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Invisibletiara
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multiple genes and fungi
    #14191363 - 03/27/11 10:12 AM (12 years, 10 months ago)

Hello all,
I'm a newbie to mycology but experienced with gardening and applied animal genetics with livestock.

Some of my questions on senescence of strains have been answered. Hayflick limit, telomeres and epigenetics are all factors I've discussed on animal genetic forums with their application to longevity and genetics.

In mammals at least, the epigenetic pattern of the parents' cells at the moment of fertilization is passed on along with the basic DNA. The epigenetic switches can change expression significantly throughout life but the early starting pattern the embryo has impacts the individual lifelong. 

The Hayflick limit may be the telomere length. Not so much an exact number of cell divisions but the toll taken on the telomeres with the divisions.

One aspect of genetics I couldn't find a discussion on with the search engine is the fairly recent- 2006- discovery that there can be more than 2 genes at each site. In some cases 4 or more genes can be stacked up. The expression of these genes from grandparents, great grandparents tosses in a wild card in the breeding program.

From an old post I'd written. There was a much more detailed article in I think Nature. If I can find the link/article, I'll post it.
My understanding of haplotypes is not very good. But I had asked myself when I read these articles what some consequences might be.
if haplotypes are multiple genes that tend to be passed on as a unit, and different haplotypes are different in numbers of genes passed on, what happens when a haplotype from on parent is larger or smaller than that of the other parent? would this be fatal to the embryo? in addition to the multiple genes could there be holes, missing genes? I found one article that indicates, yes there are missing genes and from an earlier article on DNA variability, indications that up to 4 genes can be passed on from one parent. perhaps 8 total at some loci?
so what happens when there are these multiple genes? are some genes inactivated like X chromosome inactivation?
this article http://news.bbc.co.uk/2/hi/science/nature/4355355.stm discusses how 15% of the genes are not inactivated,
this might explain some strange things. like the article some time back on reverting to DNA of grandparents, the DNA is still there, perhaps not expressed for a generation or so but available if some environmental triggers turns a gene off.
could this also explain some things like prepotency and genetic buffering? and how some breeds/lines can tolerate large amounts of inbreeding for a time at least without detectable inbreeding depression?
curiouser and curiouser!  I'm eagerly looking forward to hearing about the implications of this study.
http://www.hapmap.org/whatishapmap.html hap map project
http://news.bbc.co.uk/1/hi/health/4664541.stm missing genes
http://www.theglobeandmail.com/servlet/story/RTGAM.20050618.wxrace0618/BNStory/Front/ this article is one I posted a link to over a year ago. another main stream media article and it just seemed too strange to be true.
Geneticist Steve Scherer, a senior scientist at Toronto's Hospital for Sick Children, working with colleagues at Harvard University, discovered last August that the basic model of simple genetic inheritance science has clung to for 100 years is wrong: Mom and dad don't always make equal genetic contributions in the creation of a child's genome.

Instead, some people might end up with three, four or even more copies of a gene from one parent, instead of the single copy of each gene scientists thought each parent always contributed.

Does anyone know if fungi have a similar multiple gene potential? Apparently green plants do as well as mammals and I'm guessing other non-mammalian animals. Could senescence in fungal strains happen when the preferred gene hits some epigenetic wall and another lesser quality gene activates?

regards
tiara


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Invisibletiara
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Re: multiple genes and fungi/another link Global variation in copy number in the human genome [Re: tiara]
    #14191381 - 03/27/11 10:15 AM (12 years, 10 months ago)



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