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InvisibleFeanor
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Registered: 05/07/06
Posts: 1,546
Re: Permanent DXM tolerance? [Re: truekimbo2]
    #8433466 - 05/22/08 03:44 PM (15 years, 8 months ago)

Quote:

truekimbo2 said:
like someone else said, if i smell cough syrup now it makes me very nauseous, and if i take a tiny tiny sip i come really close to throwing up and start gagging.

whats up with that?




That's your naturally induced human instinct; it's your body trying to tell you that the shit isn't good for you! Listen to your body.

The smell of cough syrup is ok for me; however, the taste of DXM crystals, even when I just slightly think about it, makes me feel as if I am going to regurgitate my entire internal organ system.

There's a fine explanation as to why this is occurring. The specific area of Behaviorism in Psychology would suggest that both you and I, and the other guy in the thread, get this feeling because we have been aversively conditioned to DXM, due to the negative responses we have experienced off of it. For instance, the crap almost killed me. It's only natural for my brain to register this fact, and therefore, trigger a physiologically negative response in relation to the ingestion of DXM.


--------------------

May Terence McKenna Live Long

The DMT Chronicles


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InvisibledrSE
Pseudo Reality
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Registered: 12/19/03
Posts: 4,432
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Re: Permanent DXM tolerance? [Re: Feanor]
    #8433498 - 05/22/08 03:54 PM (15 years, 8 months ago)

pavlov's theory

and i was the other guy.


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Offlinesongcycle67
Gypsy Wizard

Registered: 05/14/08
Posts: 210
Last seen: 15 years, 5 months
Re: Permanent DXM tolerance? [Re: drSE]
    #8433513 - 05/22/08 03:56 PM (15 years, 8 months ago)

Quote:

drSE said:
pavlov's theory

and i was the other guy.




It must not've fucked your cognition up too bad! Pavlov's theory would definitely explain the vomiting/shitting. Excellent point.


--------------------


Check out my psychedelic acid rock: http://www.myspace.com/kingbeelovesyou

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InvisibleFeanor
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Registered: 05/07/06
Posts: 1,546
Re: Permanent DXM tolerance? [Re: drSE]
    #8433523 - 05/22/08 03:57 PM (15 years, 8 months ago)

Yeah. I enjoyed your post.

Ivan Pavlov was a cool chap, but he should have given credit to all of the females, all of whom were basically running his entire lab all the time!


--------------------

May Terence McKenna Live Long

The DMT Chronicles


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InvisibleFeanor
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Registered: 05/07/06
Posts: 1,546
Re: Permanent DXM tolerance? [Re: songcycle67]
    #8433527 - 05/22/08 03:58 PM (15 years, 8 months ago)

Quote:

songcycle67 said:
Quote:

drSE said:
pavlov's theory

and i was the other guy.




It must not've fucked your cognition up too bad! Pavlov's theory would definitely explain the vomiting/shitting. Excellent point.




LOL.

Yeah, you seem fine to me, man!


--------------------

May Terence McKenna Live Long

The DMT Chronicles


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OfflineShroomyTunes
psychedeliac

Registered: 07/10/04
Posts: 686
Loc: Ontario
Last seen: 10 years, 4 months
Re: Permanent DXM tolerance? [Re: Feanor]
    #8433837 - 05/22/08 05:24 PM (15 years, 8 months ago)

Interesting thread. Some interesting points. Also, some points that don't make sense. Most the blood-brain barrier mumbo jumbo is just that. Pretty well any psychoactive drug must cross it to induce its effects. The fact that DXM does so is not an argument for its dangers.

Also DXM does indeed bind at a specific site. It is known as the PCP site and functions to block the ion channel of glutamate receptors, which constitute a great deal of neurons (somewhere around 85%). Glutamate being the principle excitatory system in the brain, it can be seen how inhibiting a great deal of glutamatergic neurons can elicit such profound effects on both mental and motor functions.

Nothing personal to those arguing against DXM...hell, I only did the stuff a handful of times about 5 years ago and I've continued using psychedelics and holding them dear to my heart...I'm just saying most of the psychopharmacological arguments in this thread for LSD>DXM, or what have you, are not very strong.

peace
-ST


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Offlinesongcycle67
Gypsy Wizard

Registered: 05/14/08
Posts: 210
Last seen: 15 years, 5 months
Re: Permanent DXM tolerance? [Re: ShroomyTunes]
    #8434127 - 05/22/08 06:44 PM (15 years, 8 months ago)

Oh okay now that it binds to the "PCP" site, I'm in. Somebody get me a syringe and a bottle of over-the-counter cough medicine. 2% of LSD crosses the BBB--it might as well be PCP or huffed petrol, am i right?

PRIMARY ARGUMENT: EXIT TIME, HALF-LIFE AND DANGEROUS UNTIL PROVEN OTHERWISE.

Fuck this thread and fuck DXM. LSD is better. EVERYONE who uses DXM ends up socially retarded. If you take DXM more than seven times you're legally insane! DXM CAUSES CHROMOSOME DAMAGE!!! If you take DXM with a magic elf from saturn's second moon you can't be a politician. DXM has its roots in hell!!!

Nah I'm just playin, DXM is awesome. Get me that needle.


--------------------


Check out my psychedelic acid rock: http://www.myspace.com/kingbeelovesyou

Disclaimer: All posts on this site concerning illegal substances are fictional accounts. I in no way endorse the use of or use any of these substances myself.


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InvisibledrSE
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Re: Permanent DXM tolerance? [Re: songcycle67]
    #8434382 - 05/22/08 08:02 PM (15 years, 8 months ago)

Glutamate is the most common neurotransmitter in the brain. It is always excitatory, usually due to simple receptors that increase the flow of positive ions by opening ion-channels. Glutamate stimulation is terminated by a (chloride-independent) membrane transport system that is only used for re-absorbing glutamate & aspartate across the pre-synaptic membrane. Glutamate & aspartate re-enter the cell by a transporter driven by the high extracellular concentrations of Na+ and the high intracellular concentrations of K+. Soduim enters the cell along with the amino acids and potassium leaves the cell -- much the way a pulley couples the lifting of a light weight with the fall of a heavier weight. Thus, glutamate/asparate entry is indirectly powered by the ATP-driven Na+-K+-ase (sodium pump) which creates the high ion concentration gradients.

Possibly the most complicated of all neurotransmitter receptors is the NMDA glutamate receptor. N-Methyl-D-Aspartate is a synthetic chemical not naturally found in biological systems, but it binds specifically to the NMDA glutamate receptor (receptors are frequently named for artificial substances that bind to the receptor with higher specificity than their natural neurotransmitter ligands). The NMDA receptor is the only known receptor which is regulated both by a ligand (glutamate) and by voltage. There are at least 5 binding sites which regulate NMDA receptor activity, ie, sites for (1) glutamate (2) glycine (3) magnesium (4) zinc and (5) a site that binds the hallucinogenic substance phencyclidine (PCP, "angel dust"). Phencyclidine can induce psychosis -- an NMDA effect that is difficult to explain. NMDA receptors have a capacity for an activity-dependent increase in synaptic efficiency known as LTP (Long-Term Potentiation), which may be crucial to some forms of learning & memory. Inhibition of NMDA activity (and LTP) is believed to be an important part of the way ethanol affects brain functions.

NMDA receptors are most densely concentrated in the cerebral cortex (hippocampus, especially -- particularly the CA1 region), amygdala, & basal ganglia. They are particularly vulnerable to glutamic acid excitotoxicity, ie, damaging effects due to excessive excitatory neurotransmitter release. Both aspartic acid & glutamic acid (the two amino acids having 2 carboxyl groups -- the "acidic amino acids") have the capacity for destroying neurons when released in excessive amounts (although calcium seems to be more of a cause than acidity). Monosodium glutamate (MSG), a major component of soya sauce, has been shown to destroy nerve cells when fed to young animals. Insofar as glutamate does not normally cross the blood-brain barrier, it is open to question whether this is relevant to a human adult. Increased alertness (or anxiety) due to caffeine may be mainly due to blockage of adenosine receptors which normally inhibit glutamate release.

Glutamate released into synapses is either reabsorbed directly into neurons by the ion-exchange transport system described above, or is soaked-up by astrocytes (glial cells) which convert the glutamate into glutamine (a molecule which cannot cause excitotoxicity). The glutamine can then be safely transported back to neurons for re-conversion into glutamate. One of the damaging effects of mercury poisoning is swelling of astrocytes, which are rendered unable to soak-up glutamine from synapses (contributing to excitotoxicity). Excitotoxicity due to glutamic acid is a major destructive process seen in stokes and other forms of brain ischemia (see Ischemia and Reperfusion Injury in Cryonics).

Nitric oxide can act as neuromodulator when glutamate stimulation of NMDA receptors results in nitric oxide synthesis & release -- enhancing neurotransmitter release from adjacent synapses. Granule cells of the dentate gyrus of the hippocampus are rich in nitric oxide synthetase. Nitric oxide may contribute to LTP.


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Invisibletruekimbo2
Cya later, friends.
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Registered: 12/08/02
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Re: Permanent DXM tolerance? [Re: songcycle67]
    #8434385 - 05/22/08 08:03 PM (15 years, 8 months ago)



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OfflineShroomyTunes
psychedeliac

Registered: 07/10/04
Posts: 686
Loc: Ontario
Last seen: 10 years, 4 months
Re: Permanent DXM tolerance? [Re: songcycle67]
    #8437123 - 05/23/08 02:22 PM (15 years, 8 months ago)

Quote:

songcycle67 said:
Oh okay now that it binds to the "PCP" site, I'm in. Somebody get me a syringe and a bottle of over-the-counter cough medicine. 2% of LSD crosses the BBB--it might as well be PCP or huffed petrol, am i right?

PRIMARY ARGUMENT: EXIT TIME, HALF-LIFE AND DANGEROUS UNTIL PROVEN OTHERWISE.

Fuck this thread and fuck DXM. LSD is better. EVERYONE who uses DXM ends up socially retarded. If you take DXM more than seven times you're legally insane! DXM CAUSES CHROMOSOME DAMAGE!!! If you take DXM with a magic elf from saturn's second moon you can't be a politician. DXM has its roots in hell!!!

Nah I'm just playin, DXM is awesome. Get me that needle.




You should not be so defensive as it makes it harder for me and likely others to take your posts seriously. You make good points but they can be overshadowed by ones like this. I never said DXM is good for you I just said it does have a binding site. No need for a sarcastic tirade lol.

And I still don't know what the % that crosses the BBB has to do with anything. Nor am I even sure that is true. I'm pretty sure a chemical crosses, or it does not. What makes the 2% so special that only it is able to permeate? If you can link me to a source that says this is true in terms of LSD and explain it's significance pharmacologically that'd be cool. I don't understand the argument.

"2% of LSD crosses the BBB--it might as well be PCP or huffed petrol, am i right?"..I'm not even sure what you meant by that so I can't answer your question.

sorry if i sound like a jerk, i'm just sayin...


Edited by ShroomyTunes (05/23/08 02:33 PM)


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Offlinesongcycle67
Gypsy Wizard

Registered: 05/14/08
Posts: 210
Last seen: 15 years, 5 months
Re: Permanent DXM tolerance? [Re: ShroomyTunes]
    #8437290 - 05/23/08 03:32 PM (15 years, 8 months ago)

I'm no longer part of this argument. Take DXM.


--------------------


Check out my psychedelic acid rock: http://www.myspace.com/kingbeelovesyou

Disclaimer: All posts on this site concerning illegal substances are fictional accounts. I in no way endorse the use of or use any of these substances myself.


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Invisiblejellyfish


Registered: 10/02/05
Posts: 7,457
Re: Permanent DXM tolerance? [Re: songcycle67]
    #8437409 - 05/23/08 04:06 PM (15 years, 8 months ago)

I did DXM weekly for a couple months and I stopped because it gave me weird side effects like teeth chattering when it wasn't cold. I wouldn't know about the tolerance but every "trip" I had was very different, some more intense than others even with lower dosages so that could be your problem. I dunno why everyone puts it down at least its been researched other than all the research chemicals and salvia people are so willing to ingest. If dxm isn't a psychedelic because of it's behaviour in the human body and the effects on the mind then salvia sure isn't either. I think doing DXM with any sort of regularity will fuck you up though, I'm not saying it's good.


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InvisibledeCypher
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Registered: 02/10/08
Posts: 56,232
Re: Permanent DXM tolerance? [Re: unretarded]
    #8437589 - 05/23/08 05:16 PM (15 years, 8 months ago)

Quote:

unretarded said:I am not postin any sources either ,do you need a report to tell you its was the hammer that smashed your finger....did they hound einstien for his source on gravity and if they did ,could he of produced one..other than from his own head .......I would have liked to have seen him produce the source ......ahhh ......a apple told me soo man.....:rofl2:




:rofl2: is all I have to say.


--------------------
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Offlinesongcycle67
Gypsy Wizard

Registered: 05/14/08
Posts: 210
Last seen: 15 years, 5 months
Re: Permanent DXM tolerance? [Re: deCypher]
    #8438948 - 05/24/08 12:48 AM (15 years, 8 months ago)

That was a perfectly good point!! Okay seriously though I'm outta here.


--------------------


Check out my psychedelic acid rock: http://www.myspace.com/kingbeelovesyou

Disclaimer: All posts on this site concerning illegal substances are fictional accounts. I in no way endorse the use of or use any of these substances myself.


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OfflineShroomyTunes
psychedeliac

Registered: 07/10/04
Posts: 686
Loc: Ontario
Last seen: 10 years, 4 months
Re: Permanent DXM tolerance? [Re: songcycle67]
    #8439571 - 05/24/08 08:14 AM (15 years, 8 months ago)

Quote:

songcycle67 said:
I'm no longer part of this argument. Take DXM.




I wasn't arguing in favour of DXM I was arguing against what I believe is misinformation...if you had an adequate rebuttal or a source to back up your claims you would have pitched it, methinks.

The way it appears is being shown incorrect on a point led to a freak out and asking for supporting information led to a cop out. Boourns, dude.

Feel free to prove me wrong...


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OfflineAopocetx
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Re: Permanent DXM tolerance? [Re: songcycle67]
    #8439865 - 05/24/08 11:14 AM (15 years, 8 months ago)

Quote:

songcycle67 said:
I'm no longer part of this argument. Take DXM.




I agree. Every drug is dangerous if you don't know how to use it.


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Offlinesongcycle67
Gypsy Wizard

Registered: 05/14/08
Posts: 210
Last seen: 15 years, 5 months
Re: Permanent DXM tolerance? [Re: Aopocetx]
    #8440114 - 05/24/08 12:32 PM (15 years, 8 months ago)

Shroomy, you didn't read the whole thread. I retracted several of my earlier statements. My reason for being upset was because you continually ignored my primary concerns:

exit time, half-life, and unknown dangers. All of which I referenced to the best of my ability. I'm not a biochemist, I'm just a person who has lost a lot of friends to this drug.

Alright seriously this time no more posts.


--------------------


Check out my psychedelic acid rock: http://www.myspace.com/kingbeelovesyou

Disclaimer: All posts on this site concerning illegal substances are fictional accounts. I in no way endorse the use of or use any of these substances myself.


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OfflineWinterWar
Stranger
Registered: 07/20/11
Posts: 1
Last seen: 12 years, 6 months
Re: Permanent DXM tolerance? [Re: Feanor]
    #14798540 - 07/20/11 03:42 PM (12 years, 6 months ago)

well im not against LSD, but DXM is a very nice drug imo. except for the alcohol-like hangover, it has good effects. I dont know but i feel E like warmness in the body, and those same warm feelings towards others. Listening to music is a very interesting expiriences, especially with music that has vocals. I like deathcore and death metal on DXM it isamazing. And i think it doesnt cause brain damage, and I think it is less potent than LSD. I have done it about 8 times in my life, and it was during a week i took it evreyday, the next week i was a bit fucked up, but nothing compared to the E or tacha (E and Ketamine) hangover.


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