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OfflineSoftmachinethird
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linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses
    #13919568 - 02/07/11 05:44 AM (10 years, 11 months ago)

Dear Community,

Is there anybody out there that can inform me whether or not there a link between the use of Psilocybin Mushrooms and the development of Schizophrenia and other mental illnesses?


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InvisibleRahz
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Softmachinethird]
    #13919586 - 02/07/11 05:59 AM (10 years, 11 months ago)

According to some studies, it can cause latent issues to arise, though I would hesitate to classify the majority of post trip symptoms with a clinical term like that. Depends on what is being experienced. Care to give more information?


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rahz

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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Rahz]
    #13919606 - 02/07/11 06:22 AM (10 years, 11 months ago)

On a purely mental level - it depends on your psychology. If a latent issue arises during the trip and you focus on & get sucked into the problematic scope of the issue, then you might well leave the trip with that problematic issue at the forefront of your thinking.


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OfflineSoftmachinethird
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: nesm]
    #13925145 - 02/08/11 02:03 AM (10 years, 11 months ago)

Well, I suppose what I am asking is there a correlation between Schizophrenia or psychosis and the use of Psilocybin. I have yet to use Psilocybin Mushrooms, I am eager to do so. My family does not have a history of Schizophrenia or psychosis. I am just considered I may develop some mental disorder. I am actually a pretty inexperienced drug user, as far as psychedelics. Im well acquainted  with our good friend Mary Jane. I have consumed alcohol on several occoniasion, though I do not appreciate the effects of alcohol intoxication. Technically speaking, DMT has been in my system on the basis that pineal gland releases small amounts. Do think this is a legitimate concern? is there a correlation?


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InvisibledeCypher
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Softmachinethird]
    #13925185 - 02/08/11 02:12 AM (10 years, 11 months ago)

Quote:

Softmachinethird said:
Technically speaking, DMT has been in my system on the basis that pineal gland releases small amounts.




This is unfounded speculation FYI.  On topic, if you have no history in your family of mental illness and you're in a stable mind-set (not feeling depressed or manic) then you ought to be fine with a low dose.  :thumbup:


--------------------
We are all in the gutter, but some of us are looking at the stars.


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Offlinecircastes
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: deCypher]
    #13925457 - 02/08/11 03:21 AM (10 years, 11 months ago)

IME mental issues disappeared after mushroom use.


--------------------
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InvisibleIcelander
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Softmachinethird]
    #13925699 - 02/08/11 05:26 AM (10 years, 11 months ago)

Quote:

Softmachinethird said:
Well, I suppose what I am asking is there a correlation between Schizophrenia or psychosis and the use of Psilocybin. I have yet to use Psilocybin Mushrooms, I am eager to do so. My family does not have a history of Schizophrenia or psychosis. I am just considered I may develop some mental disorder. I am actually a pretty inexperienced drug user, as far as psychedelics. Im well acquainted  with our good friend Mary Jane. I have consumed alcohol on several occoniasion, though I do not appreciate the effects of alcohol intoxication. Technically speaking, DMT has been in my system on the basis that pineal gland releases small amounts. Do think this is a legitimate concern? is there a correlation?





Fear is a very normal reaction to the unknown. I'm always nervous a little when taking the dose and I've tripped literally hundreds of times.  It sounds like your just scared.


--------------------
"Don't believe everything you think". -Anom.

" All that lives was born to die"-Anom.

With much wisdom comes much sorrow,
The more knowledge, the more grief.
Ecclesiastes circa 350 BC


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InvisiblePoid
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illne [Re: circastes]
    #13927281 - 02/08/11 03:05 PM (10 years, 11 months ago)

Quote:

circastes said:
IME mental issues disappeared after mushroom use.


All of them? :rolleyes:


--------------------
Well I try my best to be just like I am, but everybody wants you to be just like them. --  Bob Dylan
fireworks_god said:
It's one thing to simply enjoy a style of life that one enjoys, but it's another thing altogether to refer to another person's choice as "wrong" or to rationalize their behavior as being pathological or resulting from some sort of inadequacy or failing so as to create a sense of superiority or separation as yet another projection of a personal fear or control issue.


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OfflineKickleM
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Icelander]
    #13927333 - 02/08/11 03:18 PM (10 years, 11 months ago)

Quote:

Icelander said:
Quote:

Softmachinethird said:
Well, I suppose what I am asking is there a correlation between Schizophrenia or psychosis and the use of Psilocybin. I have yet to use Psilocybin Mushrooms, I am eager to do so. My family does not have a history of Schizophrenia or psychosis. I am just considered I may develop some mental disorder. I am actually a pretty inexperienced drug user, as far as psychedelics. Im well acquainted  with our good friend Mary Jane. I have consumed alcohol on several occoniasion, though I do not appreciate the effects of alcohol intoxication. Technically speaking, DMT has been in my system on the basis that pineal gland releases small amounts. Do think this is a legitimate concern? is there a correlation?





Fear is a very normal reaction to the unknown. I'm always nervous a little when taking the dose and I've tripped literally hundreds of times.  It sounds like your just scared.




This.

And the correlation is that some individuals have experienced schizophrenic symptoms after ingesting a psychedelic substance. Those who persist in the symptoms have been found to have all the neurological markers of schizophrenia, suggesting that the psychedelic acted as a catalyst, or trigger. There are other suspected catalysts as well, and they typically revolve around stress. The death of a loved one, the loss of a job and financial strain are some examples. The theory is that the pathology exists from birth and requires a trigger before symptoms manifest.

Whether or not that theory is accurate, I dunno. Schizophrenia is a pretty ill-understood disorder. There is evidence to suggest that something like this is going on. And it is this theory that leads to the belief that if your family history is free from the disorder, there is little chance of having the genetic predisposition that is required for a psychedelic triggering. It's important to note that stress can bring up a lot of latent issues, regardless.

The available research on psychedelics suggests that negative outcomes are rare. Follow ups on the negative outcomes have thus far revealed no lasting ill-effects. All recent research has been completed with subjects that pass psychological assessment and have no family history of schizophrenia.


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Invisibleredgreenvines
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Kickle]
    #13932070 - 02/09/11 07:06 AM (10 years, 11 months ago)

this bugs me
Quote:

The theory is that the pathology exists from birth and requires a trigger before symptoms manifest.




a) it is not a pathology.
b) how can "the pathology" be assigned to the moment of birth.

yet it is a "common understanding" like "in god we trust"


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: redgreenvines]
    #13932790 - 02/09/11 12:08 PM (10 years, 11 months ago)

How is schizophrenia not a pathology?  :confused:


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: redgreenvines]
    #13932911 - 02/09/11 12:43 PM (10 years, 11 months ago)

Quote:

redgreenvines said:
this bugs me
Quote:

The theory is that the pathology exists from birth and requires a trigger before symptoms manifest.




b) how can "the pathology" be assigned to the moment of birth.


What do you mean by this? He's not saying that it somehow magically appears at the moment of birth, he's just saying that it exists from birth.


--------------------
Well I try my best to be just like I am, but everybody wants you to be just like them. --  Bob Dylan
fireworks_god said:
It's one thing to simply enjoy a style of life that one enjoys, but it's another thing altogether to refer to another person's choice as "wrong" or to rationalize their behavior as being pathological or resulting from some sort of inadequacy or failing so as to create a sense of superiority or separation as yet another projection of a personal fear or control issue.


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Softmachinethird]
    #16403787 - 06/19/12 03:47 PM (9 years, 6 months ago)

I have some background with this subject in relation to mushrooms.  A very close friend of mine who had a very minor case of schizophrenia started selling shrooms in the town we lived in.  Before this happened he was an incredibly social person and everyone in our highschool loved his personality.  As he started selling shrooms he got into the habit of sticking around and taking them with the people he was selling them to.  He ended up eating about an ounce over the course of one week in 3 different trip sessions.  After the 3rd time he completely lost his ability to socially interact with anybody.. even his own family.  He started avoiding all of his friends and was never comfortable leaving his own house.  We were all incredibly worried about him because it seemed that he had become a completely different person.  He lost the ability to communicate with another person. He couldn't form full sentences and when he would speak it came out as complete nonsense. "that girl has a purple brain and that girl has a striped brain!" things like that.  Its been over 3 years since he took that last dose of mushrooms and it really hurts me to say that he couldn't afford to live in his apartment due to lack of funds.  I've recently learned that hes homeless now and its hard to imagine that my old best friend is another crazy homeless person spewing nonsense on a street corner but thats the sad reality.


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: thizzymonkey]
    #16404389 - 06/19/12 05:45 PM (9 years, 6 months ago)

That my friend is the spiritual power of shrooms at work.  Isn't enlightenment fun? :haha:

Everyone must take them. :monkeydance:


--------------------
"Don't believe everything you think". -Anom.

" All that lives was born to die"-Anom.

With much wisdom comes much sorrow,
The more knowledge, the more grief.
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Invisibledustinthewind13
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: deCypher]
    #16405013 - 06/19/12 07:39 PM (9 years, 6 months ago)

Quote:

deCypher said:
Quote:

Softmachinethird said:
Technically speaking, DMT has been in my system on the basis that pineal gland releases small amounts.




This is unfounded speculation FYI.  On topic, if you have no history in your family of mental illness and you're in a stable mind-set (not feeling depressed or manic) then you ought to be fine with a low dose.  :thumbup:




The fact that DMT is endogenously produced by the pineal gland might be mere speculation, but there seems to be evidence that DMT is in fact endogenously produced. This article even claims that DMT may in fact help rather than worsen psychosis.

"The presence of the potent hallucinogenic psychoactive chemical N,N-dimethyltryptamine (DMT) in the human body has puzzled scientists for decades. Endogenous DMT was investigated in the 1960s and 1970s and it was proposed that DMT was involved in psychosis and schizophrenia. This hypothesis developed from comparisons of the blood and urine of schizophrenic and control subjects. However, much of this research proved inconclusive and conventional thinking has since held that trace levels of DMT, and other endogenous psychoactive tryptamines, are insignificant metabolic byproducts. The recent discovery of a G-protein-coupled, human trace amine receptor has triggered a reappraisal of the role of compounds present in limited concentrations in biological systems. Interestingly enough, DMT and other psychoactive tryptamine hallucinogens elicit a robust response at the trace amine receptor. While it is currently accepted that serotonin 5-HT2A receptors play a pivotal role in the activity of hallucinogenic/psychedelic compounds, we propose that the effects induced by exogenous DMT administration, especially at low doses, are due in part to activity at the trace amine receptor. Furthermore, we suggest that endogenous DMT interacts with the TA receptor to produce a calm and relaxed mental state, which may suppress, rather than promote, symptoms of psychosis. This hypothesis may help explain the inconsistency in the early analysis of endogenous DMT in humans. Finally, we propose that amphetamine action at the TA receptor may contribute to the calming effects of amphetamine and related drugs, especially at low doses."

Linky


--------------------
"It is the peculiar quality of a fool to perceive the faults of others and forget his own." - Marcus Tullius Cicero

"A room without books is like a body without a soul."  - Marcus Tullius Cicero

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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Icelander]
    #16405067 - 06/19/12 07:50 PM (9 years, 6 months ago)

Bad side effects from a hallucinogen? I don't believe it, he must not have been an authentic shaman like me.



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OfflineFreedom
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: dustinthewind13]
    #16405172 - 06/19/12 08:08 PM (9 years, 6 months ago)

that article is also unfounded speculation. more unfounded speculation says 'endogenous' dmt binds to the sigma receptor :shrug:


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Invisibledustinthewind13
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Freedom]
    #16405206 - 06/19/12 08:15 PM (9 years, 6 months ago)

Quote:

Freedom said:
that article is also unfounded speculation. more unfounded speculation says 'endogenous' dmt binds to the sigma receptor :shrug:




So there is no proof that DMT occurs endogenously in the human body?


--------------------
"It is the peculiar quality of a fool to perceive the faults of others and forget his own." - Marcus Tullius Cicero

"A room without books is like a body without a soul."  - Marcus Tullius Cicero

"Do not bite at the bait of pleasure, till you know there is no hook beneath it." -Thomas Jefferson


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: dustinthewind13]
    #16405484 - 06/19/12 09:06 PM (9 years, 6 months ago)

I shouldn't say unfounded, but it is speculation that endogenous dmt (which has been found endogenously in multiple studies) has a biological role in binding to the trace amine receptor or the sigma receptor (or serotonin receptors) in the brain.

part of the problem with this is the enzyme that is thought to make the dmt hasn't been found in the brain. so if dmt is signaling to the brain it would probably have to be released into the blood or cerbrial spinal fluid.

if dmt has some kind of normal function this way, an interesting study would be to block the n-methyltransferase and see if it has any change on attention or anxiety or dreaming or any other activity dmt is thought to have a role in.


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Freedom]
    #16405518 - 06/19/12 09:13 PM (9 years, 6 months ago)

That's better. :tongue:


--------------------
"It is the peculiar quality of a fool to perceive the faults of others and forget his own." - Marcus Tullius Cicero

"A room without books is like a body without a soul."  - Marcus Tullius Cicero

"Do not bite at the bait of pleasure, till you know there is no hook beneath it." -Thomas Jefferson


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Offlineblingbling
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: redgreenvines]
    #16407733 - 06/20/12 08:53 AM (9 years, 6 months ago)

Quote:

redgreenvines said:
this bugs me
Quote:

The theory is that the pathology exists from birth and requires a trigger before symptoms manifest.




a) it is not a pathology.
b) how can "the pathology" be assigned to the moment of birth.

yet it is a "common understanding" like "in god we trust"




"If you talk to God, you are praying; if God talks to you, you have schizophenia. If the dead talk to you, you are a spiritualist; if you talk to the dead, you are a schizophenic." - Thomas Szasz

"Schizophenia is simply a collection of syptoms judged to be maladaptive. If an individual fails to drive their automobile in a safe manner should psychiatrists address their mental health?" - blingbling


--------------------
Kupo said:
let's fuel the robots with psilocybin.

cez said:
everyone should smoke dmt for religion.

dustinthewind13 said:
euthanasia and prostitution should be legal and located in the same building.

White Beard said:
if you see the buddha on the road, rape him, then kill him. then rape him again.


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Invisibleredgreenvines
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: blingbling]
    #16412865 - 06/21/12 07:42 AM (9 years, 6 months ago)

errors:

1. endogenous dmt - there have not been numerous studies or experiments  proving the existence of endogenous dmt, instead, there have been numerous review papers published in scientific journals speculating about there being  endogenous dmt. experimental evidence is unconvincingly borderline compared to the level of belief in speculations about it. i.e. this is ANTI-SCIENCE.

2. this statement
Quote:

The theory is that the pathology exists from birth and requires a trigger before symptoms manifest.


could more accurately say
Quote:

The theory is that the potential for personality exists from birth and requires experiences before symptoms manifest.



**** the brain and body are not pathological, though they are susceptible to disorder and disease ****
calling schizophrenia a disease is a medical and legal convention.
it truly is a disorder, certainly one of the mind, but treatment for this is mostly applied to minimize impact on society - strongly indicative that this is most painfully addressed as a social disorder than as a mental disorder, and all conventions related to it are about social containment.

i.e. not from birth, unless you take fate-family dynamics-schoolyard incidents etc. as pathology - or unless we are all sick, some just coping more congenially and others getting 'treatment' for our earnest but failing attempts at dealing congenially.


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: redgreenvines]
    #16412878 - 06/21/12 07:52 AM (9 years, 6 months ago)

or unless we are all sick, some just coping more congenially and others getting 'treatment' for our earnest but failing attempts at dealing congenially.


:thumbup:  This is my conclusion.


--------------------
"Don't believe everything you think". -Anom.

" All that lives was born to die"-Anom.

With much wisdom comes much sorrow,
The more knowledge, the more grief.
Ecclesiastes circa 350 BC


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Icelander]
    #16412903 - 06/21/12 08:11 AM (9 years, 6 months ago)

if everyone is sick then there can be no standard with which we can determine health. we might as well say that everyone is healthy. imo the only thing we can say for sure is that everyone is different. when one persons difference is judged to be troublesome or maladaptive then we call that person sick. what is healthy boils down to consensus. the concepts of health and illness are arbitrary like all meaning.


--------------------
Kupo said:
let's fuel the robots with psilocybin.

cez said:
everyone should smoke dmt for religion.

dustinthewind13 said:
euthanasia and prostitution should be legal and located in the same building.

White Beard said:
if you see the buddha on the road, rape him, then kill him. then rape him again.


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: redgreenvines]
    #16412965 - 06/21/12 08:48 AM (9 years, 6 months ago)

Quote:

redgreenvines said:
errors:

1. endogenous dmt - there have not been numerous studies or experiments  proving the existence of endogenous dmt, instead, there have been numerous review papers published in scientific journals speculating about there being  endogenous dmt. experimental evidence is unconvincingly borderline compared to the level of belief in speculations about it. i.e. this is ANTI-SCIENCE.





"The identification of N:N-dimethyltryptamine in urine samples of drug-free chronic schizophrenic patients is confirmed by gas chromatography-mass spectrometry of both the free tertiary amine and the trimethylsilyl derivative. A quantitative method using single ion detection (m/e 58) is described. Urine samples from the six subjects were positive for bufotenin by both thin-layer chromatography and gas chromatography-mass spectrometry. Samples from three of the six subjects were also positive for N:N-dimethyltryptamine by both methods. Comparable results obtained by thin-layer chromatography and by single ion detection during gas chromatography-mass spectrometry showed that the levels of N:N-dimethyltryptamine in 24-hr urine samples were less than 1 μg."

linky


--------------------
"It is the peculiar quality of a fool to perceive the faults of others and forget his own." - Marcus Tullius Cicero

"A room without books is like a body without a soul."  - Marcus Tullius Cicero

"Do not bite at the bait of pleasure, till you know there is no hook beneath it." -Thomas Jefferson


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: dustinthewind13]
    #16413216 - 06/21/12 10:41 AM (9 years, 6 months ago)

I have previously read the free available part of this experiment which assesses bufotenin systemically but not in CNS and not in concentrations any way close to an amount that could be psychoactive.
I believe it was previously established that N:N-dimethyltryptamine is a breakdown product of bufotenin - If I had the full transcript of this report, I could be more specific about translating aspects of it for the layman.


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: redgreenvines]
    #16413226 - 06/21/12 10:45 AM (9 years, 6 months ago)

I didn't say anything about the CNS, concentrations or how it is biosynthesized. All I was saying is that it can endogenously occur in the human body.


--------------------
"It is the peculiar quality of a fool to perceive the faults of others and forget his own." - Marcus Tullius Cicero

"A room without books is like a body without a soul."  - Marcus Tullius Cicero

"Do not bite at the bait of pleasure, till you know there is no hook beneath it." -Thomas Jefferson


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: blingbling]
    #16413555 - 06/21/12 12:05 PM (9 years, 6 months ago)

Quote:

blingbling said:
if everyone is sick then there can be no standard with which we can determine health. we might as well say that everyone is healthy. imo the only thing we can say for sure is that everyone is different. when one persons difference is judged to be troublesome or maladaptive then we call that person sick. what is healthy boils down to consensus. the concepts of health and illness are arbitrary like all meaning.





If that works for you. :braindamage:

My "standards" include sicker and sickest. :haha:


--------------------
"Don't believe everything you think". -Anom.

" All that lives was born to die"-Anom.

With much wisdom comes much sorrow,
The more knowledge, the more grief.
Ecclesiastes circa 350 BC


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Invisibleredgreenvines
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: dustinthewind13]
    #16413562 - 06/21/12 12:08 PM (9 years, 6 months ago)

yes, I know, and I was impatient about it, and I am impatient regularly with science that is misleading.

I have also read of trace levels of DMT in non-schizophrenic individuals' urine too.

The reality is that this biochemical pathway is not what was alluded to by McKenna or Strassman.
And I am certain they were directed to the idea to support the story presented by others who were suggesting that the pineal gland is full of psychedelic stuff that gets depleted when you use LSD etc.

apologies for my impatience - do you have the full transcript?


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Invisibledustinthewind13
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: redgreenvines]
    #16413616 - 06/21/12 12:21 PM (9 years, 6 months ago)

Quote:

redgreenvines said:
yes, I know, and I was impatient about it, and I am impatient regularly with science that is misleading.

I have also read of trace levels of DMT in non-schizophrenic individuals' urine too.

The reality is that this biochemical pathway is not what was alluded to by McKenna or Strassman.
And I am certain they were directed to the idea to support the story presented by others who were suggesting that the pineal gland is full of psychedelic stuff that gets depleted when you use LSD etc.

apologies for my impatience - do you have the full transcript?




I understand why you got upset with my post. My lack of properly explaining myself in this thread could be interpreted by some as saying that what was written in the articles is all fact. However, none of the article abstracts I posted stated that the ideas they were proposing were fact, although they did state that DMT can be found in urine of subjects who did not take DMT and I decided to take that as fact, since they have proof of it being so, as they used instruments designed to detect drugs in urine.

As far as the transcript goes, no I do not have it, but I wish I did. Maybe the abstract was a faulty summary? I dunno.


--------------------
"It is the peculiar quality of a fool to perceive the faults of others and forget his own." - Marcus Tullius Cicero

"A room without books is like a body without a soul."  - Marcus Tullius Cicero

"Do not bite at the bait of pleasure, till you know there is no hook beneath it." -Thomas Jefferson


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Invisibledustinthewind13
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: dustinthewind13]
    #16413629 - 06/21/12 12:24 PM (9 years, 6 months ago)

Ok. Here is one instance where they say something as fact.

" DMT and other psychoactive tryptamine hallucinogens elicit a robust response at the trace amine receptor."

I don't know if this is so, as I do not have the article and do not know how they know this.


--------------------
"It is the peculiar quality of a fool to perceive the faults of others and forget his own." - Marcus Tullius Cicero

"A room without books is like a body without a soul."  - Marcus Tullius Cicero

"Do not bite at the bait of pleasure, till you know there is no hook beneath it." -Thomas Jefferson


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Invisibleredgreenvines
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: dustinthewind13]
    #16414408 - 06/21/12 03:04 PM (9 years, 6 months ago)

I don't know either but it is worth note that in non-human mamals  Trace amine-associated receptors, abbreviated TAAR receptors were located earlier and implicated as olfactory receptors.

one might suppose that

TAAR activation would encourage the animal (when minute trace amine concentrations were scented) to change mental state such that it has now found something of interest.

this is in some way simmilar to us getting some acid into the system and then the system reacting to release serotonin to make things more interesting, change our mental resonance to a higher state as it were.


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Invisibledustinthewind13
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: redgreenvines]
    #16414616 - 06/21/12 03:41 PM (9 years, 6 months ago)

If only those articles weren't so god damn expensive. :lol:


--------------------
"It is the peculiar quality of a fool to perceive the faults of others and forget his own." - Marcus Tullius Cicero

"A room without books is like a body without a soul."  - Marcus Tullius Cicero

"Do not bite at the bait of pleasure, till you know there is no hook beneath it." -Thomas Jefferson


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Offlinecircastes
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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: redgreenvines]
    #16414626 - 06/21/12 03:42 PM (9 years, 6 months ago)

Okay, if you are subject to the threat of schizophrenia, please listen:

Schizophrenics are Nature's gifts to human society. Schizophrenics are Nature's way of choosing messengers of truth.

Schizophrenia is also mostly indecision at the crossroads of heaven and hell.

I wouldn't be surprised if mushrooms will drive ANYONE schizophrenic, especially in this society. Ever felt while on mushrooms, that this is the way it SHOULD be? Well duh! Our little programmed sober reality is the true death, the true insanity.

All our disease and illness are a product of our common MINDSET.

"How they survive so misguided is a mystery" - Tool

Schizophrenia is when on a biological or neurological level the brain detects it is able to step up to a higher functioning and serve Nature (itself), so it forcefully destroys the "sober reality", not unlike what the mushrooms do, but the mushrooms are farrr more gentle.

Mostly if something is going wrong in your life you need to surrender to the Self.


--------------------
My solitude...
My shield...
My armour...

TESTED
WITH
FULL
FORCE


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: dustinthewind13]
    #16415053 - 06/21/12 04:44 PM (9 years, 6 months ago)

Quote:

dustinthewind13 said:
If only those articles weren't so god damn expensive. :lol:




here's a free one for you, and its the only one I'm aware of that shows activation by DMT (as well as MDMA, LSD, DOI and w bunch of other stuff, check out figure 3:

http://molpharm.aspetjournals.org/content/60/6/1181.full



Here's a free review:

http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0706948/full


there's been very little research done on these receptors, and most of that has been done on just one of them. There are 8 others that have been studied even less.


To say that endogenous DMT binds to trace amine receptors in the brain is speculation. To say that this has an anxiolytic role is wild speculation.


If you want to read a paper about the function of Taar1 that isn't based on wild speculation but actual experiments, look here: http://jpet.aspetjournals.org/content/324/3/948.long this paper convincingly shows it has a role in dopamine neurons IMO. Also the paper presents evidence of the protein in a bunch of brain areas.


--------------------


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Freedom]
    #16415245 - 06/21/12 05:11 PM (9 years, 6 months ago)

Quote:

Freedom said:
Quote:

dustinthewind13 said:
If only those articles weren't so god damn expensive. :lol:




here's a free one for you, and its the only one I'm aware of that shows activation by DMT (as well as MDMA, LSD, DOI and w bunch of other stuff, check out figure 3:

http://molpharm.aspetjournals.org/content/60/6/1181.full



Here's a free review:

http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0706948/full


there's been very little research done on these receptors, and most of that has been done on just one of them. There are 8 others that have been studied even less.


To say that endogenous DMT binds to trace amine receptors in the brain is speculation. To say that this has an anxiolytic role is wild speculation.


If you want to read a paper about the function of Taar1 that isn't based on wild speculation but actual experiments, look here: http://jpet.aspetjournals.org/content/324/3/948.long this paper convincingly shows it has a role in dopamine neurons IMO. Also the paper presents evidence of the protein in a bunch of brain areas.




I love you. :hug:


--------------------
"It is the peculiar quality of a fool to perceive the faults of others and forget his own." - Marcus Tullius Cicero

"A room without books is like a body without a soul."  - Marcus Tullius Cicero

"Do not bite at the bait of pleasure, till you know there is no hook beneath it." -Thomas Jefferson


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: circastes]
    #16416430 - 06/21/12 08:55 PM (9 years, 6 months ago)


Schizophrenics are Nature's gifts to human society. Schizophrenics are Nature's way of choosing messengers of truth.


:feelsweirdman:


--------------------
Kupo said:
let's fuel the robots with psilocybin.

cez said:
everyone should smoke dmt for religion.

dustinthewind13 said:
euthanasia and prostitution should be legal and located in the same building.

White Beard said:
if you see the buddha on the road, rape him, then kill him. then rape him again.


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Freedom]
    #16419009 - 06/22/12 07:35 AM (9 years, 6 months ago)

I really like the first link for it's clear description of the process of creating cell factories for the trace amine receptor and then methodically assessing cAMP levels in those cell factories after exposure to various interesting drugs.

what this tells me is that the body has cells that will become activated by certain trace molecules, and that their internal activation (cAMP) can cause them to send out signals for a period of time, or go into a mode that secretes some chemical for a period of time i.e. until the cAMP is back to baseline.

this alternate method of establishing a shift in 'alertness, resonance and reactivity' is very much what we would be looking for with regard to strong reactions to trace quantities of things like LSD, which will not be prevalent in enough locations to produce the serotonin flood that we consider a normal psychedelic brain cell circumstance.

We want to see what cells with the TAAR's do after they have lots of cAMP in them.

in the third link - another example of good scientific work - there was a useful exclusion of cerebellar and olfactory response noted (based upon absence of labelled LacZ expression(mRNA)) indicating that these tissues keep a stable behavior even when other parts of the brain (eg cerebrum) are in an altered state.

The focus was on TAAR1 - especially responsive to Amphetamine, and the linkage to Dopamine production was supportive of other findings for the class of drugs examined.

For me that is another clincher that they are on the right tack.

(the good articles seem to stay clear of any claims of significance to endogenous DMT or other nearly religious claims about 'the spirit molecule' (specifically), though there is much to do about traces of endogenous p-tyramine, β-phenylethylamine, octopamine, and tryptamine which are endogenous amine compounds)

For those that wish to say that schizophrenics are born not made, this is also a bit supportive - however, we need to keep clear on the matter that being high is not being sick or nuts, and that being a soft head, or easy high type person does not mean you are going to be schizophrenic. Other factors are always at play.


thanks for the intense morning read


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Jwlst]
    #16425074 - 06/23/12 12:49 PM (9 years, 6 months ago)

Dude just because your white does not mean you are not An authentic shaman. Shamans exist in all corners of the earth. The authentic shaman sees no meaning in the word shaman though.


--------------------
Orgone Conclusion...Bringing OTD to PS&P since 2007.


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Re: linkage between the use of Psilocybin Mushrooms and development of Schizophrenia and other illnesses [Re: Cactilove]
    #16432763 - 06/24/12 10:20 PM (9 years, 6 months ago)

Hook, line and sinker :haha:


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