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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 2 months
Q about drug-brain interactions
    #14259518 - 04/08/11 04:29 PM (12 years, 9 months ago)

When you take a drug your brain responds by lowering the density of the cognate receptor i.e. tolerance develops. Also because of tolerance it would normally experience lack of signalling from the respective receptor thus dependence may result.


But what if you take an inhibitor of your favourite pathway. Say something that antagonises the opiate signalling circuits. The body ought to produce more endorphins this way to compensate for the action of the antagonist.

Would taking the physiological opposite of your drug of choice lead to a mimetic sober state that would :feelsgoodman:


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InvisibleSalomon
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Registered: 01/17/09
Posts: 25,128
Loc: America, FUCK YEAH Flag
Re: Q about drug-brain interactions [Re: mellowparty]
    #14259751 - 04/08/11 05:13 PM (12 years, 9 months ago)

somthing tells me no:ifyoucanawe:


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EVERYTHING EVENTUALLY BECOMES A DESERT



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OfflineThe_Ghost
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Registered: 03/27/07
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Re: Q about drug-brain interactions [Re: mellowparty]
    #14259881 - 04/08/11 05:39 PM (12 years, 9 months ago)

Quote:

mellowparty said:
When you take a drug your brain responds by lowering the density of the cognate receptor i.e. tolerance develops. Also because of tolerance it would normally experience lack of signalling from the respective receptor thus dependence may result.


But what if you take an inhibitor of your favourite pathway. Say something that antagonises the opiate signalling circuits. The body ought to produce more endorphins this way to compensate for the action of the antagonist.

Would taking the physiological opposite of your drug of choice lead to a mimetic sober state that would :feelsgoodman:



Well yeah you would probably feel shitty at first and then :feelsgoodman: as you get off the inhibitors. Would be interesting to try but also pretty pointless. Just take moar drugs instead. :vaped:


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/ / / / / / / LISTEN TO MY MUSIC: E X E D / / / / / / /
The universe gives no fucks. And takes no fucks.
May His Circuits Ever Function


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OfflineROFL_my_ WAFFLE


Registered: 08/28/09
Posts: 3,984
Loc: Florida Flag
Last seen: 3 years, 4 months
Re: Q about drug-brain interactions [Re: The_Ghost]
    #14259931 - 04/08/11 05:47 PM (12 years, 9 months ago)

Quote:

The_Ghost said:
Quote:

mellowparty said:
When you take a drug your brain responds by lowering the density of the cognate receptor i.e. tolerance develops. Also because of tolerance it would normally experience lack of signalling from the respective receptor thus dependence may result.


But what if you take an inhibitor of your favourite pathway. Say something that antagonises the opiate signalling circuits. The body ought to produce more endorphins this way to compensate for the action of the antagonist.

Would taking the physiological opposite of your drug of choice lead to a mimetic sober state that would :feelsgoodman:



Well yeah you would probably feel shitty at first and then :feelsgoodman: as you get off the inhibitors. Would be interesting to try but also pretty pointless. Just take moar drugs instead. :vaped:





Yeah, 'mo drugs. :homerdrool:


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OfflineThe_Ghost
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Registered: 03/27/07
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Re: Q about drug-brain interactions [Re: ROFL_my_ WAFFLE]
    #14259948 - 04/08/11 05:51 PM (12 years, 9 months ago)

Quote:

ROFL_my_ WAFFLE said:
Quote:

The_Ghost said:
Quote:

mellowparty said:
When you take a drug your brain responds by lowering the density of the cognate receptor i.e. tolerance develops. Also because of tolerance it would normally experience lack of signalling from the respective receptor thus dependence may result.


But what if you take an inhibitor of your favourite pathway. Say something that antagonises the opiate signalling circuits. The body ought to produce more endorphins this way to compensate for the action of the antagonist.

Would taking the physiological opposite of your drug of choice lead to a mimetic sober state that would :feelsgoodman:



Well yeah you would probably feel shitty at first and then :feelsgoodman: as you get off the inhibitors. Would be interesting to try but also pretty pointless. Just take moar drugs instead. :vaped:





Yeah, 'mo drugs. :homerdrool:





--------------------
/ / / / / / / LISTEN TO MY MUSIC: E X E D / / / / / / /
The universe gives no fucks. And takes no fucks.
May His Circuits Ever Function


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Offline13.step
cynical bastard
Male


Registered: 08/30/09
Posts: 2,210
Last seen: 9 years, 3 months
Re: Q about drug-brain interactions [Re: mellowparty]
    #14260096 - 04/08/11 06:25 PM (12 years, 9 months ago)

I've thought about this also...but sadly I think Salomon is right,
although who knows really...:shrug:

The reason I don't think it would really work is that like in the
case of the opiate system, the endogenous ligand is simply to
"weak", meaning that it won't get you high, nor would serotonin
for that matter be hallucinogenic, maybe a bit euphoric, but something
like what SSRI's do...

Now dopamine seems more promising, but again not by much...

There is an easy way to test this theory though...naltrexone...:wink:

Or moar drugs...:fearandloathing:


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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 2 months
Re: Q about drug-brain interactions [Re: 13.step]
    #14263043 - 04/09/11 01:01 PM (12 years, 9 months ago)

Would taking naltrexone suck?


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Offline13.step
cynical bastard
Male


Registered: 08/30/09
Posts: 2,210
Last seen: 9 years, 3 months
Re: Q about drug-brain interactions [Re: mellowparty]
    #14265390 - 04/10/11 02:19 AM (12 years, 9 months ago)

:shrug: only if you had a habit I imagine...


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InvisibleBodhi of Ankou
*alternate opinion blocks path*
Other


Registered: 06/02/09
Posts: 24,778
Loc: Soviet Canukistan Flag
Re: Q about drug-brain interactions [Re: mellowparty]
    #14265419 - 04/10/11 02:33 AM (12 years, 9 months ago)

Quote:

mellowparty said:
When you take a drug your brain responds by lowering the density of the cognate receptor i.e. tolerance develops. Also because of tolerance it would normally experience lack of signalling from the respective receptor thus dependence may result.


But what if you take an inhibitor of your favourite pathway. Say something that antagonises the opiate signalling circuits. The body ought to produce more endorphins this way to compensate for the action of the antagonist.

Would taking the physiological opposite of your drug of choice lead to a mimetic sober state that would :feelsgoodman:




Well since what ever chemical you came up with would activate the receptors in the same manner as the drug, I imagine it would be a high or stoned mimicry of the actual drug its imitating.


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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 2 months
Re: Q about drug-brain interactions [Re: Bodhi of Ankou]
    #14265489 - 04/10/11 03:15 AM (12 years, 9 months ago)

Im not sure what you're talking about but say for example you take rimonabant. Its a cannabinoid antagonist and you'll experience diminished hunger as opposed to Δ9-THC. Apparently it will also make you very depressed and suicidal :shrug:

I've always been interested in how psychoactives interact just for the sake of science rather than my own inebriation. For example if you smoke salvia during an opiate high the latter should be diminished for the duration of the salvia trip. It some type of interaction between opioid receptors.

Anyone up to trying that salvia opiate experiment? I'd volunteer but I dont have the consumables :grin:


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InvisibleBodhi of Ankou
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Other


Registered: 06/02/09
Posts: 24,778
Loc: Soviet Canukistan Flag
Re: Q about drug-brain interactions [Re: mellowparty]
    #14265493 - 04/10/11 03:21 AM (12 years, 9 months ago)

Ive taken LSD and drank 10 oz of whiskey and didnt feel inebriated in the slightest. Psychedelic's effect on the consciousness is rather enigmatic for the time being.


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Invisiblecacharstar
Strange is good...
Male

Registered: 11/13/08
Posts: 4,014
Loc: The West Coast
Re: Q about drug-brain interactions [Re: mellowparty]
    #14265497 - 04/10/11 03:26 AM (12 years, 9 months ago)

Quote:

mellowparty said:
Im not sure what you're talking about but say for example you take rimonabant. Its a cannabinoid antagonist and you'll experience diminished hunger as opposed to Δ9-THC. Apparently it will also make you very depressed and suicidal :shrug:

I've always been interested in how psychoactives interact just for the sake of science rather than my own inebriation. For example if you smoke salvia during an opiate high the latter should be diminished for the duration of the salvia trip. It some type of interaction between opioid receptors.

Anyone up to trying that salvia opiate experiment? I'd volunteer but I dont have the consumables :grin:





My last saliva trip was the catalyst that made me decide to get of oxy and heroin.  But it did not counteract the effect for sure.


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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 2 months
Re: Q about drug-brain interactions [Re: Bodhi of Ankou]
    #14265528 - 04/10/11 04:09 AM (12 years, 9 months ago)

Quote:

Bodhi of Ankou said:
Ive taken LSD and drank 10 oz of whiskey and didnt feel inebriated in the slightest.



:whatwhat:


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