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The affects of psliocin on a person has nothing to do with one's weight per se. Affects are more closely related to one's sensivity to the mushrooms. There's a few 250 lbs people I know who are able to achieve a high level trip off half of what I need (180lbs) to acheive the same affects. If your friend has experieced mushrooms in the past. . . starting with a realitively low dose and working his way up, he might have a pretty good idea how sensitive he his. But generally speaking, 3 g of dried mushrooms should affect a 210 lb person the same as a 150 lb person.