:
serriously??!!

if you are using the COCA LEAF, then that is awesome!  that stuff is great, there is only a very small amount of active alkaloid in the leaf--- along with a balanced profile of vitamins and minerals.  The whole leaf is really good for people-- unlike the refined prepatation, it wont cause you harm.

the whole leaf is probably the best way to consume it... IMHO

I need to get some more leaves



This is legal in the United States.  I don't want to tell you what it's called.  They sell it with all the other legal herbs.  It's fairly safe, as long as you don't overuse it.
I tried smoking cocaine and didn't feel safe.  I wasn't sure if I should hold my hits in.  I was waiting for the deadly headrush.  I've smoked a lot of pot since I was very young.
I'd like to try chewing real coca leaves.  I had fun practicing six foot staff after the cocaine rush faded.  I learned new style and was in a definite zone.


--------------------
One Love True Indeed.  Have Good Trips.  Mike/sunshine's mom.


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