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Offlinekushfarts
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Registered: 12/26/10
Posts: 593
Last seen: 11 years, 9 months
mdma/shroom cross tolerance
    #14556356 - 06/03/11 04:12 PM (12 years, 8 months ago)

so i doubt you guys remember about two weeks ago i tried mdma for the first time and it didnt work for me. well that was the day after a shroom trip and i figured that was why.

tried the same amount from the same source last night and i rolled really hard.

it also seems that most people dont have a cross tolerance issue if they roll FIRST and then the next night they shroom. but for some reason it seems if you dose shrooms before it hurts the mdma experience the next day.

just thought id share and listen to any other thoughts on this. it was deff the same stuff, only difference was i hadn't had any shrooms the night  before.

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OfflineBothHands
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Registered: 10/28/09
Posts: 13,177
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Re: mdma/shroom cross tolerance [Re: kushfarts]
    #14556380 - 06/03/11 04:18 PM (12 years, 8 months ago)

There is cross tolerance.  Mostly if you do the MDMA first though.

MDMA releases tons of serotonin that binds to all your serotonin receptors, including the 5-HT2A receptor.  This will cause a tolerance the next day if you plan on taking a psychedelic.

The tolerance is far less noticeable the other way around though.  Psychedelics will only build a tolerance on the 5-HT2A receptor, but not on all the other receptors.  So you only have a partial tolerance.  The experience might feel like it's lacking a little something, but for the most part, it'll be the same as if you had no tolerance at all.

Yours is the second case.  You should have rolled just fine, with possibly just a little bit of something missing.  But the fact that you didn't roll at all means something else was wrong.

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