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OfflineOverStoned
Tripper
Male


Registered: 04/18/10
Posts: 296
Loc: Dark Side of the Moon
Last seen: 10 years, 7 months
Get High off of Aspartame!? It's an NMDA antagonist!
    #14314699 - 04/18/11 11:20 PM (12 years, 10 months ago)

For a long while I have wondered about common food additives being psychoactive, mainly after noticing that I felt really stimulated and odd after drinking a ton of Powerade with red dye in it. When I was a young kid I wasn't even allowed to consume red dyres because they made me so hyper.

It became quite apparent to me that food preservatives and additives may commonly be psychoactive. Not enough to get you high, but enough to feel different.

After researching for a long while, I finally found some interesting studies.

Aspartame, the sweetener used in diet sodas, is actually an NMDA antagonist! Other drugs that are NMDA antagonists include DXM, ketamine, DXM, PCP, alcohol, and most solvents. No wonder aspartame is so bad for you!

In fact, 12 year olds use aspartame to get high! LOL! The article's spelling is even funnier than the subject with words such as "Aderol®" and "sniggered."

Although it might get you high, I strongly advise you not to try it! It's shown to be extremely bad for you; it supposedly is very neurotoxic and can cause cancer.

There are a ton more studies on similar things that I'm still sifting through, so I'll try to update this thread when I find anything else interesting.


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  IT'S ALL TOO MUCH

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InvisibleMad_Larkin

Registered: 11/29/07
Posts: 18,606
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: OverStoned]
    #14314731 - 04/18/11 11:25 PM (12 years, 10 months ago)

From what I've heard aspartame isn't good shit. It's meant to be pretty bad for you, shit turns to methanol inside the body.

http://tc.engr.wisc.edu/uer/uer98/author2/index.html

Edited by Mad_Larkin (04/18/11 11:26 PM)

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InvisibleAlmostAsCoolAs
 User Gallery

Registered: 11/14/09
Posts: 7,215
Loc: California Flag
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: OverStoned]
    #14314735 - 04/18/11 11:26 PM (12 years, 10 months ago)

I hope you know that last article is a joke. Ingesting enough aspertame to get high would :feelsbadman:.


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Invisiblemuistrue
Inspired by the mystery
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Registered: 03/20/05
Posts: 12,899
Loc: Behind the Redwoods
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: OverStoned]
    #14314740 - 04/18/11 11:27 PM (12 years, 10 months ago)

I'll pass.


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Invisiblerackem
Male User Gallery


Registered: 11/27/09
Posts: 14,024
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: muistrue]
    #14314755 - 04/18/11 11:29 PM (12 years, 10 months ago)

ya ill let the 12 year oldshave it.. fuck that


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InvisibleThe Whale

Registered: 11/01/10
Posts: 2,384
Loc: Flag
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: muistrue]
    #14314757 - 04/18/11 11:30 PM (12 years, 10 months ago)

One way to judge toxicity is how much of a substance it takes to get you off.

Love,
McKenna


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OfflineMad River
Reverend, Churchof Todd
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Registered: 04/29/08
Posts: 1,114
Loc: The Great Lakes Region, U...
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Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: muistrue]
    #14314797 - 04/18/11 11:37 PM (12 years, 10 months ago)

Twenty years ago I was a lab tech in an animal testing lab. We had an aspartame study on these cute little brown mice. There were like 30 different test groups of increasing dosage. The air was so thick with aspartame, you could taste it in the air through a surgical mask.

All of the mice were seemingly normal, until you got to the final test group; the group that got the most aspartame. These mice seemed skinnier than the other mice and would stay stationary, sitting up with their little paws shaking. Actually their whole bodies quivered, as if housing powerful little motors. It was no problem at all to open any other cage in the room except the last two test groups, male and female, with the shaking mice. I called them popcorn mice, because every time, without fail, they would immediately shoot up about two feet in the air and out of their cages, running madly around the room. It took about ten minutes every time to round them all up. It was pretty wild.

They were eating what would be mountains of aspartame for a human.

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InvisibleThe Whale

Registered: 11/01/10
Posts: 2,384
Loc: Flag
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: Mad River] * 1
    #14314811 - 04/18/11 11:39 PM (12 years, 10 months ago)

Animals studies can be cruel.

They save lives or improve human lives in many cases, but often times it's just for some dumb ass grad student.


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OfflineViveka
refutation bias
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Registered: 10/21/02
Posts: 4,061
Last seen: 7 years, 4 months
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: OverStoned]
    #14314859 - 04/18/11 11:47 PM (12 years, 10 months ago)

Well, a large percentage of aspartame is metabolized into  phenylalanine, an amino acid which has a range of documented 'psychoactive' effects.  It's excitotoxic.  Some people use it for depression.  There's studies being done concerning its potential analgesic properties for some people.  It's added to 5 Hour Energy and other 'energy' products.

I have a fairly large bag of DL-phenylalanine but I haven't used much because I'm pretty sure that a few "normal" sized doses(250-500 mgs) in a day cause my brain to literally overheat.  I can feel my head get warmer.  Maybe it's the excitotoxic effect...

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Invisiblemonkiman
human being


Registered: 06/30/10
Posts: 1,030
Loc: somewhere in space time.
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: The Whale] * 1
    #14314964 - 04/19/11 12:08 AM (12 years, 10 months ago)

the body converts aspartame into formaldehyde, yes embalming fluid.:ahahaha:
look it up on wiki, but you pretty much have to scroll down forever to get to this interesting fact.
codex alimentarius


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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 3 months
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: OverStoned]
    #14315721 - 04/19/11 05:18 AM (12 years, 10 months ago)

Uh, no thanks. I'd rather have my NMDA receptors agonized instead of antagonised because :einstein: >:tard:


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OfflineSpiderbaby
?
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Registered: 08/20/06
Posts: 1,439
Loc: Ireland Flag
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Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: Mad_Larkin]
    #14315821 - 04/19/11 06:36 AM (12 years, 10 months ago)

Quote:

Mad_Larkin said:
From what I've heard aspartame isn't good shit. It's meant to be pretty bad for you, shit turns to methanol inside the body.

http://tc.engr.wisc.edu/uer/uer98/author2/index.html




You do realise the link you quoted to support that statement says this;

Quote:

In order for the body to accumulate a significant amount of formate, a human must consume 200 to 500 mg of methanol per kg of body weight [Food and Drug Administration, 1984], an amount that corresponds to drinking 600 to 1700 cans of diet soft drink at once.




and this

Quote:

only a small amount of phenylalanine can cause severe brain damage in individuals with the genetic disease phenylketonuria (PKU). These individuals must avoid products with aspartame. To date, no substantial evidence indicates that aspartame harms the rest of the population.



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OfflineMad River
Reverend, Churchof Todd
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Registered: 04/29/08
Posts: 1,114
Loc: The Great Lakes Region, U...
Last seen: 2 years, 7 months
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: Spiderbaby]
    #14315830 - 04/19/11 06:40 AM (12 years, 10 months ago)

:whathesaid:

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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,374
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: OverStoned]
    #14316059 - 04/19/11 08:28 AM (12 years, 10 months ago)

I wonder if aspartame can cross the blood brain barrier, and if so, how well. 

Dumping loads of aspartame on a petri dish of cultured neurons has minimal (if any) relevance to normal human consumption.


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...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436

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Onlinetwighead
mͯó
I'm a teapot


Registered: 08/27/08
Posts: 29,834
Loc: Glenn Gould's Fuck Windmill Flag
Last seen: 1 second
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: Spiderbaby]
    #14316129 - 04/19/11 08:46 AM (12 years, 10 months ago)

Quote:

Spiderbaby said:
Quote:

Mad_Larkin said:
From what I've heard aspartame isn't good shit. It's meant to be pretty bad for you, shit turns to methanol inside the body.

http://tc.engr.wisc.edu/uer/uer98/author2/index.html




You do realise the link you quoted to support that statement says this;

Quote:

In order for the body to accumulate a significant amount of formate, a human must consume 200 to 500 mg of methanol per kg of body weight [Food and Drug Administration, 1984], an amount that corresponds to drinking 600 to 1700 cans of diet soft drink at once.




and this

Quote:

only a small amount of phenylalanine can cause severe brain damage in individuals with the genetic disease phenylketonuria (PKU). These individuals must avoid products with aspartame. To date, no substantial evidence indicates that aspartame harms the rest of the population.






I don't trust the FDA... I'm still avoiding it.


oh and

"In order for the body to accumulate a significant amount of formate, a human must consume 200 to 500 mg of methanol per kg of body weight [Food and Drug Administration, 1984], an amount that corresponds to drinking 600 to 1700 cans of diet soft drink at once.
"

Monsanto bought the aspertame industry that same year 84' :tinfoil: :tinfoil: :tinfoil: :tinfoil:


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¿Check out some art m8?


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OfflineBrugman
antisobrietarian
Male


Registered: 05/16/01
Posts: 15,887
Loc: the land up over Flag
Last seen: 10 years, 10 months
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: Spiderbaby]
    #14316143 - 04/19/11 08:50 AM (12 years, 10 months ago)

I guess some study done at harvard recently shows that aspartame isn't linked to diabetes like originally thought.

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OfflineOverStoned
Tripper
Male


Registered: 04/18/10
Posts: 296
Loc: Dark Side of the Moon
Last seen: 10 years, 7 months
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: mellowparty]
    #14318297 - 04/19/11 04:07 PM (12 years, 10 months ago)

Quote:

AlmostAsCoolAs said:
I hope you know that last article is a joke. Ingesting enough aspertame to get high would :feelsbadman:.




Actually it's legit, the chick who wrote it is just stupid. Here's the original.


Quote:

mellowparty said:
Uh, no thanks. I'd rather have my NMDA receptors agonized instead of antagonised because :einstein: >:tard:



NMDA agonism isn't necessarily a good thing. L-Huperzine, for example, agonizes NMDA and inhibites acetylcholinesterase. The AChE inhibition improves cognition, but the NMDA agonism, while slightly improving cognition I believe, causes many individuals to feel pain all over their body. One person on BL said that L-Huperzine and piracetam triggered a long lasting episode of a sensation of extreme pain all over his body for a few months.


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  IT'S ALL TOO MUCH

Edited by OverStoned (04/24/11 11:55 PM)

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OfflineROFL_my_ WAFFLE


Registered: 08/28/09
Posts: 3,984
Loc: Florida Flag
Last seen: 3 years, 6 months
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: OverStoned]
    #14318312 - 04/19/11 04:08 PM (12 years, 10 months ago)

I love getting high of aspartame!


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InvisibleMisterMuscaria
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Registered: 05/13/08
Posts: 27,646
Loc: Flag
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: OverStoned]
    #14318325 - 04/19/11 04:13 PM (12 years, 10 months ago)

Vanilin, a common food additive is used in the synthesis of lsd and other psychoactive drugs. At least one version of the synthesis.

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InvisibleAsante
Mage
Male User Gallery

Registered: 02/06/02
Posts: 87,085
Re: Get High off of Aspartame!? It's an NMDA antagonist! [Re: MisterMuscaria]
    #14319424 - 04/19/11 07:45 PM (12 years, 10 months ago)

Quote:

Vanilin, a common food additive is used in the synthesis of lsd and other psychoactive drugs. At least one version of the synthesis.




:lolwut:

Thats not likely, I see no reason for the compound in ANY LSD synthesis, please prove me wrong, I love to learn.


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Omnicyclion.org
higher knowledge starts here

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