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Offlinedestructo_low
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Re: I got second place [Re: mellowparty]
    #14048767 - 03/01/11 02:16 PM (13 years, 4 days ago)

Quote:

mellowparty said:
Openmind posted it in the poast when u smoke thread and I also found it on the growery
Quote:


http://en.wikipedia.org/wiki/Cannabinoid
Once in the body, most cannabinoids are metabolized in the liver, especially by cytochrome P450 mixed-function oxidases, mainly CYP 2C9. Thus supplementing with CYP 2C9 inhibitors leads to extended intoxication.

http://en.wikipedia.org/wiki/CYP2C9
CYP2C9 is an important cytochrome P450 enzyme with a major role in the oxidation of both xenobiotic and endogenous compounds.

In the CYP2C9 article under CYP2C9 Ligands there's a chart entitled Selected inducers, inhibitors and substrates of CYP2C9. Cannabinoids are listed as a minor substrate, amentoflavone (constituent of Ginkgo biloba and St. John’s Wort is listed as a strong inhibitor but hyperforin (constituent of St John's Wort) is listed as a weak inducer.

I'm no scientist so maybe I missed something and am way off with this. I happened to have some St. John's Wort kicking around and took 600mg about an hour ago but i'm on my third day of what was supposed to be a week long tolerance break, so i'm not going to be able to tell if its working but i'm gonna try it anyway. What do you guys think?




A week could be a bit too long to wait :shrug: I guess 4-5 hours will do fine. Someone really should try it out.




What if you super dosed with Ginko Balboa daily to stop your body from ever breaking down THC? I wonder if you could you smoke and piss clean... Are there anything you need those enzymes that might kill you otherwise?


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Offlinemellowparty
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Re: I got second place [Re: destructo_low]
    #14048785 - 03/01/11 02:20 PM (13 years, 4 days ago)

Quote:

Are there anything you need those enzymes that might kill you otherwise?



They deal with xenobiotics. That is exogenous compounds that might harm your body in one way or another. And no you cannot inhibit them for life. You'll have to shut down their genes but thats not likely to happen :shrug:


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Offlinedestructo_low
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Re: I got second place [Re: mellowparty]
    #14048806 - 03/01/11 02:26 PM (13 years, 4 days ago)

Quote:

mellowparty said:
Quote:

Are there anything you need those enzymes that might kill you otherwise?



They deal with xenobiotics. That is exogenous compounds that might harm your body in one way or another. And no you cannot inhibit them for life. You'll have to shut down their genes but thats not likely to happen :shrug:




Damn. It would be cool to fuck up a urine test molecularly. Maybe a pill you could take to bind to the metabolite in your urine, so it won't trigger the positive result in the screen? You might could possibly create a chemical you could add to your piss in the cup to render the metabolite untestable.


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Offline13.step
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Re: I got second place [Re: destructo_low]
    #14048815 - 03/01/11 02:29 PM (13 years, 4 days ago)

There should be some irreversible inhibitors that shut them down 'till the body grows more. Those would probably stretch out the high a bit more.

You wouldn't be able to smoke and piss clean, THC itself will probably get eliminated as is and tests might pick it up (have no idea for what they test) and there is a very high chance that some other enzymes pick up the metabolism of THC.

Hmmm...you might be on to something with the binding of the metabolites in urine...that would probably work until they get smart on it.


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Offlinemellowparty
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Re: I got second place [Re: 13.step]
    #14048835 - 03/01/11 02:33 PM (13 years, 4 days ago)

Some sort of high-affinity binding protein but I have absolutely no idea what that could be or where u can get it from.

The way I'd approach that would be oxidize the metabolites. Maybe adding bleach of peroxide could work. I dont know how the tests would react to it though...


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Offline13.step
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Re: I got second place [Re: mellowparty]
    #14048862 - 03/01/11 02:37 PM (13 years, 4 days ago)

Nah...it shouldn't be that complicated...chemically binding a metabolite to some big molecule should make it hard to detect. I assume most tests are some sort of chromatography, at lest the quick ones.


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Offlinedestructo_low
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Re: I got second place [Re: 13.step]
    #14048868 - 03/01/11 02:38 PM (13 years, 4 days ago)

I think they test for 11-COOH-THC and 11-OH-THC. I'm not sure if THC would cause a false positive, but I don't know if your body could even break it down if you didn't use those enzymes.


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Offlinemellowparty
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Re: I got second place [Re: 13.step]
    #14049796 - 03/01/11 05:10 PM (13 years, 4 days ago)

I thought it was some kind of colour product reaction


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Offline13.step
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Re: I got second place [Re: mellowparty]
    #14050086 - 03/01/11 06:02 PM (13 years, 4 days ago)

I have no idea...the ones that I saw where chromatography-tests, they put a drop of biological fluid on a strip, wait a bit and it changes some colors, there is a color reaction involved, but the separation should be chromatographical...depends on the type of test though...


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InvisibleCaine
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Re: I got second place [Re: 13.step]
    #14050134 - 03/01/11 06:07 PM (13 years, 4 days ago)

Yeah, they do that, and if it tests positive on the initial test they take it to a GC-MS lab.

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Offlinemellowparty
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Re: I got second place [Re: 13.step]
    #14050140 - 03/01/11 06:08 PM (13 years, 4 days ago)

Are there any new tests that detect jwh compounds?


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InvisibleCaine
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Re: I got second place [Re: mellowparty]
    #14050164 - 03/01/11 06:10 PM (13 years, 4 days ago)

You can use GC-MS or LC-MS to find metabolites of 018, but that's pretty impractical so I doubt they'd start testing for them at work, etc.

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Offlinemellowparty
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Re: I got second place [Re: Caine]
    #14050176 - 03/01/11 06:13 PM (13 years, 4 days ago)

I wonder if there will be simple tests to detect jwh metabolites anytime soon.


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InvisibleCaine
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Re: I got second place [Re: mellowparty]
    #14050220 - 03/01/11 06:21 PM (13 years, 4 days ago)

The most prevalent metabolite seems to be the hydroxylated aromatic sections, which 018 has two of, napthalene and indole. I am starting to wonder if the suggestions about these compounds producing some possibly cancerous metabolites has any validity to it. There's 3 benzene rings in 018 alone.

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InvisiblePrisoner#1
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Re: I got second place [Re: Sleepwalker]
    #14050306 - 03/01/11 06:32 PM (13 years, 4 days ago)

Quote:

Oweyervishice said:
You didn't pay attention in elementary school.

First is the worst, second's the best.





so very true, #1 means you aint shit

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Offlinemellowparty
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Re: I got second place [Re: Prisoner#1]
    #14053265 - 03/02/11 08:24 AM (13 years, 3 days ago)

:confused2: whats the logic behind this?


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