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OfflinePsilosopherr
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Do MAOI's have possibly bad interactions with psychedelics?
    #18748909 - 08/23/13 08:34 PM (10 years, 5 months ago)

please read whole post, article link at bottom! :bow2:

So I was reading the Wikipedia article on MAOI's, to check exactly what I couldn't have before ingesting it. (hypothetically)

My main concern was, do antidepressants have harmful interactions with MAOI? According to this wiki article, it does!

Since I take antidepressants everyday, how long do you think I'd have to stop taking them to be safe? I should, and will ask a doctor but I'm asking for estimates :shrug:

NOW THE IMPORTANT PART FOR YOU GUYS!

If you look near the bottom of the article, the list of substances that can have bad interactions with MAOI are

Phenethylamines: 2C-B, Mescaline, Phenethylamine (PEA), etc.
Amphetamines: Amphetamine,[24] MDMA, Dextroamphetamine, Methamphetamine, DOM, etc.
Tryptamines: DMT, Psilocin/Psilocybin ("Magic Mushrooms"), etc.
Lysergamides: Ergolines/LSA, LSD ("Acid"), etc.
Serotonin, Norepinephrine, and/or Dopamine Reuptake Inhibitors:
Selective Serotonin Reuptake Inhibitors (SSRIs): Citalopram, Dapoxetine, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline  Others: Brompheniramine, Chlorpheniramine, Cocaine, Cyclobenzaprine, Dextromethorphan (DXM), Ketamine, MDPV, Nefazodone, Phencyclidine (PCP)


Obviously the natives who use ayahuasca know that it doesn't mix poorly with DMT. So can someone help me interpret this list, and the article explaining the list?



Heres the article by the way :grin:
http://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor


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OfflineRewindicus
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: Psilosopherr]
    #18748948 - 08/23/13 08:44 PM (10 years, 5 months ago)

To be safe get off anti depressants for a few weeks before dose and a few after. You can die from seratonin syndrome.


As to the bad reactions part......joe schmoe not looking to purposely trip his balls off and then doing so......id categorize that as a bad reaction. For most people anyways.


--------------------
“Be who you are and say what you feel because those who mind don't matter and those who matter don't mind.”- Dr. Seuss

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- Alice Roosevelt Longworth





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OfflineMrHill
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: Rewindicus]
    #18748983 - 08/23/13 08:53 PM (10 years, 5 months ago)

First off, what anti depressants are you on?
If you're on SSRI's - I'd get off of em for a few weeks since it takes so long to get back to normal..
Phenethylamines (mescaline, 2c-x, 25x-NBOME, DOx, MDxx, amphetamines, etc) are generally NOT safe to mix with MAOIs.
Tryptamines on the other hand, you get blasted when you combine those two. Look up shroomahuasca. LSD seems to be one of the only tryptamines to have diminished effects by MAOIs.
I'm not sure about RC tryptamines, though I wouldn't mess with 'em.
Shrooms, LSD, DMT should all be safe to mix.

Most drugs on that list will cause hypertensive crisis, seritonin syndrome, or death by one of those if mixed with an MAOI.
Be careful!
Do research on your specific anti-depressent, and try to figure out which catigory it falls under.
I know SSRI's are very, very dangerous to mix with MAOIs.

Stay safe!


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InvisibleDawks
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: Psilosopherr]
    #18749038 - 08/23/13 09:05 PM (10 years, 5 months ago)

MAOIs are safe with the classics: DMT, mushrooms and LSD.

With the rest I'd take it very, very slow because of the possible serotonin releasing effects of some psychedelics. AMT for instance, seems innocent enough right? WRONG powerful serotonin releaser taking it with an MAOI could kill you.

The 2c-t-x drugs are also MAOIs so that could lead to complications. For instance some people tried combining 2c-t-7 with MDMA thinking it would be like the other 2cs, not the case.


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Offlines240779
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: MrHill]
    #18749049 - 08/23/13 09:08 PM (10 years, 5 months ago)

Quote:

Parrott said:
LSD seems to be one of the only tryptamines to have diminished effects by MAOIs.





That's probably based on an indication on the following thing on Erowid (study of LSD in combination with antidepressants): "decrease in response" for the MAOI, Nardil.* I read a paper I think by Jonathan Ott -- I lost it in a hard drive crash -- which mentioned evidence of MAOIs decreasing all psychedelic drugs and also pointed out that there are many reports that shrooms, for example are heightened by MAOIs. The paper said that the decrease in response was due to the long term administration of MAOIs which would change the general activity of certain neurotransmitters. Short term use, however, increases the response.


*http://www.erowid.org/chemicals/maois/maois_info4.shtml


Here's a report of someone who got stronger effects from LSD by combining it with moclobemide.


Yes, I've tried several times LSD and moclo combo. The doses were for LSD: from 150 to about 400ug; for moclo 300-450mg. No negative effects noted

--

Little more physical stimulating than normal LSD trip, the effects on psychic were rather normal, except that it was harder and longer. Moclo is an inhibitor, which in itself has no psychoactive effect, so there is no effect on experience



27-06-2011 | rtg | http://www.bluelight.ru/vb/threads/578692-Dmt?p=9772813&viewfull=1#post9772813


Edited by s240779 (08/23/13 09:17 PM)


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Offlinekoods
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: s240779]
    #18749095 - 08/23/13 09:21 PM (10 years, 5 months ago)

I would be careful taking this advice. I think you need to do some serious research on the exact MAOI and exact drug you wish to consume, and I would go in assuming that any psychoactive AMINE may respond differently you are taking a monoAMINE oxidase inhibitor. Psilocin is an amine.

Someone wrote that DMT is fine. Well. Why the fuck do you need to take an MAOI to make it orally active? What happens if that MAOI is in your brain and not just your digestive tract?


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Edited by koods (08/23/13 09:23 PM)


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OfflineMrHill
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: s240779]
    #18749102 - 08/23/13 09:22 PM (10 years, 5 months ago)

Hmm, i've heard a few people on bluelight talking about diminished effects.
Maybe I'll try it sometime. Got a big bag of syrian rue laying around haha


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InvisibleOldHam
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: koods]
    #18749106 - 08/23/13 09:24 PM (10 years, 5 months ago)

Cuz a place called 'The Shroomery' would seem to be a legit source for non-conflicting drug info on which to stake your life.
:cookiemonster:



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OfflineMrHill
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: MrHill]
    #18749178 - 08/23/13 09:39 PM (10 years, 5 months ago)

That's why
Quote:

Parrott said:

Most drugs on that list will cause hypertensive crisis, seritonin syndrome, or death by one of those if mixed with an MAOI.
Be careful!
Do research on your specific anti-depressent, and try to figure out which catigory it falls under.
I know SSRI's are very, very dangerous to mix with MAOIs.

Stay safe!




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OfflineRewindicus
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: OldHam]
    #18749183 - 08/23/13 09:40 PM (10 years, 5 months ago)

:rofl:


--------------------
“Be who you are and say what you feel because those who mind don't matter and those who matter don't mind.”- Dr. Seuss

"Too much of a good thing, can be wonderful!" - Mae West

"If you have nothing nice to say about anyone, come sit next to me."
- Alice Roosevelt Longworth





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Offlinekoods
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: MrHill]
    #18749289 - 08/23/13 10:06 PM (10 years, 5 months ago)

Quote:

Parrott said:
That's why
Quote:

Parrott said:

Most drugs on that list will cause hypertensive crisis, seritonin syndrome, or death by one of those if mixed with an MAOI.
Be careful!
Do research on your specific anti-depressent, and try to figure out which catigory it falls under.
I know SSRI's are very, very dangerous to mix with MAOIs.

Stay safe!







But you also said that DMT should be fine. My point is that DMT is clearly metabolized by monoamine oxidase, so if you got MAOIs in your CNS, it is not being metabolized normally.

Now, tryptamines generally act mimic natural transmitters and don't release massive amounts of endogenous stored transmitters the way phenethylamines do. This gives them a safer profile, but they are not unaffected.


--------------------
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“if I believed she was 16 I would become unattracted to her”


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OfflineMrHill
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: MrHill]
    #18749309 - 08/23/13 10:11 PM (10 years, 5 months ago)

Well of course DMT is affected by it..

Quote:

Parrott said:
Tryptamines on the other hand, you get blasted when you combine those two. Look up shroomahuasca. LSD seems to be one of the only tryptamines to have diminished effects by MAOIs. 
Shrooms, LSD, DMT should all be safe to mix.



Safe as in they shouldn't cause SS, or hypertensive crisis.
I clearly (I hope clearly enough) stated that when you mix MAOIs and trypatime's, you trip hard as fuck.
Never said that they were unaffected.


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OfflinePsilosopherr
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: Rewindicus]
    #18749418 - 08/23/13 10:38 PM (10 years, 5 months ago)

Quote:

Rewindicus said:
To be safe get off anti depressants for a few weeks before dose and a few after. You can die from seratonin syndrome.


As to the bad reactions part......joe schmoe not looking to purposely trip his balls off and then doing so......id categorize that as a bad reaction. For most people anyways.



I was thinking 2 weeks before too! didn't think about after :lol:

Sounds like I've got more research to do, my anti depressant is definitely an SSRI (prozac)

And I have another medication: Wellbutrin...anyone know anything about the specific interactions that might occur with these meds and say syrian rue MAOI?

syrian rue is very likely my source of MAOI in all future experiments btw. Thanks for your help guys, important topic!!


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Invisiblemillzy
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: Dawks]
    #18749450 - 08/23/13 10:46 PM (10 years, 5 months ago)

Quote:

Dawks said:
MAOIs are safe with the classics: DMT, mushrooms and LSD.






i've heard natural maoi's like harmala are safe with tryptamines. are prescription ones safe? for some reason i wouldn't want to mess with that. maybe my intuition is wrong on that.


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OfflineMrHill
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Re: Do MAOI's have possibly bad interactions with psychedelics? [Re: millzy]
    #18749475 - 08/23/13 10:53 PM (10 years, 5 months ago)

Prescription MAOIs are a bit scary. They're not reversible MAOIs like Syrian Rue, so they last a lot longer.
With syrian rue, you generally don't have to follow the MAOI diet like you do on pharmaceutical MAOIs. Though you still must avoid certain drugs..


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