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bholzer
quasi-scientist



Registered: 03/22/11
Posts: 2,409
Last seen: 11 years, 7 months
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Weight independent drugs
#14568960 - 06/06/11 11:25 AM (12 years, 7 months ago) |
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Everyone knows that the amount of alcohol someone can drink and get drunk is based on their weight. I have noticed that my heavier friends have to smoke more than my lighter friends to get high, though I could be wrong.
I know that mushrooms and acid are weight independent, but that's it. Whenever I try to research, I just find stuff about weight loss drugs.
My question is, does anyone know what drugs are weight dependent or weight independent?
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Use these substances wisely, they have the ability to cause life altering realizations.
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JimLahey
Trailer Park Supervisor



Registered: 04/17/11
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Re: Weight independent drugs [Re: bholzer]
#14569000 - 06/06/11 11:32 AM (12 years, 7 months ago) |
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Mushrooms and Acid both change dosage depending on the weight of users... but there are many other factors too though. 3.5 for someone who weighs 120 pounds will be stronger than 3.5 for a 400 lb person I would believe.
-------------------- "Why don't you get a life, Rick? Why don't you go to community college like Julian here? Hey! I got a good idea! You could teach Living In A Car and Growing Dope 101"
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bholzer
quasi-scientist



Registered: 03/22/11
Posts: 2,409
Last seen: 11 years, 7 months
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Re: Weight independent drugs [Re: JimLahey]
#14569011 - 06/06/11 11:34 AM (12 years, 7 months ago) |
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Quote:
JimLahey said: Mushrooms and Acid both change dosage depending on the weight of users... but there are many other factors too though. 3.5 for someone who weighs 120 pounds will be stronger than 3.5 for a 400 lb person I would believe.
I could be wrong, but I actually believe this is incorrect. We'll see some other input!
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Use these substances wisely, they have the ability to cause life altering realizations.
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4DEAD2HEAD0
Stranger


Registered: 05/04/11
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Re: Weight independent drugs [Re: bholzer]
#14569085 - 06/06/11 11:52 AM (12 years, 7 months ago) |
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i'm interested in seeing what people have to say about this because i have a fairly high tolerance level. and i'm not very big.
-------------------- HEAVEN AND HELL ARE BUT A BREATH AWAY! - ANDY WARHOL http://coolgifs.tripod.com/cry.gif
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JimLahey
Trailer Park Supervisor



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Re: Weight independent drugs [Re: 4DEAD2HEAD0]
#14569089 - 06/06/11 11:54 AM (12 years, 7 months ago) |
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I think part of it also has to do with one's psyche. Some people are just real hard headed when it comes to psychedelics
-------------------- "Why don't you get a life, Rick? Why don't you go to community college like Julian here? Hey! I got a good idea! You could teach Living In A Car and Growing Dope 101"
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ScarlettKush
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Registered: 05/06/11
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Re: Weight independent drugs [Re: JimLahey]
#14569202 - 06/06/11 12:30 PM (12 years, 7 months ago) |
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It's hard to compare when each person's psyche is so different. I think we need somebody to test the theory, take a given amount then gain or lose a hundred pounds and try again!
Depending on what you're taking, it can either be somewhat soaked up by body fat, or it can release deposits of other things that are stored in your fat. If a fat person has a history of taking tons of drugs there will be more buildups. Not saying that a buildup being released will be enough to independently make you trip, but mixed with something it could cause unexpected results.
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LanLord
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It's not weight dependent. It is a matter of the number of HT receptors in the brain and the individual tolerance of the individual.
Since receptors are probably about equal across an entire species (with a small variance) the biggest issue you need to consider is individual tolerance.
-------------------- Good judgment comes from experience, and a lotta that comes from bad judgment.
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bholzer
quasi-scientist



Registered: 03/22/11
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Last seen: 11 years, 7 months
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Re: Weight independent drugs [Re: LanLord]
#14569409 - 06/06/11 01:22 PM (12 years, 7 months ago) |
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Quote:
LanLord said: It's not weight dependent. It is a matter of the number of HT receptors in the brain and the individual tolerance of the individual.
Since receptors are probably about equal across an entire species (with a small variance) the biggest issue you need to consider is individual tolerance.
Well some drugs ARE weight dependent. Alcohol is the most obvious example, 1 drink will do much more to a 90lb person than a 300lb person, because there's more tissue to absorb the alcohol.
Come to think of it, this thread probably belongs in the pharmacology forum, but it still fit here.
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Use these substances wisely, they have the ability to cause life altering realizations.
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drr

Registered: 05/20/09
Posts: 8,444
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Re: Weight independent drugs [Re: bholzer]
#14569429 - 06/06/11 01:26 PM (12 years, 7 months ago) |
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Quote:
bholzer said:
Quote:
JimLahey said: Mushrooms and Acid both change dosage depending on the weight of users... but there are many other factors too though. 3.5 for someone who weighs 120 pounds will be stronger than 3.5 for a 400 lb person I would believe.
I could be wrong, but I actually believe this is incorrect. We'll see some other input!
Why? Makes perfect sense to me.
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bholzer
quasi-scientist



Registered: 03/22/11
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Re: Weight independent drugs [Re: drr]
#14569452 - 06/06/11 01:30 PM (12 years, 7 months ago) |
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Quote:
drr said:
Quote:
bholzer said:
Quote:
JimLahey said: Mushrooms and Acid both change dosage depending on the weight of users... but there are many other factors too though. 3.5 for someone who weighs 120 pounds will be stronger than 3.5 for a 400 lb person I would believe.
I could be wrong, but I actually believe this is incorrect. We'll see some other input!
Why? Makes perfect sense to me.
It's all about how the drug is metabolized in the body I think. I've had a few of my bigger friends trip equally as hard on the same amount as some of my smaller friends. Although that can be a hard to judge, as the experience can not always be accurately rated.
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Use these substances wisely, they have the ability to cause life altering realizations.
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ifoundwaldo


Registered: 09/28/10
Posts: 8,389
Loc: Denver, CO
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Re: Weight independent drugs [Re: bholzer]
#14569493 - 06/06/11 01:40 PM (12 years, 7 months ago) |
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I believe that mushrooms and LSD dosages are LESS dependent on the weight of the user. But the weight of the user still plays a small role.
Hence, the LD50 for these drugs is still measured in mg/kg.
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joemolloy
DMT is Bullshit


Registered: 04/12/09
Posts: 6,525
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Re: Weight independent drugs [Re: bholzer]
#14569569 - 06/06/11 01:59 PM (12 years, 7 months ago) |
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Quote:
bholzer said: It's all about how the drug is metabolized in the body I think. I've had a few of my bigger friends trip equally as hard on the same amount as some of my smaller friends. Although that can be a hard to judge, as the experience can not always be accurately rated.
I've always suspected that people's ability to efficiently or inefficiently metabolize and absorb these chemicals is probably the best predictor of how high they will get. I was reading about women and alcohol it said that they lacked or had less of an enzyme that most men had and this was responsible for them getting more drunk. I bet the natural MAOIs present in your stomach affect how hard you trip. I must have a lot of them because I need high doses of shrooms to have a strong trip. I am sure that body weight plays some role in drug effects, but its a complicated interplay with many variables.
-------------------- Don't PM me with bullshit. I don't sell or trade cactus and I don't know where you can get any, other than your mother's ass.
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billyrubin
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Re: Weight independent drugs [Re: joemolloy]
#14570565 - 06/06/11 05:46 PM (12 years, 7 months ago) |
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Quote:
joemolloy said:
I've always suspected that people's ability to efficiently or inefficiently metabolize and absorb these chemicals is probably the best predictor of how high they will get. I was reading about women and alcohol it said that they lacked or had less of an enzyme that most men had and this was responsible for them getting more drunk.
Yeah.bang on. Some people, not just gender based, have lower levels of alcohol dehydrogenase (the enzyme you speak of), therefore cannot metabolise booze efficiently, so though drink is as good example of a weight dependent drug, I'm sorry to give such a crap answer to OP, but I think that no drugs metabolism is so straightforward. There will always be confounding factors affecting drug breakdown and is there truly enough study on psychedelics like Mush and LSD to say they are weight independent?
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joemolloy
DMT is Bullshit


Registered: 04/12/09
Posts: 6,525
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Re: Weight independent drugs [Re: billyrubin]
#14570590 - 06/06/11 05:50 PM (12 years, 7 months ago) |
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Quote:
Some people, not just gender based, have lower levels of alcohol dehydrogenase (the enzyme you speak of), therefore cannot metabolise booze efficiently, so though drink is as good example of a weight dependent drug,
Yeah you're right, Billy, its not just women. Native Americans lack this enzyme too.
-------------------- Don't PM me with bullshit. I don't sell or trade cactus and I don't know where you can get any, other than your mother's ass.
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