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OfflineNoviseer
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MAO to stop a trip?
    #1859864 - 08/28/03 06:50 PM (13 years, 3 months ago)

Can you buy monoamine oxide in pill form, and take it to metabolize the psilocin in your brain and stop a trip?  It would probably make you depressed cause it'd eat up your serotonin also, but then you could take some 5ht or sam-e or whatever to replace it? 

Cmon, you gotta love my uneducated-pseudo-science here.. :grin:


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namaste said:
no flamz in da ODD, if you got nothing to contribute then keep yo lips zipped
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OfflineSev
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Re: MAO to stop a trip? [Re: Noviseer]
    #1860415 - 08/28/03 09:53 PM (13 years, 3 months ago)

It's monamine oxidase.  :smile:

Naw, once the stuff is in your brain, you're along for the whole ride.  MAO stays in the gut, and certainly doesn't cross the blood-brain barrier.

At least, I think.  :wink:

Now, if you just dosed and suddenly had to make sure you didn't start tripping, it might work ... but that's assuming you can even get MAO, which I'm not sure about. 


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"Do we want the stars? We can have them. Can we borrow cups of fire from the sun? We can and must and light the world." --"On the Shoulders of Giants", Ray Bradbury

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Offlinepsychopsilocyber
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Re: MAO to stop a trip? [Re: Sev]
    #1864718 - 08/30/03 03:23 AM (13 years, 3 months ago)

Your brain also has monoamine oxidase. Your brain cells "communicate" with an axon(sender) and a dendrite(receiver). And the space between the two is called the synapse. So when a chemicle is sent from the axon it is either received into the dendrite or it is re-uptaken into a different part on the axon. When a neurotransmitter is reuptaken from the synapse, it goes into the axon where the MAO is located. So if there is no maoi you can see what happens.

So to answer your question Noviseer (I mean I'm no doctor or anything) If you were to take more mao(if possible?) it would not just matabolize the psilocin, it would eventually-because eventually enough of the psilocin would be re-uptaken, but it wouldnt work right away. I would guess it wouldnt even have much of an effect since all of what is being re-uptaken is going to be broken down by the mao that's already in there.


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OfflineFlowGnome
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Re: MAO to stop a trip? [Re: psychopsilocyber]
    #1868578 - 08/31/03 04:40 PM (13 years, 3 months ago)

Assuming that it would make it to your brain, which is possible, it would also metabolize serotonin and several other vital chemicals, possibly with more preference than the 4-HO-DMT floating around, screwing up the chemical balance of your brain.

Checking Sigma-Aldrich's catalog, MAO-A & B are $142.00 per 2.5mg and must be shipped in dry ice, so this would possibly be the most un-economical way of stopping a trip I could think of assuming that it even worked.


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OfflinePsiloman
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Re: MAO to stop a trip? [Re: Noviseer]
    #1868928 - 08/31/03 07:16 PM (13 years, 3 months ago)

First of all,i believe it is a bit naive to go to the mentality "pills to counter the effets from other drugs ,and more pills to counter the last pills taken ".Simply,it is not a healthy attitude.And if we speak about experiencing mushroom to seek some insight or gain something then the "pill" philosophy is an oxymoron.Riding it out is a very mature option i guess.After all there is no "bad trip" and tripping is not a passive activity.You can change course and you can gain great insight in the workings of your own brain/psyche.My opinionabove ,of course,can be considered garbage if one takes mushrooms to get "fucked up" or to entairtain his/hers mundane life.

THe other point i wanted to clarify is that this MAO is a PROTEIN (hence the outrageous price).If you eat a pill ogf it it will get digested to AMINOACIDS.If you inject it (like insulin,also a protein) you risk allergic reaction,let alone that it cannot enter the brain due to its molecular sizeand polarity.

Please,please ,please! Forums are to compliment knowledge already present on websites and literature.A little research and basic biology understanding can answer many questions.C'mon folks,people in here are supposed to have curious,energetic,active if not intelligent minds...So lets make use of them (our brain energy needs are about 20% of the whole body energy need.Its an "expensive organ in other words.Honour it by using its full potential)


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OfflineNoviseer
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Re: MAO to stop a trip? [Re: Psiloman]
    #1869511 - 08/31/03 11:31 PM (13 years, 3 months ago)

LOL people, people! This isn't something I was planning on doing, I'm just interested in biology and pharmacology, just shooting the shit. Sorry I'm a newbie and that I'm quite ignorant when it comes to biological science. Thats why I ask stuff like this, to have things clarified. The purpose of this post was not to find a way to stop a bad trip. Just idle curiosity.


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namaste said:
no flamz in da ODD, if you got nothing to contribute then keep yo lips zipped
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OfflineDEATH666
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Re: MAO to stop a trip? [Re: Noviseer]
    #1874020 - 09/02/03 02:17 PM (13 years, 3 months ago)

just pop a zanny and chill out


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OfflineEkstaza
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Re: MAO to stop a trip? [Re: DEATH666]
    #1874139 - 09/02/03 03:08 PM (13 years, 3 months ago)

Yea zanibars will knock you the fuck out and you just wake uo from a long nice nap.


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OfflineEvilGir
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Re: MAO to stop a trip? [Re: Ekstaza]
    #1875326 - 09/02/03 09:12 PM (13 years, 3 months ago)

"THe other point i wanted to clarify is that this MAO is a PROTEIN "

But Isnt a mao an enzyme that binds to proteins in a seratonin based chemicle.


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Invisiblepoke smot!
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Re: MAO to stop a trip? *DELETED* [Re: EvilGir]
    #1876858 - 09/03/03 09:38 AM (13 years, 3 months ago)

Post deleted by poke smot!

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OfflinePsiloman
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Re: MAO to stop a trip? [Re: poke smot!]
    #1876952 - 09/03/03 10:42 AM (13 years, 3 months ago)

Jezu,Biology lesson no 2

"What are enzymes?" Certainly NOT mystical balls of divine white light TM that magickally decompose stuff in your body...

ENZYMES ARE PROTEINS

http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=enzyme

<biochemistry> A protein molecule produced by living organisms that catalyses chemical reactions of other substances without itself being destroyed or altered upon completion of the reactions

If you are thinking of becoming a technomage get the "techno" part of the noun correctly...

No pun intented,but i wonder why people DO NOT reseatch...When i first learned about MAO and MAOis i opened books,searched the net,went to libraries tou find out as much as possible...I thought that every logical human being (logical+human being can be a contradiction) would do the same...At least a google search?! And then a search on the word enzyme!??!?!?!?!


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Offlinegnrm23
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Re: MAO to stop a trip? [Re: Psiloman]
    #1876985 - 09/03/03 11:13 AM (13 years, 3 months ago)

dr abram hoffer suggests that the reason (or at least one of the reasons) that NIACINAMIDE (& other things like SAMe, etc.) work to "stop" a trip is that they increase MAO levels & thus increase "digestion" of drugs & drug metabolites in the ol' noggin...
ymmv...


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not old enough to care


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OfflineNoviseer
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Re: MAO to stop a trip? [Re: Psiloman]
    #1877155 - 09/03/03 01:05 PM (13 years, 3 months ago)

OK!  SORRY!  :nut:


--------------------
_______________________________________________________________
namaste said:
no flamz in da ODD, if you got nothing to contribute then keep yo lips zipped
_________________________________________________________________


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OfflineRuNE
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Re: MAO to stop a trip? [Re: Psiloman]
    #1877189 - 09/03/03 01:25 PM (13 years, 3 months ago)



Psiloman: chill out dude. O_o




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OfflineNoviseer
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Re: MAO to stop a trip? [Re: RuNE]
    #1878250 - 09/03/03 06:43 PM (13 years, 3 months ago)

Quote:

!??!?!?!?! 




Look at that exclamation.  If he knew anything about biology, he'd realize that excessive stress can do serious damage to the body :wink: :grin:


--------------------
_______________________________________________________________
namaste said:
no flamz in da ODD, if you got nothing to contribute then keep yo lips zipped
_________________________________________________________________


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OfflineEvilGir
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Re: MAO to stop a trip? [Re: Noviseer]
    #1878648 - 09/03/03 08:23 PM (13 years, 3 months ago)

"why people DO NOT reseatch"

Well after a hard nights work I guess its just out of lazyness. Although I should of known better as I am doing a Bsc hons in Physiology and Pharmacology. Guess I should check my posts beter before I reply.
But there is no reason to get all stressed out just a polite correction would of done.


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Invisiblepoke smot!
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Re: MAO to stop a trip? *DELETED* [Re: gnrm23]
    #1878692 - 09/03/03 08:36 PM (13 years, 3 months ago)

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OfflineNoviseer
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Re: MAO to stop a trip? [Re: poke smot!]
    #1879844 - 09/04/03 02:03 AM (13 years, 3 months ago)

I didn't say SAM-e increased levels of MAO.  I said extra MAO could metabolize more of your serotonin, making you depressed, and possibly SAM-e or 5htp could counter that effect by helping your brain replace its supply (of SEROTONIN, not MAO).  I may be dumb but I'm not that dumb.  :blush: 

Wow, everyone's knockin the piss out of me in this thread.  I guess I'll have to go back to asking my MD father, with futile attempts to disguise the obvious drug-context of my line of questioning  :grin:


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_______________________________________________________________
namaste said:
no flamz in da ODD, if you got nothing to contribute then keep yo lips zipped
_________________________________________________________________


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Offlinegnrm23
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Re: MAO to stop a trip? [Re: poke smot!]
    #1880549 - 09/04/03 09:55 AM (13 years, 3 months ago)

ummm, sources....
well, i think the passing reference to stuff (in addition to niacinamide) that raise MAO levels was in dr hoffer's book _vitamin b3 & schizophrenia_
maybe...


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Invisiblepoke smot!
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Re: MAO to stop a trip? *DELETED* [Re: Noviseer]
    #1881309 - 09/04/03 03:41 PM (13 years, 3 months ago)

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