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OfflineBothHands
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Re: My goal is to shoot weed [Re: s240779]
    #14206716 - 03/29/11 10:43 PM (12 years, 10 months ago)

It doesn't happen like that at all.  You're right, the THC doesn't become water soluble, so it doesn't enter the blood stream until the blood cell responsible for transporting hydrophobic substances comes to pick it up.  You never have free unbound hash oil floating around your blood stream.  But when you IV it, you put it into your blood without allowing it to bind to the cells first.

Nothing enters your bloodstream in that manner.  Not even oxygen.  Oxygen has to wait for red blood cells to pick up the molecules individually.

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Offlines240779
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Re: My goal is to shoot weed [Re: BothHands]
    #14206760 - 03/29/11 10:50 PM (12 years, 10 months ago)

Quote:

BothHands said:
Nothing enters your bloodstream in that manner.  Not even oxygen.  Oxygen has to wait for red blood cells to pick up the molecules individually.




It sounds like you're saying that everything in the bloodstream has to be chaperoned by cells. If that's the case, then why does the medical field practice intravenous injection?

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Offlineastrolope
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Re: My goal is to shoot weed [Re: s240779]
    #14206803 - 03/29/11 10:57 PM (12 years, 10 months ago)

Going from what she's been saying there's cells in your blood to pick up the molecules? you really are hopeless... :facepalm:


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Edited by astrolope (03/29/11 10:58 PM)

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Offlines240779
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Re: My goal is to shoot weed *DELETED* [Re: astrolope]
    #14206842 - 03/29/11 11:03 PM (12 years, 10 months ago)

ewgeg5r

Edited by s240779 (03/29/11 11:08 PM)

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OfflineBothHands
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Re: My goal is to shoot weed [Re: s240779]
    #14206850 - 03/29/11 11:04 PM (12 years, 10 months ago)

I'm extremely stoned, so I'll need to continue this later.

But in the natural process, molecules always enter the bloodstream individually.  They don't necessarily always need to be chaperoned.  If they're water soluble, like alcohol, they can diffuse through the cells (one molecule at a time), and stay safely in the water that makes up your blood.

But hydrophobic substances are much different, and must wait for a cell to pick them up.

IVing and smoking hydrophobic substances are extremely different, and it's dangerous to assume they're not.

No doctor will EVER IV a nonpolar molecule into your bloodstream without having it dissolved in a solvent.  If they did, the molecules would clump up, and form little beads, much like if you drip some oil on top of some water.  They won't diffuse into the blood.  And when these beads reach small capilaries in the brain, they can get stuck.

Putting the molecules in a solvent will allow them to diffuse into the blood.

I'm too stoned to do this though.

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OfflineBothHands
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Re: My goal is to shoot weed [Re: s240779]
    #14206870 - 03/29/11 11:07 PM (12 years, 10 months ago)

Quote:

superhigh said:
Whether weed enters the blood stream via smoke or straight IV, by the time it reaches the BBB, it's all the same. That's what I hypothesize. she's trying to sound smart by saying "unbound cannabinoids." Nonsense.




Well, I was honestly trying to help before this comment.  But, that's fine.  IV some hash oil without dissolving it and die.  I could care less at this point.

The majority is stacked against you, and seem to point in the direction of your idiocy, not mine.

:bye:

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Offlines240779
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Re: My goal is to shoot weed [Re: s240779]
    #14206897 - 03/29/11 11:12 PM (12 years, 10 months ago)

Sorry. Your previous post is by far the best argument I've heard against doing this.

So the question is: is alcohol a sufficient solubilizing agent? Or will it fall out of solution?

Also, there's a significant amount of fats in black tar heroin and people inject that all the time. Maybe shooting stuff like weed and BTH is a stressor for the body but you can get away with it.

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OfflineBothHands
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Re: My goal is to shoot weed [Re: s240779]
    #14206964 - 03/29/11 11:23 PM (12 years, 10 months ago)

Honestly, I can't answer that question.  I know THC has been successfully IVed in many different labaratory settings, but I don't know which solvent was used.  And even if it does fall out of solution, I'm not sure it matters.  The issue would be having one large bead.  But if it falls out of solution, it'll do so one molecule at a time, and will not likely form into a bead as it would have if IV'd directly.  Though this depends on how quickly it falls out of solution.  If it falls out immediately, you could have a problem with microscopic beads running into each other and fusing to form a larger dangerous bead.  But if it stays in solution for even 10 seconds, you'd probably be safe.  But I really don't know how fast it'll fall out.

I've never shot BTH, so I can't offer much direct insight on that.  But tell me this, when you suck your BTH into a syringe, and leave the syringe for a few seconds, do the fats seperate out?  Can you look into the syringe and see a seperate fat layer?  If so, then I'd say BTH might be on par with IVing THC.

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Invisiblewow
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Re: My goal is to shoot weed [Re: BothHands]
    #14206988 - 03/29/11 11:29 PM (12 years, 10 months ago)

idk how but its POSSIBLE!!  ALCOHOL WILL GIVE YOU A HEART ATTACK!!!


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OfflinePreparationH
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Re: My goal is to shoot weed [Re: BothHands] * 1
    #14206991 - 03/29/11 11:29 PM (12 years, 10 months ago)

People poutting shrooms in their ass, superhigh wanting to IV weed...  Just do it the same way our forefathers have done guys wtf :rofl:

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Offlines240779
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Re: My goal is to shoot weed [Re: wow]
    #14207003 - 03/29/11 11:32 PM (12 years, 10 months ago)

It's not a mystery. I've looked into what the professionals do. either they use chemically modified cannabinoids which are water soluble, or they emulsify the cannabinoids (in the case of natural isolated cannabinoids). Emulsification is the method for intravenously injecting hydrophobic drugs. Off the top of my head, the emulsifying agent for cannabinoids is a concoction of polysorbate 80, albumin, and some other stuff.

http://www.docstoc.com/docs/25171820/Emulsifying-agents

THC has been administered intravenously in doses up to 5 mg. Because THC is poorly soluble in water, it must be mixed with human albumin or other solubilizing agents. Marijuana and Cannabinoid Research (2006), page 238  http://www.scribd.com/doc/14452038/Marijuana-and-Cannabinoid-Research-2006

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Invisiblewow
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Re: My goal is to shoot weed [Re: wow]
    #14207014 - 03/29/11 11:34 PM (12 years, 10 months ago)

id think you could use some oil based solution and sterilize too if you want..


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Offlines240779
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Re: My goal is to shoot weed [Re: wow]
    #14207025 - 03/29/11 11:36 PM (12 years, 10 months ago)

Well BothHands just kind of pointed out that maybe injecting straight oil isn't a good idea. Alcohol is probably the next best thing to the complicated emulsification used in the research setting (I don't know where to get pure albumin...)

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Invisiblewow
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Re: My goal is to shoot weed [Re: wow]
    #14207030 - 03/29/11 11:37 PM (12 years, 10 months ago)

it has to be isomerized and in esther base to be water soluble in water..  i know thc-o-acetate is water soluble...  but as the vid shows it may not be desirable..


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Invisiblewow
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Re: My goal is to shoot weed [Re: wow]
    #14207037 - 03/29/11 11:38 PM (12 years, 10 months ago)

maybe ethanol..


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Invisiblewow
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Re: My goal is to shoot weed [Re: wow]
    #14207048 - 03/29/11 11:40 PM (12 years, 10 months ago)

i know they use iso alcohol to induce heart attacks in high risk heart patients..


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Offlinerealfuzzhead
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Re: My goal is to shoot weed [Re: ROFL_my_ WAFFLE]
    #14207051 - 03/29/11 11:40 PM (12 years, 10 months ago)

Quote:

ROFL_my_ WAFFLE said:
Quote:

sunset_mission said:
:winning1:







:rofl:

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Offlines240779
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Re: My goal is to shoot weed [Re: s240779]
    #14207054 - 03/29/11 11:41 PM (12 years, 10 months ago)

Someone has already injected weed multiple times using alcohol methods:

I can't really describe the experience in words. There were variances in the strengths of the effects from method to method, but even the worst one was exponentially better than the first time I tried this last year with the simple trichrome extraction. It was downright hallucinagenic. I was completely hypnotized for the better part of an hour, completely on the edge between the real world and the 'void' as we love to call it on these forums. Space-time distortions, full-out sensory hallucinations (all 5 ), all coupled with a mental state that I've never experienced on any other drug (and I've done a few). It was quite overpowering. I know this is a bold statement to make, but the only thing I can compare it to is the power of DMT. It's not nearly as psychadellic, visual, or ego-shredding as my lovely Dimitry, but the all-around intensity of the experience was compariable only to that. full version -> https://tokecity.com/forums/showthread.php4?t=6775

He basically experienced the increased bioavailability of intravenous injection. I plan to inject a small amount and get just as high as I normally would and observe the difference in the come-up, which will be dealyed a little as opposed to the immedicay of smoking and that should be interenting.

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Invisiblewow
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Re: My goal is to shoot weed [Re: s240779]
    #14207072 - 03/29/11 11:44 PM (12 years, 10 months ago)

good luck!  hope your successful!!  be fucking careful!!:thumbup:


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Offlinerealfuzzhead
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Re: My goal is to shoot weed [Re: wow] * 1
    #14207096 - 03/29/11 11:48 PM (12 years, 10 months ago)

damn man.. have fun but i can see the media having a fucking field day on this.

"Local marijuana addicts, just out of highschool, are injecting marijuana and reusing needles in what they refer to as 'mary jane bangbang sessions', this is no doubt a result of Medical Marijuan blah blah durr hurr twidly dee do dumb"

have fun though dude! trip report in needed. pics would be cool

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