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OfflineMattyBong
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Registered: 03/14/10
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Ecstasy users' brains show toxic effects [CAN]
    #15472270 - 12/05/11 10:48 PM (12 years, 5 months ago)

Female Ecstasy users show long-lasting signs of toxicity in their brains, an imaging study shows.

The neurotransmitter serotonin, a critical signaling molecule, has roles in regulating mood, appetite, sleep, learning and memory.

In Monday's issue of the Archives of General Psychiatry, U.S. researchers used PET scans to look at levels of certain serotonin receptors in different regions of the brain in 15 women who had used Ecstasy compared with 10 who never taken it.

The study is important, said study author Dr. Ronald Cowan, a psychiatry professor at Vanderbilt University in Nashville, because the drug is now being tested as a treatment for post-traumatic stress disorder and anxiety associated with cancer.

"Our studies suggest that if you use Ecstasy recreationally, the more you use, the more brain changes you get,” Cowan said. Investigators will need to know the dose at which Ecstasy becomes toxic before it is used as a treatment, the study’s authors cautioned.

In the study, they found Ecstasy use produces chronic serotonin neurotoxicity in humans.

Since previous studies suggest that the use of birth control, estrogen level and age affect serotonin receptors, the researchers took those factors were taken into consideration in the analysis. But the authors acknowledged they may not have fully accounted for those variables.

"Given the broad role that serotonin plays in human brain function, the possibility for therapeutic MDMA use, and the widespread recreational popularity of this drug, our results have critical implications for human MDMA users," the investigators concluded.

To be eligible for the study, Ecstasy users couldn't take it in the nine days before the imaging study. When hair samples were analyzed to test for drug use, one woman was excluded from the study because of a positive cocaine result.

Participants were aged 18 to 25.

The study focused on healthy women and the findings may not apply to men or those with anxiety or depression, the researchers said.

The research was funded by the U.S. National Institute on Drug Abuse, the U.S. National Institute of Mental Health, and the U.S. National Center for Research Resources.

http://www.cbc.ca/news/health/story/2011/12/05/ecstasy-brain-serotonin.html


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---Man's mind, once stretched by a new idea, never regains its original dimensions---

--- A question that sometimes drives me hazy: am I or are the others crazy?---

---This sentence is false---

---You met me at a very strange time in my life---

---Reality is merely an illusion, albeit a very persistent one---

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OfflineLed Zeppelin
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Registered: 05/17/10
Posts: 3,962
Last seen: 3 years, 8 months
Re: Ecstasy users' brains show toxic effects [CAN] [Re: MattyBong]
    #15472430 - 12/05/11 11:23 PM (12 years, 5 months ago)

see they are making decisions on whether to use MDMA for scientific or theraputic purposes based on data collected from users of STREET ecstasy. thats not right. street ecstasy is a concoction of chemicals.

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InvisibleScudreloaded
psychonaut
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Registered: 03/15/09
Posts: 3,003
Loc: Wonderland
Re: Ecstasy users' brains show toxic effects [CAN] [Re: MattyBong]
    #15472439 - 12/05/11 11:27 PM (12 years, 5 months ago)

and we know what we've known for years. abuse of some stuff will fry ya. ive seen it in people


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We were somewhere around Barstow on the edge of the desert when the drugs began to take hold. - Hunter S. Thompson

- believe what you may but take the internet with a grain of salt

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OfflineRewindicus
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Registered: 06/05/11
Posts: 5,491
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: Scudreloaded]
    #15472463 - 12/05/11 11:30 PM (12 years, 5 months ago)

agreed. You play too much you pay too much.


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“Be who you are and say what you feel because those who mind don't matter and those who matter don't mind.”- Dr. Seuss

"Too much of a good thing, can be wonderful!" - Mae West

"If you have nothing nice to say about anyone, come sit next to me."
- Alice Roosevelt Longworth




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InvisibleScudreloaded
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Registered: 03/15/09
Posts: 3,003
Loc: Wonderland
Re: Ecstasy users' brains show toxic effects [CAN] [Re: Rewindicus]
    #15472489 - 12/05/11 11:35 PM (12 years, 5 months ago)

what i will bring up is this.
you do come back, it just takes time with some people.
i have a buddy who used to roll a whole bunch and got memory issues for a while, but he finally seems on track.
now i won't say i won't roll again, but its been over 3 years. its very random anymore when it happens. i find myself just drinking ( which is bad too) and smoking the good herb weed mostly anymore. but once every blue moon i do trip.
repeated abuse of MDMA or even some of the things i do can lead to issues.
my body my temple


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We were somewhere around Barstow on the edge of the desert when the drugs began to take hold. - Hunter S. Thompson

- believe what you may but take the internet with a grain of salt

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OfflineRewindicus
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Registered: 06/05/11
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: Scudreloaded]
    #15472512 - 12/05/11 11:41 PM (12 years, 5 months ago)

totally but its just ironic that alot of the people that swear up an down that rolls an drying your brain out all the time has no long term issues are usually the ones that behind their backs are referred to as the Etards/Burnouts/Fryheads.

from the beginning when i was 16 an had my first roll i never said i would let it get out of control because i had seen from my peers what it was doin to them when they abused it. nowadays alot of those same friends are on anti-depressants fucking 23/24/25 year olds that honestly have nothing to be depressed about (good jobs/homelifes/relationships ect) on meds! its kinda crazy.

please no flaming i realize alot of people on this site are on all kinds of meds an you got your own reasons for being on em but these kids really dont have anything to be depressed about and i know them well enough to say that. I think a large part of it us due to 8+ years of multiple weekly uses of drugs. but im no doctor of course just a theory.  :shrug:


--------------------
“Be who you are and say what you feel because those who mind don't matter and those who matter don't mind.”- Dr. Seuss

"Too much of a good thing, can be wonderful!" - Mae West

"If you have nothing nice to say about anyone, come sit next to me."
- Alice Roosevelt Longworth




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InvisibleScudreloaded
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Registered: 03/15/09
Posts: 3,003
Loc: Wonderland
Re: Ecstasy users' brains show toxic effects [CAN] [Re: Rewindicus]
    #15472521 - 12/05/11 11:44 PM (12 years, 5 months ago)

possibly. ive burned myself out on stuff a couple times. but i do come back.
i try not to roll anymore cause it usualy turns into a week or drugs, sex and drinking.
....and something goes bad in life and your jobless or broke or something. oh well.
sometimes i worry what a dentist will say if he sees my teeth. he'll surely see ive grinded them a bunch


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We were somewhere around Barstow on the edge of the desert when the drugs began to take hold. - Hunter S. Thompson

- believe what you may but take the internet with a grain of salt

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OfflineRewindicus
Silly Goose
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Registered: 06/05/11
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: Scudreloaded]
    #15472546 - 12/05/11 11:52 PM (12 years, 5 months ago)

dude i saw this chick grind her teeth down SO bad her first time rolling the next morning she was in a TON of pain and had def done permanent damage she had to her all her teeth capped because eating and drinking anything was just too painful.


--------------------
“Be who you are and say what you feel because those who mind don't matter and those who matter don't mind.”- Dr. Seuss

"Too much of a good thing, can be wonderful!" - Mae West

"If you have nothing nice to say about anyone, come sit next to me."
- Alice Roosevelt Longworth




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InvisibleNWlight
Just look


Registered: 01/12/10
Posts: 18,686
Re: Ecstasy users' brains show toxic effects [CAN] [Re: Rewindicus]
    #15472579 - 12/06/11 12:04 AM (12 years, 5 months ago)

"Alcohol users' brains show toxic effects"


:lolsy:


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:wizard::deemsters:

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Invisible5-HT2A
Registered: 01/30/10
Posts: 1,794
Re: Ecstasy users' brains show toxic effects [CAN] [Re: NWlight]
    #15472645 - 12/06/11 12:17 AM (12 years, 5 months ago)

This study sort of tells you nothing. It shows differences in brain scans but gives no information on how that translates to performance/well-being. It also examined a very small number of women.

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Invisiblebigmike7104
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Registered: 07/12/10
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: 5-HT2A]
    #15472703 - 12/06/11 12:36 AM (12 years, 5 months ago)

i'm sure heavy use is certainly not good for you(as is the case with most drugs(or all drugs?)

but

Quote:

in different regions of the brain in 15 women who had used Ecstasy compared with 10 who never taken it.




that's way too small of a sample size to get anything from

Quote:


"Given the broad role that serotonin plays in human brain function, the possibility for therapeutic MDMA use, and the widespread recreational popularity of this drug, our results have critical implications for human MDMA users," the investigators concluded.




i highly doubt using it once in a while affects you more than getting drunk every once in a while.

Quote:


The research was funded by the U.S. National Institute on Drug Abuse, the U.S. National Institute of Mental Health, and the U.S. National Center for Research Resources.




as in the same government that wants to continue the war on drugs, specifically pot. yea no bias there  :rolleyes:


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Over thinking, over analyzing separates the body from the mind
Withering my intuition, missing opportunities and I must
Feed my will to feel my moment drawing way outside the lines

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Offlinewithoutawire
hi
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Registered: 08/16/09
Posts: 11,384
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: bigmike7104]
    #15472723 - 12/06/11 12:40 AM (12 years, 5 months ago)

It passed FDA stage I and II trials so this article means shit.


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InvisibleNWlight
Just look


Registered: 01/12/10
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: withoutawire]
    #15472734 - 12/06/11 12:43 AM (12 years, 5 months ago)

^ /thread


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:wizard::deemsters:

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InvisibleSamuel L Jackson
Bad Motherfucker
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Registered: 12/10/09
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: bigmike7104] * 1
    #15472752 - 12/06/11 12:46 AM (12 years, 5 months ago)

i think a lot of people downplay the negatives that can result from overuse of ecstasy.... i used to do it too.

studies like this should be welcomed in the drug using community if anything so you (we) can all can be more informed about possible problems arising from the overuse of certain substances and alter the way we use those drugs accordingly.

it would be a lot cooler to have a reason to limit your use ahead of time as opposed to doing what i did last summer and saying "durrhurr government puts out only lies about drugs, nothing bad will happen if i eat a bunch of ecstasy on a regular basis" and finding out the hard way that ecstasy most definitely fucks up your brain if you do it too much.


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Offlinewithoutawire
hi
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: Samuel L Jackson]
    #15472767 - 12/06/11 12:51 AM (12 years, 5 months ago)

Oh I don't doubt MDMA has its side effects, but


Quote:

In the study, they found Ecstasy use produces chronic serotonin neurotoxicity in humans.






This ruins the legitimacy of the article, when it should say. "Chronic ecstasy use leads to serotonin neurotoxicity". Otherwise it sounds like doing ecstasy leads to severe issues, when clearly that's only the case in the more extreme circumstances. This article is an attempt to ruin the legitimacy of MDMA in psychotherapy by wording what I quoted the way it was written. That is what pisses me off, and has me all GRRR. I do know that it causes damage if abused to an extent and anyone who doesn't believe that is just kidding themselves.

The brain has the ability to recover extremely well. MDMA is far less neurotoxic that methamphetamine and I see people daily with years and years of meth abuse who are coming back to normal and functioning at basically the same capacity.


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:tigerbunny:

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InvisibleNWlight
Just look


Registered: 01/12/10
Posts: 18,686
Re: Ecstasy users' brains show toxic effects [CAN] [Re: Samuel L Jackson]
    #15472784 - 12/06/11 12:55 AM (12 years, 5 months ago)

I think people love the feeling of drugs a lot, so they tend to dismiss data that says their habits are bad for them.  Especially with ecstasy there is a lot of misinformation (partly because of genuine lack of science).

But in this case Jackson, I still think they didn't prove anything new using methods that were up-to-par.


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:wizard::deemsters:

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InvisibleSamuel L Jackson
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: withoutawire]
    #15472812 - 12/06/11 01:02 AM (12 years, 5 months ago)

even if the aim of the research is to make other mdma-related research seem less worthwhile and reasonable, they may still have some good data.

you dont overlook good data just because someone isn't on your side about a particular subject.


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Offlinewithoutawire
hi
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: Samuel L Jackson]
    #15472839 - 12/06/11 01:10 AM (12 years, 5 months ago)

Didn't I just say MDMA causes neurotoxicity? The way the article is worded is extremely poor and might not even reflect the data, which I didn't even say anything about.


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:tigerbunny:

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InvisibleSamuel L Jackson
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: withoutawire]
    #15472875 - 12/06/11 01:20 AM (12 years, 5 months ago)

well the article isnt going to actually do anything when you get down to it, so the wording of it doesnt matter. the people who would use the data mentioned in the article would get everything they need to know from the paper written by the researchers who did the study, not article x written by joe schmoe for morning newspaper version 4.235b.

its best if you just look at it for what it actually is as opposed to what the authors opinion is, as with most other things. :tongue:


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Invisiblechopstick
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Re: Ecstasy users' brains show toxic effects [CAN] [Re: withoutawire]
    #15472883 - 12/06/11 01:21 AM (12 years, 5 months ago)

Article is stupid. 15 users of "ecstasy" who in reality may have easily been taking meth/piperazines/cathinones etc. and probably doing a lot of other drugs too. Yes, MDMA is neurotoxic, but this study is still flawed.

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