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Invisible5-HT2A
Registered: 01/30/10 Happy 14th Shroomiversary!
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Drug May Help Overwrite Bad Memories
    #14530740 - 05/29/11 01:21 PM (12 years, 8 months ago)

http://www.sciencedaily.com/releases/2011/05/110526064802.htm

Recalling painful memories while under the influence of the drug metyrapone reduces the brain's ability to re-record the negative emotions associated with them, according to University of Montreal researchers at the Centre for Studies on Human Stress of Louis-H. Lafontaine Hospital. The team's study challenges the theory that memories cannot be modified once they are stored in the brain.

"Metyrapone is a drug that significantly decreases the levels of cortisol, a stress hormone that is involved in memory recall," explained lead author Marie-France Marin. Manipulating cortisol close to the time of forming new memories can decrease the negative emotions that may be associated with them. "The results show that when we decrease stress hormone levels at the time of recall of a negative event, we can impair the memory for this negative event with a long-lasting effect," said Dr. Sonia Lupien, who directed the research.

Thirty-three men participated in the study, which involved learning a story composed of neutral and negative events. Three days later, they were divided into three groups -- participants in the first group received a single dose of metyrapone, the second received double, while the third were given placebo. They were then asked to remember the story. Their memory performance was then evaluated again four days later, once the drug had cleared out.. "We found that the men in the group who received two doses of metyrapone were impaired when retrieving the negative events of the story, while they showed no impairment recalling the neutral parts of the story," Marin explained. "We were surprised that the decreased memory of negative information was still present once cortisol levels had returned to normal."

The research offers hope to people suffering from syndromes such as post-traumatic stress disorder. "Our findings may help people deal with traumatic events by offering them the opportunity to 'write-over' the emotional part of their memories during therapy," Marin said. One major hurdle, however, is the fact that metyrapone is no longer commercially produced. Nevertheless, the findings are very promising in terms of future clinical treatments. "Other drugs also decrease cortisol levels, and further studies with these compounds will enable us to gain a better understanding of the brain mechanisms involved in the modulation of negative memories."

The research is published in the Journal of Clinical Endocrinology and Metabolism.


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Offlinelimestoneman
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Re: Drug May Help Overwrite Bad Memories [Re: 5-HT2A]
    #14530830 - 05/29/11 01:43 PM (12 years, 8 months ago)

I really hope this hits the pharmacies. I need that shit bad.


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Invisiblewildernessjunkie
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Re: Drug May Help Overwrite Bad Memories [Re: 5-HT2A]
    #14530839 - 05/29/11 01:47 PM (12 years, 8 months ago)

While the discovery is amazing, the implications of this are scary as hell. Any time memories can be erased..... :nonono:


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Offlinelimestoneman
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Re: Drug May Help Overwrite Bad Memories [Re: wildernessjunkie]
    #14530896 - 05/29/11 02:00 PM (12 years, 8 months ago)

Quote:

wildernessjunkie said:
While the discovery is amazing, the implications of this are scary as hell. Any time memories can be erased..... :nonono:



That may be true, but there are some horrors I wish I could forget everyday.


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Invisiblewildernessjunkie
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Re: Drug May Help Overwrite Bad Memories [Re: limestoneman]
    #14530912 - 05/29/11 02:03 PM (12 years, 8 months ago)

Oh I understand that. Its the misuse that concerns me.

I once heard someone say that the only difference between a medicine and a poison, is the dose and application.


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Offlinelimestoneman
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Re: Drug May Help Overwrite Bad Memories [Re: wildernessjunkie]
    #14530964 - 05/29/11 02:15 PM (12 years, 8 months ago)

Quote:

wildernessjunkie said:
Oh I understand that. Its the misuse that concerns me.

I once heard someone say that the only difference between a medicine and a poison, is the dose and application.



That sounds like the apothecary doctor from Assasin's creed, but Iv get what you're saying. Still, It would be nice to finally have medicine to treat PTSD.
I don't have it, but I'm still for any possible treatment.


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Offlinelaruta_21
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Re: Drug May Help Overwrite Bad Memories [Re: wildernessjunkie]
    #14531095 - 05/29/11 02:44 PM (12 years, 8 months ago)

Quote:

wildernessjunkie said:
Oh I understand that. Its the misuse that concerns me.

I once heard someone say that the only difference between a medicine and a poison, is the dose and application.





That's a title of a song by Circa Survive


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InvisibleHarri

Registered: 10/29/08
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Re: Drug May Help Overwrite Bad Memories [Re: laruta_21]
    #14531128 - 05/29/11 02:51 PM (12 years, 8 months ago)

It's gonna be in the water man and the government is gonna rape us without us remembering it!!!! Grab you tin foil hats this is serious!!!


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OfflineLed Zeppelin
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Re: Drug May Help Overwrite Bad Memories [Re: Harri]
    #14531626 - 05/29/11 04:46 PM (12 years, 8 months ago)

were getting to the point in technolagy and drugs where there needs to be some serious caution. if this kind of shit gets into the wrong hands....


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InvisibleWise Toad
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Re: Drug May Help Overwrite Bad Memories [Re: Led Zeppelin]
    #14532174 - 05/29/11 06:27 PM (12 years, 8 months ago)

Makes me think of "eternal sunshine of the spotless mind"

This is scary, I could forget some very significant details and large chunks of my life

Lets say two guys were in a war, they survive that hell but once they get back they are put on this for PTSD, how much of the other person would they have left with them memory wise. Everything you do is a significant part of who you are, this limits you

A couple has rough breakup and starts taking the drug, then they forget they broke up

Would erasing all the bad memories merely mask underlying life problems and inhibit advancement and change

If everyone was docile things would get worse and worse because the will of the people would no longer be a worthy opposition to those in charge, brave new world anyone?

What would the significance of happiness be if there was no contrast

Still, it would be interesting to try a life clear of this tortured world


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InvisibleHarri

Registered: 10/29/08
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Re: Drug May Help Overwrite Bad Memories [Re: Wise Toad]
    #14532448 - 05/29/11 07:12 PM (12 years, 8 months ago)

You won't completely forget what happens in your life, it doesn't work like that. this is not some black hole where bad memories go it just makes the negative parts of a memory's significance lessen in there importance in memory recall. drugs work with in reason it isn't some voodoo black magic spell. I think your blowing it out of proportion in what this drug can actually do. maybe I'm wrong though.


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Invisiblewildernessjunkie
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Re: Drug May Help Overwrite Bad Memories [Re: Wise Toad]
    #14533307 - 05/29/11 10:05 PM (12 years, 8 months ago)

Quote:

Wise Toad said:
Makes me think of "eternal sunshine of the spotless mind"

This is scary, I could forget some very significant details and large chunks of my life

Lets say two guys were in a war, they survive that hell but once they get back they are put on this for PTSD, how much of the other person would they have left with them memory wise. Everything you do is a significant part of who you are, this limits you

A couple has rough breakup and starts taking the drug, then they forget they broke up

Would erasing all the bad memories merely mask underlying life problems and inhibit advancement and change

If everyone was docile things would get worse and worse because the will of the people would no longer be a worthy opposition to those in charge, brave new world anyone?

What would the significance of happiness be if there was no contrast

Still, it would be interesting to try a life clear of this tortured world




Excellent perspective. :handth:

Exactly what I was getting at.


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Offlinetwigsin
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Re: Drug May Help Overwrite Bad Memories [Re: wildernessjunkie]
    #14534093 - 05/30/11 01:23 AM (12 years, 8 months ago)

straight to the military use


--------------------
because this big old river
will kill us in time
'till then we'll drink it's weight
in cheap beer and wine
we can drink just as fast
as the river is strong
and we'll drink 'till we're gone






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OfflineAzure Essence
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Re: Drug May Help Overwrite Bad Memories [Re: twigsin]
    #14534150 - 05/30/11 01:47 AM (12 years, 8 months ago)

This article itself implies memory is some iron clad law that gets imprinted in your brain... Your memory changes every single second your mood, psysiology, and internal representations change.

NLP already has tons of techniques for changing the way we perceive the emotional impact of memories... since like the 70's


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OfflineMaye
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Re: Drug May Help Overwrite Bad Memories [Re: Harri]
    #14534236 - 05/30/11 02:39 AM (12 years, 8 months ago)

Quote:

Harri said:
You won't completely forget what happens in your life, it doesn't work like that. this is not some black hole where bad memories go it just makes the negative parts of a memory's significance lessen in there importance in memory recall. drugs work with in reason it isn't some voodoo black magic spell. I think your blowing it out of proportion in what this drug can actually do. maybe I'm wrong though.




Yea :whathesaid: Stop being so paranoid. Not everything the government spit out is inherently evil in the same way not everything "organic" is inherently good. Things aren't black and white - there are shades of grey.


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OfflineTNK
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Re: Drug May Help Overwrite Bad Memories [Re: Maye]
    #14535806 - 05/30/11 12:51 PM (12 years, 7 months ago)

Quote:

Yea :whathesaid: Stop being so paranoid. Not everything the government spit out is inherently evil in the same way not everything "organic" is inherently good. Things aren't black and white - there are shades of Grey.




I don't think they are being paranoid, If this drug has the possibility of erasing "bad memories" wouldn't it somehow hold within it's self the ability to erase any memory? that the drug could be re-designed and applicable for targeting specific memories?

It sounds like a drug that could be heavily abused not just by the government, but by general population trying to forget their bad moments.

It also sounds like a drug that could help a lot of people,
Rape Victims, PTSD along with other chronic stress and anxiety diss orders.

I wouldn't know, I'm no neru surgeon.


--------------------
Edited by TNK (02/22/22 22:22 PM)


Edited by TNK (05/30/11 12:53 PM)


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Offlinelimestoneman
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Re: Drug May Help Overwrite Bad Memories [Re: Harri]
    #14536228 - 05/30/11 02:11 PM (12 years, 7 months ago)

Quote:

Harri said:
You won't completely forget what happens in your life, it doesn't work like that. this is not some black hole where bad memories go it just makes the negative parts of a memory's significance lessen in there importance in memory recall. drugs work with in reason it isn't some voodoo black magic spell. I think your blowing it out of proportion in what this drug can actually do. maybe I'm wrong though.



My thoughts exactly.


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Invisiblenooneman
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Re: Drug May Help Overwrite Bad Memories [Re: 5-HT2A]
    #14538321 - 05/30/11 10:26 PM (12 years, 7 months ago)

I think this is awesome! Does anyone really want to remember the last time they drunk dialed their ex? What about breaking up, who the fuck wants to remember breakups? How about breaking your arm, no one wants to remember that. Bring on the memory erasing drugs!

:kingtard:


Edited by nooneman (05/30/11 10:27 PM)


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InvisibleWise Toad
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Re: Drug May Help Overwrite Bad Memories [Re: nooneman]
    #14542034 - 05/31/11 06:25 PM (12 years, 7 months ago)

If I ever did drunk dial anybody I already dont remember it, its a problem that already solves itself

:drunk:  :rofldrunk:


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