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African shrub may help drug withdrawal
    #1512218 - 05/01/03 07:47 PM (13 years, 5 months ago)


Friday April 25, 12:49 PM

African shrub may help drug withdrawal
US scientists are investigating derivatives of a compound from an African shrub that is said to cure drug addicts of their habit, reports New Scientist magazine.

Ibogaine is a compound that comes from the root of the plant Tabernanthe iboga, found in Gabon, West Africa. Followers of the Bwiti religion use it in ceremonies for its vision-giving properties. But in the early 1960s, ibogaine became associated with reducing drug cravings among heroin addicts attempting to withdraw.

Although banned in the US as a schedule 1 drug - it is classed alongside heroin - some researchers say that ibogaine is "worth investigating" as an alternative to methadone to help heroin addicts avoid the effects of withdrawal.

Dr Stanley Glick, a neuropharmacologist at New York's Albany Medical Center, studied the way ibogaine binds to a range of receptors in the brain's nerve endings. He has now teamed up with Dr Martin Kuehne from the University of Vermont to look at two of ibogaine's molecular cousins that have fewer side effects.

In research into 18-methoxycoronaridine (18-MC) - a synthetic relative of ibogaine - they discovered that rats administered with the compound reduced the amount of drugs they self-administered and had less severe withdrawal symptoms.

Dr Deborah Mash, a neuropharmacologist at the University of Miami Medical Center, has also carried out ibogaine trials in the past, and says that some patients who took the treatment have remained drug free for as long as six years.

Now Dr Mash has found that noribogaine - a natural metabolite of ibogaine - helps addicted rodents stop themselves from self-administering drugs. She believes noribogaine locks onto the mu-opoid receptor - the main binding site for morphine - and stifles the stimulus that the drug provides.

But Frank Vocci, from the US National Institute on Drug Abuse in Maryland, told New Scientist that while there were "striking stories" of drug addicts who have been helped by ibogaine, there were other anecdotes describing people who did not quit their habit and even died while taking the compound.

The leading edge researchers and scientists and other experienced people gather in NYC to discuss and present evidence about this promising tool in helping people get off mentally and physically addictive drugs.

Ibogaine Forum in NYC-

Sunday and Monday
May 4 and 5, 2003

The Walker Stage @ 75 Walker St. (at Broadway)

Sunday, May 4, 2003, Noon to 8 pm

12:00 noon - 12:45 pm
Registration $20

12:45 pm - 1:00 pm
Introductory Remarks
Rommel Washington, BENU

1:00 pm - 2:30 pm
Traditional Healing and Religious Practice
Suzanne Bellamy, ex-BPP
Laurent Sazy, Photoethnographer
Malendi, Bwiti Nganga
Awolowo Johnson, Nganga/sociologist

2:30 pm - 3:30 pm

3:30 pm - 5:30 pm
Treatment Providers Speak
Howard Lotsof
Linette Carriere, IbogaTherapyHouse
Patrick Kroupa, Ibogaine List
Adam Nodelman, INTASH
Brian Mariano, Czech Republic
Lynn Maner

5:45 pm to 8 pm
Ibogaine and the Search for Lost Sacraments
Prof. Carl Ruck, PhD, author, "The Apples of Apollo"
Daniel Pinchbeck, author,
"Breaking Open the Head"
Charles Kater, Friends of Bishop Pike
Frank Morales, Episcopalian Priest

Monday, May 5, 2003,
10 am to 6 pm

10:00 am - 10:30 am
Registration $20

10:30 am - 10:45 am
Introductory Remarks
H.S. Lotsof

10:45 am - 1:45 pm
Scientific Panel
Kenneth R. Alper, MD
Deborah C. Mash PhD
Emmanuel Onaivi, PhD
Carl M. Anderson, PhD
Jonathan Freedlander, BA

1:45 pm - 3:00 PM

3:00 pm - 5:15 pm
Politics and Availability
Dana Beal, co-author,
"The Ibogaine Story"
Vic Hernandez, Dr PH
Howard Lotsof
Bob Sisko Addiction Research Institute
Ric Doblin, MAPS

5:15 pm - 6:00 pm
Final Wrap-up Panel
Rommel Washington, BENU
& Principal Panelists

The Monday session will be attended by representatives of various
city and state agencies.


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Registered: 04/07/03
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Re: African shrub may help drug withdrawal [Re: motaman]
    #1520607 - 05/05/03 12:04 AM (13 years, 5 months ago)

I read a interesting trip report on Ibogaine at erowid

One of the reasons marijuana is illegal today because growers in the 30s lobbied against hemp farmers -- they saw it as competition, because It is not chemically addictive as is nicotine, alcohol, or caffeine.

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