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GoddessOfLove
Mother Monster


Registered: 01/10/10
Posts: 3,766
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Last seen: 1 year, 1 month
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I talked to David E Nichols and he replied to some questions ! :D
#15100760 - 09/19/11 12:46 PM (12 years, 5 months ago) |
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Trust me or not, I talked to the real one David E. Nichols and ask him some questions that he replied to me 
Ok so my english is not really good but he understand my question, so enjoy !
Question 1 : (Well my english is not very good so I hope you'll understand) Ok. It's about a chemicals that I guess you work on it it's called DOI or 2,5-Dimethoxy-4-iodoamphetamine, since it's not researched well, I would like to know since I have the opportunity in my life to talk to you, if you have any informations on how these kind of chemicals (like DOM, DOC or DOB) affects the heart and cardio vascular system to a certain degree ? I was making research on how it's affects the cardiovascular system but I can't make clue about it It is due to some receptor affinities or something?
Nichol's Answer : At usual doses they don't affect the cardiovascular system. Generally, they stimulate serotonin 5-HT2A receptors, which have most effect in the brain. There are such receptors in the blood vessels, and high doses will cause contraction, and could lead to gangrene if not treated. But usually that is only with high doses. 3 mg would not be a high dose. I don't know what doses would be toxic. I believe I heard of someone who took 50 mg of DOB and had severe vasoconstriction and ultimately had to have her legs amputated. It is such a long-acting compound that I would guess that most people wouldn't want to go much above 5-10 mg, which I doubt, in normal subjects, would cause serious vasoconstriction.
Question 2 : I have a last one question, it would be very glad if you can reply to this one since I cannot find information about it. Well, Are dosage of psychedelic is relative to the weight ? Just want to know for exemple if someone who weight 42 kg ( ~ 90 lbs) took 20 mg of 4-HO-MET and someone who weight 70 kg took 20 mg also. Will the person with the lowest weight will be more affected by the spiritual experience than the heavier person ? Does weight affect the power / strenght of a hallucinogen ? So, is a person with a low weight will be more affected by the experience instead of someone with a heavier weight. That's my last question.
Nichol's Answer : For many drugs that is the case. But for psychedelics, usually one dose will affect most people about the same. For example, 100 mcg of LSD will have the same effect in most people, at least potency-wise. There has been some discussion that it is the weight of the brain that is most important. If the drug is not distributed throughout the body, but is mostly concentrated in the brain, that would make sense. Someone who is very obese of course, has a lot of fat to absorb a drug like LSD, so I am giving just a general impression. It will vary with each person, but a thin person would not necessarily take one-half of what someone twice the weight would take. I have to go now.
Proof : 
Guys I was so excited !
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AlyDrops
Stranger

Registered: 08/05/11
Posts: 274
Last seen: 9 years, 11 months
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Re: I talked to David E Nichols and he replied to some questions ! :D [Re: GoddessOfLove]
#15100863 - 09/19/11 01:05 PM (12 years, 5 months ago) |
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Very interesting! I'm glad you asked him that question about body weight, I had been wondering about that myself for quite some time. 5-10 mg of DOB wouldn't cause serious vasoconstriction eh?... It's too bad I'm not younger and more carefree, I'd definitely go for the 10 mg dose. Damn, I'll bet that'd be a hell of a long trip though.... I mean I guess it's true, not that I'm advocating anyone go out and take these doses of DOB, but the fact that that one person did snort like 50 mg and survive (though not in a good way, and I think it was the boyfriend, I'm pretty sure the girlfriend died) does kind of suggest that using around 3 mg as our "max" oral dose may be being a little overly cautious. Not that that's a bad thing in the drug world though!
EDIT: Just looked it up, they actually took 75 mg. Now that is one massive dose.
Edited by AlyDrops (09/19/11 03:06 PM)
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GoddessOfLove
Mother Monster


Registered: 01/10/10
Posts: 3,766
Loc: VENUS
Last seen: 1 year, 1 month
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Re: I talked to David E Nichols and he replied to some questions ! :D [Re: AlyDrops]
#15100920 - 09/19/11 01:14 PM (12 years, 5 months ago) |
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I asked another question, he said he would reply later. There are my question :
Question 1 : You can reply whenever you want. I was just so curious if you have any more informations about the 25X*-NBOMe since the discovery of theses nice novel chemicals ? Do we have informations about the LD50 of theses compounds ? Also, do you have some insights about the solvent that can be used for researching theses chemicals , I head that the best solvent was Chloroform then Ether and then alcohol in terms of solubility.
I have another question if you have studies these kind of Tryptamines. I would like to know why on 4-HO-MET fumarate, my heart beat very strangely (like skipping beat or beating really fast), especially on the comedown. The experience itself is very benefic and rewardings but the comedown make my heart beating in a scary way. I heard many reports with the same things, especially while looking on Erowid.org that is was familiar but this kind of effects on the heart is making me very anxious. Do you heard anything about it ? I heard most the time that substitued tryptamines like 4-HO-MET was fairly safe both mind and body but I'm in sacred doubt now...
Best regards to you and your team.
*X means C, D or I.
I will keep you updated when He will reply to this ! Sounds interesting and promising He doesn't sound annoyed while talking about drugs since I saw wall post which he's talking about drugs so.
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Edited by GoddessOfLove (09/19/11 01:16 PM)
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