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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 3 months
I got second place
    #14048022 - 03/01/11 11:24 AM (13 years, 4 days ago)

And I needed only 0.14% to be ranked 1st in my department. To be honest I didn't even expect to be in the top10. But the thought that this one guy I cant stand beats me with a fraction of the percent is :ffffuuu:


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Invisibleifoundwaldo


Registered: 09/28/10
Posts: 8,389
Loc: Denver, CO Flag
Re: I got second place [Re: mellowparty]
    #14048040 - 03/01/11 11:29 AM (13 years, 4 days ago)

A little context might help. :smirk:

Sales?


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InvisibleP-O
#AnyoneButHarper
 User Gallery


Registered: 05/13/09
Posts: 13,636
Loc: Flag
Re: I got second place [Re: mellowparty] * 7
    #14048043 - 03/01/11 11:30 AM (13 years, 4 days ago)


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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 3 months
Re: I got second place [Re: ifoundwaldo]
    #14048052 - 03/01/11 11:32 AM (13 years, 4 days ago)

Quote:

ifoundwaldo said:
A little context might help. :smirk:

Sales?



School. Im doing a BSc in molecular biology and its fucking tough work. I got my results yesterday and was pretty amazed to see I'm second. But then I found out who was 1st in the department :crankey:

I blame it on my inconsistent piracetam regime and the lack of weed sessions to chill when I was studying.


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Edited by mellowparty (03/01/11 11:34 AM)

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Offline13.step
cynical bastard
Male


Registered: 08/30/09
Posts: 2,210
Last seen: 9 years, 4 months
Re: I got second place [Re: mellowparty]
    #14048064 - 03/01/11 11:35 AM (13 years, 4 days ago)

You know what to do...kick some teeth in to show who's boss.


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InvisibleSleepwalker
Overshoes


Registered: 05/07/08
Posts: 5,503
Re: I got second place [Re: mellowparty] * 2
    #14048082 - 03/01/11 11:41 AM (13 years, 4 days ago)

You didn't pay attention in elementary school.

First is the worst, second's the best.

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Invisibleifoundwaldo


Registered: 09/28/10
Posts: 8,389
Loc: Denver, CO Flag
Re: I got second place [Re: mellowparty]
    #14048091 - 03/01/11 11:43 AM (13 years, 4 days ago)

Quote:

mellowparty said:
Quote:

ifoundwaldo said:
A little context might help. :smirk:

Sales?



School. Im doing a BSc in molecular biology and its fucking tough work. I got my results yesterday and was pretty amazed to see I'm second. But then I found out who was 1st in the department :crankey:

I blame it on my inconsistent piracetam regime and the lack of weed sessions to chill when I was studying.




Piracetam eh? You take that regularly as a supplement?
What else?


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OfflinePatlal
You ask too many questions
Male User Gallery


Registered: 10/09/10
Posts: 44,818
Loc: Ottawa Flag
Last seen: 6 hours, 12 minutes
Re: I got second place [Re: ifoundwaldo]
    #14048102 - 03/01/11 11:46 AM (13 years, 4 days ago)

This thread is too intelligent for me.


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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 3 months
Re: I got second place [Re: ifoundwaldo]
    #14048137 - 03/01/11 11:56 AM (13 years, 4 days ago)

Quote:

ifoundwaldo said:
Quote:

mellowparty said:
Quote:

ifoundwaldo said:
A little context might help. :smirk:

Sales?



School. Im doing a BSc in molecular biology and its fucking tough work. I got my results yesterday and was pretty amazed to see I'm second. But then I found out who was 1st in the department :crankey:

I blame it on my inconsistent piracetam regime and the lack of weed sessions to chill when I was studying.




Piracetam eh? You take that regularly as a supplement?
What else?



I take it for just a month before the exam to saturate ze brain with O2 :pipesmoke:
Also to complement its effects I used to take about 500mg choline and inositol.


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Offline13.step
cynical bastard
Male


Registered: 08/30/09
Posts: 2,210
Last seen: 9 years, 4 months
Re: I got second place [Re: mellowparty]
    #14048143 - 03/01/11 11:58 AM (13 years, 4 days ago)

Hmm...doesn't it work by enhancing communication in the corpus callosum? Ginkgo Biloba is the one with the O2


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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 3 months
Re: I got second place [Re: 13.step]
    #14048158 - 03/01/11 12:04 PM (13 years, 4 days ago)

From what I've read it seems to increase the bloodflow to yer brain thus leading to increase in oxygen concentration. And as you said it works on the corpus callosum as well as some others receptors/pathways I forgot about.

As for Ginkgo biloba I know it inhibits the action of some liver cytochromes that are needed for the processing of xenobiotics. To put it in context it affects the same enzymes that degrade THC and other drugs :yesnod:


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Invisibleifoundwaldo


Registered: 09/28/10
Posts: 8,389
Loc: Denver, CO Flag
Re: I got second place [Re: mellowparty]
    #14048169 - 03/01/11 12:07 PM (13 years, 4 days ago)

Quote:

mellowparty said:
Quote:

ifoundwaldo said:
Quote:

mellowparty said:
Quote:

ifoundwaldo said:
A little context might help. :smirk:

Sales?



School. Im doing a BSc in molecular biology and its fucking tough work. I got my results yesterday and was pretty amazed to see I'm second. But then I found out who was 1st in the department :crankey:

I blame it on my inconsistent piracetam regime and the lack of weed sessions to chill when I was studying.




Piracetam eh? You take that regularly as a supplement?
What else?



I take it for just a month before the exam to saturate ze brain with O2 :pipesmoke:
Also to complement its effects I used to take about 500mg choline and inositol.




And here I am saturating my brain with O2 sober... like a sucker!


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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 3 months
Re: I got second place [Re: ifoundwaldo]
    #14048184 - 03/01/11 12:12 PM (13 years, 4 days ago)

I find piracetam quite useful for acid trips. Prior to my first acid trip I ate about 8g of piracetam and then ate a single hit. Later I found out that the hit was a bit too strong for the novice and the piracetam had made it even stronger :lol: Good times.

I definitely recommend this combo :super:


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InvisibleLobsterSauceDiscord
 User Gallery

Registered: 11/09/08
Posts: 19,884
Re: I got second place [Re: ifoundwaldo]
    #14048187 - 03/01/11 12:13 PM (13 years, 4 days ago)

Quote:

mellowparty said:
Quote:

ifoundwaldo said:
Quote:

mellowparty said:
Quote:

ifoundwaldo said:
A little context might help. :smirk:

Sales?



School. Im doing a BSc in molecular biology and its fucking tough work. I got my results yesterday and was pretty amazed to see I'm second. But then I found out who was 1st in the department :crankey:

I blame it on my inconsistent piracetam regime and the lack of weed sessions to chill when I was studying.




Piracetam eh? You take that regularly as a supplement?
What else?



I take it for just a month before the exam to saturate ze brain with O2 :pipesmoke:
Also to complement its effects I used to take about 500mg choline and inositol.




And here I am saturating my brain with O2 sober... like a sucker!




:lol: :doh:


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Offline13.step
cynical bastard
Male


Registered: 08/30/09
Posts: 2,210
Last seen: 9 years, 4 months
Re: I got second place [Re: mellowparty]
    #14048195 - 03/01/11 12:15 PM (13 years, 4 days ago)

I think we're looking at two sides of the same coin here...:lol:

What does Ginkgo do with the enzymes? Well to the drugs actually, make 'em stronger or weaker?


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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 3 months
Re: I got second place [Re: 13.step]
    #14048201 - 03/01/11 12:17 PM (13 years, 4 days ago)

It inhibits some cytochrome isoforms in the liver that normally deal with the detoxification of foreign compounds. So in essence Ginkgo should increase the potency of a weed high. If you have any lying around conduct an assay and report back :pipesmoke:


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Offline13.step
cynical bastard
Male


Registered: 08/30/09
Posts: 2,210
Last seen: 9 years, 4 months
Re: I got second place [Re: mellowparty]
    #14048266 - 03/01/11 12:31 PM (13 years, 4 days ago)

:lol:...no I don't have either of those around sadly...but that is an interesting fact, I didn't know that. I think you'd need at least a week on Ginkgo before the enzyme is properly inhibited.


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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 3 months
Re: I got second place [Re: 13.step]
    #14048598 - 03/01/11 01:44 PM (13 years, 4 days ago)

Openmind posted it in the poast when u smoke thread and I also found it on the growery
Quote:


http://en.wikipedia.org/wiki/Cannabinoid
Once in the body, most cannabinoids are metabolized in the liver, especially by cytochrome P450 mixed-function oxidases, mainly CYP 2C9. Thus supplementing with CYP 2C9 inhibitors leads to extended intoxication.

http://en.wikipedia.org/wiki/CYP2C9
CYP2C9 is an important cytochrome P450 enzyme with a major role in the oxidation of both xenobiotic and endogenous compounds.

In the CYP2C9 article under CYP2C9 Ligands there's a chart entitled Selected inducers, inhibitors and substrates of CYP2C9. Cannabinoids are listed as a minor substrate, amentoflavone (constituent of Ginkgo biloba and St. John’s Wort is listed as a strong inhibitor but hyperforin (constituent of St John's Wort) is listed as a weak inducer.

I'm no scientist so maybe I missed something and am way off with this. I happened to have some St. John's Wort kicking around and took 600mg about an hour ago but i'm on my third day of what was supposed to be a week long tolerance break, so i'm not going to be able to tell if its working but i'm gonna try it anyway. What do you guys think?




A week could be a bit too long to wait :shrug: I guess 4-5 hours will do fine. Someone really should try it out.


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Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 3 months
Re: I got second place [Re: mellowparty]
    #14048605 - 03/01/11 01:45 PM (13 years, 4 days ago)

Ah here is a decent well referenced post about it :yesnod:

http://www.growery.org/forums/showflat.php/Number/528332#528332

props to openmind :stoner:


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Offline13.step
cynical bastard
Male


Registered: 08/30/09
Posts: 2,210
Last seen: 9 years, 4 months
Re: I got second place [Re: mellowparty]
    #14048623 - 03/01/11 01:48 PM (13 years, 4 days ago)

I remember a thing about inhibition taking a bit longer to happen then induction. Probably depends on the substance and the enzyme...


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