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Offlinesomething cool
meandering

Registered: 01/30/12
Posts: 1,306
Last seen: 7 years, 7 months
Re: Warning: Grapefruit potentiates drugs [Re: something cool]
    #18685962 - 08/10/13 05:19 AM (10 years, 9 months ago)

Addressing my own question, grapefruit suppresses the enzymes CYP3A4 (also called Cytochrome P450 3A4) and CYP3A5. Cocaine is metabolized by CYP3A4, so I suspect grapefruit should strongly potentiate cocaine.

Edited by something cool (08/10/13 05:37 AM)

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OfflinePsilosopherr
A psilly goose
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Registered: 02/15/12
Posts: 12,280
Last seen: 1 month, 30 days
Re: Warning: Grapefruit potentiates drugs [Re: something cool]
    #18686706 - 08/10/13 11:06 AM (10 years, 9 months ago)

Quote:

something cool said:
Addressing my own question, grapefruit suppresses the enzymes CYP3A4 (also called Cytochrome P450 3A4) and CYP3A5. Cocaine is metabolized by CYP3A4, so I suspect grapefruit should strongly potentiate cocaine.



ooooh baby.

I was just thinkin about gettin a gram too :rail:

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Offlinesomething cool
meandering

Registered: 01/30/12
Posts: 1,306
Last seen: 7 years, 7 months
Re: Warning: Grapefruit potentiates drugs [Re: Psilosopherr]
    #18688248 - 08/10/13 07:05 PM (10 years, 9 months ago)

Great. if you do, please weight in on the grapefruit supposition!

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InvisibleMenalaus
Man of the world


Registered: 08/02/13
Posts: 220
Re: Warning: Grapefruit potentiates drugs [Re: something cool]
    #18688365 - 08/10/13 07:41 PM (10 years, 9 months ago)

When I was 9 I woke up one morning to find my dad plugging 2 whole grapefruits, this was after my mom had already over dosed on the juice and here he was plugging two pulp and all. Worst day of my life, within a month he was a homosexual

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Offlinesomething cool
meandering

Registered: 01/30/12
Posts: 1,306
Last seen: 7 years, 7 months
Re: Warning: Grapefruit potentiates drugs [Re: Menalaus]
    #18699295 - 08/13/13 10:47 AM (10 years, 9 months ago)

Has anyone yet potentiated their coke with gfj? I'll be a willing test subject soon enough, but I'm eager to know how much it does do beforehand.

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OfflinePsilosopherr
A psilly goose
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Registered: 02/15/12
Posts: 12,280
Last seen: 1 month, 30 days
Re: Warning: Grapefruit potentiates drugs [Re: something cool]
    #18699677 - 08/13/13 01:12 PM (10 years, 9 months ago)

Quote:

something cool said:
Has anyone yet potentiated their coke with gfj? I'll be a willing test subject soon enough, but I'm eager to know how much it does do beforehand.



I'll report back sometime! I'm not one of those people who just says it and never comes back :cool2:

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Offlinesomething cool
meandering

Registered: 01/30/12
Posts: 1,306
Last seen: 7 years, 7 months
Re: Warning: Grapefruit potentiates drugs [Re: Psilosopherr]
    #18704233 - 08/14/13 12:12 PM (10 years, 9 months ago)

Cool man. I would be testing now already if it weren't for one stupid thing, arggh! This evening, though. It will be done, gfj at the ready.

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