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InvisibleMidnight_Toker
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Drug Candidate SR9009 Increases Exercise Endurance
    #18736734 - 08/21/13 10:16 AM (10 years, 6 months ago)

http://scitechdaily.com/drug-candidate-sr9009-increases-exercise-endurance/

A new drug candidate, SR9009, has been shown to significantly increase exercise endurance in animal models. Researchers believe these findings may lead to better treatments for people suffering from conditions that acutely limit exercise tolerance.

An international group of scientists has shown that a drug candidate designed by scientists from the Florida campus of The Scripps Research Institute (TSRI) significantly increases exercise endurance in animal models.

These findings could lead to new approaches to helping people with conditions that acutely limit exercise tolerance, such as obesity, chronic obstructive pulmonary disease (COPD) and congestive heart failure, as well as the decline of muscle capacity associated with aging.

The study was published in the journal Nature Medicine.

The drug candidate, SR9009, is one of a pair of compounds developed in the laboratory of TSRI Professor Thomas Burris and described in a March 2012 issue of the journal Nature as reducing obesity in animal models. The compounds affect the core biological clock, which synchronizes the rhythm of the body’s activity with the 24-hour cycle of day and night.

The compounds work by binding to one of the body’s natural molecules called Rev-erbα, which influences lipid and glucose metabolism in the liver, the production of fat-storing cells and the response of macrophages (cells that remove dying or dead cells) during inflammation.

In the new study, a team led by scientists at the Institut Pasteur de Lille in France demonstrated that mice lacking Rev-erbα had decreased skeletal muscle metabolic activity and running capacity. Burris’ group showed that activation of Rev-erbα with SR9009 led to increased metabolic activity in skeletal muscle in both culture and in mice. The treated mice had a 50 percent increase in running capacity, measured by both time and distance.

“The animals actually get muscles like an athlete who has been training,” said Burris. “The pattern of gene expression after treatment with SR9009 is that of an oxidative-type muscle— again, just like an athlete.”

The authors of the new study suggest that Rev-erbα affects muscle cells by promoting both the creation of new mitochondria (often referred to as the “power plants” of the cell) and the clearance of those mitochondria that are defective.

The study, “Rev-Erbα Modulates Skeletal Muscle Oxidative Capacity by Regulating Mitochondrial Biogenesis and Autophagy” was led by Estelle Woldt and Yasmine Sebti (first authors) and Bart Staels and Hélène Duez (senior authors) of Institut Pasteur de Lille, France. Other contributors include Christian Duhem, Jérôme Eeckhoute, Charlotte Paquet, Stéphane Delhaye and Philippe Lefebvre of Institut Pasteur de Lille, France; Laura Solt, Youseung Shin, Thomas Burris and Theodore M. Kamenecka of TSRI; Steve Lancel and Rémi Nevière of Université Lille Nord de France; and Matthijs K.C. Hesselink, Gert Schaart and Patrick Schrauwen of Maastricht University Medical Center, Maastricht, the Netherlands.

The study was supported by a Marie Curie International Reintegration Grant (FP7), the European Commission (FP7) consortium Eurhythdia, Région Nord Pas-de-Calais/FEDER, a CPER “starting grant,” the European Genomic Institute for Diabetes (ANR-10-LABX-46), an unrestricted ITMO/Astra Zeneca grant, a joint Société Francophone du Diabète MSD research fellowship, Research Grant from the European Foundation for the Study of Diabetes, National Institutes of Health grant (MH093429 and DK080201) and a VICI Research grant for innovative research from the Netherlands Organization for Scientific Research (918.96.618).

Publication: Estelle Woldt, et al., “Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy,” Nature Medicine 19, 1039–1046, 2013; doi:10.1038/nm.3213


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OfflinePsilosopherr
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Re: Drug Candidate SR9009 Increases Exercise Endurance [Re: Midnight_Toker]
    #18736791 - 08/21/13 10:32 AM (10 years, 6 months ago)

So this could help restore strength and stamina you lose due to old age? Thats amazing


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InvisibleRepertoire89
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Re: Drug Candidate SR9009 Increases Exercise Endurance [Re: Midnight_Toker]
    #18736834 - 08/21/13 10:43 AM (10 years, 6 months ago)

Interesting, seems like there could be a lot of uses in physical therapy. Also sounds like some mad scientist shit :lol:


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OfflinePsilosopherr
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Re: Drug Candidate SR9009 Increases Exercise Endurance [Re: Repertoire89]
    #18736847 - 08/21/13 10:45 AM (10 years, 6 months ago)

Quote:

Repertoire89 said:
Interesting, seems like there could be a lot of uses in physical therapy. Also sounds like some mad scientist shit :lol:



oh I hadn't thought about that. People who are bedridden for months and then have to build their muscles back up.

I hear building them back up takes foreverrrr. this would totally potentially help with that :grin:


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InvisibleRepertoire89
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Re: Drug Candidate SR9009 Increases Exercise Endurance [Re: Psilosopherr]
    #18736937 - 08/21/13 11:04 AM (10 years, 6 months ago)

It could be dangerous as well, which is a given for any experimental drug. Was thinking one potential problem which would be mitigated by competent physical therapists, is to start a cycle and have the muscles grow in without proper form.
How does this affect the tendons I wonder? They're as important as muscles


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OfflinePsilosopherr
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Re: Drug Candidate SR9009 Increases Exercise Endurance [Re: Repertoire89]
    #18736969 - 08/21/13 11:13 AM (10 years, 6 months ago)

yeah, and over exertion. maybe pull/damage the muscles from over-use


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OfflineGorlax
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Re: Drug Candidate SR9009 Increases Exercise Endurance [Re: Psilosopherr]
    #18737087 - 08/21/13 11:49 AM (10 years, 6 months ago)

a quick google and you can purchase 25mg for 150$

what's the dosage on this shit


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InvisibleMidnight_Toker
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Re: Drug Candidate SR9009 Increases Exercise Endurance [Re: Gorlax]
    #18737203 - 08/21/13 12:17 PM (10 years, 6 months ago)

Please do NOT use this yourself.  Animal testing and human testing are two very very different things, and it's not like using research chemicals because that's just fucking around with different tryptamines, phenethylamines/amphetamines, cathinones, etc..  Messing with your metabolic pathways is a whole other ballgame which can have who knows how many unforeseen consequences.

I would suggest a steroid cycle if you're looking to bulk up long before suggesting anybody try this before much more testing is done.


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Offlineaj123
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Re: Drug Candidate SR9009 Increases Exercise Endurance [Re: Gorlax]
    #18737457 - 08/21/13 01:14 PM (10 years, 6 months ago)

Quote:

Gorlax said:
a quick google and you can purchase 25mg for 150$

what's the dosage on this shit




Well apparently they dosed the mice 100 mg/kg twice a day for 7 days


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InvisibleSynthe
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Re: Drug Candidate SR9009 Increases Exercise Endurance [Re: Midnight_Toker]
    #18737792 - 08/21/13 02:27 PM (10 years, 6 months ago)

A lot of experimental drugs end up making people sick and causing physical/mental disorders before they stop putting them through trials. :shrug:


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OfflineGorlax
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Re: Drug Candidate SR9009 Increases Exercise Endurance [Re: Synthe]
    #18737878 - 08/21/13 02:42 PM (10 years, 6 months ago)

I wasn't about to buy this shit lol... :goodluckwiththat2:


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OfflineD.M.T
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Re: Drug Candidate SR9009 Increases Exercise Endurance [Re: Gorlax]
    #18740055 - 08/21/13 10:01 PM (10 years, 6 months ago)

I think you need a company/organization to order from that site, but I'm not positive.


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