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Offlinejaredkjared
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Prednisone and mushrooms?
    #17081166 - 10/22/12 07:22 PM (11 years, 3 months ago)

Im currently on 40 mg of prednisone every day, and am wanting to eat some shrooms this weekend. any one know if prednisone will react badly with the shrooms? any help is great! Thanks!
Will prednisone and shrooms react badly together?
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Offlinejaredkjared
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Re: Prednisone and mushrooms? [Re: jaredkjared]
    #17088669 - 10/23/12 08:48 PM (11 years, 3 months ago)

bump


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OfflineEschalt
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Re: Prednisone and mushrooms? [Re: jaredkjared]
    #17089060 - 10/23/12 09:45 PM (11 years, 3 months ago)

How long have you been taking it thus far? How long do you have to take it for? I want to say that you're fine, however check out these short term side effects of prednisone and make sure you have not noticed any of these, as I suspect it may potentially affect the trip indirectly:

Increased blood sugar for diabetics
Difficulty controlling emotion
Difficulty in maintaining train of thought
Insomnia
Euphoria
Mania

Be careful if you are diabetic but otherwise you're likely fine. That's not an insignificant dose of prednisone you are taking, so just be cautious and safe.


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OfflineHeadacherelief
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Re: Prednisone and mushrooms? [Re: Eschalt]
    #17090183 - 10/24/12 01:50 AM (11 years, 3 months ago)

Im no doctor but I think you should be ok. Just continue to take as prescribed. From what I understand predisone can be kinda nasty to stop cold turkey. Not the the kind if thing you would want to go through while tripping. I can't see any kind of negative interactions or effects on your body as mushrooms are very benign.


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Offlinenoobhere
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Re: Prednisone and mushrooms? [Re: jaredkjared]
    #17090531 - 10/24/12 05:12 AM (11 years, 3 months ago)

While I haven't heard (and I doubt anyone does) about prednisone and psilocybin interactions, the side effects of prednisone might very well interact with your trip if you get them. Check what others said already.

Also, if you've been on prednisone for over a week, keep in mind that your body is addicted to it now. Prednisone must be retired slowly over some days to avoid problems. So, DON'T ever think of not taking the prednisone the day of the trip.

"Adrenal suppression will begin to occur if prednisone is taken for longer than seven days. Eventually, this may cause the body to temporarily lose the ability to manufacture natural corticosteroids (especially cortisol), which results in dependence on prednisone. For this reason, prednisone should not be abruptly stopped if taken for more than seven days, instead, the dosage should be gradually reduced. This weaning process may be over a few days, if the course of prednisone was short, but may take weeks or months if the patient had been on long-term treatment. Abrupt withdrawal may lead to an Addisonian crisis."


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Offlinejaredkjared
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Re: Prednisone and mushrooms? [Re: jaredkjared]
    #17129727 - 10/30/12 10:29 AM (11 years, 2 months ago)

thanks for the responses. the side effects i am experiencing are, insomnia, acne, weight gain, and increased appetite. my mood is pretty stable. so i think as far as side effects im ok. and ive been on it for 2 months. I am well aware i cant stop taking it cold turkey. GOOD NEWS! im starting to taper down! dropping 5mg a week. currently taking 35 mg a day. :smile:


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Offlinejgotti
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Re: Prednisone and mushrooms? [Re: jaredkjared]
    #17129987 - 10/30/12 11:24 AM (11 years, 2 months ago)

Interestingly, there's an old study which showed that prednisone given for several days prior to an LSD trip reduced the anxiety commonly associated with psychedelics, but did not affect the subjective experience of LSD in any other way. Below is the abstract.

Arch Gen Psychiatry. 1960;2(1):89-93.

Lysergic Acid Diethylamide (LSD-25) Antagonists:

III. Modification of Syndrome by Prior Administration of Prednisone

ABSTRACT

The influence of therapeutic doses of the corticosteroids on the mood is well known. More frequently a euphoric rather than a depressed state is encountered. The psychic effect of drugs like cortisone and prednisone has not systematically been investigated in terms of their role in the therapy of illness in general, or in mental illness itself, although some important data are available.1-3

This report deals with the result of 49 experiments designed to test the effect of prednisone on the model psychosis produced by lysergic acid diethylamide (LSD-25) in man. It has been found that prednisone administered for three to seven days proir to the patient’s taking LSD either reduced or eliminated anxiety due to the drug, without diminishing other symptoms usually induced by LSD, as measured by a questionnaire previously used in this series of experiments.

~


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Offlinejaredkjared
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Re: Prednisone and mushrooms? [Re: jgotti]
    #17134381 - 10/30/12 11:53 PM (11 years, 2 months ago)

hmmm. thats really interesting actually! only thing is. most side effects dont start taking effect on your body until after 7 days of continuous use of prednisone. so i would think before those 7 days, it wouldnt effect your experience.


Edited by jaredkjared (10/30/12 11:54 PM)


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Offlinejaredkjared
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Re: Prednisone and mushrooms? [Re: jaredkjared]
    #17265700 - 11/22/12 06:21 PM (11 years, 2 months ago)

TO ANY ONE ON PREDNISONE OR IMURAN. I TOOK THE SHROOMS, AND I AM FINE. SO GO FOR IT!


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OfflineIcepic
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Re: Prednisone and mushrooms? [Re: jgotti]
    #17265771 - 11/22/12 06:39 PM (11 years, 2 months ago)

Quote:

jgotti said:
Interestingly, there's an old study which showed that prednisone given for several days prior to an LSD trip reduced the anxiety commonly associated with psychedelics, but did not affect the subjective experience of LSD in any other way. Below is the abstract.

Arch Gen Psychiatry. 1960;2(1):89-93.

Lysergic Acid Diethylamide (LSD-25) Antagonists:

III. Modification of Syndrome by Prior Administration of Prednisone

ABSTRACT

The influence of therapeutic doses of the corticosteroids on the mood is well known. More frequently a euphoric rather than a depressed state is encountered. The psychic effect of drugs like cortisone and prednisone has not systematically been investigated in terms of their role in the therapy of illness in general, or in mental illness itself, although some important data are available.1-3

This report deals with the result of 49 experiments designed to test the effect of prednisone on the model psychosis produced by lysergic acid diethylamide (LSD-25) in man. It has been found that prednisone administered for three to seven days proir to the patient’s taking LSD either reduced or eliminated anxiety due to the drug, without diminishing other symptoms usually induced by LSD, as measured by a questionnaire previously used in this series of experiments.

~





What's the deal here, I want to sign up for an LSD study where's the fucking paperwork? I know this study is hella old, I think we need a new study that shroomerites get first crack at being involved in. Damn government!


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OfflineSulik
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Re: Prednisone and mushrooms? [Re: jaredkjared] * 1
    #28300648 - 04/30/23 04:10 AM (8 months, 24 days ago)

I took just over a gram of dry Amazonian last night and I’m on 40 mg predisolone and the come up was strong and open eye visuals. So my opinion is trip is enhanced twofold.
Peace out👍🙏🙏


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