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Beanhead
IS IRONIC PARADOX


Registered: 10/11/08
Posts: 17,257
Loc: Geospatial inversion.
Last seen: 3 years, 7 months
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unfortunately weed inhibits GABA-a which in the end results in producing anxiety.
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AntiEverything
im not a doctor



Registered: 07/07/06
Posts: 6,003
Last seen: 6 years, 9 months
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Quote:
KillerPicklez said: you need to go smoke a bowl, you've been argumentative all night. you are in no position to say what I do and do not need. You dont know anything about me.
lol? how hypocritical
and beanhead, do you have a source for cannabis producing gaba inhibition and also a source for why this causes anxiety
-------------------- You are at once both the quiet and the confusion of my heart. -Franz Kafka
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s240779


Registered: 12/07/10
Posts: 12,880
Last seen: 3 months, 11 days
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Re: any one here enjoy benzos? [Re: Locky]
#14558877 - 06/04/11 04:50 AM (12 years, 8 months ago) |
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Benzos have very little recreational value in my opinion.
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Locky
Dont Spill Me!



Registered: 11/27/10
Posts: 9,348
Loc: Over here, yes, here
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Re: any one here enjoy benzos? [Re: s240779]
#14558882 - 06/04/11 04:53 AM (12 years, 8 months ago) |
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Quote:
superhigh said: Benzos have very little recreational value in my opinion.
Yeah fuck em.
If i take them befor bed i sleep walk like crazy
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KillerPicklez



Registered: 12/13/07
Posts: 16,920
Loc:
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smoke a bowl to make you less of a dick, not to decrease your anxiety. no irony at all
you're normally pretty cool. I dont know what your problem is tonight. Not getting pussy or something?
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Beanhead
IS IRONIC PARADOX


Registered: 10/11/08
Posts: 17,257
Loc: Geospatial inversion.
Last seen: 3 years, 7 months
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Quote:
AntiEverything said:
Quote:
KillerPicklez said: you need to go smoke a bowl, you've been argumentative all night. you are in no position to say what I do and do not need. You dont know anything about me.
lol? how hypocritical
and beanhead, do you have a source for cannabis producing gaba inhibition and also a source for why this causes anxiety
Most certainly I do, here's some references: http://neuro.cjb.net/content/20/7/2470.full
**Nora Laaris et. al., "Δ9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus." Neuropharmacology, Vol. 59, No. 1-2, 121-127. 2010.[
**A. Hoffman, "Mechanisms of Cannabinoid Inhibition of GABA-A Synaptic Transmission in the Hippocampus." J. Neurosci., 20(7):2470-2479. 2000.
Marijuana causes a physiological reaction that causes anxiety.
Depression of growth hormone and cortisol response to insulin-induced hypoglycemia after prolonged oral delta-9-tetrahydrocannabinol administration in man.
Six hospitalized volunteer male subjects were given insulin, 0.15 U/kg, before and after 14 days of administration of delta-9-tetrahydrocannabinol (THC) at a dose of 210 mg/day. A diminished maximal serum human growth hormone (GH) increase followed the prolonged THC ingestion. The mean maximal GH response was: 52.6 ng/ml /- 8.7 ( /-SE) before THC and 18.8 ng/ml /- 6.7 ( /-SE) during THC, P less than 0.01; corresponding cortisol responses were 20.1 mug/dl /- 3.0 before THC and 10.0 mug/dl /- 1.1 during THC, P less than 0.05. The data suggest suppression of the hypothalamic-pituitary axis after prolonged high dose THC use. This is consistent with other reported endocrine effects of marijuana in man.
Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence.
Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA.
In addition to their physiological function, metabotropic receptors for neurotransmitter gamma-aminobutyric acid (GABA), the GABA(B) receptors, may play a role in the behavioral actions of addictive compounds. Recently, GABA(B) receptors were cloned in fruit flies (Drosophila melanogaster), indicating that the advantages of this experimental model could be applied to GABA(B) receptor research. RNA interference (RNAi) is an endogenous process triggered by double-stranded RNA and is being used as a tool for functional gene silencing and functional genomics. Here we show how cell-nonautonomous RNAi can be induced in adult fruit flies to silence a subtype of GABA(B) receptors, GABA(B)R1, and how RNAi combined with pharmacobehavioral techniques (including intraabdominal injections of active compounds and a computer-assisted quantification of behavior) can be used to functionally characterize these receptors. We observed that injection of double-stranded RNA complementary to GABA(B)R1 into adult Drosophila selectively destroys GABA(B)R1 mRNA and attenuates the behavioral actions of the GABA(B) agonist, 3-aminopropyl-(methyl)phosphinic acid. Moreover, both GABA(B)R1 RNAi and the GABA(B) antagonist CGP 54626 reduced the behavior-impairing effects of ethanol, suggesting a putative role for the Drosophila GABA(B) receptors in alcohol's mechanism of action. The Drosophila model we have developed can be used for further in vivo functional characterization of GABA(B) receptor subunits and their involvement in the molecular and systemic actions of addictive substances.
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KillerPicklez



Registered: 12/13/07
Posts: 16,920
Loc:
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Re: any one here enjoy benzos? [Re: Beanhead]
#14558915 - 06/04/11 05:08 AM (12 years, 8 months ago) |
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pwned.
he's going to come up with some bullshit to keep his argument alive.
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Individual
Bass Addict



Registered: 12/20/06
Posts: 6,666
Loc: Reality Loophole
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Re: any one here enjoy benzos? [Re: Locky]
#14558999 - 06/04/11 06:19 AM (12 years, 8 months ago) |
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Quote:
any one here enjoy benzos?
not yet, but when I down the 4 mgs of clonazepam in front of me I will
-------------------- THE PHILOSOPHY OF LIBERTY <---
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Locky
Dont Spill Me!



Registered: 11/27/10
Posts: 9,348
Loc: Over here, yes, here
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Re: any one here enjoy benzos? [Re: Individual]
#14559024 - 06/04/11 06:37 AM (12 years, 8 months ago) |
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Quote:
Individual said:
Quote:
any one here enjoy benzos?
not yet, but when I down the 4 mgs of clonazepam in front of me I will 
You enjoy that
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Individual
Bass Addict



Registered: 12/20/06
Posts: 6,666
Loc: Reality Loophole
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Re: any one here enjoy benzos? [Re: Locky]
#14559061 - 06/04/11 07:13 AM (12 years, 8 months ago) |
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I already do!
Right now I have to stick to beer, can't afford to drink anything stronger yet, I'll be playing music at a party in few hours.
-------------------- THE PHILOSOPHY OF LIBERTY <---
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limestoneman
The Return

Registered: 04/09/11
Posts: 1,997
Loc: Middle TN
Last seen: 4 years, 2 months
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Re: any one here enjoy benzos? [Re: Individual]
#14559078 - 06/04/11 07:31 AM (12 years, 8 months ago) |
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Fuck benzos. Especially Ativan.
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Asante
Mage


Registered: 02/06/02
Posts: 87,085
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Re: any one here enjoy benzos? [Re: Locky]
#14559084 - 06/04/11 07:35 AM (12 years, 8 months ago) |
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When you are in fear, 5mg Valium or 0.25mg Xanax makes a world of difference.
-------------------- Omnicyclion.org higher knowledge starts here
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Moronicus
smokehousebacon.



Registered: 05/13/09
Posts: 4,430
Last seen: 11 years, 4 months
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Re: any one here enjoy benzos? [Re: Asante]
#14559093 - 06/04/11 07:38 AM (12 years, 8 months ago) |
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Quote:
Wiccan_Seeker said: When you are in fear, 5mg Valium or 0.25mg Xanax makes a world of difference.
Bah, Xanax makes me want more, especially when it's under 1mg. I'm just so used to that loopy 2mg feeling.
--------------------
BACON RANCH, FUCK YEAH A post about m00nshine Anonymous #6 said: Yes, it is. The shine stands for his job title, which is Shoe Shiner, the moon stands for the time he comes out to be a nigger, which is best suited for the negroid camouflage.
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Locky
Dont Spill Me!



Registered: 11/27/10
Posts: 9,348
Loc: Over here, yes, here
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Re: any one here enjoy benzos? [Re: Moronicus]
#14559102 - 06/04/11 07:41 AM (12 years, 8 months ago) |
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Do most, if not all benzos feel the same?
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Moronicus
smokehousebacon.



Registered: 05/13/09
Posts: 4,430
Last seen: 11 years, 4 months
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Re: any one here enjoy benzos? [Re: Locky]
#14559105 - 06/04/11 07:43 AM (12 years, 8 months ago) |
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Quote:
Locky said: Do most, if not all benzos feel the same?
I'm almost certain of it, but apparently some of the other ones are more potent in the area that they make you black-out.
Valium and Xanax feel the same, I'm just more sloppy on Valium
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BACON RANCH, FUCK YEAH A post about m00nshine Anonymous #6 said: Yes, it is. The shine stands for his job title, which is Shoe Shiner, the moon stands for the time he comes out to be a nigger, which is best suited for the negroid camouflage.
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Locky
Dont Spill Me!



Registered: 11/27/10
Posts: 9,348
Loc: Over here, yes, here
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Re: any one here enjoy benzos? [Re: Moronicus]
#14559126 - 06/04/11 07:56 AM (12 years, 8 months ago) |
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Apperently temazepam has 1.5 times more euphoria than the other benzos
I felt no euphoria at all
I only get it from amphetamine and opiates
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Beanhead
IS IRONIC PARADOX


Registered: 10/11/08
Posts: 17,257
Loc: Geospatial inversion.
Last seen: 3 years, 7 months
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Re: any one here enjoy benzos? [Re: Locky]
#14559144 - 06/04/11 08:06 AM (12 years, 8 months ago) |
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Yeah all drugs I've tried up to now were accompagnied by euphoria in one way or another, benzo's weren't
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AntiEverything
im not a doctor



Registered: 07/07/06
Posts: 6,003
Last seen: 6 years, 9 months
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Re: any one here enjoy benzos? [Re: Beanhead]
#14559497 - 06/04/11 10:34 AM (12 years, 8 months ago) |
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Quote:
Beanhead said:
Quote:
AntiEverything said:
Quote:
KillerPicklez said: you need to go smoke a bowl, you've been argumentative all night. you are in no position to say what I do and do not need. You dont know anything about me.
lol? how hypocritical
and beanhead, do you have a source for cannabis producing gaba inhibition and also a source for why this causes anxiety
Most certainly I do, here's some references: http://neuro.cjb.net/content/20/7/2470.full
**Nora Laaris et. al., "Δ9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus." Neuropharmacology, Vol. 59, No. 1-2, 121-127. 2010.[
**A. Hoffman, "Mechanisms of Cannabinoid Inhibition of GABA-A Synaptic Transmission in the Hippocampus." J. Neurosci., 20(7):2470-2479. 2000.
Marijuana causes a physiological reaction that causes anxiety.
Depression of growth hormone and cortisol response to insulin-induced hypoglycemia after prolonged oral delta-9-tetrahydrocannabinol administration in man.
Six hospitalized volunteer male subjects were given insulin, 0.15 U/kg, before and after 14 days of administration of delta-9-tetrahydrocannabinol (THC) at a dose of 210 mg/day. A diminished maximal serum human growth hormone (GH) increase followed the prolonged THC ingestion. The mean maximal GH response was: 52.6 ng/ml /- 8.7 ( /-SE) before THC and 18.8 ng/ml /- 6.7 ( /-SE) during THC, P less than 0.01; corresponding cortisol responses were 20.1 mug/dl /- 3.0 before THC and 10.0 mug/dl /- 1.1 during THC, P less than 0.05. The data suggest suppression of the hypothalamic-pituitary axis after prolonged high dose THC use. This is consistent with other reported endocrine effects of marijuana in man.
Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence.
Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA.
In addition to their physiological function, metabotropic receptors for neurotransmitter gamma-aminobutyric acid (GABA), the GABA(B) receptors, may play a role in the behavioral actions of addictive compounds. Recently, GABA(B) receptors were cloned in fruit flies (Drosophila melanogaster), indicating that the advantages of this experimental model could be applied to GABA(B) receptor research. RNA interference (RNAi) is an endogenous process triggered by double-stranded RNA and is being used as a tool for functional gene silencing and functional genomics. Here we show how cell-nonautonomous RNAi can be induced in adult fruit flies to silence a subtype of GABA(B) receptors, GABA(B)R1, and how RNAi combined with pharmacobehavioral techniques (including intraabdominal injections of active compounds and a computer-assisted quantification of behavior) can be used to functionally characterize these receptors. We observed that injection of double-stranded RNA complementary to GABA(B)R1 into adult Drosophila selectively destroys GABA(B)R1 mRNA and attenuates the behavioral actions of the GABA(B) agonist, 3-aminopropyl-(methyl)phosphinic acid. Moreover, both GABA(B)R1 RNAi and the GABA(B) antagonist CGP 54626 reduced the behavior-impairing effects of ethanol, suggesting a putative role for the Drosophila GABA(B) receptors in alcohol's mechanism of action. The Drosophila model we have developed can be used for further in vivo functional characterization of GABA(B) receptor subunits and their involvement in the molecular and systemic actions of addictive substances.
(1)this is reffering to long term oral usage. (2) it doesnt substantiate any claim of anxiety in that article, funny if you even make a search on that page it comes up empty 
you are inferring something arbitrary from that article the line " Marijuana causes a physiological reaction that causes anxiety." was inserted by you to stilt it and make it sound like something in that article actually stated that. sorry try again
-------------------- You are at once both the quiet and the confusion of my heart. -Franz Kafka
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Beanhead
IS IRONIC PARADOX


Registered: 10/11/08
Posts: 17,257
Loc: Geospatial inversion.
Last seen: 3 years, 7 months
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Cannabis has been known to inhibit GABA-A transmission. This would be the same as the anxiety one would get if your blood level of benzos got low and you are dependent. There would not be enough GABA to cover the receptors that manage fear and anxiety.
Then again if you want to dismiss oral consumption (and this study overall by thinking I just interpreted it by reading one sentence) there is still the fact of shortness of breath and anxiolytics (sp?) that are in tobacco smoke. (want references, just ask)
Other then that I believe its likely much more complex than that, both anxiety and paranoia, are a result of your brain reacting to the abstinence of the drug you've so frequently "flooded" it with. With cannabis, smoking it would typically induce positive feelings. excessive drug use will trick your brain into relying on exogenous rather than endogenous sources. Therefore, cessation of whatever drug you typically used will leave your body without feeling comfortable, and thus responds with the opposite feeling (i.e. paranoia in the absence of calmness).
benzos respectively, are of course antianxiety/sleep aids etc, and help with such anxious/paranoid thinking. On the flip side though, CB1 induced suppresion of inhibiton at GABA receptors will lead to increased dopamine release. Both rewarding and perhaps, like other DA releasers could cause paranoia/anxiety. I guess suppression of inhibition induced DA relese is of a far smaller magnitude than that caused by stimulants and such.
Everyone is diffirent but still I think long-term smokers can expect a little bit of anxiety... Also from what I can read from diffirent forums about synthetic-cannabinoïds is that they cause anxiety and paranoia in higher (over)doses.
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Brugman
antisobrietarian



Registered: 05/16/01
Posts: 15,887
Loc: the land up over
Last seen: 10 years, 10 months
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Wow AntiEverything.. you are failing hard here! Are you stoned?
Weed is not some miracle drug, dude.
It causes anxiety in many people, it's a known fact.
I personally don't find that it kills pain. For me, it amplifies it. I think a pharmaceutical would do a better job for anxiety/pain.
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