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Offlinecanid
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Thienobenzodiazepines and Psychadellics
    #1628727 - 06/12/03 01:30 PM (13 years, 5 months ago)

I am about to start taking Olanazapine (Zyprexa), 2.5mg trial dose for two weeks, at the advice of my doctor for treatment of a manic episode because it is disrupting my sleep cycles.

My question, for anybody with relevant pharmacological knowledge, is this:
Is Olanazapine (a selective monoaminergic antagonist wich binds to the seritonin 5HT 2a/2c , dopamine D 1-4, muscarinic M 1-4, histamine H 1-4 and aderenergic a 1 receptors) likely to contraindicate the use of:

psilocybian compounds
psilocin: 3-[2-(Dimethylamino)ethyl]-1H-indol-4-ol
psilocybin:

mescaline: 3,4,5-Trimethoxybenzeneethanamine
and other known tryptamines and phenethylamines found in T. peruvianus and T. pachanoi cacti?

below is some CP info on Olanazapine:

sorry for the scan quality.


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Edited by concretefeet (06/12/03 01:34 PM)


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OfflineAsanteA
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Re: Thienobenzodiazepines and Psychadellics [Re: canid]
    #1634645 - 06/15/03 08:40 AM (13 years, 5 months ago)

Please tell Skeletor to give you promethazine as a nighttime pharm and perhaps some Alprazolam for daytime sedation. :mad: Olanzapine is NOT a benzodiazepine pharmacologically.

Olanzapine for mania is not only a poor choice, it's EVIL.

Unless you're one of those rare unipolar manics (Blissed Be to all of you!) you're likely a bipolar (manic-depressive) and clozapine-type antipsychotics are just the thing to plunge you in the depths of depression.
Blocking DA, 5-HT and adrenergic receptors are just the ticket to inverse happiness.

Pushing down 5-HT pops up the DA and vice versa. Not so with olanzapine, being a drug supressing both. That's a tedious balance. Should you stamp down 5-HTs and skyrocket DAs by using psychedelics you may get either a reduced or STRONGER trip, because the hold of Olanzapine might be broken unevenly.
"Muscarinic antagonism" is just jargon for Anticholinergic (belladonna-like) effect, which can actually blow you skyhigh or skycrazy if the other modifiers of Olanzapine are insufficient.

Be careful. I would guess it would reduce trip effects, especially emotional ones, but do little in the visuals department. Psychosis and Lysergia are two distinctly seperate entities. I suggest to use a moderate dose but I always do that.
Please post how it was, as this may help others with the same dilemma. 


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Re: Thienobenzodiazepines and Psychadellics [Re: Asante]
    #1641949 - 06/18/03 12:05 PM (13 years, 5 months ago)

i meant to eat some MG seeds at Six Flags Marine world yesterday, but found theplace to be too boring and there where too many crying children.

things i have noticed since i staretd taking Zyprexa include:

constant iritablility (went away the day before yesterday).
signifigantly increased appetite.
if i take the pill at mid day i can't keep my eyes open past 5:30.
i have been able to sleep every normal hours, though i had been doing that for two days prior to taking the medication.


--------------------



Attn PWN hunters: If you should come across a bluing Psilocybe matching P. pellicolusa please smell it.
If you detect a scent reminiscent of Anethole (anise) please preserve a specimen or two for study and please PM me.


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Mushrooms, Mycology and Psychedelics >> The Psychedelic Experience

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