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Offlinesomething cool
meandering


Registered: 01/30/12
Posts: 1,306
Last seen: 7 years, 5 months
NMDA Antagonists?
    #18560070 - 07/15/13 12:31 AM (10 years, 7 months ago)

I just read this article: http://www.webmd.com/pain-management/features/pain-relief-breakthrough-pain

Quote:

Drugs called NMDA antagonists (N-methyl-D-aspartate) have been another advance in narcotics for pain relief, says Rollin M. Gallagher, MD, MPH, director of pain management at the Philadelphia VA Medical Center. NMDA antagonists block NMDA receptors to stop or minimize opioid drug tolerance.

"NMDAs allow us to provide pain relief with a lower dose of a narcotic drug," Gallagher tells WebMD. "Opioids are very effective, very safe, because they don't damage organs like other drugs do -- but you can develop tolerance. NMDAs can help prevent tolerance." Meaning less drugs and better pain relief.




I've got the question, are NMDAs legal and readily available for purchase/some better than others?

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Offlinest1llnox
dx'd PTSD/ADHD--please don't ask
Male User Gallery


Registered: 11/27/12
Posts: 7,312
Loc: 913 KANSAS CITY 816 Flag
Last seen: 5 years, 2 months
Re: NMDA Antagonists? [Re: something cool]
    #18560156 - 07/15/13 01:06 AM (10 years, 7 months ago)

Legal:

Nitrous
Dextromethorphan (Robitussin)
Methoxetamine (MXE)

Illegal:
PCP
KETAMINE
probs various others

They reset a lot of brain circuitry including reversing opiate tolerance. I tripped balls on DXM (the only one I've read of being used with opiates) right now :smile:.


--------------------
Back, bitches.
st1lln0x: so i'm on weed, temazepam, adderall, dexedrine, dxm, dph, alcohol, nicotine, caffeine, tryptophan, GABA, and kratom
Cavemen_savemen: st1lln0x, do you feel like a robot yet?
st1lln0x: I feel like a fucking Gundam
Click to friend me on Steam for Counter-Strike
:crankey: IS LIFE SKULLFUCKING YOU!? HAVE SOME FREE MORALE! :awesomenod:
Click if you want to feel you alone can do it! Click if you want to feel confident and beastly! Click if you want courage to let go and move on! And click the message if you need someone to talk to -- I'll understand, even if we "hate" each other on here :hug: :sun:

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InvisibleSOLID BASTARD
Hella Vampires

Registered: 08/04/08
Posts: 5,087
Loc: 127.0.0.1
Re: NMDA Antagonists? [Re: something cool]
    #18560163 - 07/15/13 01:15 AM (10 years, 7 months ago)

Co-administering magnesium with your opiate of choice is a common suggestion. Some Bluelighters have also been having successful experiments with Memantine, an Alzheimer's drug. DXM (Dextromethorphan) has also been used to successfully combat and lower tolerances. Bio-assays seem to suggest that DXM lowers it the quickest, Memantine is a bit slower in lowering tolerance and more difficult to obtain, and magnesium is useful in maintaining the (lack of) tolerance you have.

Here are some links to get you started:
https://en.wikipedia.org/wiki/NMDA_receptor_antagonist#Uncompetitive_channel_blockers
http://www.bluelight.ru/vb/threads/542754-NMDA-Antagonist-Tolerance-and-Withdrawal-Concerns
http://www.bluelight.ru/vb/threads/501875-NMDA-antagonists-for-tolerance-a-collection-of-the-evidence-and-anecdotal-reports

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Offlinesomething cool
meandering


Registered: 01/30/12
Posts: 1,306
Last seen: 7 years, 5 months
Re: NMDA Antagonists? [Re: SOLID BASTARD]
    #18560227 - 07/15/13 01:46 AM (10 years, 7 months ago)

Thanks for those links, as well as your info st1llnox! Is it necessary to routinely take magnesium prior to dosing, to build it up in your system, or is it taken just before dosing?

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InvisibleLegend
RIP Sasha
Male


Registered: 03/29/10
Posts: 28,336
Loc: TX Flag
Re: NMDA Antagonists? [Re: something cool]
    #18560294 - 07/15/13 02:24 AM (10 years, 7 months ago)

mxe + oxycodone tablets would be the best thing since bottled water.


--------------------
No sympathy for the devil, keep that in mind.
[url=
]Buy the ticket, take the ride. [/url]
Are you lost?

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InvisibleShroomismM
Space Travellin
Male User Gallery

Folding@home Statistics
Registered: 02/13/00
Posts: 66,015
Loc: 9th Dimension Flag
Re: NMDA Antagonists? [Re: SOLID BASTARD]
    #18560300 - 07/15/13 02:28 AM (10 years, 7 months ago)

Magnesium is good for just about everything. Your body uses it for a lot of vital functions.
I've found the most efficient way to dose it is transdermally. a bottle of this shit will last a while http://www.amazon.com/Ancient-Minerals-Ultra-Pure-Magnesium/dp/B001AD0HL8
Coincidentally it seems a lot of people are deficient


--------------------

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Offlinehealing
Strangest
Female


Registered: 02/22/11
Posts: 6,565
Loc: the universe, the milky w...
Last seen: 6 years, 7 months
Re: NMDA Antagonists? [Re: Legend]
    #18560409 - 07/15/13 03:33 AM (10 years, 7 months ago)

Quote:

Legend said:
mxe + oxycodone tablets would be the best thing since bottled water.




Bottled water is shitty.


--------------------
Open mind, open heart, open book.


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Offlinedruqs
ALKALOIDOHOLIC
 User Gallery

Registered: 09/11/06
Posts: 8,862
Last seen: 5 months, 8 days
Re: NMDA Antagonists? [Re: healing]
    #18560417 - 07/15/13 03:36 AM (10 years, 7 months ago)

some of my favorites!

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Offlinest1llnox
dx'd PTSD/ADHD--please don't ask
Male User Gallery


Registered: 11/27/12
Posts: 7,312
Loc: 913 KANSAS CITY 816 Flag
Last seen: 5 years, 2 months
Re: NMDA Antagonists? [Re: something cool]
    #18567413 - 07/16/13 03:55 PM (10 years, 7 months ago)

Quote:

something cool said:
Thanks for those links, as well as your info st1llnox! Is it necessary to routinely take magnesium prior to dosing, to build it up in your system, or is it taken just before dosing?




No problem, OP... I LOVE the NMDA system so I almost creamed myself when I saw your thread's title. :datass:


--------------------
Back, bitches.
st1lln0x: so i'm on weed, temazepam, adderall, dexedrine, dxm, dph, alcohol, nicotine, caffeine, tryptophan, GABA, and kratom
Cavemen_savemen: st1lln0x, do you feel like a robot yet?
st1lln0x: I feel like a fucking Gundam
Click to friend me on Steam for Counter-Strike
:crankey: IS LIFE SKULLFUCKING YOU!? HAVE SOME FREE MORALE! :awesomenod:
Click if you want to feel you alone can do it! Click if you want to feel confident and beastly! Click if you want courage to let go and move on! And click the message if you need someone to talk to -- I'll understand, even if we "hate" each other on here :hug: :sun:

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Invisibleopenmind
curious
 User Gallery

Registered: 08/03/07
Posts: 13,904
Re: NMDA Antagonists? [Re: something cool]
    #18567584 - 07/16/13 04:31 PM (10 years, 7 months ago)

st1llnox pretty much covered the commons....



Bacopa monnieri and Uncaria tomentosa (Cat's Claw) are two legal herbs that are relatively mild NMDA antagonists, no where near as strong as things like DXM, ketamine, or nitrous. I take the Bacopa pretty regularly because it has major benefits all around for cognition and memory, the fact it keeps kratom tolerance somewhat in check is a plus.


Cat's claw contains rhynchophylline, which is a  non-competitive NMDA antagonist. Rhynchophylline is also found in kratom...isn't it cool how kratom, like all the medicinal plants, have a spectrum of alkaloids that synergize, balance, and potentiate each other.


When using kratom and when I dabble with opioids occasionally, I will use occasional low doses of DXM, regular low doses with occasional high doses of Bacopa monnieri & Cat's Claw, and daily magnesium supplement for keeping tolerance in check. The bacopa, Cat's Claw, and magnesium is something I take almost daily anyways, I'll just bump up the amounts a little bit or take one large dose of the bacopa once or twice a week when using kratom.



Not to go too off topic...but I also notice a very pronounced anti-depressant effect and a clear mind the days after taking more of a moderate dose of NMDA antagonists, such as DXM or K. This is something I noticed long before I heard about the studies showing the anti-depressant effect of ketamine...I always thought there was something going on there when I would feel all sorts of refreshed after a night of taking a dissociative.





-OM


.


--------------------

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Offlinest1llnox
dx'd PTSD/ADHD--please don't ask
Male User Gallery


Registered: 11/27/12
Posts: 7,312
Loc: 913 KANSAS CITY 816 Flag
Last seen: 5 years, 2 months
Re: NMDA Antagonists? [Re: openmind]
    #18567780 - 07/16/13 05:12 PM (10 years, 7 months ago)

Quote:

openmind said:
st1llnox pretty much covered the commons....



Bacopa monnieri and Uncaria tomentosa (Cat's Claw) are two legal herbs that are relatively mild NMDA antagonists, no where near as strong as things like DXM, ketamine, or nitrous. I take the Bacopa pretty regularly because it has major benefits all around for cognition and memory, the fact it keeps kratom tolerance somewhat in check is a plus.


Cat's claw contains rhynchophylline, which is a  non-competitive NMDA antagonist. Rhynchophylline is also found in kratom...isn't it cool how kratom, like all the medicinal plants, have a spectrum of alkaloids that synergize, balance, and potentiate each other.


When using kratom and when I dabble with opioids occasionally, I will use occasional low doses of DXM, regular low doses with occasional high doses of Bacopa monnieri & Cat's Claw, and daily magnesium supplement for keeping tolerance in check. The bacopa, Cat's Claw, and magnesium is something I take almost daily anyways, I'll just bump up the amounts a little bit or take one large dose of the bacopa once or twice a week when using kratom.



Not to go too off topic...but I also notice a very pronounced anti-depressant effect and a clear mind the days after taking more of a moderate dose of NMDA antagonists, such as DXM or K. This is something I noticed long before I heard about the studies showing the anti-depressant effect of ketamine...I always thought there was something going on there when I would feel all sorts of refreshed after a night of taking a dissociative.





-OM


.






Great post, openmind!

DXM, as long as you don't way overdo it, actually resets certain brain chemistry so it's not just you!


--------------------
Back, bitches.
st1lln0x: so i'm on weed, temazepam, adderall, dexedrine, dxm, dph, alcohol, nicotine, caffeine, tryptophan, GABA, and kratom
Cavemen_savemen: st1lln0x, do you feel like a robot yet?
st1lln0x: I feel like a fucking Gundam
Click to friend me on Steam for Counter-Strike
:crankey: IS LIFE SKULLFUCKING YOU!? HAVE SOME FREE MORALE! :awesomenod:
Click if you want to feel you alone can do it! Click if you want to feel confident and beastly! Click if you want courage to let go and move on! And click the message if you need someone to talk to -- I'll understand, even if we "hate" each other on here :hug: :sun:

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