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OfflineSheTripper
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Why does weight matter? .. or does it?
    #14130666 - 03/16/11 12:54 PM (12 years, 10 months ago)

This has the potential to be a stupid question lol.

I've heard when you are dosing DXM you gotta go by body weight. Is this true? And why isn't this the same for mushrooms and LSD? I know they are no where close to the same things but it goes for other things too like heroin and weed. Why does weight matter for DXM?


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InvisibleCactilove
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Re: Why does weight matter? .. or does it? [Re: SheTripper]
    #14130678 - 03/16/11 12:55 PM (12 years, 10 months ago)

I thought weight mattered in everything that's how they find the ld50's for most drugs. Usually based on a rodents weight though


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OfflineSheTripper
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Re: Why does weight matter? .. or does it? [Re: Cactilove]
    #14130705 - 03/16/11 01:01 PM (12 years, 10 months ago)

I don't think it matters for shrooms and LSD. Alcohol is effected by weight and gender. If anyone knows for sure if it does matter for everything or nothing your input is much appreciated. My curiosity is burning.


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InvisibleSamuel L Jackson
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Re: Why does weight matter? .. or does it? [Re: Cactilove]
    #14130730 - 03/16/11 01:04 PM (12 years, 10 months ago)

because more weight means more volume generally.

assume you weighed 100 pounds. assumed you took 10g of some drug.

thats .1g per pound.

if you weighed 200lbs it would be .05g per pound.

obviously if you have 2x the concentration of a drug in your blood you will get twice as fucked up.

its all about concentration really, not mass.

it applies to shrooms and lsd and stuff like that as well, but due to the fact that the active doses of drugs like that are really small (pure psilocybin/psilocin/lsd/etc) the change in concentration is minimal because the concentration in your blood is already very very small.

thats a logical explanation in my head, at least. i have no scientific backing to it (i just randomly made this post) but im fairly certain that is the reasoning behind it.


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OfflinePsil
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Re: Why does weight matter? .. or does it? [Re: Cactilove]
    #14130857 - 03/16/11 01:19 PM (12 years, 10 months ago)

SamuelLJackson speaks the truth. As body weight increases so does the volume of blood.  This means, given the same dose a heavier person will have a lower concentration of the drug in their body which will affect the availability of it in the brain where they work their magic.

However there are a lot of other factors to consider.  Receptor distribution, route of administration, tolerance and genetic factors can all play a part.


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InvisibleSamuel L Jackson
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Re: Why does weight matter? .. or does it? [Re: Psil]
    #14130890 - 03/16/11 01:23 PM (12 years, 10 months ago)

i would like to rephrase something.

the change in concentration of psychedelics isnt minimal even though your body weight doubles (as in my example). its just that the change in concentration doesnt have a large effect because our bodies are already so sensitive to those drugs, hence the fact that tiny amounts of those drugs alter your consciousness so profoundly.

alcohol and stuff like dxm require large doses (relative to lsd and such) because our bodies arent as sensitive to them. so the change in concentration is more noticeable.


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OfflineSheTripper
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Re: Why does weight matter? .. or does it? [Re: Samuel L Jackson]
    #14130993 - 03/16/11 01:35 PM (12 years, 10 months ago)

that actually makes a lot of sense, Thanks :stoned:


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InvisibleFerdinando
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Re: Why does weight matter? .. or does it? [Re: Samuel L Jackson]
    #14130996 - 03/16/11 01:35 PM (12 years, 10 months ago)

concentration is about ratio which does not depend on how big the parts are in and of themselves but only how big they are compared to each other
whether you are dealing with small or big amounts of active chemical does not matter here, the same math and general physics apply


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OfflineR2-D2
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Re: Why does weight matter? .. or does it? [Re: Samuel L Jackson]
    #14131009 - 03/16/11 01:36 PM (12 years, 10 months ago)

Weight doesn't matter for LSD, even for rats and horses and dolphins and shit afaik.
But it really really does for DXM. A LOT, as does general brain chemistry and stuff. It seems to me like DXM affects everyone quite differently, too.


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InvisibleCactilove
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Re: Why does weight matter? .. or does it? [Re: R2-D2]
    #14131298 - 03/16/11 02:14 PM (12 years, 10 months ago)

I require proof on why it's different for LSD. Link plz


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OfflineR2-D2
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Re: Why does weight matter? .. or does it? [Re: Cactilove]
    #14131578 - 03/16/11 02:56 PM (12 years, 10 months ago)

It's in John Lilly's The Scientist. Sorry, I don't have a link, but please take it with a grain of grain of salt anyways.
John Lilly inferred from this (the same dosage studies that made him conclude that dose is independent of body weight) that LSD is concentrated in the brain, which i'm pretty sure has been proven false.

But DXM dosage->effects vary a ton between different people.


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InvisibleFerdinando
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Re: Why does weight matter? .. or does it? [Re: R2-D2]
    #14131966 - 03/16/11 04:03 PM (12 years, 10 months ago)

atm I think it's true that LSD does not keep floating in blood for 12 hours or whatever and somehow does it's action in the brain during those hours without traces in the blood or quickly catalyzes some processes that end with the trip
would be nice to hear from people who know


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OfflineAzure Essence
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Re: Why does weight matter? .. or does it? [Re: Ferdinando]
    #14131991 - 03/16/11 04:10 PM (12 years, 10 months ago)

Yeah I read it's out of the body in a few hours, even before the trip is over


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OfflineRemix
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Re: Why does weight matter? .. or does it? [Re: R2-D2]
    #14132103 - 03/16/11 04:34 PM (12 years, 10 months ago)

It's possible there's a body weight factor w/LSD... it's just that LSD is so potent at such small doses that it just doesn't produce easily measurable differences.

I mean, we're talking micrograms here (1 microgram = 0.001 milligrams; 1 gram = one-million micrograms). The lower the necessary dose, the more potent the drug... which essentially means weight will be less of a factor regarding the overall perceived strength of the experience.


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OfflineAzure Essence
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Re: Why does weight matter? .. or does it? [Re: Remix]
    #14132133 - 03/16/11 04:40 PM (12 years, 10 months ago)

I think weight measurements, like Xmg/ug per Xg of bodyweight is only useful when trying to compare doses and what not.


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Invisibledrr
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Re: Why does weight matter? .. or does it? [Re: SheTripper]
    #14132219 - 03/16/11 04:58 PM (12 years, 10 months ago)

The idea is that when you ingest a substance, it goes into your bloodstream and disperses throughout your entire body, and that is why body weight is important.

But I think some substances aren't readily absorbed by the entire body, rather they make their way straight to specific sites probably in the brain and tend to stay there.

This is all my speculation I really don't know anything about bio-availability of chemicals. But I'm assuming it varies by substance. I'm also assuming that body weight is a factor in the response a person is going to get from a dose of any drug, among other factors.


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