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Invisibletheshiftingwalls
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L'hydroxy-5-tryptophan (5-HTP)
    #1767176 - 07/31/03 09:09 PM (13 years, 4 months ago)

Will L'hydroxy-5-tryptophan (5-HTP) help increase potency of mushrooms if I put 700-1000 mg of 5-HTP and mixed it with in the casing layer?


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Invisiblemicro
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Re: L'hydroxy-5-tryptophan (5-HTP) [Re: theshiftingwalls]
    #1767231 - 07/31/03 09:30 PM (13 years, 4 months ago)

Probably not, if at all it would not be to a significant extent. Tryptophan decarboxylation is inhibited by a self-feedback downregulatory mechanism so you want tryptamine or something later in the pathway (which is ???)

This has been discussed a lot on this forum, so you could do a search if you want more info.

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Invisibletheshiftingwalls
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Re: L'hydroxy-5-tryptophan (5-HTP) [Re: micro]
    #1767305 - 07/31/03 09:55 PM (13 years, 4 months ago)

Psilocybin levels might go very high. 5-HTP is more of a stimulant that converts to pure serotonin when ingested. My hypothesis is that when you ingest the mushrooms you are also ingesting the 5-HTP that would create more of an energizing effect like Pans produce.


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Invisiblemicro
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Re: L'hydroxy-5-tryptophan (5-HTP) [Re: theshiftingwalls]
    #1767381 - 07/31/03 10:24 PM (13 years, 4 months ago)

5-HTP is an amino acid -- I have no clue what you mean by "stimulant." Yes -- it's a precursor to serotonin, but has to get metabolized (I believe by the liver) so it will take more time to kick in. Hallucinogens are tricky when it comes to stuff like this -- they can act as both agonists and antagonists. People take 5-HTP to help get to sleep, so I don't think it would necessarily make the trip more intense. It's strange you mention it, though, because someone on this group tried it before and said the trip was "different" but not more intense. I guess this is more likely due to the production isomers, however, by the fungus, since 5-HTP should not have an immediate effect on the brain's serotonergic system.

As far as stuff like ayahuasca is concerned (B. caapi + P. viridis) those are MAOI inhibitors and increase the strength of the trip. These should have stimulatory effects, up to a point since norepinephrine and dopamine reuptake by MAO is inhibited as well, up to a point, but 5-HTP would not.

As for, "Psilocybin levels might go very high," I don't know what you mean -- your body doesn't make psilocybin and I really don't think this would happen in the fungus for the reason stated above.

You could go ahead and try it, though, and post your results....

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Edited by micro (07/31/03 10:32 PM)


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Invisibletheshiftingwalls
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Re: L'hydroxy-5-tryptophan (5-HTP) [Re: micro]
    #1767417 - 07/31/03 10:41 PM (13 years, 4 months ago)

I will have to do more experiments concerning this matter...


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Invisible@cro
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Re: L'hydroxy-5-tryptophan (5-HTP) [Re: theshiftingwalls]
    #1768246 - 08/01/03 04:46 AM (13 years, 4 months ago)

5-htp won't have a significant impact on mixing with psilocybin but if taken for a few days in advance of using ecstacy there will be a noticeable difference in your roll.  :grin:


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