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OfflineMello KittyS
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Re: I just did a pill of X for the first time [Re: Cyclohexylamine]
    #14100905 - 03/10/11 09:32 PM (12 years, 11 months ago)

:bigyesnod:


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Offlinepfxtc
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Re: I just did a pill of X for the first time [Re: BothHands]
    #14100906 - 03/10/11 09:32 PM (12 years, 11 months ago)

Quote:

BothHands said:
Quote:

pfxtc said:
what's fun is taking a ton of E on a friday night

then a ton of DXM or any other drug that acts on seratonin

the receptors will be so drained that the drug will just flood everything

it "fucks" you up.




That doesn't sound right at all.

MDMA causes your neurons to release large amounts of serotonin into the synapses.  This does two things - it drains your neurons of serotonin, and it also downregulates your serotonin receptors, making them less sensitive to the serotonin that is there.

Because of this, you should have a tolerance to all other serotonergic drugs, not a sensitivity.  DXM releases some serotonin, but since your neurons are drained, there isn't too much to release.  But that's its only real action on serotonin.  DXM's main activity is on the glutamate receptors.

Now maybe what you say is true, but it's not for the reason you say it is.  Your glutamate receptors and your serotonin receptors have very dependent activity, and they affect each other in a lot of ways that aren't very well understood.  If DXM works better, it's because of some sort of complex interaction between the glutamate receptors and the serotonin receptors, not because the drug is "flooding everything"




You're probably right, I don't know anything about drug intereactions, I was just saying what seemed to make sense. I know both drugs work on seratonin so I went from there.

All I know is that if I took 2 hits of E and 600mg of DXM the next day, the trip would last about 3-5 times longer, and be about 3 times more intense then if I took the DXM alone.

Thanks for setting me straight.


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koods said:
Young male going by the name "Bassfreak" entered Worcester General complaining of a sharp pain in his buttock region after attending EDM event. Attending physician considered a possible diagnosis of acute rave anus, but upon further investigation it was determined there was nothing cute about patient's anus.

Life-long trip report

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Offlinepfxtc
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Re: I just did a pill of X for the first time [Re: I AM SWIM]
    #14100914 - 03/10/11 09:33 PM (12 years, 11 months ago)

Quote:

I AM SWIM said:
FACT: Vaped DMT Euphoria > IV heroin+hydromorphone Euphoria




So I guess I'll just stick with :deemsters:

:highfive:


--------------------

koods said:
Young male going by the name "Bassfreak" entered Worcester General complaining of a sharp pain in his buttock region after attending EDM event. Attending physician considered a possible diagnosis of acute rave anus, but upon further investigation it was determined there was nothing cute about patient's anus.

Life-long trip report

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OfflineI AM SWIM
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Re: I just did a pill of X for the first time [Re: pfxtc]
    #14100974 - 03/10/11 09:40 PM (12 years, 11 months ago)

euphoria from DMT is like being God and experiencing what gods eve
Quote:

pfxtc said:
Quote:

I AM SWIM said:
FACT: Vaped DMT Euphoria > IV heroin+hydromorphone Euphoria




So I guess I'll just stick with :deemsters:

:highfive:




I would.

nothang can beat

GODS ORGASM

:feelsgoodman:


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Invisiblejustaguy
Registered: 06/12/10
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Re: I just did a pill of X for the first time [Re: pfxtc]
    #14100978 - 03/10/11 09:41 PM (12 years, 11 months ago)

definitely not overrated. its the shit


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Offlinepfxtc
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Re: I just did a pill of X for the first time [Re: I AM SWIM]
    #14100998 - 03/10/11 09:43 PM (12 years, 11 months ago)

Quote:

I AM SWIM said:
euphoria from DMT is like being God and experiencing what gods eve
Quote:

pfxtc said:
Quote:

I AM SWIM said:
FACT: Vaped DMT Euphoria > IV heroin+hydromorphone Euphoria




So I guess I'll just stick with :deemsters:

:highfive:




I would.

nothang can beat

GODS ORGASM

:feelsgoodman:




:lol: Just thinking of it is awesome

I remember my most intense trip

it was like, everything infront of me was white, if I didn't know any better I'd say I was on a spaceship or something.

My body was like screaming from feeling so amazing... I had to think myself out of it because it was just too much.


--------------------

koods said:
Young male going by the name "Bassfreak" entered Worcester General complaining of a sharp pain in his buttock region after attending EDM event. Attending physician considered a possible diagnosis of acute rave anus, but upon further investigation it was determined there was nothing cute about patient's anus.

Life-long trip report

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OfflineBothHands
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Re: I just did a pill of X for the first time [Re: pfxtc]
    #14101015 - 03/10/11 09:46 PM (12 years, 11 months ago)

I found your answer.

MDMA inhibits the CYP2D enzymes for up to a week after your dose.  CYP2D6 is the primary enzyme responsible for breaking down DXM.

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Offlinepfxtc
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Re: I just did a pill of X for the first time [Re: BothHands]
    #14101035 - 03/10/11 09:49 PM (12 years, 11 months ago)

Quote:

BothHands said:
I found your answer.

MDMA inhibits the CYP2D enzymes for up to a week after your dose.  CYP2D6 is the primary enzyme responsible for breaking down DXM.




Well Miss Maam if you're keen on doing some more research, could you tell me if said reaction is harmful or toxic at all?

I honestly feel like those experiences fucked me up a little.


--------------------

koods said:
Young male going by the name "Bassfreak" entered Worcester General complaining of a sharp pain in his buttock region after attending EDM event. Attending physician considered a possible diagnosis of acute rave anus, but upon further investigation it was determined there was nothing cute about patient's anus.

Life-long trip report

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Offlinedshow
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Re: I just did a pill of X for the first time [Re: pfxtc]
    #14101055 - 03/10/11 09:53 PM (12 years, 11 months ago)

Quote:

ongratz on the pipe, cus if it was real mdma, u would be stating otherwise




This and if you get bad pills or need to usually take more, you just in a bad region. Cali-az-vegas are the best places to get constant good shit.

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InvisibleCyclohexylamine
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Re: I just did a pill of X for the first time [Re: dshow]
    #14101061 - 03/10/11 09:53 PM (12 years, 11 months ago)

Quote:

dshow said:
Quote:

ongratz on the pipe, cus if it was real mdma, u would be stating otherwise




This and if you get bad pills or need to usually take more, you just in a bad region. Cali-az-vegas are the best places to get constant good shit.




Toronto is kind of MDMA capital :smile:
If you know where to look.
Pure pure pure.
mmmm


--------------------
Yes this is tymo - I just changed my name

Have you ever had a dream that you were so sure was real? What if you were unable to awake from that dream? How would you know the difference between that dream world and the real world?


There is NOTHING better than feeling that warm dissociative fuzz creeping up your body from IM K
Something abut that anaesthetic rush... :inlove:

Qualitative Research Chemical Effects and Experiences
The Wonderful World of Methoxetamine
The 3-Meo-PCP Chapters, Part One

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Offlinedshow
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Re: I just did a pill of X for the first time [Re: dshow]
    #14101063 - 03/10/11 09:54 PM (12 years, 11 months ago)

X is DA BOMB. You have great shit and your world becomes WINNING!

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OfflineBothHands
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Re: I just did a pill of X for the first time [Re: pfxtc]
    #14101070 - 03/10/11 09:55 PM (12 years, 11 months ago)

Well, DXM is a much more potent SRI, while DXO (the byproduct of CYP2D6 metabolism) is much less active on serotonin, and much more active on the glutamate receptors.

My guess is that the much more potent serotonin activity of your DXM experience directly following a powerful serotonergic experience on MDMA would cause more downregulation of the serotonin receptors.  This means your tolerance to your own serotonin is so high, that normal levels aren't good enough (and you're below normal levels).  That's probably why you feel like shit.  I think that if you did MDMA two days in a row, you'd have a similar experience.

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OfflineFrost
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Re: I just did a pill of X for the first time [Re: pfxtc] * 1
    #14101072 - 03/10/11 09:55 PM (12 years, 11 months ago)

Quote:

pfxtc said:


xanax is way betterer




No. That statement is fucking ludicrous. Xanax is whack compared to MDMA.

Also, taknig a random pill of ecstasy is not a good way to judge how it feels to roll. The first time I rolled there's no fucking way in hell that you'd find me on the internet posting about.
Find better X and go talk to your friends.


--------------------
“I have lived on the lip of insanity, wanting to know reasons, knocking on a door. It opens.
I've been knocking from the inside.” - Rumi

“The nitrogen in our DNA, the calcium in our teeth, the iron in our blood, the carbon in our apple pies were made in the interiors of collapsing stars. We are made of starstuff.” - Carl Sagan

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Offlinepfxtc
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Re: I just did a pill of X for the first time [Re: BothHands]
    #14101082 - 03/10/11 09:57 PM (12 years, 11 months ago)

Quote:

BothHands said:
Well, DXM is a much more potent SRI, while DXO (the byproduct of CYP2D6 metabolism) is much less active on serotonin, and much more active on the glutamate receptors.

My guess is that the much more potent serotonin activity of your DXM experience directly following a powerful serotonergic experience on MDMA would cause more downregulation of the serotonin receptors.  This means your tolerance to your own serotonin is so high, that normal levels aren't good enough (and you're below normal levels).  That's probably why you feel like shit.  I think that if you did MDMA two days in a row, you'd have a similar experience.




Well I don't know if feel like shit is the right way to phrase it, I havn't done said combo in about 2 years, but I still feel slightly retarded from it :lol:


--------------------

koods said:
Young male going by the name "Bassfreak" entered Worcester General complaining of a sharp pain in his buttock region after attending EDM event. Attending physician considered a possible diagnosis of acute rave anus, but upon further investigation it was determined there was nothing cute about patient's anus.

Life-long trip report

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Offlinepfxtc
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Re: I just did a pill of X for the first time [Re: Frost]
    #14101086 - 03/10/11 09:58 PM (12 years, 11 months ago)

Quote:

Frost said:
Quote:

pfxtc said:


xanax is way betterer




No. That statement is fucking ludicrous. Xanax is whack compared to MDMA.

Also, taknig a random pill of ecstasy is not a good way to judge how it feels to roll. The first time I rolled there's no fucking way in hell that you'd find me on the internet posting about.
Find better X and go talk to your friends.




Which part of I've done 30+ pills did you miss?

15 Ecstasy trips vs 1 Xanax trip, and I liked Xanax more.


--------------------

koods said:
Young male going by the name "Bassfreak" entered Worcester General complaining of a sharp pain in his buttock region after attending EDM event. Attending physician considered a possible diagnosis of acute rave anus, but upon further investigation it was determined there was nothing cute about patient's anus.

Life-long trip report

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OfflineBothHands
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Re: I just did a pill of X for the first time [Re: pfxtc]
    #14101092 - 03/10/11 09:59 PM (12 years, 11 months ago)

Lesions? :wow:

Joking.. :tongue2:

I really don't know, to be honest.  Maybe you just fried something.

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Offlinepfxtc
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Re: I just did a pill of X for the first time [Re: BothHands]
    #14101102 - 03/10/11 10:00 PM (12 years, 11 months ago)

I was always curious, thanks for looking it up for me :highfive:

But boy flying through space and opening doors to alternate dimensions that were more real then reality was worth it I think.


--------------------

koods said:
Young male going by the name "Bassfreak" entered Worcester General complaining of a sharp pain in his buttock region after attending EDM event. Attending physician considered a possible diagnosis of acute rave anus, but upon further investigation it was determined there was nothing cute about patient's anus.

Life-long trip report

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Offlinedshow
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Re: I just did a pill of X for the first time [Re: pfxtc] * 1
    #14101115 - 03/10/11 10:03 PM (12 years, 11 months ago)

Quote:

15 Ecstasy trips vs 1 Xanax trip, and I liked Xanax more.




You are one silly little creature.

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Offlinepfxtc
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Re: I just did a pill of X for the first time [Re: dshow]
    #14101123 - 03/10/11 10:04 PM (12 years, 11 months ago)

it's a long story

i took E on the Xanax trip too

:fire:


--------------------

koods said:
Young male going by the name "Bassfreak" entered Worcester General complaining of a sharp pain in his buttock region after attending EDM event. Attending physician considered a possible diagnosis of acute rave anus, but upon further investigation it was determined there was nothing cute about patient's anus.

Life-long trip report

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OfflineMLDSMDA
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Re: I just did a pill of X for the first time [Re: pfxtc]
    #14101164 - 03/10/11 10:10 PM (12 years, 11 months ago)

Just want to point out, in my experience at least no rolls I've ever taken will compare with a 1/4 gram of molly. I love xanax too, but everyone I know who has a script for it becomes a retarded zombie who can't remember how many pills he took. Then they take more, and an insane cycle of forgetting important shit happens.

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