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InvisibleSimplepowa
In Pursuit of Knowledge


Registered: 03/06/09
Posts: 4,310
Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And Sleep
    #18576998 - 07/18/13 04:56 PM (10 years, 9 months ago)

Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And Sleep Function, With No Side Effects

Smoking medical marijuana achieved remission in five of 11 subjects with Crohn's disease who smoked twice a day for eight weeks, as part of a study.

By Chris Weller | Jul 18, 2013 10:44 AM EDT

Crohn's disease, one of several inflammatory bowel diseases, achieved "complete remission" in nearly half the subjects of one study that were exposed to smoking medical marijuana on a regular basis.

Published in the journal Clinical Gastroenterology and Hepatology, the study examined the effects of consistent marijuana use on Crohn's patients who suffered from severe cases of the disease. The results of the 21-subject study point toward the drug's anti-inflammatory properties as being responsible for quieting symptoms in many patients, and even reaching total remission in others.
The Disease: Causes, Symptoms, And Treatments

Often mischaracterized as an autoimmune disease, Crohn's disease is in fact an immune deficiency state. Arising from a host of genetic, environmental, and immunological factors, the disease causes a chronic inflammatory disorder that attacks the person's gastrointestinal tract — anywhere from the mouth to the anus — in order to fight the body's antigens that otherwise do no harm. Symptoms of the disease range from mild abdominal pain to more severe cases of bloody diarrhea, nausea, vomiting, weight loss, and fevers.

There is no cure for Crohn's; however, various methods are aimed at limiting flare ups and keeping the disease in remission. Treatments, like disease severity, fall on a spectrum depending on the person. Simple dietary changes suffice for some, while invasive surgery to remove the affected area may be needed for others. Corticosteroids and other medications are also prescribed for less severe cases.

The disease affects around 400,000 to 600,000 people in North America, although many people do not get diagnosed until they've had the disease for years, simply because no symptoms were present.
The Study And Its Findings

Scientists at Meir Medical Center in Israel wanted to examine the effects of Cannabis sativa on patients with severe Crohn's disease, relying on the underlying drug's anti-inflammatory effects in treating other ailments, such as arthritis and multiple sclerosis.

"The marijuana plant Cannabis sativa has been reported to produce beneficial effects for patients with inflammatory bowel diseases, but this has not been investigated in controlled trials," the researchers wrote. "We performed a prospective trial to determine whether cannabis can induce remission in patients with Crohn's disease."

Twenty-one people with severe, intractable Crohn's comprised the study. Out of those 21, 11 subjects smoked two joints a day for eight weeks. The other 10 made up the placebo group.

The results were particularly telling, according to the researchers. In total, five of the 11 subjects smoking marijuana daily achieved total remission of their Crohn's. They reported greater appetites and sleep patterns. (People with severe cases of Crohn's sometimes defecate 20 times per day, and may even wake up at night to do so.) Moreover, "a clinical response" was found in 10 of those 11. Only four of the 10 placebo subjects reported any improvements.

These findings, argued the researchers, demonstrate how "THC-rich cannabis produced significant clinical, steroid-free benefits to 11 patients with active Crohn's disease, compared with placebo, without side effects."

The researchers were hesitant to call the study a total success, however, saying that the "primary end point of the study (induction of remission) was not achieved," despite the five of 11 people who reported those effects.

Still, they noted that their findings merit further attention. "Further studies, with larger patient groups and a nonsmoking mode of intake, are warranted," they wrote, pointing to the potentially diminished effects of smoking marijuana, as opposed to extracting the anti-inflammatory drugs directly from the plant.



Source: Naftali T, Lihi BL, Iris D. Cannabis Induces a Clinical Response in Patients With Crohn's Disease: A Prospective Placebo-Controlled Study. Clinical Gastroenterology and Hepatology. 2013.

http://www.medicaldaily.com/articles/17529/20130718/medical-marijuana-crohns-disease-remission-anti-inflammatory-drug-inflammatory-bowel-disease.htm


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Carl Sagan - "Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people."

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Robert Pirsig - "When one person suffers from a delusion it is called insanity. When many people suffer from a delusion it is called religion."

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Brian Cox - "[One] problem with today’s world is that everyone believes they have the right to express their opinion AND have others listen to it. The correct statement of individual rights is that everyone has the right to an opinion, but crucially, that opinion can be roundly ignored and even made fun of, particularly if it is demonstrably nonsense."

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OfflineNature Boy
Stranger than most
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Registered: 07/09/07
Posts: 8,246
Loc: Samsara
Last seen: 2 months, 5 days
Re: Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And Sleep [Re: Simplepowa]
    #18577017 - 07/18/13 04:58 PM (10 years, 9 months ago)

Another nail in the coffin of the federal scheduling of marijuana!!!!  Doin' the happy dance. :penis:

Thanks for another relevant, uplifting post!  Can't believe I never got around to rating you before today.  A total oversight on my part.  Forgive me, bro!

N.B.


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All submitted posts under this user name are works of pure fiction or outright lies.  Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit.  Note well:  Sorry, but I do not answer PM's unless you are a long-time trusted friend.  If you have a question, ask it in the appropriate thread.

                                                                               

Edited by Nature Boy (07/18/13 05:04 PM)

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OfflineRexter
Tripper


Registered: 05/03/09
Posts: 10,047
Loc: Florida Flag
Last seen: 10 years, 9 months
Re: Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And Sleep [Re: Nature Boy]
    #18577090 - 07/18/13 05:11 PM (10 years, 9 months ago)

I have IBS with IbD symptoms (I'm going to a special university to figure it out) would love to believe this but not a large enough sample group :sad:


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new trade list 
my own WCA V: I

"Ha! Marshall you're so funny man You should be a comedian, god damn!" Unfortunately I am I just hide behind the tears of a clown"

Meteloides said:
Stick to naturally occurring substances! Like Shrooms! And DMT! And Datura! And Amanita Phalloides! And Nutmeg! And Hemlock!
That'll expand the shit out of your DNA.
:ancientaliens:

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OfflineCan-i-bus
Melting


Registered: 01/22/13
Posts: 1,162
Loc: WA Flag
Last seen: 14 hours, 21 minutes
Re: Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And Sleep [Re: Rexter]
    #18578732 - 07/18/13 10:52 PM (10 years, 9 months ago)

I was actually diagnosed with a severe form of IBD called pancolitis and cannabis keeps me in remission...that's all I need to know

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OfflineRexter
Tripper


Registered: 05/03/09
Posts: 10,047
Loc: Florida Flag
Last seen: 10 years, 9 months
Re: Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And Sleep [Re: Can-i-bus]
    #18579748 - 07/19/13 07:03 AM (10 years, 9 months ago)

It works for my pain nausea and using the bathroom appropriatly. Just saying I wish it was a larger sample group.


--------------------
new trade list 
my own WCA V: I

"Ha! Marshall you're so funny man You should be a comedian, god damn!" Unfortunately I am I just hide behind the tears of a clown"

Meteloides said:
Stick to naturally occurring substances! Like Shrooms! And DMT! And Datura! And Amanita Phalloides! And Nutmeg! And Hemlock!
That'll expand the shit out of your DNA.
:ancientaliens:

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OfflineSillyputty67

Registered: 10/06/12
Posts: 2,239
Loc: Netherlands
Last seen: 9 years, 8 months
Re: Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And Sleep [Re: Rexter]
    #18579832 - 07/19/13 07:37 AM (10 years, 9 months ago)

Soon my Brethren. The rolling hills will be covered in cannabis. Corn fields will become pot fields. Today is yesterdays future.


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1) Everything I ever posted or say is a lie.

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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,379
Re: Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And Sleep [Re: Rexter]
    #18579891 - 07/19/13 08:04 AM (10 years, 9 months ago)

Quote:

Rexter said:
wish it was a larger sample group.




And this is what's required for the legal definition of "established medical use".  Nobody understands this fact though, and they think the existing (often poorly blinded) small studies of relative efficacy constitute "medical use".  They don't.


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...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436

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InvisibleVitalux
Stranger from the next universe
Male User Gallery


Registered: 02/15/11
Posts: 2,695
Loc: Canada Flag
Re: Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And S [Re: badchad]
    #18579936 - 07/19/13 08:19 AM (10 years, 9 months ago)

what I can't understand is

Eating Pot is where you get the best cures and effects for top medical use.

Why the fuck don't they talk more about it.

When you smoke it, you kill every live and healthy thing in the marijuana.

I eat the damn oil of the budd and my colitus and Crohn's Disease stays in remission.

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OfflineRexter
Tripper


Registered: 05/03/09
Posts: 10,047
Loc: Florida Flag
Last seen: 10 years, 9 months
Re: Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And S [Re: Vitalux]
    #18580087 - 07/19/13 09:22 AM (10 years, 9 months ago)

I somewhat agree.  I'm scripted marinol (waiting to be filled ATM) and it works better then smoking and I get as high or higher (or sometimes not as high at all)

Definitely prefered.


--------------------
new trade list 
my own WCA V: I

"Ha! Marshall you're so funny man You should be a comedian, god damn!" Unfortunately I am I just hide behind the tears of a clown"

Meteloides said:
Stick to naturally occurring substances! Like Shrooms! And DMT! And Datura! And Amanita Phalloides! And Nutmeg! And Hemlock!
That'll expand the shit out of your DNA.
:ancientaliens:

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OfflineSillyputty67

Registered: 10/06/12
Posts: 2,239
Loc: Netherlands
Last seen: 9 years, 8 months
Re: Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And S [Re: Rexter]
    #18580118 - 07/19/13 09:28 AM (10 years, 9 months ago)

I dont have too many issues. I just like to smoke pot. Lets just say its preventative measures. :devil:


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1) Everything I ever posted or say is a lie.

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Offlinedokunai
Cactus, Cannabis, Cubensis

Registered: 01/31/10
Posts: 1,878
Loc: Hyphal Heights, USA
Last seen: 7 years, 4 months
Re: Medical Marijuana Achieves ‘Complete Remission’ Of Crohn's Disease; Drug Improves Appetite And S [Re: Vitalux]
    #18583445 - 07/20/13 01:32 AM (10 years, 9 months ago)

Quote:

sloantbone said:
what I can't understand is

Eating Pot is where you get the best cures and effects for top medical use.

Why the fuck don't they talk more about it.

When you smoke it, you kill every live and healthy thing in the marijuana.

I eat the damn oil of the budd and my colitus and Crohn's Disease stays in remission.




OK, no.  I get almost no effect from eaten cannabinoids.

I have chronic muscle spasms, and though it's thankfully now in remission, ulcerative colitis.  I'm really glad you found an ROA that works for you, but don't presume to tell me that's how I have to ingest my medicine. 

Quote:

When you smoke it, you kill every live and healthy thing in the marijuana.




OK because you say so right?  I dare you to point me to a study that agrees with you.

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