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OfflineVisionary Tools
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Registered: 06/23/07
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Warning: Grapefruit potentiates drugs
    #18662724 - 08/05/13 09:50 AM (10 years, 9 months ago)

Summary: Grapefruits contain chemicals that interfere with enzymes in the gut, enzymes that normally diminish the effects of orally taken prescription medicine.

http://www.dailymail.co.uk/health/article-2239520/Grapefruit-warning-Doctors-says-cause-dangerous-reaction-host-common-drugs.html

Article that I lazily highlighted and pasted follows below:

Breakfasting on half a grapefruit has long been seen as one of the healthiest ways to start the day, a virtuous alternative to tucking into cereal or a cooked breakfast. But could this supposed ‘superfood’, which is packed with vital vitamins and minerals, really be doing you more harm than good?

This week, researchers warned that the fruit reacts with a large number of medicines taken by millions of Britons every day, causing devastating side-effects ranging from stomach bleeding to kidney problems, muscle aches and irregular heartbeats.

Doctors say the public are woefully ignorant about the dangers of mixing grapefruit with medicine and that many are putting themselves needlessly at risk.
Half a grapefruit has long been seen as one of the healthiest ways to start the day but researchers have warned that the fruit reacts with a large number of medicines causing devastating side-effects

Bad breakfast: Half a grapefruit has long been seen as one of the healthiest ways to start the day but researchers have warned that the fruit reacts with a large number of medicines causing devastating side-effects

So what is the truth behind the scare, and how can such a ‘healthy’ fruit pose such a threat?

WHAT IS THE PROBLEM?

Astonishingly, just one glass of grapefruit juice is enough to treble the potency of some cancer, heart, cholesterol and painkilling drugs.

More than 20 years ago doctors discovered that grapefruit makes some prescriptions dangerously strong. But since then, the list of medicines affected by the fruit has soared.

More...

    'Vegetarians have a better sex life': Eating tofu can boost you in the bedroom, new study claims
    Just one soft drink a day raises men's risk of aggressive prostate cancer by 40%
    The health foods doctors say don't work: From blueberries to cod liver oil and margarine that 'cuts cholesterol'

Over the past four years, the number known to interact with grapefruit and cause serious side-effects has gone from 17 to 43, according to a report in the Canadian Medical Journal.

In the UK, almost all of those drugs are available on prescription (see table below). Another 42 medicines are thought to have milder, although still disturbing, side-effects.

Doctors are supposed to advise patients about the risks, while the warning also appears on patient leaflets that accompany drugs. But sometimes, amid the flurry of information that patients get when prescribed a new drug, the warning is overlooked or quickly forgotten.
The concentrations in grapefruit can interfere with a naturally produced chemical in our intestines and is involved in the metabolism of some drugs, controlling the amount that enters the bloodstream

Disturbing side-effects: The concentrations in grapefruit can interfere with a naturally produced chemical in our intestines and is involved in the metabolism of some drugs, controlling the amount that enters the bloodstream

And the side-effects of grapefruit-related overdoses can be horrendous. Some patients suffer low blood pressure and immune system collapse.

HOW DOES THIS HAPPEN?

Scientists have only recently worked out how grapefruit makes drugs more potent.

The problem lies in chemicals in the fruit called furanocoumarins. These are produced by plants often as a defence mechanism against predators.

The concentrations in grapefruit are not toxic, but they interfere with a chemical naturally produced in our intestines called cytochrome P450 3A4.

This enzyme sits in the lining of the intestines and is involved in the metabolism of some drugs, controlling the amount that enters the bloodstream. Drug companies have to increase the dosage of some tablets to compensate for the action of the enzyme.
Just one glass of grapefruit juice is enough to treble the potency of some cancer, heart, cholesterol and painkilling drugs

Glassful: Just one glass of grapefruit juice is enough to treble the potency of some cancer, heart, cholesterol and painkilling drugs

However, if furanocoumarins are present in the intestine, they stop cytochrome P450 3A4 from working.  As a result, more of the drug gets into the bloodstream and a patient is at risk of an overdose.

A single helping of grapefruit can have an effect, even if consumed hours before the patient takes their medicine.

The effects of mixing medicine and grapefruit can be dramatic. In tests, patients taking the blood pressure drug felodipine had three times the level of the medicine in their blood after drinking grapefruit juice than those patients who’d had a glass of water.

People who eat lots of the fruit over a long period of time appear to be at even higher risk.
Dr David Bailey said one tablet with a glass of grapefruit juice was like taking five or ten tablets with water

Unintentionally toxic: Dr David Bailey said one tablet with a glass of grapefruit juice was like taking five or ten tablets with water

Researchers have shown that taking the cholesterol-lowering drug simvastatin with a 200ml glass of grapefruit juice every day for three days increased the drug’s concentration in the blood three-fold.

Dr David Bailey, a researcher at the Lawson Health Research Institute in London, Ontario, who published this week’s study, said in summary: ‘One tablet with a glass of grapefruit juice can be like taking five or ten tablets with a glass of water. So you can unintentionally go from a therapeutic level [of the drug] to a toxic level just by consuming grapefruit juice.’

WHAT DRUGS ARE AFFECTED?

The range of drugs affected by grapefruit is vast and covers virtually every type of medicine, from painkillers and sedatives to drugs that fight cancer and lower blood pressure.

One of the most common groups are the statins — simvastatin, lovastatin and atorvastatin — taken by some seven million Britons to lower cholesterol.

The antibiotic erythromycin is another common medicine made more potent when taken with grapefruit. It is used, among other things, to treat skin and urinary infections.

The drug is not particularly toxic, but an overdose can cause nasty symptoms including stomach upsets. And, crucially, too much erythromycin in the blood interferes with the way other drugs work.

The blood-thinning drug clopidogrel is also on the list. It is commonly prescribed after heart attacks, strokes or angina. Unusually it doesn’t become more potent with grapefruit, but can stop working completely. The list of danger medicines also includes antipsychotic drugs — including treatments for anxiety, depression, bipolar disorder and schizophrenia — drugs for kidney, skin and blood cancers, blood-thinning medication and painkillers.

The one thing that all the drugs have in common is that they are taken orally, usually as pills.

WHAT ARE THE EFFECTS OF MIXING GRAPEFRUIT AND MEDICINES?

The side-effects of mixing grapefruit with medicines vary hugely from drug to drug. But some can be deadly. Overdosing on cancer drugs, antibiotics and some antipsychotic drugs can cause irregular heart rhythms and even sudden death.

In the Nineties, a patient in America died from an irregular heartbeat after taking the antihistamine allergy medicine Terfenadine twice a day while also drinking grapefruit juice two to three times a week. Doctors believed the two were connected.

High doses of anti-cancer drugs can suppress the activity of bone marrow, which creates blood cells and fights infection — putting people with weakened immune systems at further risk of illness.
Stomach bleeding can result from an overdose of blood-thinning drugs such as apixaban and rivaroxaban.
A single helping of grapefruit can have an effect, even if consumed hours before the patients takes their medicine

Overdose risk: A single helping of grapefruit can have an effect, even if consumed hours before the patients takes their medicine

Overdosing on statins can lead to the painful and potentially dangerous breakdown of muscle tissue. As muscle proteins enter the blood, it can put the kidneys under extreme strain and may lead to kidney failure. Other symptoms include muscle pain and swelling, vomiting and diarrhoea.

Older people — who are less able to tolerate overdoses — are more likely to become seriously ill as a result.

CAN OTHER FRUITS HAVE THIS EFFECT?

Grapefruit is the biggest threat, but other fruits can interfere with drugs, too.

Seville oranges, used to make marmalade, and limes contain the same active ingredients that cause the drug problems.

One patient in Dr Bailey’s study suffered from kidney problems while taking the drug tacrolimus to suppress their immune system after an organ transplant.

He had eaten a staggering 1.5kg of marmalade during the preceding week — more than enough to make the drugs more potent.

Past research by Dr Bailey showed that orange and apple juices may reduce the effectiveness of drugs used to treat cancer, heart conditions and high blood pressure.

In tests, beta-blockers, antibiotics and hay fever treatments were all weakened by juice drunk up to two hours previously.

The problem was caused by naringin (a chemical which makes citrus fruits bitter) which stopped the drugs moving from the small intestine into the bloodstream — the opposite of what happens with grapefruit.
Seville oranges (pictured), used to make marmalade, and limes contain the same ingredients that cause the drug problems

Active ingredient: Seville oranges (pictured), used to make marmalade, and limes contain the same ingredients that cause the drug problems

WHAT SHOULD PATIENTS DO?

Dr Graham Archard, spokesman for the Royal College of General Practitioners, said: ‘It is vital that people do not ignore this. If they are on these medications, it is sensible not to eat grapefruit. While you may not have had problems in the past, that doesn’t mean you won’t get them in the future.

‘The majority of these medications are prescription-only, and the doctor should inform patients if there are problems with grapefruit.

‘But sometimes patients don’t take in all the information they are given, and sometimes doctors may forget, so it’s important to read the patient information leaflet.’
DRUGS THAT INTERACT WITH GRAPEFRUIT...

ANTI-CANCER
Dasatinib (leukaemia)
Erlotinib (lung cancer and pancreatic cancer)
Everolimus (kidney cancer)
Lapatinib (breast cancer)
Nilotinib  (leukaemia)
Pazopanib (kidney cancer)
Sunitinib (kidney/gastrointestinal cancer)
Vandetanib (thyroid cancer)
Venurafenib (skin cancer)

ANTI-INFECTIVE
Erythromycin (antibiotic)
Halofantrine (malaria)
Maraviroc (HIV)
Primaquine (malaria)
Quinine (malaria)
Rilpivirine (HIV)

ANTI-CHOLESTEROL
Atorvastatin
Lovastatin
Simvastatin

CARDIOVASCULAR
Amiodarone (heart rhythm disorders)
Apixaban (anti-clotting)
Dronedarone (heart rhythm disorders)
Eplerenone (heart failure)
Felodipine (high blood pressure/angina)
Nifedipine (high blood pressure/angina)
Quinidine  (heart rhythm disorder)
Rivaroxaban (anti-blood clotting)
Ticagrelor (anti-blood clotting after heart attack)

CENTRAL NERVOUS SYSTEM
Oral Alfentanil (painkiller)
Oral fentanyl (painkiller)
Oral ketamine (painkiller, sedative)
Lurasidone (schizophrenia/mental health problems)
Oxycodone (painkiller)
Pimozide (schizophrenia/other mental health problems)
Ziprasidone (schizophrenia, mania, bipolar disorder)

GASTROINTESTINAL
Domperidone (anti-nausea)

IMMUNO-SUPPRESSANTS
Cyclosporine (post organ transplant, rheumatoid arthritis, psoriasis)
Sirolimus (post organ transplant)
Tacrolimus (post organ transplant)

URINARY TRACT
Solifenacin (urinary frequency/incontinence)
Silodosin (enlarged prostate)
Tamsulosin (enlarged prostate)


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Edited by Visionary Tools (08/05/13 09:54 AM)

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OfflineVisionary Tools
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Re: Warning: Grapefruit potentiates drugs [Re: Visionary Tools]
    #18662741 - 08/05/13 09:56 AM (10 years, 9 months ago)

Now, this article struck my interest (thus why I'm sharing it here)

Many know of the lemon tek, but has anyone tried mushrooms with grapefruit? Was that why Raul Duke kept a large supply at hand constantly during fear and loathing?


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InvisibleAbstraKt_I_Am


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Re: Warning: Grapefruit potentiates drugs [Re: Visionary Tools]
    #18662890 - 08/05/13 10:31 AM (10 years, 9 months ago)

All I know is you dont mix grapefruit with any sort of drug. Its not good for you and with many different drugs.. potentially a fatal combination.


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OfflinePeteza34
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Re: Warning: Grapefruit potentiates drugs [Re: AbstraKt_I_Am]
    #18662928 - 08/05/13 10:40 AM (10 years, 9 months ago)

I think the moral of the story is:  Grapefruit is bad.

Right?


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OfflineSulfurshelfsean
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Re: Warning: Grapefruit potentiates drugs [Re: Visionary Tools]
    #18662948 - 08/05/13 10:45 AM (10 years, 9 months ago)

I used to drink grapefruit juice to potentiate opiodes. If I couldn't get something strong and ot stuck with viccodine or something I'd drink a glass of white grapefruit juice like 20 minutes before hand. Definitely dangerous. I didn't think it potentiated all these other drugs though.


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Everything is better when it is done ON TOP OF A MOUNTAIN!

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Offlinehgmstl
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Re: Warning: Grapefruit potentiates drugs [Re: Sulfurshelfsean]
    #18662954 - 08/05/13 10:47 AM (10 years, 9 months ago)

This has been known for ages and ages.


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Yo yo yo

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Offlinehidenseek1
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Registered: 12/22/12
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Re: Warning: Grapefruit potentiates drugs [Re: hgmstl] * 2
    #18662981 - 08/05/13 10:53 AM (10 years, 9 months ago)

Quote:

hgmstl said:
This has been known for ages and ages.




yes but now that its "news" we can BAN GRAPFRUIT


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You can drink at 7 A.M., because the Beastie Boys fought for that right
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pons asinorum
--------------------------------------------------------------------------
lsd and the vietnam war changed music forever

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OfflineHardTrippin
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Re: Warning: Grapefruit potentiates drugs [Re: hidenseek1] * 1
    #18663302 - 08/05/13 12:13 PM (10 years, 9 months ago)

Quote:

hidenseek1 said:
Quote:

hgmstl said:
This has been known for ages and ages.




yes but now that its "news" we can BAN GRAPFRUIT



I'm already writing a letter to my local MP. I'm just thinking of the children, you know?

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OfflineSillyputty67

Registered: 10/06/12
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Re: Warning: Grapefruit potentiates drugs [Re: HardTrippin] * 1
    #18663340 - 08/05/13 12:24 PM (10 years, 9 months ago)

Lol, the evil grapefruit.

Perhaps its the pharmaceuticals that are bad???

If they were not taking the pharmaceuticals, the issues would not present themselves.

Since when did just eating grapefruit pose a heath risk to someone who wasnt full of additional chemicals?


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1) Everything I ever posted or say is a lie.

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OfflineVisionary Tools
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Re: Warning: Grapefruit potentiates drugs [Re: Sillyputty67]
    #18663406 - 08/05/13 12:43 PM (10 years, 9 months ago)

Quote:

malicom said:
Lol, the evil grapefruit.

Perhaps its the pharmaceuticals that are bad???

If they were not taking the pharmaceuticals, the issues would not present themselves.

Since when did just eating grapefruit pose a heath risk to someone who wasnt full of additional chemicals?




No you are wrong THE GRAPEFRUIT IS BAD it was here first. We need to emergency schedule grapefruit, make it CLASS A, life for anyone that grows it. Then we can grow them in Afghanistan along with all the opium.


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InvisibleKT-BC
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Re: Warning: Grapefruit potentiates drugs [Re: Visionary Tools]
    #18663592 - 08/05/13 01:23 PM (10 years, 9 months ago)

Quote:

Visionary Tools said:
Now, this article struck my interest (thus why I'm sharing it here)

Many know of the lemon tek, but has anyone tried mushrooms with grapefruit? Was that why Raul Duke kept a large supply at hand constantly during fear and loathing?





i make it a goal to eat a bunch of citrus fruit when high on psychedelics, i thought everyone knew this. to be honest :lol

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OfflineAedan
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Re: Warning: Grapefruit potentiates drugs [Re: KT-BC] * 1
    #18663725 - 08/05/13 01:51 PM (10 years, 9 months ago)

I used to make pharmahuasca and dissolve it in grapefruit juice. I think it is a potentiator. I have grapefruit trees growing in my backyard. They are interesting fruit.

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InvisibleMenalaus
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Re: Warning: Grapefruit potentiates drugs [Re: Visionary Tools]
    #18663729 - 08/05/13 01:53 PM (10 years, 9 months ago)

Grapefruit killed my mom and made my dad a homosexual

:sad:
:crankey:

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Offlinehidenseek1
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Re: Warning: Grapefruit potentiates drugs [Re: Menalaus]
    #18663736 - 08/05/13 01:54 PM (10 years, 9 months ago)

in that order??


--------------------
You can drink at 7 A.M., because the Beastie Boys fought for that right
--------------------------------------------------------------------------
pons asinorum
--------------------------------------------------------------------------
lsd and the vietnam war changed music forever

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InvisibleMenalaus
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Re: Warning: Grapefruit potentiates drugs [Re: hidenseek1]
    #18663758 - 08/05/13 02:00 PM (10 years, 9 months ago)

:sadyes:

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OfflineSillyputty67

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Re: Warning: Grapefruit potentiates drugs [Re: Menalaus]
    #18663763 - 08/05/13 02:02 PM (10 years, 9 months ago)

I wonder if grapefruits can cure homosexuals, or does it just have the power to make them?


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1) Everything I ever posted or say is a lie.

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OfflineSillyputty67

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Re: Warning: Grapefruit potentiates drugs [Re: Sillyputty67]
    #18663770 - 08/05/13 02:04 PM (10 years, 9 months ago)

Buck up son. It wasnt the grapefruits fault that the fruit truck smashed your moms car, and your dad was already gay. :rofl:


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1) Everything I ever posted or say is a lie.

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InvisibleMenalaus
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Re: Warning: Grapefruit potentiates drugs [Re: Sillyputty67] * 1
    #18663823 - 08/05/13 02:20 PM (10 years, 9 months ago)

Quote:

malicom said:
Buck up son. It wasnt the grapefruits fault that the fruit truck smashed your moms car, and your dad was already gay. :rofl:




You don't know power of Grapefruit, it trebles homosexuality.

:crankey:

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Offlinehidenseek1
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Re: Warning: Grapefruit potentiates drugs [Re: Menalaus]
    #18663840 - 08/05/13 02:26 PM (10 years, 9 months ago)

i heard grapefruit potentiates  teh gays when you do shrooms


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You can drink at 7 A.M., because the Beastie Boys fought for that right
--------------------------------------------------------------------------
pons asinorum
--------------------------------------------------------------------------
lsd and the vietnam war changed music forever

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InvisibleFuturesight
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Re: Warning: Grapefruit potentiates drugs [Re: KT-BC]
    #18663861 - 08/05/13 02:33 PM (10 years, 9 months ago)

Quote:

KT-BC said:
Quote:

Visionary Tools said:
Now, this article struck my interest (thus why I'm sharing it here)

Many know of the lemon tek, but has anyone tried mushrooms with grapefruit? Was that why Raul Duke kept a large supply at hand constantly during fear and loathing?





i make it a goal to eat a bunch of citrus fruit when high on psychedelics, i thought everyone knew this. to be honest :lol



Me too, plus it tastes amazing! Last week I ate an entire lemon, peel and all. Like an apple. Then I was launched on up to level four. :feelsgoodman:


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Offlinesomething cool
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Re: Warning: Grapefruit potentiates drugs [Re: Futuresight] * 1
    #18663879 - 08/05/13 02:37 PM (10 years, 9 months ago)

Can anyone comment whether GFJ works it's trebling magic on cocaine? And for those who've used it with opiates/oids, how much trebling did it cause?

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Offlinebackfire16
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Re: Warning: Grapefruit potentiates drugs [Re: something cool]
    #18664337 - 08/05/13 04:31 PM (10 years, 9 months ago)

Quote:

something cool said:
Can anyone comment whether GFJ works it's trebling magic on cocaine? And for those who've used it with opiates/oids, how much trebling did it cause?




I'm just taking a stab at this but I believe grapefruit's only potentiate drugs that are taken orally. Therefore any drug that is consumed via any other method besides oral should not be potentiated.

I tried it with opiates years ago and it didn't seem to make a difference to me :crazy:

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OfflineGorlax
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Re: Warning: Grapefruit potentiates drugs [Re: backfire16]
    #18664859 - 08/05/13 06:53 PM (10 years, 9 months ago)

It works for a lot of drugs that metabolize through the cp 450 enzyme (most opiates and benzos). I used to buy large grapefruits, take a few vicodin then eat a huge grapefruit. You do notice it.

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Offlinech1ck3n.s0up
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Re: Warning: Grapefruit potentiates drugs [Re: hidenseek1]
    #18665765 - 08/05/13 10:37 PM (10 years, 9 months ago)

Quote:

hidenseek1 said:
Quote:

hgmstl said:
This has been known for ages and ages.




yes but now that its "news" we can BAN GRAPFRUIT




:noargument:


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"Inspiration ~ Move me brightly ~ light the song with sense and color ~ hold away despair ~ more than this I will not ask ~ faced with mysteries dark and vast ~ statements just seem vain at last" --Jerry Garcia, Terrapin Station

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Invisibletealeaf
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Re: Warning: Grapefruit potentiates drugs [Re: ch1ck3n.s0up]
    #18665793 - 08/05/13 10:45 PM (10 years, 9 months ago)

this is their way of saying the pharms arn't bad, its the dang grapefruit's fault!


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:dancingbear:

SonicTitan said:
"Id rail the same amount of come to crack"

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OfflineIoRhinz
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Re: Warning: Grapefruit potentiates drugs [Re: tealeaf]
    #18665908 - 08/05/13 11:11 PM (10 years, 9 months ago)

Quote:

Quote:

Quote:

Visionary Tools said:
Now, this article struck my interest (thus why I'm sharing it here)

Many know of the lemon tek, but has anyone tried mushrooms with grapefruit? Was that why Raul Duke kept a large supply at hand constantly during fear and loathing?




KT-BC said:
i make it a goal to eat a bunch of citrus fruit when high on psychedelics, i thought everyone knew this. to be honest :lol




Futuresight said:
Me too, plus it tastes amazing! Last week I ate an entire lemon, peel and all. Like an apple. Then I was launched on up to level four.




Probably everyone has tried lemon tek, but as Visionary Tools asked: has anyone tried GRAPEFRUIT, not just orange or lemon or lime.


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OfflinePsilosopherr
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Re: Warning: Grapefruit potentiates drugs [Re: IoRhinz]
    #18665980 - 08/05/13 11:25 PM (10 years, 9 months ago)

I really wanna try grapefruit juice with oral DMT now!

And lemon tek substituted with GF juice as well.

Just sounds like we should be careful, extremely careful.

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OfflineLSDreams
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Re: Warning: Grapefruit potentiates drugs [Re: Psilosopherr]
    #18666221 - 08/06/13 12:17 AM (10 years, 9 months ago)

im thinkng :leaf: brownie plus grapefruit :homerdrool:

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OfflineLord_McLovin
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Re: Warning: Grapefruit potentiates drugs [Re: LSDreams]
    #18666708 - 08/06/13 03:13 AM (10 years, 9 months ago)

As far as I know there already is a grapefruit tek for consuming shrooms. Search the forums!


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OfflineMagick
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Re: Warning: Grapefruit potentiates drugs [Re: Lord_McLovin]
    #18667237 - 08/06/13 08:32 AM (10 years, 9 months ago)

This has me thinking about the combination of grapefruit juice and oyster mushrooms.

Oyster mushrooms contain a decent amount of lovastatin, which is specifically listed as one of the drugs not to combine with grapefruit.

A potentially deadly meal? Hmmm..

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OfflineChuckfinely
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Re: Warning: Grapefruit potentiates drugs [Re: Futuresight]
    #18667506 - 08/06/13 10:14 AM (10 years, 9 months ago)

Quote:

Futuresight said:
Quote:

KT-BC said:
Quote:

Visionary Tools said:
Now, this article struck my interest (thus why I'm sharing it here)

Many know of the lemon tek, but has anyone tried mushrooms with grapefruit? Was that why Raul Duke kept a large supply at hand constantly during fear and loathing?





i make it a goal to eat a bunch of citrus fruit when high on psychedelics, i thought everyone knew this. to be honest :lol



Me too, plus it tastes amazing! Last week I ate an entire lemon, peel and all. Like an apple. Then I was launched on up to level four. :feelsgoodman:





Holy hell would that make me sick. eating a lemon straight up? I usually brew tea with my mushrooms cause they always make me sick, and i usually add a little lemon juice to the water to help extract all the goodies, but even then that couple table spoons of lemon juice kills my stomach  :crazybaby:


Everyone that I know or have known that likes to take benzos has always slammed a glass of grapefruit juice right after taking their bars. I've tried it a few times...makes 5mg of alprozolam feel like 10mg :shrug:

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OfflineRedpill


Registered: 01/23/13
Posts: 421
Loc: Lake Wobegon, MN
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Re: Warning: Grapefruit potentiates drugs [Re: Magick]
    #18667508 - 08/06/13 10:14 AM (10 years, 9 months ago)

Dextromethorphan (DXM), the cough suppressant and dissociative NMDAR Antagonist, should also be on that list of things potentiated by grapefruit.

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OfflineSillyputty67

Registered: 10/06/12
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Re: Warning: Grapefruit potentiates drugs [Re: Redpill]
    #18667549 - 08/06/13 10:30 AM (10 years, 9 months ago)

This is only loosely related. These little pills make sour foods taste sweet. Its called flavor tripping. My wife and I did it once. We ate lemons, orange, and grapefruit. It was amazing.

These little chewable pills have a protein that binds to your flavor receptors, and alters the signal sent to your brain.

http://www.thinkgeek.com/product/ab3f/?pfm=caffeine_featured_ab3f_3


--------------------
1) Everything I ever posted or say is a lie.

Edited by Sillyputty67 (08/06/13 10:31 AM)

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InvisibleMenalaus
Man of the world


Registered: 08/02/13
Posts: 220
Re: Warning: Grapefruit potentiates drugs [Re: Sillyputty67]
    #18670276 - 08/06/13 08:23 PM (10 years, 9 months ago)

Quote:

malicom said:

Its called flavor tripping.




That's just what we need in America, they can sell it at gas stations and fat-food places

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InvisibleBoutang
AKMC
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Re: Warning: Grapefruit potentiates drugs [Re: Visionary Tools]
    #18671488 - 08/07/13 12:58 AM (10 years, 9 months ago)

I noticed in that list at the end they don't list Xanax.  Why is that?  I'm looking at my bottle and my girls bottle and there is the grape fruit warning label on it.


--------------------

North to the future is our motto I'm still up north no future to follow
We do these things and we don't give a fuck, we fire up a blunt in the car bumping Cougnut.

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OfflineChuckfinely
another round for me an my buddy

Registered: 06/27/13
Posts: 628
Last seen: 4 years, 6 months
Re: Warning: Grapefruit potentiates drugs [Re: Boutang]
    #18674788 - 08/07/13 06:04 PM (10 years, 9 months ago)

Quote:

Boutang said:
I noticed in that list at the end they don't list Xanax.  Why is that?  I'm looking at my bottle and my girls bottle and there is the grape fruit warning label on it.





I speak from personal experience that an 8 oz glass of grape fruit juice taken with your xanax will double its potency for most people

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Offlinecrimsonking91
Stranger

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Re: Warning: Grapefruit potentiates drugs [Re: Chuckfinely]
    #18675868 - 08/07/13 10:25 PM (10 years, 9 months ago)

Grapefruit juice is awesome, I wanna try it with dxm, and yes I can get "real drugs" I still love dxm enough to do once in a while but the magic is almost gone I've tripped for years and years on that stuff

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Offlinebackfire16
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Re: Warning: Grapefruit potentiates drugs [Re: crimsonking91]
    #18678545 - 08/08/13 02:43 PM (10 years, 9 months ago)

Does anyone have the slightest idea as to whether this would potentiate mushrooms?

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InvisibleKT-BC
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Registered: 10/24/12
Posts: 2,209
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Re: Warning: Grapefruit potentiates drugs [Re: backfire16]
    #18679312 - 08/08/13 05:11 PM (10 years, 9 months ago)

yes it would. ive done it.

enjoy

:trippinballs:

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InvisibleFuturesight
Mind Mage
Male


Registered: 01/19/13
Posts: 1,188
Loc: The Candy Kingdom
Re: Warning: Grapefruit potentiates drugs [Re: backfire16]
    #18679517 - 08/08/13 05:57 PM (10 years, 9 months ago)

Quote:

backfire16 said:
Does anyone have the slightest idea as to whether this would potentiate mushrooms?



On an amazing level, ate one whole grapefruit, went from level 3 to level 4 within five minutes. and this was AFTER the original "peak."
Definitely recommended! :cookiemonster:


--------------------

Edited by Futuresight (08/08/13 05:58 PM)

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Offlinesomething cool
meandering

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Re: Warning: Grapefruit potentiates drugs [Re: something cool]
    #18685962 - 08/10/13 05:19 AM (10 years, 9 months ago)

Addressing my own question, grapefruit suppresses the enzymes CYP3A4 (also called Cytochrome P450 3A4) and CYP3A5. Cocaine is metabolized by CYP3A4, so I suspect grapefruit should strongly potentiate cocaine.

Edited by something cool (08/10/13 05:37 AM)

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OfflinePsilosopherr
A psilly goose
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Re: Warning: Grapefruit potentiates drugs [Re: something cool]
    #18686706 - 08/10/13 11:06 AM (10 years, 9 months ago)

Quote:

something cool said:
Addressing my own question, grapefruit suppresses the enzymes CYP3A4 (also called Cytochrome P450 3A4) and CYP3A5. Cocaine is metabolized by CYP3A4, so I suspect grapefruit should strongly potentiate cocaine.



ooooh baby.

I was just thinkin about gettin a gram too :rail:

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Offlinesomething cool
meandering

Registered: 01/30/12
Posts: 1,306
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Re: Warning: Grapefruit potentiates drugs [Re: Psilosopherr]
    #18688248 - 08/10/13 07:05 PM (10 years, 9 months ago)

Great. if you do, please weight in on the grapefruit supposition!

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InvisibleMenalaus
Man of the world


Registered: 08/02/13
Posts: 220
Re: Warning: Grapefruit potentiates drugs [Re: something cool]
    #18688365 - 08/10/13 07:41 PM (10 years, 9 months ago)

When I was 9 I woke up one morning to find my dad plugging 2 whole grapefruits, this was after my mom had already over dosed on the juice and here he was plugging two pulp and all. Worst day of my life, within a month he was a homosexual

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Offlinesomething cool
meandering

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Re: Warning: Grapefruit potentiates drugs [Re: Menalaus]
    #18699295 - 08/13/13 10:47 AM (10 years, 9 months ago)

Has anyone yet potentiated their coke with gfj? I'll be a willing test subject soon enough, but I'm eager to know how much it does do beforehand.

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OfflinePsilosopherr
A psilly goose
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Registered: 02/15/12
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Re: Warning: Grapefruit potentiates drugs [Re: something cool]
    #18699677 - 08/13/13 01:12 PM (10 years, 9 months ago)

Quote:

something cool said:
Has anyone yet potentiated their coke with gfj? I'll be a willing test subject soon enough, but I'm eager to know how much it does do beforehand.



I'll report back sometime! I'm not one of those people who just says it and never comes back :cool2:

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Offlinesomething cool
meandering

Registered: 01/30/12
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Re: Warning: Grapefruit potentiates drugs [Re: Psilosopherr]
    #18704233 - 08/14/13 12:12 PM (10 years, 9 months ago)

Cool man. I would be testing now already if it weren't for one stupid thing, arggh! This evening, though. It will be done, gfj at the ready.

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