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Invisiblemicrobe
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Tryptamine/Phenethylamine additives
    #1616184 - 06/07/03 07:26 AM (13 years, 6 months ago)

Ok, so my FOAF's FOAF has been playing around with the idea of adding Tryptamines/Phenethylamines to the next batch of shrooms that he grows. The Tryptamine under consideration is 5-Meo-AMT, and the Phenethylamine under consideration is 2C-T-2. His question is has anyone else experimented with this idea before? And if so, what procedure was followed? Also, what were the results?

I guess the main question is, would it be worth it?


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OfflineAnnoA
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Re: Tryptamine/Phenethylamine additives [Re: microbe]
    #1616192 - 06/07/03 07:54 AM (13 years, 6 months ago)

>His question is has anyone else experimented with this idea before?

Yes.
If you do a search in this forum you will find plenty of threads.


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Offlinehawksapprentice
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Re: Tryptamine/Phenethylamine additives [Re: Anno]
    #1617659 - 06/08/03 03:54 AM (13 years, 6 months ago)

I am in the process of experimenting with this as we speak, i have also posted a question on this, only using L-5-hydroxytyrptophan. I'll let you know what happens.
Hawk


--------------------
"I celebrate the Earth, my home, my mother, my grave, and as long as men are Man they must, if they would preserve the integrated being, do the same---[and preserve]--this rank casual hungry smelly sweaty lusting transitory body, my oozy pulpy liquid-bag-swollen body, bones, blood, hair glands, my bejeweled sex; I love and celebrate it all.  never to let men forget that they are animals as much as gods---that is one thing I shall say."

  Edward Abbey


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OfflineYellowPurpleHills
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Post deleted by Administrator [Re: Anno]
    #1619589 - 06/09/03 02:05 AM (13 years, 6 months ago)



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OfflineAnnoA
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Re: Tryptamine/Phenethylamine additives [Re: YellowPurpleHills]
    #1619793 - 06/09/03 04:17 AM (13 years, 6 months ago)



Edited by Anno (06/09/03 04:19 AM)


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Invisiblemicrobe
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Re: Tryptamine/Phenethylamine additives [Re: Anno]
    #1621057 - 06/09/03 04:38 PM (13 years, 6 months ago)

Thanks for the responses guys.


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OfflineElemicin
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Re: Tryptamine/Phenethylamine additives [Re: microbe]
    #1667350 - 06/27/03 04:20 PM (13 years, 5 months ago)

neither the AMT nor the 2c-t-7 will increase alkaloid production.
Why?
AMT is an alpha-methyl-trytamine which means its going to have a CH3 bond on the "alpha" carbon. I don't believe mushrooms carry enzymes to cleave this methyl bond. I recommend you go with something similar to psilocin and psilocybin.

The 2C-T-7, will not work because it is a phenethylamine, most of the chems produced by mushrooms are indole based, and thus tryptamines.

I personally don't think it would be worth it. Trying tryptamine.hcl would work wonders, my idea is to find foods veggie foods that are high in tryptamines and use that in your substate, that or purchasing tryptamine.hcl (can be made 4 cheap, expensive 2 buy).

Good luck.



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Invisiblemicrobe
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Re: Tryptamine/Phenethylamine additives [Re: Elemicin]
    #1797468 - 08/10/03 07:11 AM (13 years, 4 months ago)

wow....thanks a lot for the info on that....that last post was very helpful by far...much appreciated


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Invisiblemicro
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Re: Tryptamine/Phenethylamine additives [Re: microbe]
    #1798183 - 08/10/03 03:04 PM (13 years, 4 months ago)

Elemicin -- are you telling me you think mushrooms have no way to demethylate things? Of course they do....

Anything with tryptophan, though, shouldn't work very well; I've stated why in other threads.

--
Micro


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Edited by micro (08/10/03 03:06 PM)


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OfflineFlux
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Re: Tryptamine/Phenethylamine additives [Re: micro]
    #1803076 - 08/11/03 09:09 PM (13 years, 4 months ago)

I personally think eating 2c-t-7 yourself would be much better then feeding it to your shrooms, just a thought :smirk: 


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Offlinexorbitol
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Re: Tryptamine/Phenethylamine additives [Re: Flux]
    #1803524 - 08/11/03 11:42 PM (13 years, 4 months ago)

My dogs elf friend lives in an area where various species of mimosa
grow.Some of these mimosa plants contain as much as 2 percent DMT in there dried rootbark and sawdust.My question is " Would adding perhaps 20 percent of the most potent mimosa sawdust to a substrate cause an elevation of the psilocin in the resulting fruits? "Just thought I'd ask.


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OfflineThE_JafF
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Re: Tryptamine/Phenethylamine additives [Re: xorbitol]
    #1806045 - 08/12/03 04:29 PM (13 years, 3 months ago)

Don't be so hasty Elemicin... There is no good reason to believe that the fungus won't process phenethylamines. Granted there is no proof, but there is a precedent. Check this out:

Mack, J.P.G. and Slaytor, M. (1979), Indolethylamine N-Methyltransferases of Phalaris tuberosa, Purification and Properties. Phytochem, 18, 1921.

The highlights are as follows (I skipped the table they mention):

"The specificities of the amine substrates to accept methyl groups using the step 3 preparation are listed in Table 5. 5-Methyltryptamine and 5-MeOT are methylated at the same rate as T. Other substituents in the indole nucleus cause methylation to proceed at a lower rate, e.g. 6-methoxytryptamine is methylated at 30% of the rate at which tryptamine is methylated. MT and 5-MeOMT are methylated at ca 2.5 times the tryptamine rate, reflecting the higher levels of SIM activity compared to PIM in the preparation. Phenylethylamines are methylated at a lower rate than the tryptamines. The ratio of activity towards N-methylphenylethylamine and phenylethylamine is 3:1, about the same as that found for the corresponding tryptamine substrates. Thus it seems that both PIM and SIM have the ability to accept a benzene ring instead of the normal indole nucleus. Substitution of the phenyl ring by bulky methoxy groups does not change the ability to methylate these compounds. The methoxy groups would occupy the space normally occupied by the benzene ring of the indole nucleus,and thus they offer no steric hindrance for binding to PIM. None of the tetrahydro-beta-carbolines, the ring closed analogues of the tryptamines were methylated, i.e. the ethylamine side chain must be in a position othe than that found in the tetrahydro-beta-carbolines. Consistent with this is the fact that the tetrahydroisoquinolines were also not methylated.
------------------------------------------------

So while I know its not exactly the same, the same mechanisms are in place. We know from research done by Jochen Gartz, that our fungal friends will produce various tryptamines, that aren't naturally produced if the substrate contains the proper precursors. i.e. diethyltryptamine to 4-hydroxy-diethyltryptamine. It isn't that much of a leap.. Now I'm not saying its so, just that you don't want to go stifling explorers before they leave port.

I wouldn't recomend doing it if it isn't legal in your particular state/country/providence, but if thats not a problem, by all means try it and report back..

ThE JafF


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