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Offlinebbl337
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Re: Can you get brain damage from a DMT overdose? [Re: Infrared]
    #13726605 - 01/03/11 07:27 PM (13 years, 27 days ago)

Quote:

Infrared said:
i think he was being sarcastic because this question is absurb. dmt is a natural neuro chemical, the  ld 50 of it is so high that you would go completely insane and black out before it kills you




why do people make blanket statements like this?  Arsenic is found in our bodies in minute quantities too, doesn't mean it's safe in larger quantities.

Odds are there could be some possible (albeit mild) downregulation of some receptors if used frequently, along with oxidative stress causing some damage, but the amount would be mild and I wouldn't worry too much.  Just don't go bat shit crazy with it and take obscene amounts and you're probably fine


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OfflineOverdoseLiving
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Re: Can you get brain damage from a DMT overdose? [Re: bbl337]
    #13739573 - 01/06/11 06:03 AM (13 years, 24 days ago)

Most people are not aware of all of the different levels of factors that come into play when discussing stuff like this.


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Offlinethe spiral
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Re: Can you get brain damage from a DMT overdose? [Re: OverdoseLiving]
    #13760597 - 01/09/11 10:23 PM (13 years, 21 days ago)

I don't think it's possible to overdose on DMT in the classical sense.  No matter how much you packed the vaporizer or bowl with, you'd rather quickly reach a point where you had ingested a sufficient amount of DMT to leave your body - and with it, any consciousness of trying to smoke a whole lot.

Because of this, and also because of the structural similarity of DMT to Psilocin (5-HO-DMT), I think that the evidence is rather strong that any overdose on DMT would almost certainly be an oberdose of MAOIs on an Ayahuasca journey - rather than overdosing on DMT itself.  The MAOis (like Harmine/harmaline) do not have anything approaching the index of safety that DMT does; pharmaceutical MAOIs (and harmine/harmline) list a whole host of contraindcated foods, for example, that if you eat too soon before, during, or after dosing, can cause things like hypertensive crises.  MAOIs aare also capable of lots of other strange side effects - this is not surprising, considering how important a role MAO plays in breaking down (and thus regulating) certain neurotransmitter systems.  Tryptamine pshcyedelics like DMT, on the other hand, act on cells by binding to various (mostly serotonergic) receptors but so far as we know can NOT have the kind of disseminated (systemic: heart rate, blood pressure, respiration, etc.) effects that a drug that massively inhibits an essential brain enzyme (as MAOIs affect monoamine oxidase) can have. 


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Offlinemattritt
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Re: Can you get brain damage from a DMT overdose? [Re: the spiral]
    #13768922 - 01/11/11 01:26 PM (13 years, 19 days ago)

Quote:

the spiral said:
I don't think it's possible to overdose on DMT in the classical sense.  No matter how much you packed the vaporizer or bowl with, you'd rather quickly reach a point where you had ingested a sufficient amount of DMT to leave your body - and with it, any consciousness of trying to smoke a whole lot.

Because of this, and also because of the structural similarity of DMT to Psilocin (5-HO-DMT), I think that the evidence is rather strong that any overdose on DMT would almost certainly be an oberdose of MAOIs on an Ayahuasca journey - rather than overdosing on DMT itself.  The MAOis (like Harmine/harmaline) do not have anything approaching the index of safety that DMT does; pharmaceutical MAOIs (and harmine/harmline) list a whole host of contraindcated foods, for example, that if you eat too soon before, during, or after dosing, can cause things like hypertensive crises.  MAOIs aare also capable of lots of other strange side effects - this is not surprising, considering how important a role MAO plays in breaking down (and thus regulating) certain neurotransmitter systems.  Tryptamine pshcyedelics like DMT, on the other hand, act on cells by binding to various (mostly serotonergic) receptors but so far as we know can NOT have the kind of disseminated (systemic: heart rate, blood pressure, respiration, etc.) effects that a drug that massively inhibits an essential brain enzyme (as MAOIs affect monoamine oxidase) can have. 




^^You know how I know you don't know what you're talking about? :facepalm:

Remember an overdose doesnt mean you die.  If the effects deeply disturbed you psychologically then you could easily be scarred in some way I believe, in certain cases.  This is why people should be cautious with dosage.  Why blow your brains out everytime from the start.  Work your way up so that you learn how to navigate the space.  Work WITH the compound, don't try to dominate it.  You will find much better results this way.


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**Metaphysical Crystal, Stones, Gems, and Minerals**
Every individual reacts differently to every chemical.
Know your Body - Know your Mind - Know your Substance - Know your Source.
:bongload:  :gethigh:  "You need more THC to your brain, faster." - Drr  :gethigh:  :bongload:


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Offlinethe spiral
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Re: Can you get brain damage from a DMT overdose? [Re: mattritt]
    #13781596 - 01/13/11 04:52 PM (13 years, 17 days ago)

note that I said "in the classical sense."  I was not addressing psychological damage (except for the kind that's the direct result of "brain damage" ie. cell death), which even low doses of various psychedelics can encourage. 

There's no need to say that I have no idea what I'm talking about, by the way.  I'd have preferred an encouraging "well, actually, psilocin is 4-substituted."  To which I'd have said "oops, I was thinking about DMT, and had a brain-fart - especially considering (from what I recall) psiloc(y)bin is the only naturally occuring 4-substituted tryptamine.  Terence McKenna used to like to point that out as "evidence" that psilocybin is extraterrestrial in nature :smile:.  Since I heard him say it, I can't say I've found a counterexample.

Anyway, oops =p

Edit: I should also note that it was erroneous of me to really make any remarks about DMTs activity in the body based on its structural similarity to psilocin .  One needs only compare methanol to ethanol, or methane to methanol, and so on, to see that a very "small" structural modification can have a very large impact on a drug's pharmacology.


Edited by the spiral (01/13/11 05:15 PM)


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OfflineWizzy
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Re: Can you get brain damage from a DMT overdose? [Re: the spiral]
    #13781808 - 01/13/11 05:27 PM (13 years, 17 days ago)

I don't know much about DMT or it's chemistry... but I'd imagine an "Overdose" of anything can't be good for your brain, buddy.


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Offlinemattritt
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Re: Can you get brain damage from a DMT overdose? [Re: Wizzy]
    #13781898 - 01/13/11 05:43 PM (13 years, 17 days ago)

Quote:

Wizzy said:
I don't know much about DMT or it's chemistry... but I'd imagine an "Overdose" of anything can't be good for your brain, buddy.




For Truth


--------------------
**Metaphysical Crystal, Stones, Gems, and Minerals**
Every individual reacts differently to every chemical.
Know your Body - Know your Mind - Know your Substance - Know your Source.
:bongload:  :gethigh:  "You need more THC to your brain, faster." - Drr  :gethigh:  :bongload:


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Invisiblemuistrue
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Re: Can you get brain damage from a DMT overdose? [Re: Wizzy]
    #13781917 - 01/13/11 05:46 PM (13 years, 17 days ago)

Quote:

Wizzy said:
I don't know much about DMT or it's chemistry... but I'd imagine an "Overdose" of anything can't be good for your brain, buddy.




Brain changes due to drugs is already written into my brain budget so it's all good.


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OfflineROFL_my_ WAFFLE


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Re: Can you get brain damage from a DMT overdose? [Re: muistrue]
    #13781925 - 01/13/11 05:48 PM (13 years, 17 days ago)

You'd have to IV that shit.


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Offlinemattritt
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Re: Can you get brain damage from a DMT overdose? [Re: muistrue]
    #13782692 - 01/13/11 08:00 PM (13 years, 17 days ago)

Quote:

FractalDust said:
Quote:

Wizzy said:
I don't know much about DMT or it's chemistry... but I'd imagine an "Overdose" of anything can't be good for your brain, buddy.




Brain changes due to drugs is already written into my brain budget so it's all good.



As long as your accountant's worked it into the book then you should be fine. :wink:


--------------------
**Metaphysical Crystal, Stones, Gems, and Minerals**
Every individual reacts differently to every chemical.
Know your Body - Know your Mind - Know your Substance - Know your Source.
:bongload:  :gethigh:  "You need more THC to your brain, faster." - Drr  :gethigh:  :bongload:


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Offlinedmtisnot4me
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Re: Can you get brain damage from a DMT overdose? [Re: Dogomush]
    #16182989 - 05/04/12 06:53 PM (11 years, 8 months ago)

I have to disagree.. My friend gave me a high dose of Dmt that I smoked over 1 .5 years ago and I have not felt right in body and soul since then. I always have this back and forth feeling in my body or mind. like being at sea when im sitting completely still. I have slso had many heart palpitations that have gotten worse and muscles stiffness.  Also I cant sleep and when i do i wake in terror feeling like I was goin to die as wake up gaspin for air.. It messed me up. I might of had a  underlying neurological issue before that was dorminant but this is not cool. I now on disability.


Edited by dmtisnot4me (05/12/12 03:03 AM)


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