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Invisible5-HT2A
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Genetic Variants in Two Genes Linked With Caffeine Intake
    #14252784 - 04/07/11 12:08 PM (12 years, 9 months ago)

http://www.sciencedaily.com/releases/2011/04/110406091731.htm

Two genes in which variation affects intake of caffeine, the most widely consumed stimulant in the world, have been discovered. A team of investigators from the National Cancer Institute, Harvard School of Public Health, Brigham and Women's Hospital, and the University of North Carolina at Chapel Hill examined genetic variation across the entire genome of more than 47,000 individuals from the U.S., as described in the open-access journal PLoS Genetics.

The genes identified were CYP1A2, which has previously been implicated in the metabolism of caffeine, and AHR, involved in the regulation of CYP1A2. Individuals with the highest-consumption genotype for either gene consumed ~40 mg more caffeine than those with the lowest-consumption genotype, equivalent to the amount of 1/3 cup of caffeinated coffee, or 1 can of cola.

Caffeine is implicated in numerous physiological and medical conditions; it affects sleep patterns, energy levels, mood, and mental and physical performance. The identification of genes that have an impact on daily consumption offers opportunities to better understand these conditions. Further exploration of the identified genetic variants may provide insight into the speed of caffeine metabolism, how long caffeine circulates in the blood, or how strong the physiological effects of consuming a given amount of caffeine are.

Apart from smoking, genetic determinants of lifestyle behaviors have generally not been consistently described. This study is among the first to examine the entire genome for a relationship between genetics and caffeine intake, a lifestyle behavior relevant to over 90% of U.S. adults. The study's success also suggests that additional genetic determinants of dietary and lifestyle behaviors may be identified in the future using a similar genome-based research strategy.


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OfflineFreedom
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Re: Genetic Variants in Two Genes Linked With Caffeine Intake [Re: 5-HT2A]
    #14253020 - 04/07/11 01:01 PM (12 years, 9 months ago)

exual behaviour in mice is thought to be driven by their sense of smell.

Professor Keith Kendrick, a neuroscientist at the Babraham Institute in Cambridge, said: "In terms of having potential relevance to understanding human sexual preference/orientation, we are of course far less influenced by odour cues in this context than mice are.

"There is some very limited evidence for altered responses to selective serotonin uptake inhibitors (SSRIs) in the brains of homosexuals, but we have been using psychoactive drugs which either increase or decrease serotonin function for quite some time now, and while effects on sexual arousal, impulsivity and aggression have often been reported, no effects on sexual preference/orientation have.

"At this time therefore any potential links between serotonin and human sexual preferences must be considered somewhat tenuous."


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Offlinedestructo_low
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Re: Genetic Variants in Two Genes Linked With Caffeine Intake [Re: Freedom]
    #14253212 - 04/07/11 01:40 PM (12 years, 9 months ago)

You posted in the wrong thread.


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There is a molecule for every purpose. There are only actions and reactions. Cut out the middle men. Everything I say is a lie.


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