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North Spore Shop: Bulk Substrate

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Invisibledurian_2008
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Registered: 04/02/08
Posts: 17,096
Loc: Raccoon City
MAOI question
    #13751524 - 01/08/11 10:36 AM (13 years, 1 month ago)

How long does this effect normally last?


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OfflineOpenQwerty
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Registered: 08/05/10
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Re: MAOI question [Re: durian_2008]
    #13753082 - 01/08/11 03:33 PM (13 years, 1 month ago)

Which MAOI ? There are different types of MAOI. From Wikipedia (http://en.wikipedia.org/wiki/MAOI):

“[....]The early MAOIs inhibited monoamine oxidase irreversibly. When they react with monoamine oxidase, they permanently deactivate it, and the enzyme cannot function until it has been replaced by the body, which can take about two weeks. A few newer MAOIs, notably moclobemide, are reversible, meaning that they are able to detach from the enzyme to facilitate usual catabolism of the substrate. The level of inhibition in this way is governed by the concentrations of the substrate and the MAOI.
Harmaline found in Peganum harmala, as well as the Ayahuasca vine, Banisteriopsis caapi and tobacco is a reversible inhibitor of MAO-A .

In addition to reversibility, MAOIs differ by their selectivity of the MAO receptor. Some MAOIs inhibit both MAO-A and MAO-B equally, other MAOIs have been developed to target one over the other.[....]”

I guess you want to know the duration of the effects of Harmine and Harmaline. Both  belong to the group of  B-carbolines. About  B-carbolines I found this  in “Pharmahuasca: On Phenethylamines and Potentiation”:  (  http://www.maps.org/news-letters/v06n3/06332ott.html ) :
“[....] There are gross differences in dose regimen, toxicity and pharmacodynamics of B-carbolines, as opposed to medicinal MAOI like Marplan - the latter are potent, generally irreversible inhibitors (that is, they bind irreversibly to MAO molecules, thus destroying them) which are ingested daily over lengthy periods, taking from a few days to a few months to exert their maximum effect, which may persist for a like time even after cessation of daily ingestion. In other words, their use involves a chronic, full-scale alteration of biochemistry, not just of the serotonin system. In the case of the B-carbolines, these are reversible MAOI (that is, they compete with normal substrates for active sites on the enzyme molecules, but do not bind to them permanently) taken in single doses, with a transient effect, estimated by Callaway to last only "for several hours" [MAPS BULLETIN IV(2): 31, 1993].[....]”
I hope this answers your question.


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Invisibledurian_2008
Cornucopian Eating an Elephant
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Registered: 04/02/08
Posts: 17,096
Loc: Raccoon City
Re: MAOI question [Re: OpenQwerty]
    #13753297 - 01/08/11 04:13 PM (13 years, 1 month ago)

Tobacco. Just being extra careful, but don't want to get exposed to rustica before going to the doctor. 

Trying to find someone in so Cal to help me remove a few plants.


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North Spore Shop: Bulk Substrate


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